Tobacco Induced Diseases最新文献

{"title":"Association between urinary NNAL concentrations and osteoarthritis: Evidence from NHANES 2007-2012.","authors":"Jun Liu, Jihong Zhang, Zhou Guo, Zhipeng Wang, Song Zhou, Junming Huang","doi":"10.18332/tid/236205","DOIUrl":"10.18332/tid/236205","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoarthritis (OA) is the most prevalent degenerative joint disorder globally, yet the impact of smoking on its development remains contentious. The compound 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a principal metabolite of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is a well-recognized biomarker for smoking exposure. This study aimed to use urinary NNAL as a biomarker to evaluate the association between tobacco exposure and OA.</p><p><strong>Methods: </strong>This study was a secondary cross-sectional analysis of pooled data from the 2007-2012 cycles of the National Health and Nutrition Examination Survey (NHANES), including 10848 adults. OA was assessed using self-reported physician diagnosis and radiographic examination, with a Kellgren-Lawrence grade ≥2 indicating radiographic OA; urinary NNAL concentration was used as the biomarker of tobacco exposure. Survey-weighted multivariable logistic regression analysis and subgroup analyses were performed after adjusting for confounding factors.</p><p><strong>Results: </strong>Elevated urinary NNAL concentrations were positively associated with greater odds of OA. In the fully adjusted model, urinary NNAL concentrations >0.077925 ng/mL were associated with greater odds of OA (adjusted odds ratio, AOR=1.55; 95% CI: 1.36-1.76). Evidence of interaction was observed for age (p for interaction <0.001), but not for sex (p=0.231) or BMI (p=0.127). Among adults aged <60 years, the AOR for the highest versus lowest NNAL category was 1.69 (95% CI: 1.46-1.95), whereas the corresponding AOR was 0.98 (95% CI: 0.82-1.17) among adults aged ≥60 years.</p><p><strong>Conclusions: </strong>Higher urinary NNAL was associated with an increased likelihood of OA, with more prominent effects observed in middle-aged adults. Given the cross-sectional design, temporality and causality cannot be established, and the potential association requires confirmation in longitudinal and mechanistic studies.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13602397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E-cigarette use among university students in Vietnam following the 2025 e-cigarette ban policy: A multicity cross-sectional survey.","authors":"Thi Thanh Huong Le, Bich Thao Nguyen Thi, Xuan Quy Luu, Anh Quynh Nguyen, Thi Thu Trang Phan, Thi Hoa Mai Tran, Hoang Minh Dao Le, Thi Thu Huyen Doan, Minh Tan Luong","doi":"10.18332/tid/231598","DOIUrl":"10.18332/tid/231598","url":null,"abstract":"<p><strong>Introduction: </strong>Electronic cigarette (e-cigarette, EC) use is a growing public health concern among young people worldwide. In Vietnam, Resolution No. 173/2024/QH15 prohibited e-cigarettes and heated tobacco products from January 2025. However, evidence on EC use among university students after implementation of this policy remains limited. This study assessed the prevalence of EC use and associated factors among Vietnamese university students in the post-ban period.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 2462 students recruited using a multi-stage cluster sampling approach from universities in Hanoi, Hue, Da Nang, and Ho Chi Minh City representing major urban regions, between October and December 2025. Data were collected using a structured self-administered questionnaire. Multivariable logistic regression, adjusted for sociodemographic and social/behavioral covariates, was performed to identify factors associated with e-cigarette use.