Toxin Reviews最新文献_第10页

Pollution assessment and estimation of the percentages of toxic elements to be removed to make polluted drinking water safe: a case from Nigeria 为使受污染的饮用水安全而需清除的有毒元素百分比的污染评估和估计:来自尼日利亚的一个案例

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-17 DOI: 10.1080/15569543.2021.2025401

J. C. Egbueri, Daniel A. Ayejoto, J. C. Agbasi

引用次数: 20

Acrylamide in foods: from regulation and registered levels to chromatographic analysis, nutritional relevance, exposure, mitigation approaches, and health effects 食品中的丙烯酰胺：从法规和注册水平到色谱分析、营养相关性、暴露、缓解方法和健康影响

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-11 DOI: 10.1080/15569543.2021.2018611

Mónica Quesada-Valverde, Graciela Artavia, F. Granados-Chinchilla, Carolina Cortés-Herrera

{"title":"Acrylamide in foods: from regulation and registered levels to chromatographic analysis, nutritional relevance, exposure, mitigation approaches, and health effects","authors":"Mónica Quesada-Valverde, Graciela Artavia, F. Granados-Chinchilla, Carolina Cortés-Herrera","doi":"10.1080/15569543.2021.2018611","DOIUrl":"https://doi.org/10.1080/15569543.2021.2018611","url":null,"abstract":"Abstract Herein we explore the latest research on a chemical compound resulting from food processing and during the Maillard reaction: Acrylamide (ACR). ACR is formed during high-temperature cooking processes (i.e. >120 °C), such as frying, roasting, and baking. Considering the relevance of ACR in the food industry, first, we briefly explored the nature of ACR and its mechanisms of formation and current available legislative framework (with especial emphasis on baked goods and cereals, potato-based products, and coffee). Special attention was given to which foods are more likely to contain considerable amounts of ACR and the particulars of chromatographic methodologies involved in its testing (including extraction). Additionally, health effects caused by ACR were addressed that include an introduction to eukaryotic and prokaryotic ACR metabolism, biotransformation, and fate. Risk assessment, including a margin of exposure (MOE) and tolerance levels for ACR, was highlighted. Finally, we concluded our review with a section regarding methods and strategies available to reduce ACR in foods; this includes the role of asparagine (Asn), operation units available to industry, and the addition of natural products. ACR is still a relevant compound regarding food safety, and still, research is ongoing to develop methods for accurate surveillance and strategies for quenching its formation at the processing stage.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"41 1","pages":"1343 - 1373"},"PeriodicalIF":3.1,"publicationDate":"2022-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49388024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Polycyclic aromatic hydrocarbons in soil situated around solid waste dumpsite in Awka, Nigeria 尼日利亚奥卡市固体废物倾倒场周围土壤中的多环芳烃

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-06 DOI: 10.1080/15569543.2021.2022700

C. Aralu, P. Okoye, K. Akpomie, H. O. Chukwuemeka-Okorie, H. O. Abugu

{"title":"Polycyclic aromatic hydrocarbons in soil situated around solid waste dumpsite in Awka, Nigeria","authors":"C. Aralu, P. Okoye, K. Akpomie, H. O. Chukwuemeka-Okorie, H. O. Abugu","doi":"10.1080/15569543.2021.2022700","DOIUrl":"https://doi.org/10.1080/15569543.2021.2022700","url":null,"abstract":"Abstract Polycyclic aromatic hydrocarbons (PAHs) are common contaminants in the environment that can threaten the populace living close to contaminated soil. Soil samples were collected from the study and control areas which were analyzed for PAHs using Gas chromatography. The detected PAHs concentrations varied from ND to 6.83 ± 10.58 µg/kg for the study sample and ND − 3.23 ± 4.72 µg/kg for the control sample for the wet season. The study sample dry season concentration values of PAHs ranged from ND to 4.73 ± 5.69 µg/kg and varied from ND to 3.67 ± 5.49 µg/kg for the control sample in the dry season. The study sample ( PAHs) values were significantly higher than the control location in both seasons. The detected 2–3 ringed PAHs values were higher than the 4–6 ringed PAHs for both locations and seasons. The ratios of the molecular groups indicated that the PAHs were delivered to the soil from pyrolytic and petrogenic sources. The values of the cancer risks for adults and children ranged from 1.02 − 5.68 to 2.27 − 4.3 for dermal and ingestion pathways respectively which makes cancer risks unlikely for both age categories in both locations.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"42 1","pages":"122 - 131"},"PeriodicalIF":3.1,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44204306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

New insights about scorpion venom hyaluronidase; isoforms, expression and phylogeny 蝎毒透明质酸酶研究进展；异构体、表达与系统发育

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-06 DOI: 10.1080/15569543.2021.2018613

