Topics in companion animal medicine最新文献

{"title":"Cardiac involvement in European canine babesiosis - a pathological perspective","authors":"Doroteja Huber,&nbsp;Dunja Vlahović,&nbsp;Ivana Mihoković Buhin,&nbsp;Lidija Medven Zagradišnik,&nbsp;Branka Artuković,&nbsp;Marko Hohšteter,&nbsp;Ivan-Conrado Šoštarić-Zuckermann","doi":"10.1016/j.tcam.2026.101060","DOIUrl":"10.1016/j.tcam.2026.101060","url":null,"abstract":"<div><div>Canine babesiosis is an important and potentially life-threatening disease of worldwide significance. European babesiosis encompasses all protozoan parasites of the genus <em>Babesia</em> that have been reported to cause canine disease in Europe. Despite its importance, cardiac pathology associated with European babesiosis remains poorly characterized. The aim of this study was to assess cardiac lesions in dogs that succumbed to European babesiosis.</div><div>For this study, the archive of the Department of Veterinary Pathology, Faculty of Veterinary Medicine Zagreb, was retrospectively searched for necropsied dogs which died as a consequence of naturally acquired European babesiosis. Babesiosis was diagnosed by detection of trophozoites within erythrocytes, but not lymphocytes, in cytological and/or histological slides. Necropsy reports, photographs of cardiac gross lesions, and histologic slides of the heart were reviewed, and all changes were noted.</div><div>The most common gross pathologies were hemorrhage and pericardial effusion, while intravascular monocytic leukostasis, hemorrhage, endomysial edema, myocardial necrosis, congestion, and myocarditis were the most frequent histologic findings. Based on results of the current study, cardiac lesions in clinical cases of complicated European babesiosis should be expected and patients should be evaluated for such damage.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"71 ","pages":"Article 101060"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of zoonotic vector-borne pathogens in domestic dogs from rural areas in northern Peru","authors":"Luis A. Julca ,&nbsp;Martha Y. Salas-Fajardo ,&nbsp;Soraya Guevara ,&nbsp;Claudio Muro ,&nbsp;Ana Vargas-Calla ,&nbsp;Luis A. Gomez-Puerta","doi":"10.1016/j.tcam.2026.101056","DOIUrl":"10.1016/j.tcam.2026.101056","url":null,"abstract":"<div><div>This study was performed to determine the seroprevalence of zoonotic vector-borne diseases (ehrlichiosis, anaplasmosis, dirofilariasis, and Lyme disease) in domestic dogs in northern Peru, in rural areas of the Tumbes department. Blood samples were collected from dogs (n = 169) from three districts of the province of Tumbes: Garbanzal (n = 59), Puerto Pizarro (n = 59) and Rica Playa (n = 51). The samples were tested using a commercial enzyme-linked immunosorbent assay to check for <em>Ehrlichia</em> spp., <em>Anaplasma</em> spp., <em>Borrelia burgdorferi</em>, and <em>Dirofilaria immitis</em>. The results showed a seroprevalence of 77.5% (131/169) for <em>Ehrlichia</em> spp., 37.9% (64/169) for <em>Anaplasma</em> spp., and 26% (44/169) for <em>D. immitis</em>. No positive dogs for <em>B. burgdorferi</em> antibodies were detected in this study. A statistically significant association was found between dogs seropositive for <em>Ehrlichia</em> spp. and the variables age (p = 0.002), breeding place (p = 0.003), and breed type (p = 0.032). Furthermore, dogs infected with <em>D. immitis</em> were associated with the age (p = 0.001), locality (p &lt; 0.001), and breeding place (p = 0.001). These findings confirm a high prevalence of zoonotic vector-borne diseases affecting domestic dogs in rural areas of northern Peru.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"71 ","pages":"Article 101056"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of reproductive tract disease incidence in intact female African pygmy hedgehogs (Atelerix albiventris)","authors":"Lucia Kasalová ,&nbsp;Hana Černochová ,&nbsp;Radka Dvořáková ,&nbsp;Aneta Angelová ,&nbsp;Kristína Řeháková","doi":"10.1016/j.tcam.2026.101061","DOIUrl":"10.1016/j.tcam.2026.101061","url":null,"abstract":"<div><h3>Background</h3><div>Reproductive tract disease is frequently reported in African pygmy hedgehogs, yet the true prevalence and spectrum of lesions remain unclear. Clinical information is often limited to case description, and mild or chronic pathologies may be underdiagnosed.