Topics in companion animal medicine最新文献

筛选
英文 中文
Reassessing neonatal hypoglycemia in kittens: Clinical relevance beyond the laboratory value 重新评估小猫新生儿低血糖:临床相关性超越实验室价值。
IF 1.2 3区 农林科学
Topics in companion animal medicine Pub Date : 2026-10-01 Epub Date: 2026-09-25 DOI: 10.1016/j.tcam.2026.101105
Nayane Magda Santos de Oliveira, Monyk Dias Carneiro, Ivia Carmem Talieri, Vanessa Martins Fayad Milken, Fernanda Nastri Gouvêa, Sofia Borin-Crivellenti, Leandro Zucolotto Crivellenti
{"title":"Reassessing neonatal hypoglycemia in kittens: Clinical relevance beyond the laboratory value","authors":"Nayane Magda Santos de Oliveira,&nbsp;Monyk Dias Carneiro,&nbsp;Ivia Carmem Talieri,&nbsp;Vanessa Martins Fayad Milken,&nbsp;Fernanda Nastri Gouvêa,&nbsp;Sofia Borin-Crivellenti,&nbsp;Leandro Zucolotto Crivellenti","doi":"10.1016/j.tcam.2026.101105","DOIUrl":"10.1016/j.tcam.2026.101105","url":null,"abstract":"<div><div>The underdeveloped metabolism in newborn kittens, along with the quick use of liver sugar reserves and the limited ability to produce glucose, makes them prone to low blood sugar levels during this time. This condition may be potentially fatal, although reduced blood glucose values do not necessarily manifest with clinical signs. Fifteen neonatal kittens born to three clinically healthy pregnant queens were evaluated during the first three days of life. Apgar scoring was done daily, and blood glucose measurements began within the first hour after birth (T1), followed by evaluations every 2 hours, with a total of six measurements each day from T2 to T6. Samples were obtained via capillary puncture with alternating digital pads and analyzed using a glucometer validated for cats. A total of 270 glycemic measurements were performed, demonstrating instability during the first hours of life. On the first day, there was a mean glucose concentration of 61.7 ± 22.2 mg/dL. On the second day, it dropped to 53.9 ± 16.5 mg/dL. On the third day, metabolic recovery occurred (68.5 ± 14.7 mg/dL). All neonates maintained adequate Apgar scores and showed no clinical signs of hypoglycemia (&lt; 50 mg/dL; weakness, apathy, or reduced suckling reflex). Marked fluctuations in blood glucose levels were observed during the first 48 hours, characterized by wide glycemic variability (22–165 mg/dL on day 1 and 21–86 mg/dL on day 2). A high frequency of hypoglycemic values was recorded, reaching 51.1% on the first day and 60% on the second, indicating initial metabolic instability despite intermediate mean glucose levels. Progressive stabilization was observed by the third day (range 26–95 mg/dL), with the rate of hypoglycemic events dropping to 22.2%, reflecting the maturation of neonatal metabolic homeostasis. Despite the laboratory diagnosis of hypoglycemia, none of the kittens exhibited clinical manifestations or required intervention.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"73 ","pages":"Article 101105"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149067003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful management of nesidioblastosis in a dog with persistent hyperinsulinemic hypoglycemia following staged bilateral partial pancreatectomies 成功管理的nesidioblastosis犬与持续高胰岛素低血糖后分期双侧部分胰腺切除术。
IF 1.2 3区 农林科学
Topics in companion animal medicine Pub Date : 2026-10-01 Epub Date: 2026-09-24 DOI: 10.1016/j.tcam.2026.101103
Santiago Teyssandier, Marianela Elisabeth Rendon, Hernan Lameroli, Belen Centurion, Sara Galac
{"title":"Successful management of nesidioblastosis in a dog with persistent hyperinsulinemic hypoglycemia following staged bilateral partial pancreatectomies","authors":"Santiago Teyssandier,&nbsp;Marianela Elisabeth Rendon,&nbsp;Hernan Lameroli,&nbsp;Belen Centurion,&nbsp;Sara Galac","doi":"10.1016/j.tcam.2026.101103","DOIUrl":"10.1016/j.tcam.2026.101103","url":null,"abstract":"<div><div>Nesidioblastosis is a rare but important differential diagnosis for hyperinsulinemic hypoglycemia in dogs, a condition most commonly associated with insulinoma. A nine-year-old spayed female dog was presented with recurrent episodes of collapse and documented hyperinsulinemic hypoglycemia. Diagnostic imaging failed to identify a pancreatic mass, prompting exploratory laparotomy with left partial pancreatectomy and regional