F. Salabi, H. Jafari

{"title":"New insights about scorpion venom hyaluronidase; isoforms, expression and phylogeny","authors":"F. Salabi, H. Jafari","doi":"10.1080/15569543.2021.2018613","DOIUrl":"https://doi.org/10.1080/15569543.2021.2018613","url":null,"abstract":"Abstract Venom hyaluronidase is an enzyme belonging to the glycoside hydrolase family that plays a critical role in systemic envenomation by spreading toxins in tissue and destruction of the extracellular matrix. The roles of venom hyaluronidase during envenomation have been widely studied, but the identification of its variants and isoforms is still under investigation. In this study, we developed a filtering method to identify the exon-intron pattern, alternative splicing events and isoforms of hyaluronidase in A. crassicauda and H. lepturus scorpions using the RNA-seq technique. Furthermore, in silico analysis was performed to identify and characterize the hyaluronidases. The most important findings were that the scorpion hyaluronidase gene contains 5 exons, 4 introns and undergo to alternative splicing events. In A. crassicauda and H. lepturus datasets, a sequence denominated AcHase-1 and three denominated HLHase1, HLHase2 and HLHase3 were identified as hyaluronidase variants respectively, which were found to have multiple isoforms that differed in the coding, non-coding or untranslated regions. The results showed that exon skipping, intron retention and alternative 3' splice site led to dysregulation of gene expression. To clarify the evolutionary history of scorpions based on hyaluronidase molecular phylogenetic studies, we used the phylogenetic tree to deduce the origins of this protein in different species of scorpions, spiders and bees. Hyaluronidase gene performed well for divergences and accurately separated closely related species. Our work provides insights into the diversity of Hase proteins during scorpion evolution and may direct further studies consisting of synthesis, purification and recombinant production of Hase proteins.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"42 1","pages":"69 - 84"},"PeriodicalIF":3.1,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48395782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Exploring the potent inhibitor β-stigmasterol from Pittosporum dasycaulon Miq. leaves against snake venom phospholipase A2 protein through in vitro and molecular dynamics behavior approach 海桐中有效抑制剂β-豆甾醇的研究。叶片抗蛇毒磷脂酶A2蛋白的体外及分子动力学行为研究

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-05 DOI: 10.1080/15569543.2021.2021946

Riyas Chakkinga Thodi, Junaida M. Ibrahim, A. Nair, Swapna Thacheril Sukumaran

{"title":"Exploring the potent inhibitor β-stigmasterol from Pittosporum dasycaulon Miq. leaves against snake venom phospholipase A2 protein through in vitro and molecular dynamics behavior approach","authors":"Riyas Chakkinga Thodi, Junaida M. Ibrahim, A. Nair, Swapna Thacheril Sukumaran","doi":"10.1080/15569543.2021.2021946","DOIUrl":"https://doi.org/10.1080/15569543.2021.2021946","url":null,"abstract":"Abstract β-Stigmasterol, responsible for antivenom activity against abundant PLA2 protein of Viper (Daboia russelii) and Cobra (Naja naja) venom, was identified, characterized, and isolated from Pittosporum dasycaulon leaves extract. The compound purity was checked by RP-HPLC analysis, and structure was elucidated by FTIR and NMR analysis, followed by in-vitro as well as in-silico studies. The structural stability of the docked complexes was evaluated by molecular dynamic simulation, and the binding free energies were calculated by MM-PBSA analysis. The in-vitro analysis revealed that the isolated compound β-SS is effective against D. russelii PLA2 (IC50 40.903 ± 0.479 μg/mL) than N. naja venom PLA2 (42.340 ± 0.11 μg/mL). The in-silico approaches helps to conclude that the β-SS-PLA2 D. russelii complex showed a stable conformation with a reduced degree of flexibility throughout the dynamics simulation time period with high-affinity docking energy −10.60 kcal/mol than β-SS-PLA2 N. naja complex, which observed docking energy of −10.39 kcal/mol.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"42 1","pages":"85 - 98"},"PeriodicalIF":3.1,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44314728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

‎‎Lethality and effects on biological and population growth parameters of ladybird predator Hippodamia variegata (Goeze) treated by some plant essential oils 几种植物精油对瓢虫捕食者斑姬瓢虫(Hippodamia variegata, Goeze)的致死性及生物学和种群生长参数的影响

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-03 DOI: 10.1080/15569543.2021.2018612

Saeed Shaltoki, Hooshang Rafiee Dastjerdi, A. Golizadeh, M. Hassanpour, A. Ebadollahi, V. Mahdavi

引用次数: 3

Correction 修正

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-02 DOI: 10.1080/15569543.2022.2029167

引用次数: 0

Environmentally occurring aflatoxins B1 and M1 notifyably harms pancreatic islets 环境中产生的黄曲霉毒素B1和M1明显损害胰岛

