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Thirty-six novel HLA alleles: 7 HLA-A, 11 HLA-B, 15 HLA-C and 3 HLA-DRB1. 36个新的HLA等位基因:7个HLA- a, 11个HLA- b, 15个HLA- c和3个HLA- drb1。
Tissue antigens Pub Date : 2009-11-01 Epub Date: 2009-09-09 DOI: 10.1111/j.1399-0039.2009.01334.x
J D H Anholts, M Aneq, H L J M Dirks, A Tas, W Verduyn, M Oudshoorn
{"title":"Thirty-six novel HLA alleles: 7 HLA-A, 11 HLA-B, 15 HLA-C and 3 HLA-DRB1.","authors":"J D H Anholts,&nbsp;M Aneq,&nbsp;H L J M Dirks,&nbsp;A Tas,&nbsp;W Verduyn,&nbsp;M Oudshoorn","doi":"10.1111/j.1399-0039.2009.01334.x","DOIUrl":"https://doi.org/10.1111/j.1399-0039.2009.01334.x","url":null,"abstract":"<p><p>Thirty-six novel human leukocyte antigen (HLA) alleles are described in this article: A*9225N, A*9234, A*030106, A*0337, A*2317, A*2480, A*3023; B*070206, B*0759, B*0761, B*0765, B*150106, B*1827, B*352002, B*3585, B*3943, B*4082, B*5151; Cw*0342, Cw*0343, Cw*0344, Cw*0428, Cw*0430, Cw*0433, Cw*050104, Cw*0519, Cw*060203, Cw*070109, Cw*070202, Cw*0750, Cw*0815, Cw*120306, Cw*1409; DRB1*0336, DRB1*0473 and DRB1*1382.</p>","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"74 5","pages":"424-8"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1399-0039.2009.01334.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28393865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Genetic polymorphisms and haplotype structures of HSPA5 gene in the Han population of Southern China. 华南汉族人群HSPA5基因遗传多态性及单倍型结构
Tissue antigens Pub Date : 2009-11-01 DOI: 10.1111/j.1399-0039.2009.01333.x
X Zhu, J Cheng, J Zhao, L Chen, S Hou, G Zhao, F Lan, W Wang, H Kung, M He
{"title":"Genetic polymorphisms and haplotype structures of HSPA5 gene in the Han population of Southern China.","authors":"X Zhu,&nbsp;J Cheng,&nbsp;J Zhao,&nbsp;L Chen,&nbsp;S Hou,&nbsp;G Zhao,&nbsp;F Lan,&nbsp;W Wang,&nbsp;H Kung,&nbsp;M He","doi":"10.1111/j.1399-0039.2009.01333.x","DOIUrl":"https://doi.org/10.1111/j.1399-0039.2009.01333.x","url":null,"abstract":"<p><p>The heat shock 70 kDa protein 5 (HSPA5) gene is known to be involved in stress-associated diseases. In this study, the promoter, exons, 3' untranslated region (3'UTR), and subtotal introns of the HSPA5 gene were sequenced in a sub-population of 161 healthy Han Chinese. Nine single-nucleotide polymorphisms (SNPs) including a new one (-86bp T > A from the estimated translation start site) were found and 15 haplotypes (frequencies > 1%) were inferred. Polymorphisms rs391957 and rs11355458 were completely linked in our population (r (2) = 1.00). Using this information, fellow scientists may be able to decrease the number of SNPs to be genotyped in future disease case-control studies.</p>","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"74 5","pages":"420-3"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1399-0039.2009.01333.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28449420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A frame shift due to a two-nucleotide deletion results in an HLA-B null allele, B*9549N. 由于两个核苷酸缺失导致的帧移位导致HLA-B空等位基因B*9549N。
Tissue antigens Pub Date : 2009-11-01 DOI: 10.1111/j.1399-0039.2009.01344.x
H-Y Zou, Z Li, S-Z Jin, X Cheng, L-H Cheng
{"title":"A frame shift due to a two-nucleotide deletion results in an HLA-B null allele, B*9549N.","authors":"H-Y Zou,&nbsp;Z Li,&nbsp;S-Z Jin,&nbsp;X Cheng,&nbsp;L-H Cheng","doi":"10.1111/j.1399-0039.2009.01344.x","DOIUrl":"https://doi.org/10.1111/j.1399-0039.2009.01344.x","url":null,"abstract":"<p><p>This report describes the identification of a new human leukocyte antigen (HLA) class I null allele, B*9549N, resulting from a premature stop codon in exon 3.</p>","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"74 5","pages":"447-9"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1399-0039.2009.01344.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28449427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Identification of a novel HLA-A*680202 allele by sequence-based typing in an African American individual. 非裔美国人HLA-A*680202等位基因序列分型鉴定
