Toxin Reviews最新文献_第10页

New insights about scorpion venom hyaluronidase; isoforms, expression and phylogeny 蝎毒透明质酸酶研究进展；异构体、表达与系统发育

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-06 DOI: 10.1080/15569543.2021.2018613

F. Salabi, H. Jafari

{"title":"New insights about scorpion venom hyaluronidase; isoforms, expression and phylogeny","authors":"F. Salabi, H. Jafari","doi":"10.1080/15569543.2021.2018613","DOIUrl":"https://doi.org/10.1080/15569543.2021.2018613","url":null,"abstract":"Abstract Venom hyaluronidase is an enzyme belonging to the glycoside hydrolase family that plays a critical role in systemic envenomation by spreading toxins in tissue and destruction of the extracellular matrix. The roles of venom hyaluronidase during envenomation have been widely studied, but the identification of its variants and isoforms is still under investigation. In this study, we developed a filtering method to identify the exon-intron pattern, alternative splicing events and isoforms of hyaluronidase in A. crassicauda and H. lepturus scorpions using the RNA-seq technique. Furthermore, in silico analysis was performed to identify and characterize the hyaluronidases. The most important findings were that the scorpion hyaluronidase gene contains 5 exons, 4 introns and undergo to alternative splicing events. In A. crassicauda and H. lepturus datasets, a sequence denominated AcHase-1 and three denominated HLHase1, HLHase2 and HLHase3 were identified as hyaluronidase variants respectively, which were found to have multiple isoforms that differed in the coding, non-coding or untranslated regions. The results showed that exon skipping, intron retention and alternative 3' splice site led to dysregulation of gene expression. To clarify the evolutionary history of scorpions based on hyaluronidase molecular phylogenetic studies, we used the phylogenetic tree to deduce the origins of this protein in different species of scorpions, spiders and bees. Hyaluronidase gene performed well for divergences and accurately separated closely related species. Our work provides insights into the diversity of Hase proteins during scorpion evolution and may direct further studies consisting of synthesis, purification and recombinant production of Hase proteins.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"42 1","pages":"69 - 84"},"PeriodicalIF":3.1,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48395782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Exploring the potent inhibitor β-stigmasterol from Pittosporum dasycaulon Miq. leaves against snake venom phospholipase A2 protein through in vitro and molecular dynamics behavior approach 海桐中有效抑制剂β-豆甾醇的研究。叶片抗蛇毒磷脂酶A2蛋白的体外及分子动力学行为研究

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-05 DOI: 10.1080/15569543.2021.2021946

Riyas Chakkinga Thodi, Junaida M. Ibrahim, A. Nair, Swapna Thacheril Sukumaran

{"title":"Exploring the potent inhibitor β-stigmasterol from Pittosporum dasycaulon Miq. leaves against snake venom phospholipase A2 protein through in vitro and molecular dynamics behavior approach","authors":"Riyas Chakkinga Thodi, Junaida M. Ibrahim, A. Nair, Swapna Thacheril Sukumaran","doi":"10.1080/15569543.2021.2021946","DOIUrl":"https://doi.org/10.1080/15569543.2021.2021946","url":null,"abstract":"Abstract β-Stigmasterol, responsible for antivenom activity against abundant PLA2 protein of Viper (Daboia russelii) and Cobra (Naja naja) venom, was identified, characterized, and isolated from Pittosporum dasycaulon leaves extract. The compound purity was checked by RP-HPLC analysis, and structure was elucidated by FTIR and NMR analysis, followed by in-vitro as well as in-silico studies. The structural stability of the docked complexes was evaluated by molecular dynamic simulation, and the binding free energies were calculated by MM-PBSA analysis. The in-vitro analysis revealed that the isolated compound β-SS is effective against D. russelii PLA2 (IC50 40.903 ± 0.479 μg/mL) than N. naja venom PLA2 (42.340 ± 0.11 μg/mL). The in-silico approaches helps to conclude that the β-SS-PLA2 D. russelii complex showed a stable conformation with a reduced degree of flexibility throughout the dynamics simulation time period with high-affinity docking energy −10.60 kcal/mol than β-SS-PLA2 N. naja complex, which observed docking energy of −10.39 kcal/mol.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"42 1","pages":"85 - 98"},"PeriodicalIF":3.1,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44314728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

‎‎Lethality and effects on biological and population growth parameters of ladybird predator Hippodamia variegata (Goeze) treated by some plant essential oils 几种植物精油对瓢虫捕食者斑姬瓢虫(Hippodamia variegata, Goeze)的致死性及生物学和种群生长参数的影响

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-03 DOI: 10.1080/15569543.2021.2018612

Saeed Shaltoki, Hooshang Rafiee Dastjerdi, A. Golizadeh, M. Hassanpour, A. Ebadollahi, V. Mahdavi

引用次数: 3

Correction 修正

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-02 DOI: 10.1080/15569543.2022.2029167

引用次数: 0

Environmentally occurring aflatoxins B1 and M1 notifyably harms pancreatic islets 环境中产生的黄曲霉毒素B1和M1明显损害胰岛

IF 3.1 4区医学

Toxin Reviews Pub Date : 2021-12-27 DOI: 10.1080/15569543.2021.2010758

J. Mehrzad, T. Zahraei Salehi, A. Khosravi, S. Hosseinkhani, Yaser Tahamtani, Ensiyeh Hajizadeh-Saffar, M. Moazenchi, A. Malvandi