IF 3.1 4区医学

Toxin Reviews Pub Date : 2021-12-27 DOI: 10.1080/15569543.2021.2010758

J. Mehrzad, T. Zahraei Salehi, A. Khosravi, S. Hosseinkhani, Yaser Tahamtani, Ensiyeh Hajizadeh-Saffar, M. Moazenchi, A. Malvandi

引用次数: 2

Sub-lethal effects of thiamethoxam on Apis mellifera Linnaeus 噻虫嗪对蜜蜂的亚致死作用

IF 3.1 4区医学

Toxin Reviews Pub Date : 2021-12-26 DOI: 10.1080/15569543.2021.1958868

A. Choudhary, Bharathi Mohindru, A. K. Karedla, Jaspal Singh, P. Chhuneja

{"title":"Sub-lethal effects of thiamethoxam on Apis mellifera Linnaeus","authors":"A. Choudhary, Bharathi Mohindru, A. K. Karedla, Jaspal Singh, P. Chhuneja","doi":"10.1080/15569543.2021.1958868","DOIUrl":"https://doi.org/10.1080/15569543.2021.1958868","url":null,"abstract":"Abstract Bees are the important natural resources, play a crucial role in maintaining diversity and sustaining food security. In the past couple of years, these tiny animals are facing problems due to various factors like climate change, loss of habitat, loss of bee pasturage, reduced immunity, pesticide poisoning, etc. Among these, the insecticides, particularly the ones belonging to the class neonicotinoids have been blamed worldwide. Thiamethoxam is the one among various insecticides in this group. It is a systemic insecticide whose residues have been reported to contaminate the nectar and pollen. Since it has been classified as a highly toxic insecticide to bees, several cases of acute toxicity to adult bees have been reported. Besides this, sub-lethal doses have also been reported to cause negative effects on workers, queen bee, and drones. Some of the negative effects on important physiological or behavioral processes are reduced brood development, altered locomotion, incapability in maintaining thorax temperature, sensitivity to sucrose, effect on olfactory learning and foraging, etc. At the same time, the effects on the reproductive capacity of the colony due to the negative effects on queen bee and drone have also been observed. The work has also been carried out to find the basis, at the molecular level, governing such effects. Since there are several negative effects even due to the sub-lethal doses of thiamethoxam, it becomes imperative to sum up all the generated knowledge on this topic. Hence, the present review has been prepared which will provide critical information to the various stakeholders who may use the information to safeguard the bees/apiaries in a better way.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"41 1","pages":"1044 - 1057"},"PeriodicalIF":3.1,"publicationDate":"2021-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43982930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycotoxins and mycotoxigenic fungi in aquaculture and seafood: a review and new perspective 水产养殖和海产品中的真菌毒素和产毒真菌:综述和新展望

IF 3.1 4区医学

Toxin Reviews Pub Date : 2021-12-14 DOI: 10.1080/15569543.2021.2010759

Adel Mirza Alizadeh, Amin Mousavi Khaneghah, H. Hosseini

{"title":"Mycotoxins and mycotoxigenic fungi in aquaculture and seafood: a review and new perspective","authors":"Adel Mirza Alizadeh, Amin Mousavi Khaneghah, H. Hosseini","doi":"10.1080/15569543.2021.2010759","DOIUrl":"https://doi.org/10.1080/15569543.2021.2010759","url":null,"abstract":"Abstract Food contamination with mycotoxins has now become a serious global food safety issue. Mycotoxins can harm human and animal health if consumed through contaminated feed and food, in addition to creating economic losses in the food industry. Mycotoxins in aquatic environments have been a substantial cause of concern for both animals and humans in recent years. It is critical for humans to identify the quantities of these contaminants in aquatic food products due to their widespread consumption. Until yet, only a few investigations have been conducted to assess the extent of these toxicants in various marine species and their foodstuffs. The amount of contamination with mycotoxigenic fungus and the quantities of various kinds of mycotoxins in the edible tissues of raw and processed seafood were assessed in this review research. According to the research results, the most common species in infected seafood are Aspergillus sp. and Penicillium sp. Additionally, seafood contains varying levels of mycotoxins, including AFs, ENs, DON, ZEA, and OTA, all of which are hazardous to human health. Highlights Mycotoxigenic fungi can grow on fresh and undesirable processed seafood. One of the most acute risks of seafood consumption is exposure to mycotoxins. Aspergillus sp. and Penicillium sp. are the predominant species in contaminated seafood. Mycotoxins including AFs, ENs, DON, ZEA, and OTA can be found in seafood.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"41 1","pages":"1058 - 1065"},"PeriodicalIF":3.1,"publicationDate":"2021-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48001438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4