Plasma concentrations of sucralose in children and adults.

IF 1.1 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES
Allison C Sylvetsky, Viviana Bauman, Jenny E Blau, H Martin Garraffo, Peter J Walter, Kristina I Rother
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引用次数: 20

Abstract

Sucralose is partially absorbed after oral ingestion, with the majority excreted in the feces. We aimed to measure plasma sucralose concentrations following ingestion of doses reflecting a range of consumption (from one can of diet soda up to multiple sodas over the course of a day) and to compare concentrations in children and adults. Eleven adults (7 females, 4 males) consumed 355 mL water containing 0 mg sucralose (control) or 68, 170, or 250 mg sucralose (equivalent to 1-4 diet sodas). A second group of adults (n=11, 6 females and 5 males) consumed 355 mL Diet Rite Cola™ (68 mg sucralose and 41 mg acesulfame-potassium (ace-K)) or 68 mg sucralose and 41 mg ace-K in seltzer. Beverages were provided at separate visits in randomized order, prior to an oral glucose tolerance test. Eleven children (7 females and 4 males) consumed 0 or 68 mg sucralose in 240 mL water, in an identical study design. Blood was collected before beverage ingestion and serially for 120 min. Sucralose doses (corrected for weight) resulted in similar plasma concentrations in children and adults. Children reached peak concentrations of 145-400 ng/mL after 68 mg (mean 262.3 ± 24.6 ng/mL). Most adults reached similar peak concentrations (200-400 ng/mL after 250 mg (365.6 ± 69.9 ng/mL)) with the exception of two adults (1520 ng/mL and 1557 ng/mL, respectively). Concentrations were comparable whether sucralose was administered in water, combined with ace-K, or in diet soda. Due to their lower body weight and blood volume, children have markedly higher plasma sucralose concentrations after consumption of a typical diet soda, emphasizing the need to determine the clinical implications of sucralose use in children.

Abstract Image

儿童和成人三氯蔗糖的血药浓度。
三氯蔗糖部分经口服吸收,大部分随粪便排出体外。我们的目的是测量血浆中三氯蔗糖的浓度,这些浓度反映了摄入剂量的范围(一天中从一罐无糖汽水到多罐汽水),并比较儿童和成人的浓度。11名成年人(7名女性,4名男性)饮用了355毫升含有0毫克三氯蔗糖(对照)或68、170或250毫克三氯蔗糖(相当于1-4杯无糖汽水)的水。第二组成年人(n=11, 6名女性和5名男性)饮用355毫升健怡可乐™(68毫克三氯蔗糖和41毫克乙酰磺胺钾(ace-K))或68毫克三氯蔗糖和41毫克钾苏打水。在口服葡萄糖耐量试验之前,按随机顺序在单独的访问中提供饮料。在相同的研究设计中,11名儿童(7名女性和4名男性)在240毫升水中摄入0或68毫克三氯蔗糖。在饮用饮料前连续采集血液120分钟。三氯蔗糖剂量(根据体重校正)导致儿童和成人的血浆浓度相似。68 mg后患儿浓度达到峰值145 ~ 400 ng/mL(平均262.3±24.6 ng/mL)。大多数成人在250 mg(365.6±69.9 ng/mL)后达到相似的峰值浓度(200-400 ng/mL),只有两名成人例外(分别为1520 ng/mL和1557 ng/mL)。无论三氯蔗糖是在水中,还是与ace-K结合,还是在无糖汽水中,其浓度都是相当的。由于儿童的体重和血容量较低,在饮用普通无糖汽水后,他们的血浆三氯蔗糖浓度明显较高,这强调了确定儿童使用三氯蔗糖的临床意义的必要性。
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来源期刊
Toxicological and Environmental Chemistry
Toxicological and Environmental Chemistry ENVIRONMENTAL SCIENCES-TOXICOLOGY
CiteScore
3.50
自引率
5.60%
发文量
0
期刊介绍: The journal is interdisciplinary in outlook, and manuscripts published in it cover all relevant areas: • inorganic chemistry – trace elements in food and the environment, metal complexes and chelates; • organic chemistry – environmental fate, chemical reactions, metabolites and secondary products, synthesis of standards and labelled materials; • physical chemistry – photochemistry, radiochemistry; • environmental chemistry – sources, fate, and sinks of xenochemicals, environmental partitioning and transport, degradation and deposition; • analytical chemistry – development and optimisation of analytical methods, instrumental and methodological advances, miniaturisation and automation; • biological chemistry – pharmacology and toxicology, uptake, metabolism, disposition of xenochemicals, structure-activity relationships, modes of action, ecotoxicological testing.
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