Toxicological and Environmental Chemistry最新文献

Perfluorobutanesulfonic Acid (PFBS) Induces Fat Accumulation in HepG2 Human Hepatoma. 全氟丁烷磺酸(PFBS)诱导HepG2人肝癌脂肪堆积。

IF 1.8 4区环境科学与生态学

Toxicological and Environmental Chemistry Pub Date : 2020-01-01 Epub Date: 2020-08-26 DOI: 10.1080/02772248.2020.1808894

Weipeng Qi, John M Clark, Alicia R Timme-Laragy, Yeonhwa Park

{"title":"Perfluorobutanesulfonic Acid (PFBS) Induces Fat Accumulation in HepG2 Human Hepatoma.","authors":"Weipeng Qi, John M Clark, Alicia R Timme-Laragy, Yeonhwa Park","doi":"10.1080/02772248.2020.1808894","DOIUrl":"https://doi.org/10.1080/02772248.2020.1808894","url":null,"abstract":"Per- and poly-fluoroalkyl substances, especially perfluorooctanesulfonic acid, have been extensively used for over 50 years. A growing body of evidence has emerged demonstrating the potential adverse effects of these substances, including its effect on the development of non-alcoholic fatty liver disease, as one of the most prevalent chronic liver diseases. Nonetheless, there is no report of effects of perfluorobutanesulfonic acid, the major replacement for perfluorooctanesulfonic acid, on non-alcoholic fatty liver disease. Therefore, the effects of perfluorobutanesulfonic acid exposure on fat accumulation in a human hepatoma cell line were examined. Cells were exposed to perfluorobutanesulfonic acid with or without 300 μmol/L fatty acid mixture (oleic acid:palmitic acid = 2:1) conjugated by bovine serum albumin as an inducer of steatosis for 48 hours. Perfluorobutanesulfonic acid at 200 μmol/L significantly increased the triglyceride level in the presence of fatty acid compared to the control, but not without fatty acid, which was abolished by a specific peroxisome proliferator-activated receptor gamma antagonist. Perfluorobutanesulfonic acid upregulated key genes controlling lipogenesis and fatty acid uptake. Perfluorobutanesulfonic acid treatment also promoted the production of reactive oxygen species, an endoplasmic reticulum stress marker and cytosolic calcium. In conclusion, perfluorobutanesulfonic acid increased fat accumulation, in part, via peroxisome proliferator-activated receptor gamma-mediated pathway in hepatoma cells.","PeriodicalId":23122,"journal":{"name":"Toxicological and Environmental Chemistry","volume":"102 10","pages":"585-606"},"PeriodicalIF":1.8,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/02772248.2020.1808894","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25513074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Per- and Polyfluoroalkyl Substances and Obesity, Type 2 Diabetes and Non-alcoholic Fatty Liver Disease: A Review of Epidemiologic Findings. 全氟和多氟烷基物质与肥胖症、2 型糖尿病和非酒精性脂肪肝：流行病学研究综述》。

IF 1.8 4区环境科学与生态学

Toxicological and Environmental Chemistry Pub Date : 2020-01-01 Epub Date: 2020-05-22 DOI: 10.1080/02772248.2020.1763997

Weipeng Qi, John M Clark, Alicia R Timme-Laragy, Yeonhwa Park

{"title":"Per- and Polyfluoroalkyl Substances and Obesity, Type 2 Diabetes and Non-alcoholic Fatty Liver Disease: A Review of Epidemiologic Findings.","authors":"Weipeng Qi, John M Clark, Alicia R Timme-Laragy, Yeonhwa Park","doi":"10.1080/02772248.2020.1763997","DOIUrl":"10.1080/02772248.2020.1763997","url":null,"abstract":"Per- and polyfluoroalkyl substances, a group of fluoro-surfactants widely detected in the environment, wildlife and humans, have been linked to adverse health effects. A growing body of literature has addressed their effects on obesity, diabetes and non-alcoholic fatty liver disease/ non-alcoholic steatohepatitis. This review summarizes the brief historical use and chemistry of per- and polyfluoroalkyl substances, routes of human exposure, as well as the epidemiologic evidence for associations between exposure to per- and polyfluoroalkyl substances and the development of obesity, diabetes and non-alcoholic fatty liver disease/ non-alcoholic steatohepatitis. We identified 22 studies on obesity and 32 studies on diabetes, while only 1 study was found for non-alcoholic fatty liver disease/ non-alcoholic steatohepatitis by searching PubMed for human studies. Approximately 2/3 of studies reported positive associations between per- and polyfluoroalkyl substances exposure and the prevalence of obesity and/or type 2 diabetes. Causal links between per- and polyfluoroalkyl substances and obesity, diabetes and non-alcoholic fatty liver disease/ non-alcoholic steatohepatitis, however, require further large-scale prospective cohort studies combined with mechanistic laboratory studies to better assess these associations.","PeriodicalId":23122,"journal":{"name":"Toxicological and Environmental Chemistry","volume":"102 1-4","pages":"1-36"},"PeriodicalIF":1.8,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723340/pdf/nihms-1643636.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38699484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma concentrations of sucralose in children and adults. 儿童和成人三氯蔗糖的血药浓度。

