Topics in companion animal medicine最新文献

{"title":"First description of a primary esophageal histiocytic sarcoma in a dog","authors":"Anelise Bonilla Trindade-Gerardi ,&nbsp;Camila Alves da Silveira ,&nbsp;Janyni Duz ,&nbsp;Isabella Teixeira Caçapietra Pires da Silva ,&nbsp;Tainã Normanton Guim ,&nbsp;Saulo Petinatti Pavarini ,&nbsp;Cristiano Gomes ,&nbsp;Daniel Guimarães Gerardi","doi":"10.1016/j.tcam.2024.100856","DOIUrl":"10.1016/j.tcam.2024.100856","url":null,"abstract":"<div><p>An 11-year-old male Schnauzer dog was referred for investigation of cough and regurgitation of one month duration and gradual hyporexia for the previous five months. Complete blood count showed severe leukocytosis. On ventrodorsal and lateral thoracic radiographs a soft tissue mass was visible in the craniodorsal mediastinum. Endoscopy showed esophageal dilatation and an irregular, nodular, friable, exophytic mass in the thoracic esophagus, which was invasive, vascularized and had ulcerated areas. The mass occluded approximately 90% of the esophageal lumen. The mucosa in the orad portion of the thoracic esophagus was pale and the aborad portion was hyperemic (red) with hemorrhages. The mucosa of the cervical and abdominal esophagus was macroscopically unremarkeble. Multiple biopsies using endoscopic cup biopsy forceps were taken from the mass for histopathologic analysis and a percutaneous endoscopic gastrostomy was performed. Histopathologic analysis of the biopsy samples was inconclusive due to the marked necrosis. The poor clinical condition of the dog precluded a more invasive approach, and palliative and supportive treatment was continued. After 100 days of follow-up, clinical signs worsened, and that day the dog had a fatal cardiac arrest due to aspiration pneumonia and sepsis. Postmortem examination showed a multilobulated mass in the esophageal wall with infiltration into the overlying esophageal mucosa and pulmonary and renal metastases. Histological examination revealed a poorly differentiated sarcoma. On immunohistochemical examination, the neoplastic cells showed marked cytoplasmic staining for vimentin and Iba-1. The proliferative rate was approximately 30% by Ki-67. Histological and immunohistochemical examination revealed the esophageal mass to be a primary histiocytic sarcoma. Histiocytic sarcoma is an extremely rare primary esophageal neoplasm in humans, and so far, there is no description in dogs. To the best of the authors knowledge this is the first case of primary esophageal histiocytic sarcoma in dogs. The clinical information reported here should improve recognition and aid in diagnosis of future cases.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"59 ","pages":"Article 100856"},"PeriodicalIF":1.1,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139718197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical insights to address canine strongyloidosis in daily practice","authors":"Antonella Colella ,&nbsp;Dora Buonfrate ,&nbsp;Federica Lo Tempio ,&nbsp;Serena Digiaro ,&nbsp;Alessandra Recchia ,&nbsp;Beatrice Greco ,&nbsp;Paola Paradies","doi":"10.1016/j.tcam.2024.100845","DOIUrl":"10.1016/j.tcam.2024.100845","url":null,"abstract":"<div><p>Canine strongyloidosis by <em>Strongyloides stercoralis</em> is a parasitic disease emerging in Europe, which represents both a veterinary clinical issue and a public health challenge because of the zoonotic potential. The disease, not yet frequent in Europe, could induce severe clinical signs in dogs; thus, an early diagnosis and appropriate treatment are desirable. The aim of the present work is to retrospectively investigate the clinical and paraclinical findings in sick dogs naturally infected by <em>S. stercoralis</em>, with particular attention to ultrasound (US) changes at the gastrointestinal level. Twelve dogs were included in the study. The diagnosis was made by means of larval morphological identification on faecal samples and PCR. Most dogs presented with gastrointestinal signs; diarrhea and weight loss were the most common presenting complaint. Only one dog showed respiratory signs, associated to a parasitic cutaneous nodule. Hypoproteinaemia, anaemia, leucocytosis and an increase in alpha2-globulin fraction at serum protein electrophoresis were common (&gt;50%) but not constant findings. The most reported US picture was a fluid-filled, distended, atonic small intestine mostly associated with altered wall layering, while the wall thickness commonly associated with chronic enteritis was only rarely reported. These changes, associated with other clinical and paraclinical alterations, could increase the suspicion of canine strongyloidosis and may direct clinicians to include strongyloidosis in the differential diagnosis of dogs with diarrhea. The histological examination at the intestinal level, available in five dogs, revealed the presence of parasites from the full-thickness biopsy, but not from the endoscopic biopsy. The critical points of diagnosis in clinical practice are also discussed.