引用次数: 2

Sub-lethal effects of thiamethoxam on Apis mellifera Linnaeus 噻虫嗪对蜜蜂的亚致死作用

IF 3.1 4区医学

Toxin Reviews Pub Date : 2021-12-26 DOI: 10.1080/15569543.2021.1958868

A. Choudhary, Bharathi Mohindru, A. K. Karedla, Jaspal Singh, P. Chhuneja

{"title":"Sub-lethal effects of thiamethoxam on Apis mellifera Linnaeus","authors":"A. Choudhary, Bharathi Mohindru, A. K. Karedla, Jaspal Singh, P. Chhuneja","doi":"10.1080/15569543.2021.1958868","DOIUrl":"https://doi.org/10.1080/15569543.2021.1958868","url":null,"abstract":"Abstract Bees are the important natural resources, play a crucial role in maintaining diversity and sustaining food security. In the past couple of years, these tiny animals are facing problems due to various factors like climate change, loss of habitat, loss of bee pasturage, reduced immunity, pesticide poisoning, etc. Among these, the insecticides, particularly the ones belonging to the class neonicotinoids have been blamed worldwide. Thiamethoxam is the one among various insecticides in this group. It is a systemic insecticide whose residues have been reported to contaminate the nectar and pollen. Since it has been classified as a highly toxic insecticide to bees, several cases of acute toxicity to adult bees have been reported. Besides this, sub-lethal doses have also been reported to cause negative effects on workers, queen bee, and drones. Some of the negative effects on important physiological or behavioral processes are reduced brood development, altered locomotion, incapability in maintaining thorax temperature, sensitivity to sucrose, effect on olfactory learning and foraging, etc. At the same time, the effects on the reproductive capacity of the colony due to the negative effects on queen bee and drone have also been observed. The work has also been carried out to find the basis, at the molecular level, governing such effects. Since there are several negative effects even due to the sub-lethal doses of thiamethoxam, it becomes imperative to sum up all the generated knowledge on this topic. Hence, the present review has been prepared which will provide critical information to the various stakeholders who may use the information to safeguard the bees/apiaries in a better way.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"41 1","pages":"1044 - 1057"},"PeriodicalIF":3.1,"publicationDate":"2021-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43982930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycotoxins and mycotoxigenic fungi in aquaculture and seafood: a review and new perspective 水产养殖和海产品中的真菌毒素和产毒真菌:综述和新展望

IF 3.1 4区医学

Toxin Reviews Pub Date : 2021-12-14 DOI: 10.1080/15569543.2021.2010759

Adel Mirza Alizadeh, Amin Mousavi Khaneghah, H. Hosseini

{"title":"Mycotoxins and mycotoxigenic fungi in aquaculture and seafood: a review and new perspective","authors":"Adel Mirza Alizadeh, Amin Mousavi Khaneghah, H. Hosseini","doi":"10.1080/15569543.2021.2010759","DOIUrl":"https://doi.org/10.1080/15569543.2021.2010759","url":null,"abstract":"Abstract Food contamination with mycotoxins has now become a serious global food safety issue. Mycotoxins can harm human and animal health if consumed through contaminated feed and food, in addition to creating economic losses in the food industry. Mycotoxins in aquatic environments have been a substantial cause of concern for both animals and humans in recent years. It is critical for humans to identify the quantities of these contaminants in aquatic food products due to their widespread consumption. Until yet, only a few investigations have been conducted to assess the extent of these toxicants in various marine species and their foodstuffs. The amount of contamination with mycotoxigenic fungus and the quantities of various kinds of mycotoxins in the edible tissues of raw and processed seafood were assessed in this review research. According to the research results, the most common species in infected seafood are Aspergillus sp. and Penicillium sp. Additionally, seafood contains varying levels of mycotoxins, including AFs, ENs, DON, ZEA, and OTA, all of which are hazardous to human health. Highlights Mycotoxigenic fungi can grow on fresh and undesirable processed seafood. One of the most acute risks of seafood consumption is exposure to mycotoxins. Aspergillus sp. and Penicillium sp. are the predominant species in contaminated seafood. Mycotoxins including AFs, ENs, DON, ZEA, and OTA can be found in seafood.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"41 1","pages":"1058 - 1065"},"PeriodicalIF":3.1,"publicationDate":"2021-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48001438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Cytotoxic, necrotic, apoptotic, and autophagic properties of venom sac extract of Vespa orientalis in T47D and MCF10A breast cell lines 东方黄蜂毒液囊提取物对T47D和MCF10A乳腺细胞株的细胞毒、坏死、凋亡和自噬特性

IF 3.1 4区医学

Toxin Reviews Pub Date : 2021-12-07 DOI: 10.1080/15569543.2021.2007404

Seyed Mohammad-Hossein Shetab-Boushehri, A. Hosseini, J. Rafinejad, Alireza Ebadollahi-Natanzi, S. V. Shetab-Boushehri

引用次数: 2

Role of leptin/STAT3 signaling and RIP-kinases in fucoxanthin influences on mice exposed to LPS and gamma radiation 瘦素/STAT3信号传导和RIP激酶在岩藻毒素对LPS和γ辐射小鼠影响中的作用

IF 3.1 4区医学

Toxin Reviews Pub Date : 2021-12-01 DOI: 10.1080/15569543.2021.2008451

Mohamed K. Abdel-Rafei, N. Thabet, Ghada El Tawel, Nermeen M. El Bakary, N. E. El Fatih, Khaled Sh Azab

引用次数: 0

Synthesis and screening of kojic acid derivatives for their bio-efficacy against diamondback moth (Plutella xylostella L.) 曲酸衍生物的合成及其对小菜蛾生物药效的筛选

IF 3.1 4区医学

Toxin Reviews Pub Date : 2021-11-25 DOI: 10.1080/15569543.2021.1996394

Simmi Sharma, Kajal Kaliya, Nandita Chauhan, Shudh Kirti Dolma, S. Reddy, S. Maurya

引用次数: 0