</p><p><strong>Results: </strong>The mean age of the study participants was 19.5 years (SD=1.3). The prevalence of ever use (defined as former and current use) and current e-cigarette use was 17.7% and 3.3%, respectively. Female students were less likely than males to report ever use (adjusted odds ratio, AOR=0.70; 95% CI: 0.51-0.96) and current use (AOR=0.30; 95% CI: 0.13-0.72). Ever e-cigarette use was associated with peer use of e-cigarettes or heated tobacco products (AOR=3.17; 95% CI: 2.40-4.19), conventional cigarette smoking (AOR=21.00; 95% CI: 15.74-28.04), and exposure to e-cigarette advertising (AOR=1.36; 95% CI: 1.03-1.79). Current use was associated with family member use (AOR=2.62; 95% CI: 1.17-5.87), peer use (AOR=3.35; 95% CI: 1.92-5.87), conventional cigarette smoking (AOR=14.83; 95% CI: 7.91-27.83), and exposure to e-cigarette advertising (AOR=2.49; 95% CI: 1.47-4.21).</p><p><strong>Conclusions: </strong>Although current e-cigarette use was lower than levels reported in several pre-ban university studies, use remains. Male students, conventional cigarette smokers, students with peers or family members using ECs or heated tobacco products, and those exposed to advertising were more likely to report use. Continued surveillance and further longitudinal studies are needed to monitor EC use trends and to evaluate the long-term impact of the ban among Vietnamese university students.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13602399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of combined smoking and drinking with subjective and objective olfactory dysfunction: A secondary dataset analysis of NHANES 2013-2014.","authors":"Lu He, Jianhong Wang, Yuansheng Rao, Fan Yang","doi":"10.18332/tid/235830","DOIUrl":"10.18332/tid/235830","url":null,"abstract":"<p><strong>Introduction: </strong>The association between smoking, alcohol consumption, and olfactory dysfunction (OD) remains inconclusive, and few studies have simultaneously examined their relationships with both subjective and objective OD in large population-based samples. This study aimed to investigate the associations of different smoking and drinking statuses with subjective and objective OD among US adults aged ≥40 years.</p><p><strong>Methods: </strong>This secondary dataset analysis of NHANES 2013-2014 included 3376 adults aged ≥40 years who completed the chemosensory questionnaire, smoking and alcohol use questionnaires, and the odor identification test. Subjective OD was based on self-reported olfactory impairments from the NHANES chemosensory questionnaire, and objective OD was assessed using an 8-item odor identification test (score 0-5 indicating impairment). Smoking status was classified based on smoking index, serum cotinine, and time to first cigarette; heavy drinking was defined based on daily drinking habits during any period in life. Multivariable logistic regression models adjusted for demographic factors and OD-related risk factors.</p><p><strong>Results: </strong>The prevalence of subjective and objective OD was 20.3% and 18.3%, respectively. For subjective OD, significantly elevated adjusted odds were observed for chronic smoker (AOR=1.47; 95% CI: 1.12-1.93), chronic active smoker (AOR=1.55; 95% CI: 1.16-2.08), high dependent active smoker (AOR=1.69; 95% CI: 1.19-2.40), chronic smoker-heavy drinker (AOR=1.72; 95%CI: 1.14-2.60), and active smoker-heavy drinker (AOR=1.90; 95% CI: 1.25-2.88). For objective OD, significantly higher adjusted odds were found for chronic smoker (AOR=1.64; 95% CI: 1.26-2.12), chronic active smoker (AOR=1.59; 95% CI: 1.10-2.32), high dependent smoker-heavy drinker (AOR=2.69; 95% CI: 1.36-5.34), and chronic smoker-heavy drinker (AOR=1.67; 95% CI: 1.12-2.50).</p><p><strong>Conclusions: </strong>Chronic smoking and heavy drinking, particularly in combination, are significantly associated with both subjective and objective OD in US adults aged ≥40 years. These findings suggest that smoking and heavy alcohol use may represent modifiable risk factors for olfactory impairment. Further longitudinal studies are warranted to confirm these associations and explore underlying mechanisms.