Tissue antigens Pub Date : 2009-11-01 DOI: 10.1111/j.1399-0039.2009.01365.x
Y Serov, G Hommel-Berrey, A Lobashevsky
{"title":"Identification of a novel HLA-A*680202 allele by sequence-based typing in an African American individual.","authors":"Y Serov,&nbsp;G Hommel-Berrey,&nbsp;A Lobashevsky","doi":"10.1111/j.1399-0039.2009.01365.x","DOIUrl":"https://doi.org/10.1111/j.1399-0039.2009.01365.x","url":null,"abstract":"<p><p>The new HLA-A*680202 differs from HLA-A*680201 by one synonymous nucleotide substitution at position 618 (ACG --> ACT).</p>","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"74 5","pages":"435-7"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1399-0039.2009.01365.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28449423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Identification of a new HLA-Cw*01 variant, Cw*0121, by sequence-based typing in a Chinese patient. 基于序列分型的中国患者HLA-Cw*01新变异Cw*0121的鉴定
Tissue antigens Pub Date : 2009-11-01 Epub Date: 2009-09-08 DOI: 10.1111/j.1399-0039.2009.01346.x
Z Li, H Zhang, S-Z Jin
{"title":"Identification of a new HLA-Cw*01 variant, Cw*0121, by sequence-based typing in a Chinese patient.","authors":"Z Li,&nbsp;H Zhang,&nbsp;S-Z Jin","doi":"10.1111/j.1399-0039.2009.01346.x","DOIUrl":"https://doi.org/10.1111/j.1399-0039.2009.01346.x","url":null,"abstract":"<p><p>HLA-Cw(*)0121 allele was identified in a Chinese patient. It is identical to Cw(*)0104 except for five nucleotides changes.</p>","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"74 5","pages":"449-51"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1399-0039.2009.01346.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28389764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The CD226 gene in susceptibility of type 1 diabetes. CD226基因与1型糖尿病易感性的关系。
Tissue antigens Pub Date : 2009-11-01 Epub Date: 2009-07-15 DOI: 10.1111/j.1399-0039.2009.01320.x
K Douroudis, V Nemvalts, T Rajasalu, K Kisand, R Uibo
{"title":"The CD226 gene in susceptibility of type 1 diabetes.","authors":"K Douroudis,&nbsp;V Nemvalts,&nbsp;T Rajasalu,&nbsp;K Kisand,&nbsp;R Uibo","doi":"10.1111/j.1399-0039.2009.01320.x","DOIUrl":"https://doi.org/10.1111/j.1399-0039.2009.01320.x","url":null,"abstract":"<p><p>The rs763361 single nucleotide polymorphism (SNP) within the CD226 gene has recently been reported as a novel susceptible locus for type 1 diabetes. The CD226 gene is implicated in the regulation of a number of cells involved in immune mechanisms leading to beta-cell destruction in type 1 diabetes. The aim of the present study was to confirm the association of the CD226 gene with type 1 diabetes in Estonian population. The TT genotype [odds ratio (OR) = 2.29, 95% confidence interval (CI) = 1.25-4.18, P = 0.0071) and the T allele (OR = 1.48, 95% CI = 1.11-1.98, P = 0.0084) of the rs763361 SNP were associated with the risk of type 1 diabetes. The current study replicates the novel association of the rs763361 SNP in susceptibility of type 1 diabetes and supports the CD226 gene as a susceptible candidate locus for type 1 diabetes outside the major histocompatibility complex region.</p>","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"74 5","pages":"417-9"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1399-0039.2009.01320.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28395171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
A novel HLA-DRB1*120204 allele found in a Chinese individual. 一个新的HLA-DRB1*120204等位基因在中国个体中被发现。
Tissue antigens Pub Date : 2009-11-01 Epub Date: 2009-09-07 DOI: 10.1111/j.1399-0039.2009.01340.x
Y Ji, Y Sun, J H Xie, J H Yang, Y Liu, K M Du
