Topics in companion animal medicine最新文献

{"title":"Pathological Aspects and Immunohistochemical Evaluation of Troponin C in the Cardiovascular System of Dogs With Pheochromocytoma","authors":"Fernando F. Argenta ,&nbsp;Mônica Slaviero ,&nbsp;Lauren S. de Mello ,&nbsp;Joanna V.Z. Echenique ,&nbsp;Alexia A. Zorzan ,&nbsp;Fernanda G. Cony ,&nbsp;Marcele B. Bandinelli ,&nbsp;Márcio B. de Castro ,&nbsp;Saulo P. Pavarini ,&nbsp;David Driemeier ,&nbsp;Luciana Sonne","doi":"10.1016/j.tcam.2023.100777","DOIUrl":"10.1016/j.tcam.2023.100777","url":null,"abstract":"<div><p>Functional pheochromocytomas secrete catecholamines and have been associated with cardiovascular lesions in dogs. This study aimed to describe the postmortem pathological findings in the cardiovascular system of dogs with pheochromocytoma and to evaluate the expression of cardiac troponin C in these dogs using immunohistochemical analysis. Twelve cases were identified, with a mean age of 10.6 years. The heart of all dogs was enlarged and with concentric hypertrophy of the left ventricular myocardium. Histological analysis showed cardiomyocyte necrosis and degeneration in the myocardium, with frequent bands of contraction, fibrosis, inflammation, and thickening of the medium-caliber arteries in the myocardium. There was a marked decrease or absence of immunolabeling in necrotic cardiomyocytes. We conclude that IHC for troponin C can be a useful tool for detecting myocardial necrosis in dogs with pheochromocytomas, including early cases of necrosis with only incipient cardiac changes where overt histologic abnormalities are not immediately apparent in the cardiomyocytes.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"53 ","pages":"Article 100777"},"PeriodicalIF":1.1,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9647388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injury Risk Factors Associated With Training and Competition in Flyball Dogs","authors":"Scott P. Blake,&nbsp;Vicky A. Melfi,&nbsp;Gillian F. Tabor,&nbsp;Alison P. Wills","doi":"10.1016/j.tcam.2023.100774","DOIUrl":"10.1016/j.tcam.2023.100774","url":null,"abstract":"<div><p>Flyball is a fast-paced, high-energy canine sport which has received negative press regarding the potential for injury, and possible welfare implications for canine competitors. Whilst frequency of injury within the sport has been investigated, evidence gaps remain regarding cause. The aim of this study was therefore to identify risk factors for injury within the sport, with a view to improving competitor safety. An online questionnaire was used to obtain data on dogs that had competed in flyball in the last 5 years but remained injury free, and a second questionnaire obtained data on dogs that had also competed within the last 5 years but sustained an injury. Data relating to conformation and performance was collected for 581 dogs, with the same data plus information relating to injury collected from an additional 75 injured dogs. Data were then compared using univariable, multivariable and multinomial logistic regression.</p><p>Dogs completing a flyball course in less than 4 seconds had the highest level of injury risk (<em>P</em> = .029), which reduced as time taken increased. There was an association between risk of injury and increasing age, with dogs over 10 years old most likely to be injured during their career in the sport (<em>P</em> = .004). Furthermore, dogs using an angle of flyball box of between 45° and 55° had a greater risk of injury, while using an angle between 66° and 75° reduced the risk of injury by 67.2% (OR: 0.328). Use of carpal bandaging was significantly associated with carpal injuries (<em>P</em> = .042). These findings identify new risk factors for injury within flyball which can be used to improve welfare and safety for competitors.