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"60 ","pages":"Article 100845"},"PeriodicalIF":1.1,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1938973624000011/pdfft?md5=9282d341c18d039433a319eab089ee9f&pid=1-s2.0-S1938973624000011-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139105368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of sphingosine-1-phosphate receptor 1 in neuroinflammation of canine brains","authors":"Taesik Yun ,&nbsp;Sanggu Kim ,&nbsp;Yoonhoi Koo ,&nbsp;Yeon Chae ,&nbsp;Dohee Lee ,&nbsp;Hakhyun Kim ,&nbsp;Mhan-Pyo Yang ,&nbsp;Byeong-Teck Kang ,&nbsp;Soochong Kim","doi":"10.1016/j.tcam.2024.100847","DOIUrl":"10.1016/j.tcam.2024.100847","url":null,"abstract":"<div><p><span><span>Sphingosine-1-phosphate (S1P) is a signaling lipid mediator that is involved in multiple biological processes. The S1P/S1P receptor (S1PR) signaling pathway has an important role in the central nervous system. It contributes to physiologic cellular </span>homeostasis<span><span> and is also associated with neuroinflammation. Therefore, this study was performed to evaluate the expression of S1PR in dogs<span><span> with meningoencephalitis of unknown etiology (MUE) and </span>experimental autoimmune encephalomyelitis<span> (EAE). The analysis used 12 brain samples from three neurologically normal dogs, seven dogs with MUE, and two </span></span></span>canine EAE models. Anti-S1PR1 antibody was used for </span></span>immunohistochemistry<span>. In normal brain tissues, S1PR1s were expressed on neurons, astrocytes, oligodendrocytes<span>, and endothelial cells<span>. In MUE and EAE lesions, there was positive staining of S1PR1 on leukocytes. Furthermore, the expression of S1PR1 on neurons, astrocytes, oligodendrocytes, and endothelial cells was upregulated compared to normal brains. This study shows that S1PR1s are expressed in normal brain tissues and leukocytes in inflammatory lesions, and demonstrates the upregulation of S1PR1 expression on nervous system cells in inflammatory lesions of MUE and EAE. These findings indicate that S1P/S1PR signaling pathway might involve physiologic homeostasis and neuroinflammation and represent potential targets for S1PR modulators to treat MUE.</span></span></span></p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"60 ","pages":"Article 100847"},"PeriodicalIF":1.1,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139104693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reporting perceived capability, motivations, and barriers to reducing treat feeding amongst dog and cat caregivers","authors":"Shelby A. Nielson ,&nbsp;Deep K. Khosa ,&nbsp;Katie M. Clow ,&nbsp;Adronie Verbrugghe","doi":"10.1016/j.tcam.2024.100846","DOIUrl":"10.1016/j.tcam.2024.100846","url":null,"abstract":"<div><p>Obesity remains a significant concern for dogs and cats, and reducing or eliminating treats is commonly recommended as a strategy for weight management. Caregivers can struggle with adherence to such dietary recommendations. Previous research suggests caregivers are reluctant to reduce treats but there is limited understanding of the underlying factors contributing to these behaviours and decisions. The objective of this study was to explore caregivers’ motivations and barriers to reducing treat feeding, and their reported capability to do so. An online questionnaire including multiple choice and Likert scale questions was disseminated to dog and cat caregivers (n=1053) primarily from Canada and the USA from September to November 2021. Caregivers commonly expressed a wide range of motivations to reduce treat feeding with their pet, though barriers to reducing treat feeding were less defined. Changing their pet's routine was a reported barrier by more than 30% of respondents and was predictive of caregivers finding reducing treat giving to be difficult (OR=1.67, p=0.017). Results from multivariable logistic regression also revealed that caregivers who consider their companion animal to be obese as more likely to perceive reducing treats to be difficult. The results highlight the role of treats in the relationship and routine of caregivers’ and their pets, and the importance of considering the individualised needs and circumstance of the caregiver and pet in veterinary discussions surrounding reducing treat feeding. Identifying these perspectives can improve self-efficacy with veterinary nutrition recommendations surrounding treats.