{"title":"A novel HLA-DRB1*120204 allele found in a Chinese individual.","authors":"Y Ji,&nbsp;Y Sun,&nbsp;J H Xie,&nbsp;J H Yang,&nbsp;Y Liu,&nbsp;K M Du","doi":"10.1111/j.1399-0039.2009.01340.x","DOIUrl":"https://doi.org/10.1111/j.1399-0039.2009.01340.x","url":null,"abstract":"<p><p>The HLA-DRB1*120204 allele differs by a single synonymous nucleotide change from the DRB1*120201 allele at position 203 in exon 2 from C to G.</p>","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"74 5","pages":"462-3"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1399-0039.2009.01340.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28389765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Identification of a novel HLA-Cw*070206 allele. HLA-Cw*070206等位基因的鉴定。
Tissue antigens Pub Date : 2009-11-01 DOI: 10.1111/j.1399-0039.2009.01370.x
D-M Wang, S-Q Gao, Y-P Xu, Z-H Deng
{"title":"Identification of a novel HLA-Cw*070206 allele.","authors":"D-M Wang,&nbsp;S-Q Gao,&nbsp;Y-P Xu,&nbsp;Z-H Deng","doi":"10.1111/j.1399-0039.2009.01370.x","DOIUrl":"https://doi.org/10.1111/j.1399-0039.2009.01370.x","url":null,"abstract":"<p><p>The novel HLA-Cw*070206 allele differs from the closest allele Cw*07020101 by single nucleotide change at genomic DNA nt 877 C>T (codon 143 ACC > ACT) in exon 3.</p>","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"74 5","pages":"457-8"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1399-0039.2009.01370.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28449428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Identification of HLA-B*9521 in Taiwan. 台湾地区HLA-B*9521的鉴定。
Tissue antigens Pub Date : 2009-11-01 Epub Date: 2009-09-08 DOI: 10.1111/j.1399-0039.2009.01350.x
C-C Chu, Y-F Chen, H-L Lee, C-Y Lin, M Lin
{"title":"Identification of HLA-B*9521 in Taiwan.","authors":"C-C Chu,&nbsp;Y-F Chen,&nbsp;H-L Lee,&nbsp;C-Y Lin,&nbsp;M Lin","doi":"10.1111/j.1399-0039.2009.01350.x","DOIUrl":"https://doi.org/10.1111/j.1399-0039.2009.01350.x","url":null,"abstract":"<p><p>We here report a new HLA-B allele, B*9521, which differs from B*1544 at codon 67 (TCC-->TGC).</p>","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"74 5","pages":"445-6"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1399-0039.2009.01350.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28389261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Polymorphisms within the HLA-DR4 haplotypes. Various DQ subtypes detected with monoclonal antibodies. HLA-DR4单倍型的多态性。单克隆抗体检测多种DQ亚型。
Tissue antigens Pub Date : 2008-12-11 DOI: 10.1111/J.1399-0039.1986.TB01494.X
R. Bontrop, G. Schreuder, E. Mikulski, R. V. van Miltenburg, M. Giphart
{"title":"Polymorphisms within the HLA-DR4 haplotypes. Various DQ subtypes detected with monoclonal antibodies.","authors":"R. Bontrop, G. Schreuder, E. Mikulski, R. V. van Miltenburg, M. Giphart","doi":"10.1111/J.1399-0039.1986.TB01494.X","DOIUrl":"https://doi.org/10.1111/J.1399-0039.1986.TB01494.X","url":null,"abstract":"Polymorphisms among HLA class II molecules expressed by cells with different HLA-DR4 haplotypes were analysed biochemically (isoelectrofocussing and 2D gels), cellularly (HLA-Dw) and serologically (monoclonal antibodies). The results confirm the correlation which exists between HLA-D specificity and DR beta chain isoelectric point polymorphism. Furthermore, a biochemical polymorphism was observed among DQw3 molecules. No correlation was found with HLA-Dw types. On the other hand a correlation was found between DQ-polymorphism and TA10 and 2B3 specificities defined by monoclonal antibodies. The comparison of different methods defining polymorphisms of HLA class II molecules will be discussed.","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"27 1 1","pages":"22-31"},"PeriodicalIF":0.0,"publicationDate":"2008-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/J.1399-0039.1986.TB01494.X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62843304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 42
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