东方黄蜂毒液囊提取物对T47D和MCF10A乳腺细胞株的细胞毒、坏死、凋亡和自噬特性

IF 3.3 4区医学 Q2 TOXICOLOGY

Toxin Reviews Pub Date : 2021-12-07 DOI:10.1080/15569543.2021.2007404

Seyed Mohammad-Hossein Shetab-Boushehri, A. Hosseini, J. Rafinejad, Alireza Ebadollahi-Natanzi, S. V. Shetab-Boushehri

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引用次数: 2

摘要

摘要蜜蜂（Apis mellifera）被归类于蜂科，而黄蜂和大黄蜂则被归类于胡蜂科。本工作研究并测量了东方胡蜂毒囊提取物（VSE）对T47D（癌性）和MCF10A（正常）乳腺细胞系的细胞毒性、坏死、凋亡和自噬作用。结果表明，在一定浓度下，东方大黄蜂的VSE对两种细胞系都表现出比凋亡和自噬更强的坏死作用。他们还表明，东方大黄蜂VSE的坏死、凋亡和自噬作用在T47D上比MCF10A细胞更显著。此外，VSE对东方大黄蜂的坏死作用比其凋亡和自噬作用更强。结果还表明，东方大黄蜂的VSE比MCF10A（正常）细胞更快地杀死T47D（癌）细胞。

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Cytotoxic, necrotic, apoptotic, and autophagic properties of venom sac extract of Vespa orientalis in T47D and MCF10A breast cell lines

Abstract Honey bee, Apis mellifera, is classified in the Apidae family while wasps and hornets are classified in the Vespidae family. The present work has investigated and measured cytotoxic, necrotic, apoptotic, and autophagic effects of venom sac extract (VSE) of Vespa orientalis hornet on T47D (cancerous) and MCF10A (normal) breast cell lines. The results showed that the VSE of oriental hornet displays a stronger necrotic effect than apoptotic and autophagic effects in a given concentration on both cell lines. They also indicated that necrotic, apoptotic, and autophagic effects of VSE of oriental hornets are more prominent on T47D than MCF10A cells. Moreover, the necrotic effect of VSE on oriental hornets is more potent than its apoptotic and autophagic effects. The results also showed that the VSE of oriental hornets kills T47D (cancerous) cells more rapidly than MCF10A (normal) cells.

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来源期刊

Toxin Reviews 医学-毒理学

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Toxin Reviews provides an international forum for publishing state-of-the-art reviews and guest-edited single topic special issues covering the multidisciplinary research in the area of toxins derived from animals, plants and microorganisms. Our aim is to publish reviews that are of broad interest and importance to the toxinology as well as other life science communities. Toxin Reviews aims to encourage scientists to highlight the contribution of toxins as research tools in deciphering molecular and cellular mechanisms, and as prototypes of therapeutic agents. Reviews should emphasize the role of toxins in enhancing our fundamental understanding of life sciences, protein chemistry, structural biology, pharmacology, clinical toxinology and evolution. Prominence will be given to reviews that propose new ideas or approaches and further the knowledge of toxinology.