Topics in companion animal medicine最新文献

{"title":"Occurrence of zoonotic enteric parasites in fecal samples from dogs in shelters, parks, squares and public roads, and the dog guardians’ perception of zoonoses as for the risk to public health in the city of Guarapuava, Paraná, Brazil","authors":"Karine Cristine Almeida ,&nbsp;Fernanda Pinto-Ferreira ,&nbsp;Italmar Teodorico Navarro ,&nbsp;Kamila Libano Souza ,&nbsp;Leticia Santos Balbino ,&nbsp;Juliana Correa Bernardes ,&nbsp;Danielle Louisy Bahia dos Santos ,&nbsp;Margarete Kimie Falbo","doi":"10.1016/j.tcam.2023.100826","DOIUrl":"10.1016/j.tcam.2023.100826","url":null,"abstract":"<div><p>The aim of this study was to determine the occurrence of zoonotic enteroparasites in the feces of dogs from public shelters, squares, parks, and public roads in the city of Guarapuava, Paraná, Brazil, and to evaluate the perception of dog guardians regarding zoonoses and their risk to public health. Fecal samples were collected, coproparasitological examinations were performed to detect zoonotic enteroparasites, and polymerase chain reaction (PCR) was used to identify <em>Giardia</em> spp. and <em>Cryptosporidium</em> spp. Questionnaires were given to guardians who walked their dogs in parks, squares, and public roads, as to assess their perception of zoonoses. A total of 333 samples were collected, of these 75, 123, and 135 of them were from public shelters, squares and parks, and public roads, respectively. One or more parasites were identified in 166 (50 %) samples, of which 58/75 (77 %) were from public shelters, 50/123 (41 %) from squares and parks, and 58/135 (43 %) from public roads. The parasites detected included <em>Ancylostoma</em> spp., <em>Giardia</em> spp., <em>Trichuris</em> spp., <em>Toxocara</em> spp., and <em>Cystoisospora</em> spp., with <em>Ancylostoma</em> spp. having the highest occurrence. PCR was performed on 161 samples for convenience due to financial limitations, because only a portion of the study was funded by the municipal government, of which 15.6 % were positive for Giardia spp., and all were negative for <em>Cryptosporidium</em> spp. In total, 246 guardians were interviewed, of which 36 % said they did not collect their animals' feces during walks, 20 % did not use anti-helminthics on their dogs, and 23 % did not know which diseases could be transmitted by feces. Therefore, we conclude that there is a high infection rate of parasites with zoonotic potential in public places, showing the need to raise awareness among guardians about the diseases transmitted by dog feces, correct vermifugation and the importance of collecting feces in public places.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"58 ","pages":"Article 100826"},"PeriodicalIF":1.1,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54233018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory Distress Caused by Neoplastic Upper Respiratory Tract Obstructions in 2 Pet Rats (Rattus Norvegicus Domestica)","authors":"Rachael Figueroa ,&nbsp;Miranda J. Sadar ,&nbsp;Chad Frank ,&nbsp;Megan A. McCarthy ,&nbsp;Michael K. Keel ,&nbsp;David Sanchez-Migallon Guzman","doi":"10.1016/j.tcam.2023.100823","DOIUrl":"10.1016/j.tcam.2023.100823","url":null,"abstract":"<div><p>Respiratory disease is one of the primary reasons for pet owners to seek veterinary attention for their rats. While chronic respiratory disease complex is most often responsible for respiratory signs in pet rats and is well characterized, upper respiratory obstructive disease has been rarely reported in the literature. This report describes 2 pet fancy rats (<em>Rattus norvegicus domestica</em>) presenting with a several day history of progressive respiratory signs that were minimally responsive to supportive therapies, including antibiotics, nonsteroidal anti-inflammatories, and fluid and oxygen support. Survey radiographs were performed under sedation in both cases. In the first case, no cause for the clinical signs could be identified, in part due to suboptimal radiographic positioning, although severe aerophagia was noted. In the second case, cervical tracheal luminal narrowing and increased soft tissue opacity along the walls of the trachea were identified. Both rats declined while under sedation, resulting in cardiopulmonary arrest in