IF 1.8 4区环境科学与生态学

Toxicological and Environmental Chemistry Pub Date : 2017-01-01 Epub Date: 2016-10-17 DOI: 10.1080/02772248.2016.1234754

Allison C Sylvetsky, Viviana Bauman, Jenny E Blau, H Martin Garraffo, Peter J Walter, Kristina I Rother

{"title":"Plasma concentrations of sucralose in children and adults.","authors":"Allison C Sylvetsky, Viviana Bauman, Jenny E Blau, H Martin Garraffo, Peter J Walter, Kristina I Rother","doi":"10.1080/02772248.2016.1234754","DOIUrl":"https://doi.org/10.1080/02772248.2016.1234754","url":null,"abstract":"Sucralose is partially absorbed after oral ingestion, with the majority excreted in the feces. We aimed to measure plasma sucralose concentrations following ingestion of doses reflecting a range of consumption (from one can of diet soda up to multiple sodas over the course of a day) and to compare concentrations in children and adults. Eleven adults (7 females, 4 males) consumed 355 mL water containing 0 mg sucralose (control) or 68, 170, or 250 mg sucralose (equivalent to 1-4 diet sodas). A second group of adults (n=11, 6 females and 5 males) consumed 355 mL Diet Rite Cola™ (68 mg sucralose and 41 mg acesulfame-potassium (ace-K)) or 68 mg sucralose and 41 mg ace-K in seltzer. Beverages were provided at separate visits in randomized order, prior to an oral glucose tolerance test. Eleven children (7 females and 4 males) consumed 0 or 68 mg sucralose in 240 mL water, in an identical study design. Blood was collected before beverage ingestion and serially for 120 min. Sucralose doses (corrected for weight) resulted in similar plasma concentrations in children and adults. Children reached peak concentrations of 145-400 ng/mL after 68 mg (mean 262.3 ± 24.6 ng/mL). Most adults reached similar peak concentrations (200-400 ng/mL after 250 mg (365.6 ± 69.9 ng/mL)) with the exception of two adults (1520 ng/mL and 1557 ng/mL, respectively). Concentrations were comparable whether sucralose was administered in water, combined with ace-K, or in diet soda. Due to their lower body weight and blood volume, children have markedly higher plasma sucralose concentrations after consumption of a typical diet soda, emphasizing the need to determine the clinical implications of sucralose use in children.","PeriodicalId":23122,"journal":{"name":"Toxicological and Environmental Chemistry","volume":"99 3","pages":"535-542"},"PeriodicalIF":1.8,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/02772248.2016.1234754","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35244001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Response to 'Letter to the Editor: regarding Sylvetsky et al. 2017 Plasma concentrations of sucralose in children and adults'. 对“致编辑的信:关于Sylvetsky等人2017年儿童和成人三氯蔗糖血浆浓度”的回应。

IF 1.8 4区环境科学与生态学

Toxicological and Environmental Chemistry Pub Date : 2017-01-01 Epub Date: 2017-03-01 DOI: 10.1080/02772248.2017.1288317

Allison C Meni Sylvetsky, Kristina I Rother

引用次数: 0

Assessment of physico-chemical properties and metal contents of water and sediments of Bodo Creek, Niger Delta, Nigeria 尼日利亚尼日尔三角洲博多河水体及沉积物理化性质及金属含量评价

IF 1.8 4区环境科学与生态学

Toxicological and Environmental Chemistry Pub Date : 2015-02-07 DOI: 10.1080/02772248.2015.1041526