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"53 ","pages":"Article 100774"},"PeriodicalIF":1.1,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9585267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Craniectomies for Dogs With Skull Multilobular Osteochondrosarcoma Using the Misonix Bone Scalpel: Cadaveric Evaluation and Retrospective Case Series","authors":"Alexander M. Piazza ,&nbsp;Jonathan F. McAnulty ,&nbsp;Peter Early ,&nbsp;Julien Guevar","doi":"10.1016/j.tcam.2023.100772","DOIUrl":"10.1016/j.tcam.2023.100772","url":null,"abstract":"<div><p>To evaluate the Misonix bone scalpel (MBS) for craniotomies in dogs and describe clinical findings and surgical experience in 3 dogs with large multilobular osteochondrosarcoma (MLO) of the skull. Cadaver evaluation and retrospective case series. One canine cadaver; 3 client-owned dogs. Craniotomies of different sizes and at different locations were performed with MBS. Dural tear and bone discoloration were recorded. Clinical, imaging, and surgical findings of dogs diagnosed with MLO and where MBS was used for craniectomies were retrospectively included. Cadaveric evaluation identified MBS as an efficient tool for rapid craniectomies (&gt;5minutes) albeit dural tears and some small foci of bone discoloration were observed. Craniectomies could be performed without complications in 3 dogs with MLO without dural tear or bone discoloration. .Excision was in complete in all cases. The short-term outcome was good, and the long-term outcome was fair to good. Piezoelectric bone surgery with the Misonix bone scalpel is an alternative technology to perform craniectomies in dogs. It was not associated with complications in 3 dogs diagnosed and surgically treated for MLO. Dural tears and suspected bone necrosis can occur. Great care should be taken when using CT to establish disease free surgical osteotomy.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"53 ","pages":"Article 100772"},"PeriodicalIF":1.1,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9585253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Intravenous Pimobendan on Cardiovascular Parameters in Healthy Sedated Cats","authors":"Keisuke Sugimoto,&nbsp;Yohei Mochizuki,&nbsp;Natsuki Akashi,&nbsp;Teppei Kanda,&nbsp;Fumio Hoshi","doi":"10.1016/j.tcam.2023.100769","DOIUrl":"10.1016/j.tcam.2023.100769","url":null,"abstract":"<div><p>This study aimed to investigate the effects of intravenous pimobendan on cardiovascular function and to determine the appropriate dose for clinical usage in cats. Six purpose-bred cats received one of the following treatments: intravenous pimobendan at a single dose of 0.075 mg/kg (low dose [LD] group), 0.15 mg/kg (middle dose [MD] group), 0.3 mg/kg (high dose [HD] group), or saline at 0.1 mL/kg (placebo group). Echocardiography and blood pressure measurements were performed before and 5, 15, 30, 45, and 60 minute after drug administration for each treatment. In the MD and HD groups, the fractional shortening, peak systolic velocity, cardiac output, and heart rate increased significantly. There were no significant differences in blood pressure among the groups. Intravenous pimobendan at 0.15-0.3 mg/kg increased the fractional shortening, peak systolic velocity, cardiac output in healthy cats.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"53 ","pages":"Article 100769"},"PeriodicalIF":1.1,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9591491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to <Successful Treatment With Prednisolone and Mycophenolate Mofetil in a Dog With Recurrent Erythema Multiforme Minor> Topics in Companion Animal Medicine, 52C (2022)100755","authors":"Taesik Yun,&nbsp;Mingyun Son,&nbsp;Yoonhoi Koo,&nbsp;Yeon Chae,&nbsp;Dohee Lee,&nbsp;Hakhyun Kim,&nbsp;Mhan-Pyo Yang,&nbsp;Byeong-Teck Kang","doi":"10.1016/j.tcam.2023.100761","DOIUrl":"10.1016/j.tcam.2023.100761","url":null,"abstract":"","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"53 ","pages":"Article 100761"},"PeriodicalIF":1.1,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9588743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to Propofol at Single Bolus and Continuous Rate Infusion Significantly Increases Serum Triglycerides, but not Cholesterol, In Healthy Bitches Undergoing Elective Ovariohysterectomy. Topics in Companion Animal