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"60 ","pages":"Article 100846"},"PeriodicalIF":1.1,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1938973624000023/pdfft?md5=7e33114ed479b44eb99382fb3083c303&pid=1-s2.0-S1938973624000023-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139104695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allele and genotype frequencies for primary hereditary cataract, multifocal retinopathy 1, and degenerative myelopathy in Pyrenean Mountain dog from Italy","authors":"R. Moretti ,&nbsp;G. Massimello ,&nbsp;S. Chessa ,&nbsp;S. Sartore ,&nbsp;A. Tranchero ,&nbsp;M. Profiti ,&nbsp;P. Sacchi","doi":"10.1016/j.tcam.2023.100844","DOIUrl":"10.1016/j.tcam.2023.100844","url":null,"abstract":"<div><p>Pyrenean Mountain Dog (PMD) is an ancient dog breed firstly described in XIV century in the Pyrenees Region and nowadays diffused both in Europe and in the US. Hereditary Cataract (HC), defined as the inherited opacity of the lens, involves clinical signs ranging from reduced vision to glaucoma. A molecular basis of HC was firstly described in Staffordshire Bull Terriers and then reported in multiple canine breeds. The HC-associated variation is a single nucleotide deletion in <em>HSF4</em> gene that introduces a premature stop codon (c.962del, p.Ala321*). Multifocal Retinopathy 1 (MR) is an ocular disorder characterized by multiple areas of retinal degeneration, caused in various dog breeds (including PMD) by a single nucleotide variant (SNV) in <em>BEST1</em> gene that generates a premature stop codon (c.73G&gt;A, p.Arg25*). Degenerative Myelopathy (DM) is an adult-onset, progressive neurodegenerative disease and it is associated to a SNV in <em>SOD1</em> gene causing a change in aminoacidic sequence of the protein (c.118G&gt;A, p.Glu40Lys). This causative variant has been described in various dog breeds, including PMD. Aim of this study was to determine the allele frequencies for the abovementioned three genetic diseases in the Italian breeding PMD population. The survey found no dogs carrying the allele (deletion) associated with HC, while three dogs (6 %) were heterozygous (G/A) for the MR-associated variant, and seven dogs (13 %) were heterozygous (G/A) for the DM-associated alteration, indicating that the variant alleles frequency were 0  %, 3 %, and 7 %, respectively. Appropriate mating management is suggested for the prevention of genetic diseases spreading in the PMD population.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"58 ","pages":"Article 100844"},"PeriodicalIF":1.1,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1938973623000843/pdfft?md5=475f11cdf73a5574f71ff81d9c0ba638&pid=1-s2.0-S1938973623000843-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138565738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between systolic blood pressure and target organ damage in naturally occurring cases of systemic hypertension in the dog","authors":"Priyanka Mahadappa ,&nbsp;K. Jeyaraja ,&nbsp;P.S. Thirunavakkarasu ,&nbsp;Narayanan Krishnaswamy","doi":"10.1016/j.tcam.2023.100843","DOIUrl":"10.1016/j.tcam.2023.100843","url":null,"abstract":"<div><p><span><span><span>Chronic elevation in the systolic blood pressure (SBP) adversely affects the lifespan in the </span>dog<span><span> by causing injury to the eye, heart, kidney and </span>brain. Understanding the association between SBP and target organ damage (TOD) helps in risk categorization and treatment planning. Therefore, a prospective study was undertaken to find the association between SBP and renal resistive index (RI) in naturally occurring cases of </span></span>canine<span> systemic hypertension. Based on the ACVIM guidelines 2018, dogs (n=135) were categorized into four risk groups of SBP, </span></span><em>viz.</em><span>, A (minimal), B (low), C (moderate), and D (high). Ophthalmoscopy and echocardiography<span> were used to assess ocular and cardiac changes, respectively. Nephrosonography, urinalysis, and RI were used to assess kidney damage. Odds ratio (OR) was used to quantify the risk of TOD for different categories of SBP. One-way Anova with Tukey's </span></span><em>post-hoc</em><span> test was used to test the effect of different SBP risk groups on urine protein creatinine ratio (UPC) and RI as well as the effect of number of TOD on the RI. Pearson's correlation test was done to see the relation of SBP with UPC and RI. Tortuous retinal vessels were common in group B with an OR of 11 (95% CI: 0.59-207). Retinal hemorrhage and left ventricular hypertrophy were common in group D with an OR of 13 (95% CI: 0.67-234) and 11 (95% CI: 0.61-207), respectively. A significant strong positive correlation of SBP with UPC (R</span>²=0.65) and RI (R²=0.58) was observed. The renal RI significantly increased when the number of TOD was ≥ 2. It was concluded that SBP and RI are associated with the number and severity of TOD and might be valuable in risk classification in hypertensive dogs.