</div></div><div><h3>Objectives</h3><div>To determine the prevalence, types, and clinical characteristics of reproductive tract disease in female African pygmy hedgehogs, and to evaluate the diagnostic value of haematology, plasma biochemistry, vaginal cytology, ultrasonography, histopathology, and microbiological culture.</div></div><div><h3>Methods</h3><div>A retrospective study was performed of 53 female hedgehogs presented between May 2O22 and June 2024. Three previously sterilised animals were excluded. Clinical signs, diagnostic findings, and histopathological results were analysed descriptively.</div></div><div><h3>Results</h3><div>Reproductive tract disease was identified in 32% (16/50) of intact females. The median age of affected animals was 3.5 years. Uterine masses were detected in 56% (9/16) of affected females. Neoplasia was confirmed in 55% (5/9) cases of these presented uterine masses(stromal sarcoma, leiomyosarcoma an including endometrial polyp). Chronic superficial endometritis and cystic endometrial hyperplasia occurred in 50% (8/16)of cases. Bacterial culture was positive in 44% of the obtained samples (4/9), predominantly <em>Escherichia coli, Streptococcus dysgalactiae, Klebsiella oxytoca,</em> and <em>Proteus vulgaris</em>. Common haematological abnormalities included monocytosis and anaemia. Ultrasonography reliably detected uterine enlargement, fluid accumulation, cystic changes, and mass-like lesions. Vaginal cytology provided supportive evidence of inflammation.</div></div><div><h3>Conclusion</h3><div>Reproductive tract disease in female African pygmy hedgehogs presents a broader range of inflammatory and hyperplastic conditions than previously recognised. Ultrasonography, haematology, and vaginal cytology offer valuable diagnostic information, and preventive sterilisation should be considered to reduce the risk of reproductive pathology.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"71 ","pages":"Article 101061"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147871156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of safety profile and analgesia provided by grapiprant and metamizole alone or combined for postoperative analgesia of queens undergoing elective ovariohysterectomy","authors":"Jean Carlos Gasparotto ,&nbsp;Luciana Gonçalves Teixeira ,&nbsp;Charline Vanessa Vaccarin ,&nbsp;Paula Ivanir Schimites ,&nbsp;Júlia Mariani Griesang ,&nbsp;Daniel Vargas ,&nbsp;Emanuelle Bortolotto Degregori ,&nbsp;Cínthia Melazzo Andrade ,&nbsp;Beatriz Perez Floriano ,&nbsp;Gabrielle Coelho Freitas ,&nbsp;André Vasconcelos Soares","doi":"10.1016/j.tcam.2026.101055","DOIUrl":"10.1016/j.tcam.2026.101055","url":null,"abstract":"<div><div>The purpose of this study was to assess the efficacy of grapiprant combined with metamizole for postoperative analgesia of healthy queens undergoing elective ovariohysterectomy, as well as the effects of both drugs on laboratory variables of blood and urine samples. Twenty-six mixed-breed adult queens deemed healthy based on clinical examination and scheduled for elective ovariohysterectomy were randomly allocated in three groups comprising three analgesia protocols: MET, metamizole at 25 mg/kg q8 hours (n=8); GRA, grapiprant at 2 mg/kg q24 hours (n=10); and GRAMET, grapiprant at 2 mg/kg q24 hours + metamizole 25 mg/kg q8 hours (n=8). Drugs were given orally in all groups 2 hours prior to extubation. Postoperative pain was assessed using multidimensional pain scales (UNESP and Glasgow) adapted for cats. Evaluations were carried out preoperatively (baseline) and 1, 3, 6, 8, 12 and 24 hours (T1, T3, T6, T8, T12 and T24, respectively) postoperatively. Venous blood samples were obtained at baseline and 24 hours following administration of treatment drugs for complete blood count and serum analysis (ALT, AST, GGT, ALP, creatinine, and urea). Urine samples were obtained at baseline and 24 hours following extubation for urinalysis. Blood glucose was assessed at baseline and 1 hour following extubation. Pain scores differed significantly over time among the three groups with both scales. Rescue analgesia