Medicine, 45 (2021), 100560","authors":"M.A. Chagas ,&nbsp;L.P. Custodio ,&nbsp;B.S. Gusmão ,&nbsp;I.M. Costa ,&nbsp;G.H. Julião ,&nbsp;S.L.S. Bordolini ,&nbsp;L.R. Costa ,&nbsp;M.R.M. Bosculo ,&nbsp;T.F. Moreira ,&nbsp;B.F.M. Almeida ,&nbsp;N.P. Reis Filho ,&nbsp;F.G. Romão ,&nbsp;C.J.X. Abimussi ,&nbsp;B.P. Floriano","doi":"10.1016/j.tcam.2023.100760","DOIUrl":"10.1016/j.tcam.2023.100760","url":null,"abstract":"","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"53 ","pages":"Article 100760"},"PeriodicalIF":1.1,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9960877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Conscious Minimally Invasive Approach to the Removal of a Trichofolliculoma in an American Guinea Pig: A Case Study","authors":"Rachael Loek ,&nbsp;David Gardiner ,&nbsp;Carine Laporte","doi":"10.1016/j.tcam.2023.100771","DOIUrl":"10.1016/j.tcam.2023.100771","url":null,"abstract":"<div><p>Trichofolliculomas are the most common nonmalignant cutaneous tumors in guinea pigs. While the treatment of choice is surgical excision, complications may occur with general anesthesia and postoperative healing and discomfort after large tissue resection. We describe a case of a trichofolliculoma treated with a conscious, minimally invasive surgical procedure utilizing injectable lidocaine as local anesthetic, with no complications and excellent cosmetic results.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"53 ","pages":"Article 100771"},"PeriodicalIF":1.1,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9965612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Grade Mammary Gland Tumors in Dogs Have Greater VEGF-A and BMP2 Immunostaining and Higher CD31 Blood Vessel Density","authors":"Pablo I.R. Franco ,&nbsp;Jonathas X. Pereira ,&nbsp;Hugo H. Ferreira ,&nbsp;Liliana B. de Menezes ,&nbsp;Marina P. Miguel","doi":"10.1016/j.tcam.2023.100778","DOIUrl":"10.1016/j.tcam.2023.100778","url":null,"abstract":"<div><p>Tumor angiogenesis is an important process in tumor growth, and different molecules are involved in its regulation including VEGF-A, BMP2, and CD31, which can be considered possible prognostic markers. The aim of this study was to verify whether the VEGF-A and BMP2 immunostaining area, and microvascular density (MVD) might be associated with the degree of malignancy in malignant mammary neoplasms of dogs. For this purpose, samples of mammary malignancies from female dogs embedded in wax were used and separated into 4 main histomorphological types: tubulopapillary carcinomas, solid, complex, and carcinosarcoma, which were separated based on high and low degrees of malignancy. Immunohistochemical analysis was performed on tissue microarray blocks using anti-CD31 antibodies for evaluation of MVD and vascular lumen area, and with anti-VEGF-A and anti-BMP2 to determine the immunostaining area using the DAKO EnVision FLEX+ kit. MVD and vascular lumen area were higher in tubulopapillary carcinomas as were the areas stained by VEGF-A and BMP2. Immunostaining for CD31 was higher in low-grade carcinomas as well as in areas immunostained by VEGF-A and BMP2. There was a positive correlation between VEGF and BMP2 in high (<em>r</em> = 0.556, <em>P</em> &lt; .0001) and low-grade (<em>r</em> = 0.287, <em>P</em> &lt; .0001) carcinomas and between MVD and VEGF-A in low-grade carcinomas (<em>r</em> = 0.267, <em>P</em> = .0064). Thus, the markers evaluated showed greater immunostaining in canine mammary tumors with a lower degree of malignancy.