lymphadenectomy. Histopathological examination excluded insulinoma and established a diagnosis of nesidioblastosis. Although clinical signs initially resolved following surgery, hypoglycemia recurred 45 days later, prompting a right partial pancreatectomy. Following the second procedure, the patient remained euglycemic and free of clinical signs, without evidence of clinical diabetes mellitus or exocrine pancreatic insufficiency throughout an eight-month follow-up period. This case underscores the importance of considering nesidioblastosis in dogs with hyperinsulinemic hypoglycemia when a pancreatic mass is not identified. Furthermore, this case suggests that recurrence after unilateral partial pancreatectomy may occur because of the diffuse nature of nesidioblastosis. In this patient, staged bilateral partial pancreatectomy was associated with sustained glycemic control and clinical remission, without clinically apparent endocrine or exocrine pancreatic dysfunction during an eight-month follow-up period.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"73 ","pages":"Article 101103"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149043112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological response stability of refrigerated cosacthen after opening and non-hormonal effects of ACTH stimulation testing in healthy dogs 冷冻Cosacthen打开后的生物反应稳定性及健康犬ACTH刺激试验的非激素效应。
IF 1.2 3区 农林科学
Topics in companion animal medicine Pub Date : 2026-10-01 Epub Date: 2026-10-09 DOI: 10.1016/j.tcam.2026.101106
Milena Cleff de Oliveira, Taís Bock Nogueira, Fernanda de Lucena Gouvêa, Juliana Moura Oliveira, Luciano Trevizan, Álan Gomes Pöppl
{"title":"Biological response stability of refrigerated cosacthen after opening and non-hormonal effects of ACTH stimulation testing in healthy dogs","authors":"Milena Cleff de Oliveira,&nbsp;Taís Bock Nogueira,&nbsp;Fernanda de Lucena Gouvêa,&nbsp;Juliana Moura Oliveira,&nbsp;Luciano Trevizan,&nbsp;Álan Gomes Pöppl","doi":"10.1016/j.tcam.2026.101106","DOIUrl":"10.1016/j.tcam.2026.101106","url":null,"abstract":"<div><div>The adrenocorticotropic hormone stimulation test (ACTHST) is widely used to evaluate adrenal reserve in dogs. This study assessed the effects of refrigerated storage of tetracosactide (Cosacthen) after opening for up to three weeks and investigated hematological, biochemical, and electrolyte changes following ACTH stimulation. Ten healthy beagle dogs (five males and five females) were enrolled. Each dog received tetracosactide (5 μg/kg, IV) at vial opening (T0) and at 7-day intervals over 3 weeks (T1 to T3), using aliquots from the same vial stored at 2–8°C. Blood samples were collected before and 1 hour after ACTH administration to measure cortisol, hematology, biochemistry, and electrolytes. Clinical monitoring was performed after each test. Cortisol concentrations increased significantly after ACTH administration at all time points (T0–T3). Delta-cortisol was higher at T1 than at T0 (P = 0.0104) and lower at T2 than at T1 (P = 0.0059), with no differences among T0, T2, and T3. After ACTH administration, red blood cell count, hematocrit, hemoglobin, albumin, alkaline phosphatase, triglycerides, cholesterol, potassium, and total calcium decreased significantly, whereas glucose increased. All values remained within reference intervals, and no adverse effects were observed. Refrigerated storage of Cosacthen after opening did not alter cortisol responses. Post-ACTH changes in laboratory variables should be considered when interpreting results.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"73 ","pages":"Article 101106"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Giant mammary fibroadenoma in four female dogs 四只雌性犬的巨大乳腺纤维腺瘤。
IF 1.2 3区 农林科学
Topics in companion animal medicine Pub Date : 2026-07-01 Epub Date: 2026-06-09 DOI: 10.1016/j.tcam.2026.101077
Marina Possa dos Reys, Carolina Gonçalves de Sousa, Tatiane Caroline Fernandes Santana, Karen Yumi Ribeiro Nakagaki, Geovanni Dantas Cassali