I. Vincent-Akpu, A. Tyler, Clare Wilson, G. MacKinnon

{"title":"Assessment of physico-chemical properties and metal contents of water and sediments of Bodo Creek, Niger Delta, Nigeria","authors":"I. Vincent-Akpu, A. Tyler, Clare Wilson, G. MacKinnon","doi":"10.1080/02772248.2015.1041526","DOIUrl":"https://doi.org/10.1080/02772248.2015.1041526","url":null,"abstract":"Some physico-chemical properties and the concentrations of the metals Fe, Mn, Ni, Cd, Cr, Co, Cu, Pb, and Zn in water and sediments were examined from September 2011 to January 2012 in Bodo Creek, where oil spills have been recurrent. Temperature, pH, total dissolved solid, conductivity, salinity, dissolved oxygen, biological oxygen demand (BOD), chemical oxygen demand (COD), total hardness, sulfate, nitrate, and phosphate were determined in surface water. Particle size, total organic matter (TOM), and pH were also determined in the sediments. The parameters were within permissible limits except the mean values of BOD, COD, total hardness, and sulfate that exceeded levels permissible for domestic use. The sediments consisted mainly of sand, with TOM ranging from 0.2% to 5.5%. With the exception of cadmium that was below detection limit, metal levels (mg kg−1) in the sediments were 12 (Mn), 1070 (Fe), 10 (Cu), 10 (Zn), 5.3 (Cr), 1.1 (Pb), 1.0 (Ni), and 0.5 (Co) while in water they were 24, 98, 21, 6.9, 4.0, 0.6, 0.18, and 0.16, respectively. The latter were higher than World Health Organization recommended permissible levels for both surface and drinking water.","PeriodicalId":23122,"journal":{"name":"Toxicological and Environmental Chemistry","volume":"174 1","pages":"135 - 144"},"PeriodicalIF":1.8,"publicationDate":"2015-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76919734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Do Antioxidant Enzymes and Glutathione Play Roles in the Induction of Hepatic Oxidative Stress in Mice upon Subchronic Exposure to Mixtures of Dichloroacetate and Trichloroacetate? 抗氧化酶和谷胱甘肽在亚慢性暴露于二氯乙酸和三氯乙酸混合物的小鼠肝氧化应激诱导中起作用吗?

IF 1.8 4区环境科学与生态学

Toxicological and Environmental Chemistry Pub Date : 2014-03-01 DOI: 10.1080/02772248.2014.947988

Ezdihar Hassoun, Jacquelyn Cearfoss

{"title":"Do Antioxidant Enzymes and Glutathione Play Roles in the Induction of Hepatic Oxidative Stress in Mice upon Subchronic Exposure to Mixtures of Dichloroacetate and Trichloroacetate?","authors":"Ezdihar Hassoun, Jacquelyn Cearfoss","doi":"10.1080/02772248.2014.947988","DOIUrl":"https://doi.org/10.1080/02772248.2014.947988","url":null,"abstract":"Dichloroacetate (DCA) and trichloroacetate (TCA) are water chlorination byproducts, and their mixtures were previously found to induce additive to greater than additive effects on hepatic oxidative stress (OS) induction in mice after subchronic exposure. To investigate the roles of antioxidant enzymes and glutathione (GSH) in those effects, livers of B6C3F1 mice treated by gavage with 7.5, 15, or 30 mg DCA/kg/day, 12.5, 25, or 50 mg TCA/kg/day, and mixtures (Mix I, Mix II and Mix III) at DCA:TCA ratios corresponding to 7.5:12.5, 15:25 and 25:50 mg/kg/day, respectively, for 13 weeks. Livers were assayed for superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), as well as for GSH levels. In general, DCA suppressed SOD and GSH-Px activities and GSH levels but caused no changes in CAT activity; TCA increased SOD and CAT activities, suppressed GSH-Px activity, but did not change GSH levels; mixtures of DCA and TCA increased SOD and CAT activities and suppressed GSH-Px activity and GSH levels. In conclusion, antioxidant enzymes contribute to DCA-, TCA- and mixtures-induced OS, but not to changes from additive to greater than additive effects produced by different mixture compositions of the compounds. GSH on the hand may contribute to these changes.","PeriodicalId":23122,"journal":{"name":"Toxicological and Environmental Chemistry","volume":"96 3","pages":"482-490"},"PeriodicalIF":1.8,"publicationDate":"2014-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/02772248.2014.947988","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32927511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Amelioration of Acute Mercury Toxicity by a Novel, Non-Toxic Lipid Soluble Chelator N,N'bis-(2-mercaptoethyl)isophthalamide: Effect on Animal Survival, Health, Mercury Excretion and Organ Accumulation. 新型无毒脂溶性螯合剂 N,N'双-(2-巯基乙基)间苯二甲酰胺对急性汞毒性的改善：对动物生存、健康、汞排泄和器官积累的影响