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"58 ","pages":"Article 100843"},"PeriodicalIF":1.1,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138049107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic applications of canine platelets and their derivatives: a narrative review","authors":"Deeksha Bharti ,&nbsp;Y. Ajith ,&nbsp;Khan Sharun ,&nbsp;S. Amitha Banu ,&nbsp;Akshay Kumar ,&nbsp;Abhishek Bhardwaj ,&nbsp;Shiv Kumar Sidar ,&nbsp;Dhaleshwari","doi":"10.1016/j.tcam.2023.100840","DOIUrl":"10.1016/j.tcam.2023.100840","url":null,"abstract":"<div><p><span><span>Platelets contain a multitude of growth factors and play a crucial role in physiological processes such as thrombogenesis, tissue repair, and angiogenesis. As a result, platelet-derived products have significant potential for efficient utilization in the realm of </span>regenerative medicine due to their therapeutic and biological attributes. Numerous studies have already substantiated the therapeutic viability of platelets in various </span>canine<span><span> ailments. The existing literature indicates a substantial surge in the clinical application of canine platelets, positioning platelet-derived products as a viable alternative to conventional therapeutic agents. Platelet concentrates, including platelet-rich plasma and platelet-rich fibrin are commonly used as a therapeutic modality in clinical cases. These therapeutic derivatives exhibit effectiveness in tissue regeneration and can serve as complementary therapies. Notably, they offer a cost-effective and easily accessible therapeutic option, which has demonstrated its benefits in chronic inflammatory disorders such as osteoarthritis and </span>tendinitis, ophthalmic conditions, wound healing, and mandibular injuries in canine patients. The broad spectrum of therapeutic effects displayed by platelets is providing researchers with novel perspectives for crafting therapeutic models in future investigations. This review centers on exploring the therapeutic potential of canine platelets across diverse disorders. Further exploration into platelet products, encompassing their preparation and applicability in canine medicine, is imperative. These inquiries hold the promise of unveiling fresh horizons for the domain of regenerative medicine.</span></p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"58 ","pages":"Article 100840"},"PeriodicalIF":1.1,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138049110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer morbidity in Croatian cats: Retrospective study on spontaneously arising tumors (2009–2019)","authors":"Doroteja Huber ,&nbsp;Krešimir Severin ,&nbsp;Dunja Vlahović ,&nbsp;Stefani Križanac ,&nbsp;Sanja Mofardin ,&nbsp;Ivana Mihoković Buhin ,&nbsp;Lidija Medven Zagradišnik ,&nbsp;Ivan-Conrado Šoštarić-Zuckermann ,&nbsp;Andrea Gudan Kurilj ,&nbsp;Branka Artuković ,&nbsp;Marko Hohšteter","doi":"10.1016/j.tcam.2023.100841","DOIUrl":"10.1016/j.tcam.2023.100841","url":null,"abstract":"<div><p>One of the current leading causes of death in pet cats is neoplasia. The scarcity of data on tumor prevalence in cats from south-eastern Europe led to this retrospective study which reports an abundant collection of tumors diagnosed in cats living in Croatia. Archived histopathology findings (diagnosis, cell origin, and biological behavior), and epidemiological data (breed, sex, age, and anatomical site of the tumor) of the cats diagnosed with at least one tumor were collected and statistically analyzed.</p><p>For the research, 2338 archived feline samples, obtained from 2009-2019, have been reviewed. In 659 samples (28.1%) one or more tumors were diagnosed. Tumors have most often affected non-pedigree cats, cats between 7 and 15 years of age, and female cats. Most tumors showed malignant behavior (85.7%). The most frequent diagnoses were mammary adenocarcinoma, lymphoma, and squamous cell carcinoma. Regarding origin, most samples were epithelial (46.9%), but mesenchymal (28.7%) and lymphoid tumors (17.0%) were also frequently found. Tumors most often occurred in the skin and subcutis, mammary gland (in females), digestive system, and hemolymphatic system (in males). Statistical analysis did not reveal breed, sex, and age predisposition, but female animals and non-pedigree cats were significantly more likely to develop malignant tumors.</p><p>This detailed study gives insight into the most frequent tumors that occur in cats from Croatia, and the data reported here is likely applicable to other countries. This data will contribute to clinical veterinary oncology, as it presents the most extensive tumor index of cats in south-eastern Europe.