the first case and humane euthanasia in the second. On necropsy, the first case had a oropharyngeal squamous cell carcinoma originating from the Zymbal's gland, which was obstructing the larynx. The second case had an intra-luminal tracheal mass obstructing the airway. This was mostly likely B-cell lymphoma or a plasma cell tumor, although definitive diagnosis was unable to be obtained. For future such cases empiric management of respiratory disease in rats with antimicrobials, anti-inflammatories, and supportive care is often appropriate based on the high prevalence of infectious agents, however, other noninfectious causes should be considered, such as neoplastic processes leading to upper airway obstructive disease and diagnostic imaging may be indicated.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"58 ","pages":"Article 100823"},"PeriodicalIF":1.1,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41172686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tranexamic Acid in Reducing Intraoperative Bleeding in Dogs Undergoing Thoracolumbar and Lumbar Hemilaminectomy and Intervertebral Disc Fenestration","authors":"Dênis Antonio Ferrarin ,&nbsp;Marcelo Luís Schwab ,&nbsp;Mathias Reginatto Wrzesinski ,&nbsp;Júlia da Silva Rauber ,&nbsp;Julya Nathalya Felix Chaves ,&nbsp;Angel Ripplinger ,&nbsp;Alexandre Mazzanti","doi":"10.1016/j.tcam.2023.100820","DOIUrl":"10.1016/j.tcam.2023.100820","url":null,"abstract":"<div><p>Hemilaminectomy associated with intervertebral disc fenestration (HF) is the most used spinal decompression surgical technique for the treatment of intervertebral disc extrusion (IVDE). The surgical procedure can be hampered by excessive bleeding from the venous sinuses; however, tranexamic acid intravenously (IV) is a possible adjunct to hemostasis in these patients. This study aimed to verify the effectiveness of tranexamic acid in reducing intraoperative bleeding in dogs with thoracolumbar and lumbar IVDE submitted to HF. Sixteen dogs with IVDE undergoing HF were included. These were distributed into a TXA group (tranexamic acid 20 mg/kg IV bolus, followed by 2 mg/kg/h IV continuous infusion) (n = 8) and a control group, with saline solution (n = 8). Blood loss was measured using the gravimetric method. The difficulty of operative visualization due to bleeding was classified by the surgeon. Median blood loss (%) in patients in the TXA group was lower than those in the control group (2.75 ± 1.23 and 4.99 ± 4.44, respectively) (<em>P</em> = .028). Intraoperative visualization difficulty due to bleeding occurred in 10 patients in the control group, and in no patients in the TXA group. A severe arterial thromboembolic complication was recorded, potentially due to tranexamic acid. The use of intraoperative tranexamic acid was effective in reducing bleeding and facilitating operative visualization in dogs with IVDE undergoing hemilaminectomy and intervertebral disc fenestration.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"58 ","pages":"Article 100820"},"PeriodicalIF":1.1,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41170263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Potential of Thrombocyte Indices, Acute Phase Proteins, Electrolytes and Acid-Base Markers in Canine Parvovirus Infected Dogs With Systemic Inflammatory Response Syndrome","authors":"Babul Rudra Paul ,&nbsp;Ujjwal Kumar De ,&nbsp;Varun Kumar Sarkar ,&nbsp;Jitendra Singh Gandhar ,&nbsp;Manas Kumar Patra ,&nbsp;Mithilesh Kumar Singh ,&nbsp;Srishti Soni ,&nbsp;Chethan Gollahalli Eregowda","doi":"10.1016/j.tcam.2023.100803","DOIUrl":"10.1016/j.tcam.2023.100803","url":null,"abstract":"<div><p>Dogs with canine parvovirus enteritis (CPVE) that develop systemic inflammatory response syndrome (SIRS) frequently have a poor prognosis. The aim of the study was to assess the prognostic potential of thrombocyte indices, acute phase proteins, electrolytes, and acid-base markers in CPVE puppies with SIRS (CPVE-SIRS+) at admission. A case-controlled, prospective, and observational study was performed on 36 CPVE puppies. Mean concentrations of C-reactive protein (CRP), albumin, thrombocyte count, mean platelet volume (MPV), platelet distribution width (PDW), sodium (Na⁺), potassium (K⁺), chloride (Cl⁻) and ionized calcium (iCa) were measured and