IF 1.8 4区环境科学与生态学

Toxicological and Environmental Chemistry Pub Date : 2012-01-01 DOI: 10.1080/02772248.2012.657199

David Clarke, Roger Buchanan, Niladri Gupta, Boyd Haley

{"title":"Amelioration of Acute Mercury Toxicity by a Novel, Non-Toxic Lipid Soluble Chelator N,N'bis-(2-mercaptoethyl)isophthalamide: Effect on Animal Survival, Health, Mercury Excretion and Organ Accumulation.","authors":"David Clarke, Roger Buchanan, Niladri Gupta, Boyd Haley","doi":"10.1080/02772248.2012.657199","DOIUrl":"10.1080/02772248.2012.657199","url":null,"abstract":"The toxic effects of mercury are known to be complex with specific enzyme inhibitions and subsequent oxidative stress adding to the damaging effects. There are likely other factors involved, such as the development of impaired metal ion homeostasis and depletion of thiol and selenium based metabolites such as cysteine and selenium. Much of the toxicity of mercury occurs at the intracellular level via binding of Hg(2+) to thiol groups in specific proteins. Therefore, amelioration of mercury toxicity by the use of chelation would likely be enhanced by the use of a chelator that could cross the cell membrane and the blood brain barrier. It would be most favorable if this compound was of low toxicity, had appropriate pharmacokinetics, bound and rendered mercury cation non-toxic and had antioxidant properties. Herein we report on such a chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI), and, using an animal model, show that it prevented the toxic effects associated with acute exposure induced by injected mercury chloride.","PeriodicalId":23122,"journal":{"name":"Toxicological and Environmental Chemistry","volume":"94 3","pages":"616-640"},"PeriodicalIF":1.8,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346673/pdf/nihms353530.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30607015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Aryl Hydrocarbon Receptor Influences Transplant Outcomes in Response to Environmental Signals. 芳基烃受体对环境信号的响应影响移植结果。

IF 1.8 4区环境科学与生态学

Toxicological and Environmental Chemistry Pub Date : 2012-01-01 Epub Date: 2012-06-20 DOI: 10.1080/02772248.2012.688546

S Kyle Pauly, John H Fechner, Xiaoji Zhang, Jose Torrealba, Christopher A Bradfield, Joshua D Mezrich

{"title":"The Aryl Hydrocarbon Receptor Influences Transplant Outcomes in Response to Environmental Signals.","authors":"S Kyle Pauly, John H Fechner, Xiaoji Zhang, Jose Torrealba, Christopher A Bradfield, Joshua D Mezrich","doi":"10.1080/02772248.2012.688546","DOIUrl":"https://doi.org/10.1080/02772248.2012.688546","url":null,"abstract":"The aryl hydrocarbon receptor (AHR) is a cytosolic transcription factor with numerous endogenous and xenobiotic ligands, most notably 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Recent data suggests that TCDD may induce regulatory T cells, while a second AHR ligand, FICZ, promotes Th17 differentiation. The aim was to examine whether injection of recipient mice with either TCDD or FICZ altered skin allograft rejection in a fully mismatched model. TCDD or FICZ was given to recipient C57BL/6 mice intraperitoneally (IP). Twenty-four hr later, donor skin was grafted from BALB/c mice. An additional dose of FICZ was given on day 3. Treatment with TCDD delayed graft rejection for more than 4 weeks while FICZ treatment accelerated rejection by 1 - 2 days. In vivo exposure with TCDD led to a rise in the frequency of FoxP3(+) CD4(+) T cells in the spleen, while FICZ increased IL-17 secretion by splenocytes from treated animals. Activation of the AHR receptor by different AHR ligands in vivo resulted in opposing effects on skin graft survival. AHR serves as a sensor to environmental signals, with effects on the acquired immune system that may alter outcomes after organ transplantation. This model will be useful to further delineate direct effects of the environment on the immune system and outcomes of organ transplantation.","PeriodicalId":23122,"journal":{"name":"Toxicological and Environmental Chemistry","volume":"94 6","pages":"1175-1187"},"PeriodicalIF":1.8,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/02772248.2012.688546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30925324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Low blood lead levels and hemoglobin concentrations in preschool children in China. 中国学龄前儿童低血铅水平和血红蛋白浓度。