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13595438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cigarette, e-cigarette and dual use among Malaysian adolescents: A secondary analysis of the 2017 and 2022 adolescent health surveys.","authors":"Kuang Kuay Lim, Maznieda Mahjom, S Maria Awaluddin, Noor Syaqilah Shawaluddin, Ying Ying Chan, Hamizatul Akmal Abd Hamid, Hui Li Lim, Kee Chee Cheong, Kuang Hock Lim","doi":"10.18332/tid/226883","DOIUrl":"10.18332/tid/226883","url":null,"abstract":"<p><strong>Introduction: </strong>Tobacco usage continues to pose a considerable public health challenge in Malaysia, with a predominant number of smokers initiating use during adolescence. The rapid increase of alternative nicotine products, especially e-cigarettes, has changed tobacco consumption trends among adolescents. This study examined changes in the prevalence of cigarette, e-cigarette, and dual use among Malaysian adolescents between 2017 and 2022.</p><p><strong>Methods: </strong>This was a secondary analysis of cross-sectional data from the National Health and Morbidity Survey (NHMS) 2017 and 2022 Adolescent Health Survey (AHS), which employed a consistent multistage, stratified, cluster sampling design. Data were collected via self-administered questionnaires. Primary outcomes were past 30-day cigarette-only use, e-cigarette-only use, and dual use of both products. Weighted prevalence estimates and multivariable logistic regression analyses were applied to identify associated factors.</p><p><strong>Results: </strong>The survey achieved response rates of 89.0% in both 2017 and 2022. Between 2017 and 2022, cigarette-only use declined from 4.9% to 0.9% (p<0.001), while e-cigarette-only use increased from 6.3% to 8.4% (p=0.002). Dual use decreased slightly from 5.6% to 4.5% (p=0.045). Multivariable logistic regression revealed that males, upper secondary students, and those with parental tobacco use had higher odds of tobacco use across all categories. Ethnic differences were also observed.</p><p><strong>Conclusions: </strong>The nicotine landscape among Malaysian adolescents has shifted significantly, with a sharp decline in cigarette smoking but a concerning rise in e-cigarette use. Males, upper secondary students, and those with parental tobacco use remain at higher risk. Future longitudinal studies should examine initiation patterns and the influence of peer factors, socioeconomic status, and regulatory changes.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13595845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of key molecular targets in nicotine-induced spontaneous abortion through network toxicology and multi-omics integration.","authors":"Kaiyan Yang, Xinying Song, Pengyan Zhai, Huiyan Wang, Wenbo Zhou","doi":"10.18332/tid/230997","DOIUrl":"10.18332/tid/230997","url":null,"abstract":"<p><strong>Introduction: </strong>Spontaneous abortion (SA) remains a prevalent reproductive health challenge, with tobacco-derived nicotine emerging as a significant risk factor. This study sought to decipher the molecular underpinnings of nicotine-induced pregnancy loss through comprehensive multi-omics profiling to identify novel biomarkers and potential intervention targets.</p><p><strong>Methods: </strong>An integrated bioinformatics approach was implemented combining network toxicology, transcriptomic profiling, and machine learning algorithms to elucidate nicotine's pathological mechanisms in SA. The analytical pipeline encompassed functional enrichment analysis, expression pattern characterization, diagnostic biomarker evaluation, immune microenvironment assessment, causal inference through Mendelian randomization (MR), single-cell RNA sequencing, and molecular docking simulations of nicotine-protein interactions.</p><p><strong>Results: </strong>Differential expression analysis identified 2451 DEGs between SA and control groups. Integration with 645 nicotine targets yielded 69 candidate genes. Five hub genes - CTNNB1, TINAGL1, RAD50, FGF2, and VIM - were identified as critical mediators in nicotine-triggered SA pathogenesis. These genes exhibited good diagnostic capability and significant correlations with immune cell infiltration patterns. MR analysis confirmed causal associations for RAD50 (OR=1.08; 95% CI: 1.01-1.15, p=0.019) and FGF2 (OR=1.21; 95% CI: 1.11-1.33, p=4.69×10^-5). Single-cell analyses revealed cell-type-specific expression signatures across trophoblasts and immune populations, while molecular docking showed binding energies ranging from -5.0 to -6.9 kcal/mol.