strong ion difference 3 (SID₃)_, A_TOT-albumin and A_{TOT-total protein} were determined in CPVE-SIRS+ survivors and nonsurvivors. A prognostic cut-off value for predicting the disease outcome was determined by receiver operating characteristic (ROC) curve analysis. The mean values of MPV, PDW and CRP were significantly higher and the mean values of albumin, Cl⁻ and A_TOT-albumin were significantly lower in CPVE-SIRS+ nonsurvivor than CPVE-SIRS+ survivor puppies on the day of admission, but the thrombocyte count, Na⁺, K⁺, iCa, SID₃ and A_{TOT- total protein} values did not differ significantly. The positive predictive values (PPVs) for survival using cut-off value of MPV (≤15.08 fL), PDW (≤14.85%), CRP (≤180.7 mg/L), albumin (≥1.795 g/dL), Cl⁻ (≥96.00 mmol/L), and A_TOT-albumin (≥7.539) were determined as 100%, 100%, 100%, 80%, 100%, and 80%, respectively with better area under ROC curve and sensitivity. Based on sensitivity, specificity, and PPVs from ROC analysis, it is concluded that the determination of Cl⁻ concentration and MPV at admission followed by CRP will serve as the most appropriate biomarkers in predicting the disease outcome of CPVE puppies that develop SIRS.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"56 ","pages":"Article 100803"},"PeriodicalIF":1.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10031943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Urinary Bladder Tumors in Three Guinea Pigs (Cavia Porcellus)","authors":"Anna Linda Nógrádi ,&nbsp;Iain Cope ,&nbsp;Attila Arany-Toth ,&nbsp;Linda Müller ,&nbsp;Dóra Csatári ,&nbsp;Csaba Hetyey ,&nbsp;Zoltán Dudás-Györki ,&nbsp;Ferenc Manczur ,&nbsp;Norbert Schuster ,&nbsp;Csaba Jakab ,&nbsp;Tibor Németh","doi":"10.1016/j.tcam.2023.100805","DOIUrl":"10.1016/j.tcam.2023.100805","url":null,"abstract":"<div><p>Urinary bladder tumors are not common in guinea pigs, but case numbers being diagnosed have increased in the past years. The authors present 3 referred cases of primary urinary bladder tumors in pet guinea pigs diagnosed using diagnostic imaging (CT, radiography, and ultrasonography) and exploratory laparotomy. Excision was not possible in the first case as the tumor was located at the neck of the urinary bladder and the owner opted for intraoperative euthanasia. The second and third cases both had tumors originating from the apex of the urinary bladder. The third guinea pig went into cardiac arrest during surgery and resuscitation was unsuccessful. The tumor was removed from the urinary bladder using partial cystectomy in the second case and 1-month postsurgery ultrasonographic examination showed no signs of tumor reoccurrence. Late recognition is the main reason for a negative outcome, as by this time tumors are already large and extensive. Whenever prolonged symptoms of hematuria are present and urolithiasis has been ruled out, ultrasonography should be undertaken to determine if a urinary tumor is the cause. Rechecks should be scheduled on a regular basis for guinea pigs when a definitive diagnosis can not be made at the initial presentation for vague clinical signs, as outcome and survival can reduce significantly when definitive treatment is delayed.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"56 ","pages":"Article 100805"},"PeriodicalIF":1.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10041913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Locking conical coupling plates in small animal orthopedics: A review","authors":"Renato Otaviano do Rego ,&nbsp;Bianca Marfil Dias ,&nbsp;Mathieu Manassero ,&nbsp;Anderson Fernando de Souza ,&nbsp;André Luis do Valle De Zoppa ,&nbsp;Cássio Ricardo Auada Ferrigno","doi":"10.1016/j.tcam.2023.100827","DOIUrl":"10.1016/j.tcam.2023.100827","url":null,"abstract":"<div><p>Conical coupling locking plates (CCP) have become an interesting alternative in veterinary orthopedics and traumatology. Available data in this regard, however, must be interpreted with caution, and several studies are still required to reach definitive conclusions on the clinical use of these implants. In this context, this review aims to discuss CCP applications and mechanical aspects in small animals and summarize <em>in vivo, in vitro</em> and <em>ex vivo</em> study results.