IF 1.8 4区环境科学与生态学

Toxicological and Environmental Chemistry Pub Date : 2012-01-01 Epub Date: 2011-10-28 DOI: 10.1080/02772248.2011.628001

Jianghong Liu, Linda McCauley, Chonghuai Yan, Xiaoming Shen, Jennifer A Pinto-Martin

{"title":"Low blood lead levels and hemoglobin concentrations in preschool children in China.","authors":"Jianghong Liu, Linda McCauley, Chonghuai Yan, Xiaoming Shen, Jennifer A Pinto-Martin","doi":"10.1080/02772248.2011.628001","DOIUrl":"https://doi.org/10.1080/02772248.2011.628001","url":null,"abstract":"It is well known that lead (Pb) produces reduced haemoglobin (Hb) levels and risk of anemia when blood lead levels (BPb) are greater than 20 µg dL-1. Two recent studies reported an increased risk of anemia in children with BPb between 10-20 µg dL-1, but few studies examined the association between Hb levels or risk of anemia and BPb under 10 µg dL-1. In the present study this association was examined using data of 140 preschool children from a larger prospective cohort study in China. Data showed that compared to children with BPb <5 µg dL-1, children with BPb between 7.5-10 µg dL-1 had significantly lower Hb levels, but there were no marked differences for other groups. A linear regression model showed a negative relationship between BPb and Hb levels after controlling for age, gender, height, weight, and iron (Fe) deficiency. This finding, although limited by a small sample size, suggests it may be important to examine Pb-induced hemosynthesis effect at concentrations less than 10 µg dL-1.","PeriodicalId":23122,"journal":{"name":"Toxicological and Environmental Chemistry","volume":"94 2","pages":"423-426"},"PeriodicalIF":1.8,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/02772248.2011.628001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35819400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Indoor and Outdoor Air Pollution and Lung Cancer in New Hampshire and Vermont. 在新罕布什尔州和佛蒙特州的室内和室外空气污染与肺癌。

IF 1.8 4区环境科学与生态学

Toxicological and Environmental Chemistry Pub Date : 2012-01-01 DOI: 10.1080/02772248.2012.659930

Chantel D Sloan, Angeline S Andrew, Joann F Gruber, Kevin M Mwenda, Jason H Moore, Tracy Onega, Margaret R Karagas, Xun Shi, Eric J Duell

{"title":"Indoor and Outdoor Air Pollution and Lung Cancer in New Hampshire and Vermont.","authors":"Chantel D Sloan, Angeline S Andrew, Joann F Gruber, Kevin M Mwenda, Jason H Moore, Tracy Onega, Margaret R Karagas, Xun Shi, Eric J Duell","doi":"10.1080/02772248.2012.659930","DOIUrl":"https://doi.org/10.1080/02772248.2012.659930","url":null,"abstract":"Indoor and outdoor air pollution is known to contribute to increased lung cancer incidence. This study is the first to address the contribution of home heating fuel and geographical course particulate matter (PM10) concentrations to lung cancer rates in New Hampshire, U.S. First, Pearson correlation analysis and Geographically weighted regression were used to investigate spatial relationships between outdoor PM10 and lung cancer rates. While the aforementioned analyses did not indicate a significant contribution of PM10 to lung cancer in the state, there was a trend towards a significant association in the northern and southwestern regions of the state. Second, case-control data were used to estimate the contributions of indoor pollution and second hand smoke to risk of lung cancer with adjustment for confounders. Increased risk was found among those who used wood or coal to heat their homes for more than 10 winters before the age of 18, with a significant increase in risk per winter. Resulting data suggest that further investigation of the relationship between heating-related air pollution levels and lung cancer risk is needed.","PeriodicalId":23122,"journal":{"name":"Toxicological and Environmental Chemistry","volume":"94 3","pages":""},"PeriodicalIF":1.8,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/02772248.2012.659930","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31900661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14