</p><p><strong>Conclusions: </strong>This study illuminates a complex, multi-target mechanism underlying tobacco-induced pregnancy loss. This work advances understanding of nicotine's reproductive toxicity pathways and identifies promising molecular targets for early diagnosis and further mechanistic studies.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13596037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and factors associated with e-cigarette use among aspiring media professionals: A cross-sectional survey at a vocational college.","authors":"Congcong Li, Mingbiao Zhang, Jing Zhao, Anliang Zhao, Jiangtao Ye, Yusui Zhao, Xiaofeng Hou","doi":"10.18332/tid/235831","DOIUrl":"10.18332/tid/235831","url":null,"abstract":"<p><strong>Introduction: </strong>E-cigarette use among college students is an emerging public health concern, particularly among those in media-related fields who may influence youth as future role models. This study examined the prevalence and factors associated with e-cigarette use among students at a vocational performing arts college in eastern China.</p><p><strong>Methods: </strong>A cross-sectional census survey was conducted from April to May 2025 at Hengdian College of Film and Television. All enrolled students present on campus were invited to complete an online questionnaire adapted from the National Tobacco Survey for College Students. Data on demographic characteristics, e-cigarette use, exposure to advertising and health information, and knowledge of tobacco hazards were collected. Chi-squared tests and binary logistic regression were used to identify factors associated with current e-cigarette use.</p><p><strong>Results: </strong>Among 9197 valid respondents (99.70% response rate; 69.90% female; mean age 18.83 years), the current e-cigarette use rate was 2.05%. Multivariate analysis identified the following significant associated factors: inadequate knowledge versus adequate knowledge (adjusted odds ratio, AOR=4.69; 95% CI: 3.44-6.40), maternal smoking versus neither parent smokes (AOR=9.44; 95% CI: 3.46-25.76), junior year versus freshman (AOR=3.46; 95% CI: 1.96-6.11), both parents smoking vs neither (AOR=3.04; 95% CI: 1.71-5.42), witnessing public smoking versus not (AOR=2.67; 95% CI: 1.82-3.91), male versus female (AOR=2.36; 95% CI: 1.74-3.20), sophomore year versus freshman (AOR=1.44; 95 CI: 1.09-1.91), and having smoking roommates versus not (AOR=1.26; 95% CI: 1.07-1.48). Nearly half reported exposure to e-cigarette advertising, while over 60% encountered anti-e-cigarette information.</p><p><strong>Conclusions: </strong>The associations identified highlight the need for further longitudinal investigation into modifiable factors and environmental influences. Special attention should be given to students with maternal smoking and those in smoking-normalized environments.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13595437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating proteins as key genetically proxied mediators in the pathway from smoking to intracranial aneurysm disease: A mediation Mendelian randomization analysis.","authors":"Yaqi Liu, Hao Yuan, Chi Huang, Jiwan Huang, Can Li, Runze Ge, Jiancheng Lin, Xiru Zhang, Mengshi Huang, Xin Feng, Chuan Zhi Duan","doi":"10.18332/tid/226836","DOIUrl":"10.18332/tid/226836","url":null,"abstract":"<p><strong>Introduction: </strong>The molecular mechanisms linking smoking to intracranial aneurysmal disease remain elusive. In this study, we aimed to employ Mendelian randomization (MR) analysis to identify proteomic pathways that mediate this relationship.</p><p><strong>Methods: </strong>We conducted a two-step, two-sample MR study using summary-level GWAS data from the GSCAN (GWAS & Sequencing Consortium of Alcohol and Nicotine Use, release up to 2019) and the FinnGen study (release R12, 2024). In the first step, we estimated the effects of genetically proxied smoking, using the Lifetime Smoking Index (LSI) as the primary exposure, on circulating protein levels. In the second step, we assessed the associations of smoking-related proteins with the risk of unruptured intracranial aneurysms (uIAs) and aneurysmal subarachnoid hemorrhage (aSAH). Proteins that showed significant associations in both steps were considered potential mediators, and we calculated their mediation proportions using the product-of-coefficients method.