Per- and Polyfluoroalkyl Substances and Obesity, Type 2 Diabetes and Non-alcoholic Fatty Liver Disease: A Review of Epidemiologic Findings.

IF 1.1 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES
Weipeng Qi, John M Clark, Alicia R Timme-Laragy, Yeonhwa Park
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引用次数: 0

Abstract

Per- and polyfluoroalkyl substances, a group of fluoro-surfactants widely detected in the environment, wildlife and humans, have been linked to adverse health effects. A growing body of literature has addressed their effects on obesity, diabetes and non-alcoholic fatty liver disease/ non-alcoholic steatohepatitis. This review summarizes the brief historical use and chemistry of per- and polyfluoroalkyl substances, routes of human exposure, as well as the epidemiologic evidence for associations between exposure to per- and polyfluoroalkyl substances and the development of obesity, diabetes and non-alcoholic fatty liver disease/ non-alcoholic steatohepatitis. We identified 22 studies on obesity and 32 studies on diabetes, while only 1 study was found for non-alcoholic fatty liver disease/ non-alcoholic steatohepatitis by searching PubMed for human studies. Approximately 2/3 of studies reported positive associations between per- and polyfluoroalkyl substances exposure and the prevalence of obesity and/or type 2 diabetes. Causal links between per- and polyfluoroalkyl substances and obesity, diabetes and non-alcoholic fatty liver disease/ non-alcoholic steatohepatitis, however, require further large-scale prospective cohort studies combined with mechanistic laboratory studies to better assess these associations.

全氟和多氟烷基物质与肥胖症、2 型糖尿病和非酒精性脂肪肝:流行病学研究综述》。
全氟和多氟烷基物质是一类广泛存在于环境、野生动物和人类体内的氟表面活性剂,与不良健康影响有关。越来越多的文献探讨了它们对肥胖症、糖尿病和非酒精性脂肪肝/非酒精性脂肪性肝炎的影响。本综述概述了全氟烷基和多氟烷基物质的简要历史用途和化学性质、人体接触途径,以及接触全氟烷基和多氟烷基物质与肥胖症、糖尿病和非酒精性脂肪肝/非酒精性脂肪性肝炎之间的流行病学证据。通过在 PubMed 上搜索人类研究,我们发现了 22 项关于肥胖症的研究和 32 项关于糖尿病的研究,而关于非酒精性脂肪肝/非酒精性脂肪性肝炎的研究只有 1 项。约有三分之二的研究报告称,接触全氟和多氟烷基物质与肥胖和/或 2 型糖尿病的发病率呈正相关。不过,全氟和多氟烷基物质与肥胖、糖尿病和非酒精性脂肪肝/非酒精性脂肪性肝炎之间的因果关系还需要进一步的大规模前瞻性队列研究和机理实验室研究来更好地评估这些关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Toxicological and Environmental Chemistry
Toxicological and Environmental Chemistry ENVIRONMENTAL SCIENCES-TOXICOLOGY
CiteScore
3.50
自引率
5.60%
发文量
0
期刊介绍: The journal is interdisciplinary in outlook, and manuscripts published in it cover all relevant areas: • inorganic chemistry – trace elements in food and the environment, metal complexes and chelates; • organic chemistry – environmental fate, chemical reactions, metabolites and secondary products, synthesis of standards and labelled materials; • physical chemistry – photochemistry, radiochemistry; • environmental chemistry – sources, fate, and sinks of xenochemicals, environmental partitioning and transport, degradation and deposition; • analytical chemistry – development and optimisation of analytical methods, instrumental and methodological advances, miniaturisation and automation; • biological chemistry – pharmacology and toxicology, uptake, metabolism, disposition of xenochemicals, structure-activity relationships, modes of action, ecotoxicological testing.
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