was predominantly necessary within 3 hours following surgery (87.5% for MET, 50.0% for GRA and 62.5% for GRAMET). Lowest pain scores were found in MET and GRAMET as of T3 postoperatively. There were no changes in blood and urine variables throughout the study. Blood glucose increased in all groups at T1 compared with baseline. While metamizole and grapiprant were well tolerated in this study either given alone or in combination, postoperative analgesia was insufficient in healthy queens subjected to elective ovariohysterectomy. Neither drug was associated with any significant changes on laboratory variables over 24 hours of postoperative evaluation.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"71 ","pages":"Article 101055"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-based aortic elasticity predicts systemic hypertension in dogs with mitral valve disease: A randomized clinical trial","authors":"Edwin Buriticá-Gaviria ,&nbsp;Diego Echeverry-Bonilla ,&nbsp;Miguel Naranjo-Medellín ,&nbsp;Giovana Ruviano-Tuleski ,&nbsp;Gilberto Serighelli-Júnior ,&nbsp;Marlos Gonçalves-Sousa","doi":"10.1016/j.tcam.2026.101059","DOIUrl":"10.1016/j.tcam.2026.101059","url":null,"abstract":"<div><div>This study aimed to evaluate whether abdominal aortic elasticity (AAE), a noninvasive ultrasonographic measurement, could assist in the clinical staging and blood pressure (BP) monitoring of dogs with myxomatous mitral valve disease (MMVD). A second aim was to determine an AAE cut-off predictive of systemic hypertension. Thirty-seven client-owned dogs (6.8 ± 3.9 kg; 10.7 ± 4.4 years) were enrolled in a prospective, randomized, blinded study and stratified into three groups based on the 2019 ACVIM consensus: healthy controls (G1, n = 8), asymptomatic MMVD stage B2 dogs (G2, n = 19), and symptomatic MMVD stage C dogs (G3, n = 10). Abdominal ultrasonography was used to calculate AAE, while systolic arterial pressure was measured using a validated oscillometric device. Comparative analysis of AAE values among groups revealed a progressive decline associated with disease severity, with mean AAE of 11.4 ± 5.3% in healthy controls, 8.4 ± 3.8% in stage B2 dogs, and 5.9 ± 3.1% in stage C dogs. The reduction in AAE was statistically significant between stage C and control groups (P &lt; 0.05). A strong inverse correlation was observed between AAE and systolic pressure (r = –0.7352; p &lt; 0.001), suggesting that reduced aortic compliance may reflect increased vascular resistance in the context of cardiac remodeling and hypertension. An AAE value ≤6.1% predicted systemic hypertension with 80.0% sensitivity and 75.6% specificity. These findings indicate AAE is inversely correlated with systolic BP and may support hypertension screening in dogs with MMVD. Further studies are needed to confirm its diagnostic performance.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"71 ","pages":"Article 101059"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147825357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of using a propofol priming and coinduction with ketamine or S(+) Ketamine on the dose of induction and duration of propofol in cats","authors":"Vieira Lisiane Saremba ,&nbsp;Arboit Francini ,&nbsp;Arend Nadine ,&nbsp;Souza Andressa Rodrigues ,&nbsp;Paraguassú Amanda Oliveira ,&nbsp;Oliveira Júlia Odorissi ,&nbsp;Biaggio Mario Leite ,&nbsp;Rodrigues Ayuá Kaus Harr ,&nbsp;Soares André Vasconcelos ,&nbsp;Freitas Gabrielle Coelho ,&nbsp;Floriano Beatriz Perez","doi":"10.1016/j.tcam.2026.101058","DOIUrl":"10.1016/j.tcam.2026.101058","url":null,"abstract":"<div><div>The study aimed to evaluate the effects of racemic ketamine and S (+) ketamine coinduction with propofol, comparing these to propofol alone and propofol as its own coinductor, on anesthetic induction, cardiorespiratory parameters, intubation conditions, and recovery in cats. Thirty-two healthy cats were divided into four groups (<em>n</em> = 8): GC (propofol at 1 mg/kg/min, titrated to effect, administered via a syringe infusion pump), GP (propofol priming of 1 mg/kg and 0.5 ml of NaCl 0.9% bolus as placebo, followed by propofol to effect at 1 mg/kg/min), GKet (propofol priming of 1 mg/kg and a racemic ketamine bolus of 2 mg/kg, followed