{"title":"Giant mammary fibroadenoma in four female dogs","authors":"Marina Possa dos Reys,&nbsp;Carolina Gonçalves de Sousa,&nbsp;Tatiane Caroline Fernandes Santana,&nbsp;Karen Yumi Ribeiro Nakagaki,&nbsp;Geovanni Dantas Cassali","doi":"10.1016/j.tcam.2026.101077","DOIUrl":"10.1016/j.tcam.2026.101077","url":null,"abstract":"<div><div>Fibroadenoma is a benign neoplasm with high prevalence in women but is rare in dogs. Its giant variant is defined by the lesion’s size (exceeding 5 cm) and weight. The standard treatment is surgical excision. The objective of this study was to demonstrate that the subclassification of giant fibroadenoma, as described in humans, can also be observed in female dogs, as evidenced by four cases analyzed. The evaluation comprised macroscopic examination and histopathological analysis, underscoring the importance of differential diagnosis and the characterization of this condition in the canine species.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"72 ","pages":"Article 101077"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148214154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiographic evaluation of abdominal wall herniation in budgerigars (MELOPSITTACUS UNDULATUS) 虎皮鹦鹉腹壁疝的影像学评价。
IF 1.2 3区 农林科学
Topics in companion animal medicine Pub Date : 2026-07-01 Epub Date: 2026-08-04 DOI: 10.1016/j.tcam.2026.101091
Üzeyir Yiğit Uysal, Ebuderda Günay, Serhat Özsoy, Ozan Gündemir, Tomasz Szara
{"title":"Radiographic evaluation of abdominal wall herniation in budgerigars (MELOPSITTACUS UNDULATUS)","authors":"Üzeyir Yiğit Uysal,&nbsp;Ebuderda Günay,&nbsp;Serhat Özsoy,&nbsp;Ozan Gündemir,&nbsp;Tomasz Szara","doi":"10.1016/j.tcam.2026.101091","DOIUrl":"10.1016/j.tcam.2026.101091","url":null,"abstract":"<div><div>This retrospective descriptive study evaluated the radiographic features of abdominal wall herniation in 72 budgerigars (Melopsittacus undulatus) presented with abdominal or caudoventral coelomic distension, abnormal abdominal contour, or suspected protrusion of coelomic contents. The study population consisted of 71 females and 1 male; age was available for 65 birds, ranging from 2 to 8 years. All birds underwent plain radiographic examination, followed by contrast-enhanced radiography after oral administration of iohexol at 1 mL per bird, corresponding to 300 mg iodine per bird. Radiographic assessment focused on the location and contour of the protruded abdominal wall region, suspected herniated contents, gastrointestinal contrast filling patterns, suspected free fluid or localized gas accumulation, mineralized egg-related material, overlying skin and subcutaneous tissue thickening, and associated skeletal findings. Polyostotic hyperostosis was recorded in 49 of 72 birds (68.1%), and mineralized material compatible with egg-related remnants was identified in 10 of 72 birds (13.9%). The herniation was recorded as ventral or ventrocaudal in 40 birds (55.6%) and dorsocaudal or perineal in 4 birds (5.6%); location was not clearly recorded in 28 birds (38.9%). Contrast-enhanced radiography improved visualization of gastrointestinal involvement, particularly intestinal loops, and helped differentiate contrast-filled intestinal segments from adjacent soft tissue or non-gastrointestinal components. In selected cases, ultrasonography provided additional diagnostic value by helping differentiate fluid-filled or cystic structures when radiographic findings were inconclusive. Overall, this study provides an imaging-based descriptive reference for assessing abdominal wall herniation in budgerigars and highlights the practical value of plain and contrast-enhanced radiography as well as complementary ultrasonography for clinical assessment and preoperative planning.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"72 ","pages":"Article 101091"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148703340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro evaluation of temperature-dependent stability and antimicrobial activity of reconstituted cefovecin sodium 体外温度依赖性稳定性及抑菌活性评价。
IF 1.2 3区 农林科学
Topics in companion animal medicine Pub Date : 2026-07-01 Epub Date: 2026-06-09 DOI: 10.1016/j.tcam.2026.101080
Toshiharu Fukayama, Michio Iwahana, Hidetoshi Yamada, Lina Hamabe
