K Douroudis, V Nemvalts, T Rajasalu, K Kisand, R Uibo
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引用次数: 17
摘要
CD226基因内的rs763361单核苷酸多态性(SNP)最近被报道为1型糖尿病的一个新的易感位点。CD226基因参与了一些细胞的调节，这些细胞参与了导致1型糖尿病中β细胞破坏的免疫机制。本研究的目的是确认CD226基因与爱沙尼亚人群中1型糖尿病的关联。rs763361 SNP的TT基因型[比值比(OR) = 2.29, 95%可信区间(CI) = 1.25 ~ 4.18, P = 0.0071]和T等位基因(OR = 1.48, 95% CI = 1.11 ~ 1.98, P = 0.0084)与1型糖尿病的发病风险相关。目前的研究重复了rs763361 SNP与1型糖尿病易感性的新关联，并支持CD226基因作为主要组织相容性复合体区域外1型糖尿病的易感候选位点。
The CD226 gene in susceptibility of type 1 diabetes.
The rs763361 single nucleotide polymorphism (SNP) within the CD226 gene has recently been reported as a novel susceptible locus for type 1 diabetes. The CD226 gene is implicated in the regulation of a number of cells involved in immune mechanisms leading to beta-cell destruction in type 1 diabetes. The aim of the present study was to confirm the association of the CD226 gene with type 1 diabetes in Estonian population. The TT genotype [odds ratio (OR) = 2.29, 95% confidence interval (CI) = 1.25-4.18, P = 0.0071) and the T allele (OR = 1.48, 95% CI = 1.11-1.98, P = 0.0084) of the rs763361 SNP were associated with the risk of type 1 diabetes. The current study replicates the novel association of the rs763361 SNP in susceptibility of type 1 diabetes and supports the CD226 gene as a susceptible candidate locus for type 1 diabetes outside the major histocompatibility complex region.
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