曲酸衍生物的合成及其对小菜蛾生物药效的筛选

IF 3.3 4区医学 Q2 TOXICOLOGY

Toxin Reviews Pub Date : 2021-11-25 DOI:10.1080/15569543.2021.1996394

Simmi Sharma, Kajal Kaliya, Nandita Chauhan, Shudh Kirti Dolma, S. Reddy, S. Maurya

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引用次数: 0

摘要

摘要合成了含有尿素和硫脲键的曲酸衍生物，并在实验室条件下对小菜蛾二龄幼虫进行了实验研究。多数化合物对小菜蛾二龄幼虫的死亡率≥50%。化合物3b在处理96 h后对小菜蛾有较好的防治效果(在10000 ppm下死亡率为83.3%)。其他具有显著死亡率的化合物为4h, 4j (10,000 ppm下死亡率为80%)和3c, 4c, 4m (10,000 ppm下死亡率为76.6%)。在所合成的化合物库中，最有前途的化合物可能是进一步开发以获得铅分子的候选化合物。

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Synthesis and screening of kojic acid derivatives for their bio-efficacy against diamondback moth (Plutella xylostella L.)

Abstract Kojic acid derivatives containing urea and thiourea linkage has been synthesized and tested against second instar larvae of diamondback moth (Plutella xylostella) under laboratory conditions. Most of the compounds showed ≥ 50% mortality against second instar larvae of P. xylostella. Compound 3b was found more effective against P. xylostella (83.3% mortality at 10,000 ppm) after 96 h of treatment. Other compounds with significant mortality were 4h, 4j (80% mortality at 10,000 ppm), and 3c, 4c, 4m (76.6% mortality at 10,000 ppm). The most promising compounds among the synthesized library could be candidates for further development to obtain lead molecules.

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来源期刊

Toxin Reviews 医学-毒理学

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Toxin Reviews provides an international forum for publishing state-of-the-art reviews and guest-edited single topic special issues covering the multidisciplinary research in the area of toxins derived from animals, plants and microorganisms. Our aim is to publish reviews that are of broad interest and importance to the toxinology as well as other life science communities. Toxin Reviews aims to encourage scientists to highlight the contribution of toxins as research tools in deciphering molecular and cellular mechanisms, and as prototypes of therapeutic agents. Reviews should emphasize the role of toxins in enhancing our fundamental understanding of life sciences, protein chemistry, structural biology, pharmacology, clinical toxinology and evolution. Prominence will be given to reviews that propose new ideas or approaches and further the knowledge of toxinology.