</p><p><strong>Results: </strong>Genetically proxied smoking was associated with increased risks of uIAs and aSAH. Each one standard deviation increase in LSI was associated with a 2.99-fold higher risk of uIAs (OR=2.99; 95% CI: 1.77-5.06) and a 2.51-fold higher risk of aSAH (OR=2.51; 95% CI: 1.72-3.66). After multiple-testing correction, LSI was causally associated with 427 circulating proteins; 22 correlated with aSAH and 22 with uIAs, with eight shared. Mediation analysis confirmed six mediators (CD74, HEG1, YAP1, FGF23, SFRP1, PGF) for the LSI-aSAH pathway and four (CD74, YAP1, ANGPT2, RTN4R) for the LSI-uIA pathway. CD74 and YAP1 were shared mediators with the highest mediation ratios.</p><p><strong>Conclusions: </strong>Eight distinct circulating proteins mediate smoking-induced intracranial aneurysm development and rupture via independent biological cascades. CD74 and YAP1 may serve as priority candidate mediators for future mechanistic and translational investigations aimed at refining risk stratification in smoking-related intracranial aneurysms.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13595440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tobacco-driven digestive disease burden: A China-US comparative analysis, 1990-2035.","authors":"Zhuo Cheng, Xue Luo, Da Yan, Qiuyu Chen, Han Lang, Yaxin Wu, Hongquan Pang","doi":"10.18332/tid/226881","DOIUrl":"10.18332/tid/226881","url":null,"abstract":"<p><strong>Introduction: </strong>Smoking is a well-established risk factor for digestive diseases, yet direct comparisons of smoking-attributable digestive disease burden between nations with divergent tobacco control trajectories remain scarce. This study compared temporal trends, driving factors, and future projections of this burden in China and the United States from 1990 to 2023.</p><p><strong>Methods: </strong>Using Global Burden of Disease 2023 data, we analyzed smoking-attributable digestive disease deaths and disability-adjusted life years. Joinpoint regression assessed temporal trends. Decomposition analysis partitioned burden changes into population growth, aging, and epidemiological components. Bayesian age-period-cohort models projected burden to 2035.</p><p><strong>Results: </strong>From 1990 to 2023, age-standardized mortality rates for smoking-attributable digestive diseases declined by 77.2% in China (average annual percentage change, AAPC= -4.32; 95% CI: -4.42 - -4.21; p<0.001) and 58.0% in the United States (AAPC= -2.57; 95% CI: -2.66 - -2.48; p<0.001). Despite these rate reductions, absolute smoking-attributable deaths among those aged 90-94 years increased by 663.6% in China and 131.5% in the United States. Epidemiological change was the dominant driver of burden reduction, contributing 374.4% and 349.8% of the overall smoking-attributable death reduction in China and the United States, respectively, outweighing combined demographic pressures. Joinpoint analysis identified a transient increase in US smoking-attributable death rates during 2018-2021 (APC=2.51; p<0.05). Projections indicated continued declines in smoking-attributable rates through 2035.</p><p><strong>Conclusions: </strong>Despite substantial epidemiological improvements, population aging increasingly offsets rate declines, particularly among the oldest adults. Sustained, age-targeted tobacco control strategies are essential to address the evolving demographic burden.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13594414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of smoking behaviors with GOLD biological age acceleration and potential mediation: Evidence from NHANES 1999-2023.","authors":"Jiaqi Wang, Jiajun He, Yangzhi Li, Zhiqun Yu, Fei Yao, Jimin Zhu, Baikun Li","doi":"10.18332/tid/231597","DOIUrl":"10.18332/tid/231597","url":null,"abstract":"<p><strong>Introduction: </strong>The association between smoking and biological age acceleration, such as KDM and PhenoAge, has been reported, but the dose-response relationship between smoking and the acceleration of GOLD biological age remains unclear. This study aims to explore the association between smoking behavior and the acceleration of GOLD biological age, and to assess the potential mediating roles of oxidative stress and inflammation.