{"title":"In vitro evaluation of temperature-dependent stability and antimicrobial activity of reconstituted cefovecin sodium","authors":"Toshiharu Fukayama,&nbsp;Michio Iwahana,&nbsp;Hidetoshi Yamada,&nbsp;Lina Hamabe","doi":"10.1016/j.tcam.2026.101080","DOIUrl":"10.1016/j.tcam.2026.101080","url":null,"abstract":"<div><div>Cefovecin sodium is a long-acting third-generation cephalosporin widely used in dogs and cats. After reconstitution, refrigerated storage for a limited period is recommended; however, experimental data regarding the effects of alternative controlled storage temperatures on drug stability and antimicrobial activity are limited. This study evaluated, under in vitro conditions, the impact of storage temperature on the physicochemical stability and antimicrobial activity of reconstituted cefovecin sodium. Samples were stored at room temperature (25 ± 2°C), refrigerated conditions (4°C), or frozen conditions (-20°C) for up to 12 weeks. Visual appearance, absorbance at 360 nm, minimum inhibitory concentrations (MICs) against <em>E. coli</em> and Staphylococcus aureus, and cefovecin sodium concentrations determined by liquid chromatography–tandem mass spectrometry (LC-MS/MS) were assessed over time. Room temperature storage resulted in progressive discoloration, increased absorbance, elevated MIC values, and a significant decrease in drug concentration at later time points. Refrigerated storage delayed these changes, although mild increases in absorbance and MIC values were descriptively observed at later time points. In contrast, frozen storage preserved physicochemical properties, antimicrobial activity, and measured drug concentrations throughout the study period. These findings demonstrate that storage temperature influences the stability and in vitro antimicrobial activity of reconstituted cefovecin sodium in a condition-dependent manner. The results provide experimental reference data under controlled laboratory conditions and do not support clinical use outside the manufacturer’s approved storage instructions.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"72 ","pages":"Article 101080"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrochemotherapy with carboplatin and bleomycin associated with mastectomy in cats with mammary carcinoma: A pilot study 卡铂和博来霉素电化疗与乳腺癌猫乳房切除术相关:一项初步研究。
IF 1.2 3区 农林科学
Topics in companion animal medicine Pub Date : 2026-07-01 Epub Date: 2026-06-13 DOI: 10.1016/j.tcam.2026.101078
Renata Regadas, Graziela Souza Dias, Carlos Henrique Maciel Brunner, Vitor de Moraes Pina de Carvalho, Laís Pereira Silva, Karine Araújo Damasceno, Thanielle Novaes Fontes, Marcos André Nino Rocha, Stella Maria Barrouin-Melo, Marília Carneiro de Araújo Machado, Alessandra Estrela-Lima
{"title":"Electrochemotherapy with carboplatin and bleomycin associated with mastectomy in cats with mammary carcinoma: A pilot study","authors":"Renata Regadas,&nbsp;Graziela Souza Dias,&nbsp;Carlos Henrique Maciel Brunner,&nbsp;Vitor de Moraes Pina de Carvalho,&nbsp;Laís Pereira Silva,&nbsp;Karine Araújo Damasceno,&nbsp;Thanielle Novaes Fontes,&nbsp;Marcos André Nino Rocha,&nbsp;Stella Maria Barrouin-Melo,&nbsp;Marília Carneiro de Araújo Machado,&nbsp;Alessandra Estrela-Lima","doi":"10.1016/j.tcam.2026.101078","DOIUrl":"10.1016/j.tcam.2026.101078","url":null,"abstract":"<div><div>In cats, the high incidence of malignant mammary neoplasms with elevated rates of metastasis and recurrence underscores the need for more effective therapies to prevent disease progression. This preliminary study evaluated the impact of carboplatin or bleomycin electrochemotherapy on recurrence rates, adverse effects, and overall survival in female cats with mammary carcinoma undergoing mastectomy. Thirty-four female cats with mammary carcinoma were assigned to four groups: Group 1 (mastectomy), Group 2 (mastectomy plus chemotherapy), Group 3 (mastectomy plus electrochemotherapy with carboplatin and chemotherapy), and Group 4 (mastectomy plus electrochemotherapy with bleomycin and chemotherapy). The tumors were classified and graded histologically, and the proliferative index was assessed using Ki-67. Most cases were stage III, and 50% had nodal metastases. The predominant tumor types included cribriform carcinoma and histological grade II. All groups showed a high Ki-67 proliferation index (&gt;20%), with no significant differences (p = 0.753). Hematocrit values in the fourth chemotherapy session were higher in G3 than in G2 (p = 0.022). The highest numerical recurrence rate occurred in G1, while no recurrences were observed in G2 or G4 during follow-up; however, this