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"58 ","pages":"Article 100841"},"PeriodicalIF":1.1,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138049108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous pneumothorax in a dog with a history of successfully treated heartworm disease: A case report","authors":"Destinee Gardiner ,&nbsp;Christina Whitley Bray ,&nbsp;Steven Frederick","doi":"10.1016/j.tcam.2023.100842","DOIUrl":"10.1016/j.tcam.2023.100842","url":null,"abstract":"<div><h3>Objective</h3><p><span>To describe a dog presented with spontaneous </span>pneumothorax<span> secondary to chronic pulmonary changes associated with a history of resolved canine<span> heartworm disease.</span></span></p></div><div><h3>Case or series summary</h3><p>A 7-year-old 25.2kg female spayed German Shepherd mix was presented for management of spontaneous pneumothorax. The dog had a history of heartworm disease that underwent therapy prior to adoption, and the dog was heartworm antigen negative (SNAP 4Dx) during hospitalization for the pneumothorax. An exploratory thoracotomy was performed due to an unresolving pneumothorax requiring multiple thoracocenteses. Perioperatively, the lungs did not expand with positive pressure ventilation and diffuse, multifocal to coalescing areas of darkened tissue that were grossly consistent with necrosis and/or hemorrhage were noted. The dog was euthanized intraoperatively due to an assumed poor prognosis. Histopathologic examination findings were consistent with chronic reactive changes related to previous heartworm infection. No neoplastic or infectious etiologies were identified.</p></div><div><h3>New or unique information provided</h3><p>Spontaneous pneumothorax is a known complication of active heartworm infection. However, this case represents the first report of spontaneous pneumothorax secondary to chronic pulmonary changes caused by resolved heartworm infection.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"58 ","pages":"Article 100842"},"PeriodicalIF":1.1,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138049109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nephrectomy in 52 dogs for the treatment of Dioctophyme renale infection – Knowing the enemy to win","authors":"Pâmela Caye ,&nbsp;Josaine Cristina da Silva Rappeti ,&nbsp;Soliane Carra Perera ,&nbsp;Hecson Jesser Segat ,&nbsp;Patrícia Silva Vives ,&nbsp;Fabrício de Vargas Arigony Braga ,&nbsp;Marlete Brum Cleff ,&nbsp;Ana Raquel Mano Meinerz ,&nbsp;Guilherme Albuquerque de Oliveira Cavalcanti ,&nbsp;Vanessa Milech ,&nbsp;Bernardo Nascimento Antunes ,&nbsp;Daniel Curvello de Mendonça Müller ,&nbsp;Maurício Veloso Brun","doi":"10.1016/j.tcam.2023.100828","DOIUrl":"10.1016/j.tcam.2023.100828","url":null,"abstract":"<div><p><em>Dioctophyme renale</em> (<em>D. renale</em>) is a nematode that parasitizes the kidney of mammals. Treatment is often surgical, with removal of the affected organ. This retrospective study aims to evaluate the epidemiological, clinical, and surgical aspects, the interval between diagnosis and treatment, the occurrence of pre- and intraoperative complications, and the postoperative survival time of dogs parasitized by <em>D. renale</em> undergoing therapeutic nephrectomy. Records of fifty-two dogs treated in a single hospital service were analyzed. We collected epidemiological data, laboratory results, diagnostic method, anesthetic protocol, surgical technique and time, type of antimicrobial prophylaxis, pre- and intraoperative complications, location and number of parasites, and postoperative survival time. Of the 52 dogs undergoing right nephrectomy by laparotomy, 61.5 % were female and 63.4 % were adults. Although the most common clinical sign was hematuria (25 %), 61.5 % of the patients were asymptomatic. Eosinophilia and increased serum urea were the only laboratory changes found. The interval between diagnosis and surgery was 27.4 ± 23 days and no patient showed changes suggestive of surgical emergency. The most common surgical approach was the right paracostal (61.5 %), and a continuous suture pattern was predominant. Intraoperative complications occurred in 9.6 % of the procedures, varying from mild to severe hemorrhage. Mean postoperative survival was 835.5 ± 428 days. Dioctophymosis was effectively controlled by nephrectomy of the affected kidney, allowing a mean survival of more than 830 days. No serious complications caused by intervals between diagnosis and treatment have been reported. This is the largest retrospective study evaluating dogs infected with <em>D. renale</em> that were surgically treated.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"58 ","pages":"Article 100828"},"PeriodicalIF":1.1,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61567116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}