by propofol to effect at 1 mg/kg/min), and GKet+ (propofol priming of 1 mg/kg and a S (+) ketamine bolus of 2 mg/kg, followed by propofol to effect at 1 mg/kg/min). Cats were premedicated with gabapentin (150 mg/cat) one hour before procedures to minimize stress. Propofol infusion began 30 seconds after coinduction and was titrated until loss of jaw tone and laryngotracheal reflex. Heart rate, respiratory rate, temperature, and systolic blood pressure were recorded every 10 min until the return of the laryngotracheal reflex. Recovery times, intubation attempts, and adverse effects were recorded and analyzed. Baseline parameters were similar across groups, except for temperature (<em>P</em> = 0.003). Propofol doses were significantly lower in the GKet+ compared to GC (<em>P</em> = 0.004). Intubation attempts and reinduction doses did not differ between groups. Heart rate changes were significant between 0 and 20 min in the placebo and S (+) ketamine groups. Recovery exhibited a notable difference in ocular bulb centralization between GC and GKet+ (<em>P</em> = 0.008). Other parameters did not show differences. S (+) ketamine coinduction with propofol priming reduced propofol requirements in cats without increasing adverse effects and maintained stable cardiorespiratory parameters. Recovery profiles were comparable, with a slight delay in ocular bulb return to a central position in the S (+) ketamine group. These findings highlight the potential of S (+) ketamine and propofol priming as effective and safe strategies in veterinary anesthetic protocols.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"71 ","pages":"Article 101058"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urethral reconstruction using a preputial mucosa free flap and autologous mesenchymal stromal cells in a male alpaca (Vicugna pacos)","authors":"Daniele Zambelli ,&nbsp;Giulia Ballotta ,&nbsp;Marco Cunto ,&nbsp;Angelita Capone ,&nbsp;Penelope Maria Gugole ,&nbsp;Barbara Merlo ,&nbsp;Eleonora Iacono","doi":"10.1016/j.tcam.2026.101054","DOIUrl":"10.1016/j.tcam.2026.101054","url":null,"abstract":"<div><div>Like small ruminants, alpacas are prone to urethral obstruction, commonly caused by urolithiasis. Surgical intervention, such as perineal urethrostomy, is often necessary, though recurrent strictures and impaired healing pose significant challenges. A 2-year-old, 40 kg neutered male alpaca was referred for severe urinary retention and hemorrhage following an unsuccessful previous perineal urethrostomy. Due to extensive tissue damage observed after the previous urethrostomy, a conventional surgical approach was not viable, leading to the decision to reconstruct the urethra using a free preputial mucosal flap seeded with autologous mesenchymal stromal cells (MSCs). Cells were isolated from subcutaneous adipose tissue, expanded in vitro and characterized. Two months post-initial surgery, urethral reconstruction was performed, and MSCs were applied both within the graft and as a topical gel. Postoperatively, the alpaca recovered well, with proper wound healing, no signs of infection, and no recurrence of urethral stricture. In this case report, for the first time in alpacas, MSC-seeded graft for urethral reconstruction was used. The successful outcome highlights the potential of MSC-based therapies in veterinary regenerative medicine, particularly for addressing complex urethral defects and improving long-term surgical success. Further studies are needed to explore the broader applications of MSCs in New World camelid surgery.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"71 ","pages":"Article 101054"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal demise and delayed parturition following post-mating administration of depot progesterone for contraception in three hunting dogs","authors":"Buse Öztürk,&nbsp;Aslıhan Ayalp-Erkan,&nbsp;Yusuf Bilal Çetinkaya,&nbsp;Tunahan Öztürk,&nbsp;Nevzat Saat,&nbsp;Barış Güner","doi":"10.1016/j.tcam.2025.101044","DOIUrl":"10.1016/j.tcam.2025.101044","url":null,"abstract":"<div><div>Depot medroxyprogesterone acetate (MPA) is used in dogs to suppress estrus or prevent pregnancy. This report describes three cases in which post-mating administration of