瘦素/STAT3信号传导和RIP激酶在岩藻毒素对LPS和γ辐射小鼠影响中的作用

IF 3.3 4区医学 Q2 TOXICOLOGY

Toxin Reviews Pub Date : 2021-12-01 DOI:10.1080/15569543.2021.2008451

Mohamed K. Abdel-Rafei, N. Thabet, Ghada El Tawel, Nermeen M. El Bakary, N. E. El Fatih, Khaled Sh Azab

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引用次数: 0

摘要

由于全身炎症反应引起的高死亡率，内毒素血症仍然是一个关键的临床难题，这往往导致严重的肝损伤和免疫失调。本研究旨在探讨岩藻黄素(FX)和γ-辐射(IR)对lps诱导的脾、肝损伤的调节作用。LPS致敏小鼠表现为脾脏和肝脏TLR4/NF-κ b -信号通路增强，脾脏α- 7nachr表达抑制，肝脏RIPK/HMGB-1信号通路激活，肝瘦素/STAT-3信号通路受损，广泛的氧化应激，严重退行性组织病理学检查显示明显凋亡。FX和/或IR保护肝脏和脾脏免受LPS引起的有害影响。总的来说，FX和/或IR对内毒素血症具有保护作用。图形抽象

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Role of leptin/STAT3 signaling and RIP-kinases in fucoxanthin influences on mice exposed to LPS and gamma radiation

Abstract Endotoxemia remains a critical clinical dilemma due to high mortality rate provoked by the systemic inflammatory response, which often leads to sever hepatic injury and immune dysregulation. This study aimed at delineating the modulatory effect of fucoxanthin (FX) and γ-radiation (IR) on LPS-induced spleen and liver injury. LPS sensitized mice showed enhanced splenic and hepatic TLR4/NF-κB- signaling, suppressed splenic α-7nAchR-expression, activated hepatic RIPK/HMGB-1, impaired hepatic leptin/STAT-3 signaling, extensive oxidative stress, and marked apoptosis with sever degenerative histopathological examination. FX and/or IR protected liver and spleen against detrimental effects evoked by LPS. Overall, FX and/or IR exhibited protective effect against endotoxemia. Graphical Abstract

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来源期刊

Toxin Reviews 医学-毒理学

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Toxin Reviews provides an international forum for publishing state-of-the-art reviews and guest-edited single topic special issues covering the multidisciplinary research in the area of toxins derived from animals, plants and microorganisms. Our aim is to publish reviews that are of broad interest and importance to the toxinology as well as other life science communities. Toxin Reviews aims to encourage scientists to highlight the contribution of toxins as research tools in deciphering molecular and cellular mechanisms, and as prototypes of therapeutic agents. Reviews should emphasize the role of toxins in enhancing our fundamental understanding of life sciences, protein chemistry, structural biology, pharmacology, clinical toxinology and evolution. Prominence will be given to reviews that propose new ideas or approaches and further the knowledge of toxinology.