</p><p><strong>Methods: </strong>This cross-sectional study used data from 12 cycles of NHANES (1999-2023), a survey with a complex multi-stage probability sampling design, and included eligible participants. Smoking exposure (daily amount and status) was assessed via standardized self-report questionnaires. The outcome, GoldBioAge-BAaccel, was calculated as residuals from regressing GOLD biological age on chronological age. Multivariable linear regression and restricted cubic splines were applied to evaluate associations, with subgroup analyses stratified by sex, age, and other covariates, and Wald tests for interaction. Sensitivity analyses were performed to test robustness, and mediation analyses explored the mediating effects of uric acid and C-reactive protein.</p><p><strong>Results: </strong>The study included 12941 eligible participants. In multivariable linear regression models, each additional cigarette smoked per day was associated with a 0.0763-year increase in BAaccel (β=0.0763; 95% CI: 0.0522-0.1003). Compared with never smokers, current smokers had a 1.5387-year higher BAaccel (β=1.5387; 95% CI: 1.1197-1.9577). Restricted cubic spline analysis showed no evidence of a nonlinear association between CPD and BAaccel (p for nonlinearity=0.285). The association between current smoking and BAaccel differed significantly by age group (p for interaction=0.019). The findings remained consistent across multiple sensitivity analyses. CRP and UA mediated 14.88% and 5.10% of the total effect between daily smoking amount and BAaccel, respectively; for current smoking status (vs never smoking), the corresponding mediated proportions were 9.19 % and 2.40%.</p><p><strong>Conclusions: </strong>Smoking behavior is positively associated with GOLD biological age acceleration, and this association is partially mediated by systemic inflammation and oxidative stress.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13595439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between e-cigarette use and sleep health: A systematic review and meta-analysis.","authors":"Ishnaa Gulati, Sashini Kosgoda, Anasua Kundu, Robert Schwartz, Apsara Ali Nathwani, Jennifer Soer, Jessie Tian, Michael Chaiton","doi":"10.18332/tid/225458","DOIUrl":"10.18332/tid/225458","url":null,"abstract":"<p><strong>Introduction: </strong>E-cigarette use has raised concerns about health impacts beyond nicotine dependence, yet evidence on the relationship between vaping and sleep disturbance remains limited. This systematic review and meta-analysis examined the association between exclusive e-cigarette use and sleep health.</p><p><strong>Methods: </strong>MEDLINE, Embase and PsycINFO were searched up to July 2025 for English-language, peer reviewed human studies. Eligible studies were peer-reviewed observational studies of people who used nicotine e-cigarettes without combustible cigarette use, compared with non-users, that reported sleep health outcomes such as sleep duration and quality. Two independent reviewers screened all records, extracted data using the STROBE checklist, and assessed quality with the Joanna Briggs Institute Critical Appraisal tool. Effect sizes were pooled using random-effects models, and odds ratios (ORs) and 95% confidence intervals (CIs) are reported.</p><p><strong>Results: </strong>Sixteen cross-sectional studies met inclusion criteria, of which twelve were included in the meta-analysis, most of moderate quality. Past 30-day exclusive e-cigarette users had a 38% greater likelihood of poor sleep health than never users (OR=1.38; 95% CI: 1.24-1.55), with similar associations in adolescents (OR=1.32; 95% CI: 1.06-1.66) and adults (OR=1.36; 95% CI: 1.15-1.61).</p><p><strong>Conclusions: </strong>E-cigarette use was associated with poorer sleep health, with similar associations in adolescents and adults. Given rising youth vaping, longitudinal studies with objective measures are needed to inform public health strategies.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}