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"56 ","pages":"Article 100827"},"PeriodicalIF":1.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61567114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presence of Gastrointestinal Paraneoplastic Syndrome at Diagnosis in Dogs With Cutaneous Mast Cell Tumors and Its Influence on Disease-Free Interval and Survival","authors":"Gabriela Reis Ledur ,&nbsp;Anelise Bonilla Trindade-Gerardi ,&nbsp;Saulo Petinatti Pavarini ,&nbsp;Luciana Oliveira de Oliveira ,&nbsp;Keylla Hörbe Steffen dos Santos ,&nbsp;Laerte Ferreiro ,&nbsp;Daniel Guimarães Gerardi","doi":"10.1016/j.tcam.2023.100808","DOIUrl":"10.1016/j.tcam.2023.100808","url":null,"abstract":"<div><p>Paraneoplastic syndrome (PNS) is a combination of signs unrelated to the physical presence of a tumor and/or its metastases. Its presence may result in poorer clinical outcomes and prognosis. Gastrointestinal ulceration is a well-known PNS in animals with cutaneous MCT. This retrospective study analyzed the occurrence of gastrointestinal (GI) PNS at the time of diagnosis. Using medical records, we attempted to correlate the occurrence of these GI signs with clinical and histologic criteria, as well as to evaluate their influence on the disease-free interval (DFI) and survival (ST) over a 6-year follow-up period (2013-2020). The medical records of 41 dogs with a confirmed diagnosis of cutaneous MCT treated between 2013 and 2014 were included. All dogs underwent surgical biopsy or tumor excision, endoscopic and histologic examination to evaluate possible GI lesions. The presence and severity of GI signs were recorded. Clinical data such as the history of recurrence, number of tumors, tumor size, presence of ulceration, local pruritus, edema and erythema, histopathological classification, and mitotic index were extracted from medical records. Clinical signs relating to the GI system were observed in 41.5% of the dogs and were classified as mild in 94.1% at the time of diagnosis. Endoscopic examination of the upper digestive tract showed evidence of inflammation, but histologic examination of the mucosa showed no serious lesions in any case. There was no significant association between the occurrence of clinical GI signs and any of the variables studied. Follow-up issues meant that only 38 dogs were included for evaluation of the ST and 32 for DFI analysis. DFI was 25.1 months for dogs with GI signs and 14.8 months for dogs without GI signs. At the end of the study, 71.1% of patients had died. Survival time for dogs with GI signs was 54.9 months and 48 months for dogs without GI signs. Over the 6 years of the study, no differences were observed between the ST and the DFI, and the presence or absence of GI PNS at the time of diagnosis.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"56 ","pages":"Article 100808"},"PeriodicalIF":1.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10476411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of open wounds in dogs using a bioresorbable polymeric wound matrix: 14 Cases (2019-2021)","authors":"A.J. Carrillo,&nbsp;M.L. Mancuso,&nbsp;E.A. Maxwell","doi":"10.1016/j.tcam.2023.100825","DOIUrl":"10.1016/j.tcam.2023.100825","url":null,"abstract":"<div><p>The objective of this retrospective case series is to evaluate clinical outcomes associated with the use of a bioresorbable polymeric wound matrix (MicroLyte Vet; Imbed Biosciences) for the management of soft tissue wounds of various etiologies in dogs. Medical records were reviewed between August 2019 and November 2021 for signalment, wound etiology, location, size, initial wound management, antibiotic therapy, time to initial application, number of applications, time between applications, secondary dressing used, time to wound closure, complications, and clinical outcomes. Time to initial application ranged from 1 to 61 days (median, 7.5). The number of applications ranged from 1 to 15 (median, 4.5). Time between applications ranged from 1 to 8 days (median, 3.7). Additional surgical interventions were implemented in 3 dogs. Wound closure by second intention healing (n=14) ranged from 2 to 12 weeks (median, 5). There were no adverse events attributed to the use of bioresorbable polymeric wound matrix. Complete wound healing occurred with use of the bioresorbable polymeric wound matrix in all dogs.