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"53 ","pages":"Article 100778"},"PeriodicalIF":1.1,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9585256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral and Physiologic Effects of a Single Dose of Oral Gabapentin in Rabbits (Oryctolagus cuniculus)","authors":"Rachel E. Conway ,&nbsp;Mollie Burton ,&nbsp;Khursheed Mama ,&nbsp;Sangeeta Rao ,&nbsp;Lon V. Kendall ,&nbsp;Marion Desmarchelier ,&nbsp;Miranda J. Sadar","doi":"10.1016/j.tcam.2023.100779","DOIUrl":"10.1016/j.tcam.2023.100779","url":null,"abstract":"<div><p>Stress in rabbits (<em>Oryctolagus cuniculus</em>) may influence veterinarians’ ability to assess their health and can lead to complications such as gastrointestinal hypomotility and poor anesthetic outcomes. Gabapentin has been used as an anxiolytic in various species, but little information is available on its use in rabbits. To assess the effect of gabapentin on stress in rabbits, 5 female and 3 male New Zealand white rabbits, aged 8-12 months, weighing 3-4.5 kg, were administered a single dose (25 mg/kg) of oral compounded gabapentin. Effects on individual behaviors and selected physiologic parameters were assessed by a blinded observer using a human intruder test and tractability score (summed total 0-8, most to least tractable). Heart and respiratory rate, rectal temperature, body weight, and fecal output were also recorded. Baseline measurements for each rabbit were assessed immediately prior to gabapentin administration, and at 1, 2, and 4 hours post-administration. With this method rabbits acted as their own concurrent control group. Rabbits were assessed at 7 AM, 11 AM, and 3 PM. Data were analyzed as continuous, binary, and continuous nonparametric (<em>P</em> ≤ .05). No significant differences in physiologic parameters were observed between baseline and the post-administration timepoints. Fecal output was reduced similar to baseline measurements. Behaviors <em>pressing down</em> decreased (at 2 and 4 hours; <em>P = .</em>05 and <em>P = .</em>013, respectively) and <em>approaching human</em> increased (at 2 hours; <em>P = .</em>022) post-gabapentin compared to baseline. Tractability scores were improved at the 2-hour timepoint compared to baseline (Friedman <em>P = .</em>0461; Wilcoxon <em>P = .</em>0413). These results suggest gabapentin 25 mg/kg orally decreased reactivity with a peak effect at 2 hours, without significant effects on measured physiologic parameters. Oral gabapentin in rabbits should be considered to reduce stress in the presence of humans and to facilitate handling.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"53 ","pages":"Article 100779"},"PeriodicalIF":1.1,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9636729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Survival of Subdermal Plexus Skin Flaps in 8 Cats After Injection of Platelet Rich Plasma","authors":"Vasileia Angelou ,&nbsp;Dimitra Psalla ,&nbsp;George Kazakos ,&nbsp;Christina Marouda ,&nbsp;Kyriakos Chatzimisios ,&nbsp;Zacharenia Kyrana ,&nbsp;Maria Karayannopoulou ,&nbsp;Lysimachos Papazoglou","doi":"10.1016/j.tcam.2023.100770","DOIUrl":"10.1016/j.tcam.2023.100770","url":null,"abstract":"<div><p>The aim of the present study was to evaluate the effect of platelet-rich plasma injection on the survival of experimentally developed subdermal plexus skin flaps in cats. Two flaps, 2 cm wide and 6 cm long were created bilaterally in the dorsal midline in 8 cats. Each flap was randomized to 1 of 2 groups: platelet-rich plasma injection and control. After flap development, the flaps were immediately placed back on the recipient bed. Then 1.8 mL of platelet-rich plasma was equally injected into 6 different parts of the treatment flap. All flaps were evaluated macroscopically daily and on days 0, 7, 14, and 25 by planimetry, Laser Doppler flowmetry, and histology. Mean flap survival on day 14 was 80.437 % (±22.745) for the treatment group and 66.516 % (±24,12) for the control group with no statistically significant difference between the 2 groups (<em>P</em> = .158). Histologically, a significant difference was found between the base of the PRP and the control flap in edema score on day 25 (<em>P</em> = .034). In conclusion, there is no evidence to support the use of platelet-rich plasma in subdermal plexus flaps in cats. However, the use of platelet-rich plasma may aid in reducing edema of subdermal plexus flaps.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"53 ","pages":"Article 100770"},"PeriodicalIF":1.1,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9591494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}