difference did not reach statistical significance (p = 0.086). Overall survival analysis showed a 82% mortality rate; G1 had 100% mortality, with a significant difference compared with the other groups (p = 0.0287). More chemotherapy sessions (≥5) were significantly associated with increased overall survival (p = 0.002), adding a mean of 39.1 days to disease-free survival per additional session. Taken together, these preliminary findings suggest that mastectomy alone was insufficient to control progression the cancer. Carboplatin-based protocols, whether used as conventional chemotherapy or combined with electrochemotherapy, showed lower recurrence rates, fewer adverse effects, and longer overall survival. However, due to the limited sample size, these results should be interpreted with caution. Further studies with larger cohorts are warranted to confirm these observations</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"72 ","pages":"Article 101078"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148255300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of 24-hour sedation during mechanical ventilation on hematological, biochemical, and coagulation parameters in bitches: A randomized clinical study 机械通气时24小时镇静对母狗血液学、生化和凝血参数的影响:一项随机临床研究。
IF 1.2 3区 农林科学
Topics in companion animal medicine Pub Date : 2026-07-01 Epub Date: 2026-08-03 DOI: 10.1016/j.tcam.2026.101092
Doughlas Regalin, Barbara Ataíde Adorno, Natielly Dias Chimenes, Diego Ribeiro, Reiner Silveira de Moraes, Luíz Guilherme Dércore Benevenuto, Gilberto Serighelli-Júnior, Mere Erika Saito, Felipe Comassetto, Bruna Ditzel da Costa Regalin, Vanessa Sasso Padilha, Julieta Volpato, Nilson Oleskovicz
{"title":"Effect of 24-hour sedation during mechanical ventilation on hematological, biochemical, and coagulation parameters in bitches: A randomized clinical study","authors":"Doughlas Regalin,&nbsp;Barbara Ataíde Adorno,&nbsp;Natielly Dias Chimenes,&nbsp;Diego Ribeiro,&nbsp;Reiner Silveira de Moraes,&nbsp;Luíz Guilherme Dércore Benevenuto,&nbsp;Gilberto Serighelli-Júnior,&nbsp;Mere Erika Saito,&nbsp;Felipe Comassetto,&nbsp;Bruna Ditzel da Costa Regalin,&nbsp;Vanessa Sasso Padilha,&nbsp;Julieta Volpato,&nbsp;Nilson Oleskovicz","doi":"10.1016/j.tcam.2026.101092","DOIUrl":"10.1016/j.tcam.2026.101092","url":null,"abstract":"<div><div>The effects of prolonged sedation on hematological, biochemical, and coagulation variables have not been previously investigated in veterinary medicine. Twelve healthy adult mixed-breed female dogs were included. Blood samples (6 mL) were collected at baseline (M0) for complete blood count (CBC), biochemical testing, prothrombin time (PT), activated partial thromboplastin time (PTT) and fibrinogen. After M0, dogs were allocated into two groups: midazolam-fentanyl-propofol group (MFG; n = 6), which received a continuous infusion of midazolam (0.5 mg/kg/h), fentanyl (10 µg/kg/h), and propofol (18 mg/kg/h); and ketamine-morphine-propofol group (KMG; n = 6), which received a continuous infusion of ketamine (0.6 mg/kg/h), morphine (0.26 mg/kg/h), and propofol (18 mg/kg/h). The infusion was maintained for 24 hours under mechanical ventilation. Laboratory parameters were reassessed from 12 to 24 hours after the beginning of infusion (M12 and M24), and at 12, 24, and 48 hours after the infusion (T12, T24, and T48). Both protocols significantly reduced erythrocyte count, packed cell volume, and haemoglobin concentration. In KMG, TTP decreased significantly at M12, M24, and T24; TSP at M24; and lymphocytes at M12 and M24. No significant changes were observed in ALP, ALT, albumin, globulins, creatinine, urea, glucose and blood coagulation. Triglyceride and cholesterol concentrations increased significantly from M6 to T48, but without biochemical evidence of hepatic, renal, or coagulation impairment. Overall, both protocols induced transient hematological and biochemical changes without clinically meaningful alterations in hepatic or renal function, supporting their use in healthy dogs mechanically ventilated for 24 hours.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"72 ","pages":"Article 101092"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simply adding positive end-expiratory pressure has limited effects on oxygenation in obese dogs 简单地增加呼气末正压对肥胖狗的氧合作用有限。