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"56 ","pages":"Article 100825"},"PeriodicalIF":1.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61567115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flumazenil Treatment for Diazepam-Associated Neurological Signs in a Cat With a Portosystemic Shunt","authors":"Renata S. Costa ,&nbsp;Jared A. Jaffey ,&nbsp;Jason Evans","doi":"10.1016/j.tcam.2023.100806","DOIUrl":"10.1016/j.tcam.2023.100806","url":null,"abstract":"<div><p>A 7-month-old female spayed domestic short hair cat was presented for evaluation of inadequate clinical response to medical management for hepatic encephalopathy (HE). An abdominal computed tomography (CT) was to be performed but the cat developed 2 grand mal seizures shortly after presentation. Minimal handling and no drugs had been administered before the seizures. A single dose of diazepam (0.3 mg/kg, IV) was administered after each seizure. Another seizure occurred 24 hours after hospitalization and diazepam (0.5 mg/kg, IV) was once again administered. Seizures ceased but neurological signs worsened and included head pressing, loss of menace response, and a stuporous mentation. Due to unresponsiveness to treatment that included administration of intravenous fluids, levetiracetam, ampicillin/sulbactam, and retention enemas (water with lactulose), a dose of flumazenil (0.01 mg/kg) was administered IV and resulted in immediate but transient improvement of clinical signs. The stuporous state returned after 60 min post-treatment and an additional dose of IV flumazenil (0.01 mg/kg) was administered with the same outcome. Based on this positive clinical response, IV infusion of flumazenil was initiated at 0.01 mg/kg/h following a loading dose of 0.005 mg/kg. Due to minimal improvement in neurological signs, flumazenil IV infusion was increased gradually until reaching the effective dose of 0.1 mg/kg/h. Flumazenil IV infusion was continued for 24 hours with improvements in neurological signs, which did not return upon gradual decrease of the flumazenil dose. This is the first report describing the use of a flumazenil IV infusion to improve neurological signs in a cat with a PSS and HE treated with diazepam.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"56 ","pages":"Article 100806"},"PeriodicalIF":1.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10586604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune-Mediated Hemolytic Anemia and Clinically Suspected Acute Pancreatitis in Dogs, a Pilot Study","authors":"Giulia Gianesini ,&nbsp;Michele Drigo ,&nbsp;Andrea Zoia","doi":"10.1016/j.tcam.2023.100821","DOIUrl":"10.1016/j.tcam.2023.100821","url":null,"abstract":"<div><p><span><span>Acute pancreatitis can be a complication of massive hemolysis, above all when intravascular in nature. Therefore, the aim of this study was to investigate the association between </span>canine<span> immune mediated hemolytic anemia (IMHA) and clinically suspected acute pancreatitis (CSAP) and the role of calculated free plasma hemoglobin (Hbfp) in CSAP occurrence/development. In this cohort study<span> the records of 95 dogs with IMHA and 95 sick dogs with pathologies other than IMHA were compared for CSAP occurrence/development. At presentation, 12/95 dogs with IMHA met criteria for CSAP, while only 3/95 sick control dogs met these criteria (χ</span></span></span>² =1.58, <em>P</em> = .008). Within 7 days of hospitalization 9 additional dogs with IMHA had developed CSAP. The Hbfp was calculated and compared for dogs with IMHA that had/developed CSAP and for those without CSAP. In dogs with IMHA, a calculated Hbfp concentration ≥ 0.08 g/dL resulted in an increased relative risk (RR) of having/developing CSAP (RR = 2.54, 95% CI, 1.51-4.29; <em>P</em> = .003). No significant effect on short-term prognosis in dogs with IMHA was found between those having/developing CSAP and those without CSAP. This study showed that dogs with IMHA have an increased risk of having CSAP and Hbfp concentration may be involved in the pathogenesis of acute pancreatitis.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"56 ","pages":"Article 100821"},"PeriodicalIF":1.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41177797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}