MPA resulted in failure of parturition and fetal death in hunting dogs. In all cases, MPA was administered within 1–7 days post-mating at a fixed dose of 150 mg. The dogs presented with signs of prolonged pregnancy and absence of labor. Ultrasonographic examinations confirmed the presence of non-viable fetuses, and ovariohysterectomy was performed in each case. In these dogs, serum progesterone concentrations ranged between 2.20 and 9.03 ng/mL at the time of parturition and remained within this range for up to two weeks postpartum. These hormonal alterations were likely due to exogenous MPA, which interfered with luteolysis, delaying the onset of labor. These findings underscore the importance of restricting depot progesterone use to appropriate reproductive stages to prevent iatrogenic reproductive failure and to ensure animal welfare.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"70 ","pages":"Article 101044"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating illicit dog health supplements using various analytical techniques","authors":"Ricoveer Shergill,&nbsp;Shakthy Sharma,&nbsp;Rora Wisby,&nbsp;Bhavik Anil Patel","doi":"10.1016/j.tcam.2025.101039","DOIUrl":"10.1016/j.tcam.2025.101039","url":null,"abstract":"<div><div>Health supplements are widely used by pet owners to provide a long and healthy life for their pets. Despite the widespread use of pet health supplements, the regulation of these products remains limited, so they are more likely to be targeted to be made as illegal products. Within this study we investigated two dog supplements used for joint care that were suspected to be illicit using a range of analytical measurement techniques. Visual inspection of the external packaging showed similarities between the real and illicit products, but there were clear differences in the blister pack and appearance of the supplements. The illicit supplements had a lower weight and increased hardness. The infra-red spectra of the real and illicit supplement were closely correlated, but there were a significantly lower amount of vitamin C, vitamin E, manganese and Omega-3 fatty acids present within the illicit tablets. Our findings showcase that the illicit tablets are falsified as they contain a lower quantity of ingredients by cutting real original tablets with bulking agents to vastly increase the yield. Our findings showcase that illicit pet supplements are being produced and sold using online marketplaces providing considerable risk to pet owners and therefore there is a need for greater awareness on the risks posed by illicit products.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"70 ","pages":"Article 101039"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145717249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological findings, KIT expression, and clinical course of cutaneous mast cell tumours in pet Syrian hamsters (Mesocricetus auratus)","authors":"Hirotaka Kondo ,&nbsp;Iori Koizumi ,&nbsp;Saki Kawahara ,&nbsp;Tomosige Baba","doi":"10.1016/j.tcam.2025.101041","DOIUrl":"10.1016/j.tcam.2025.101041","url":null,"abstract":"<div><div>This report describes the histopathological and immunohistochemical features, as well as the biological behaviour, of cutaneous mast cell tumours for the first time in two Syrian hamsters. Both cases presented with a raised cutaneous mass, one in the preputial region and one on the ear pinna, respectively. The masses showed similar histological and immunohistochemical findings and were composed of solid sheets of round cells with moderate amounts of basophilic intracytoplasmic granules. These granules showed prominent metachromasia on toluidine blue staining. Immunohistochemically, the neoplastic cells had diffuse, granular cytoplasmic labelling to anti-KIT antibody. There was no evidence of recurrence in both cases, and no metastatic lesions were observed in Case 1 on necropsy and subsequent histopathological examination, suggesting that, compared with other animals, mast cell tumours have a benign clinical course in Syrian hamsters during the initial follow-up period.</div></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"70 ","pages":"Article 101041"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}