IF 1.2 3区 农林科学
Topics in companion animal medicine Pub Date : 2026-07-01 Epub Date: 2026-08-03 DOI: 10.1016/j.tcam.2026.101090
Manuel Martin-Flores, Joaquin Araos, Taylor A. Rondon
{"title":"Simply adding positive end-expiratory pressure has limited effects on oxygenation in obese dogs","authors":"Manuel Martin-Flores,&nbsp;Joaquin Araos,&nbsp;Taylor A. Rondon","doi":"10.1016/j.tcam.2026.101090","DOIUrl":"10.1016/j.tcam.2026.101090","url":null,"abstract":"<div><div>Positive end-expiratory pressure (PEEP) can be used to prevent atelectasis during anesthesia. We evaluated the effect of PEEP on intra- and postoperative oxygenation on obese dogs admitted for stifle surgery. Dogs received no PEEP (ZEEP; n = 10) or 7 cmH<sub>2</sub>O PEEP (n = 9) at random during general anesthesia. The partial pressure of arterial oxygen (PaO<sub>2</sub>) and its ratio to inspired fractional oxygen (PaO<sub>2</sub>:FiO<sub>2</sub>) were measured at start and end of surgery (FiO<sub>2</sub> 1.0), and 20, 120, and 240 minutes after extubation (FiO<sub>2</sub> 0.2). Cases of hypoxemia (PaO<sub>2</sub> &lt; 80 mmHg) were identified. There were no differences between treatment for either variable (P &gt; 0.1 for treatment and P &gt; 0.6 for treatment*time, for both variables). There were three cases of postoperative hypoxemia in the ZEEP treatment (P = 0.21). No significant improvement was achieved when PEEP 7 cmH<sub>2</sub>O was applied in isolation. Successful use of PEEP may require additional maneuvers.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"72 ","pages":"Article 101090"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-reported knowledge and practices of dog owners regarding canine overweight: a cross-sectional questionnaire survey 狗主人自我报告的关于狗超重的知识和行为:一项横断面问卷调查。
IF 1.3 3区 农林科学
Topics in companion animal medicine Pub Date : 2026-04-01 Epub Date: 2026-04-25 DOI: 10.1016/j.tcam.2026.101057
Felipe Gaia de Sousa , Ana Cristina Ribeiro Mendes , Eduarda Cristina Pereira Severino , Fernanda do Carmo Magalhães
{"title":"Self-reported knowledge and practices of dog owners regarding canine overweight: a cross-sectional questionnaire survey","authors":"Felipe Gaia de Sousa ,&nbsp;Ana Cristina Ribeiro Mendes ,&nbsp;Eduarda Cristina Pereira Severino ,&nbsp;Fernanda do Carmo Magalhães","doi":"10.1016/j.tcam.2026.101057","DOIUrl":"10.1016/j.tcam.2026.101057","url":null,"abstract":"<div><div>Excess body weight (overweight or obesity) is among the most common nutritional conditions in dogs and is frequently associated with an imbalance between caloric intake and energy expenditure. Its detection and management depend on owners’ recognition and management of their pets’ body condition. This study aimed to assess dog owners’ self-reported knowledge and practices regarding excess body weight and to identify the factors associated with it. An online questionnaire was administered to 122 dog owners between November 2024 and January 2025. Statistical analyses included descriptive statistics, correlation analyses, and ordered regression, with a significance level of 5% (<em>p</em> ≤ 0.05). Excess body weight was observed in 46.7% of the dogs, accompanied by a high frequency of daily snack offerings. Although 100% of owners recognized the health risks associated with excess weight, and 92.6% acknowledged the importance of veterinary supervision for management, some reported practices appeared to be inconsistent with this knowledge, such as ad libitum feeding and poor adherence to professional advice. Significant correlations were observed between body condition score and both the animal’s size and the frequency of snack offerings. Regression analysis showed that owners’ time spent at home, as well as dogs’ age, sex, breed type, and type of food, were associated with body condition score. Despite expressed theoretical knowledge, some potentially suboptimal practices were reported. Ongoing educational efforts and collaborative management strategies involving both owners and professionals are essential and may support improvements in management practices and improve dogs’ health and quality of life.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"71 ","pages":"Article 101057"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书