Thermal Science and Engineering Progress最新文献_第4页

Thermal performance analysis of PCM-integrated structures using the resistance-capacitance model: Experiments and numerics 利用电阻-电容模型分析 PCM 一体化结构的热性能：实验和数值分析

IF 5.1 3区工程技术

Thermal Science and Engineering Progress Pub Date : 2024-11-02 DOI: 10.1016/j.tsep.2024.103019

Inzamam Ahmad , Ravinder kumar , Uddipta Ghosh , Atul Bhargav , Rachid Bennacer , Mohammed El Ganaoui

{"title":"Thermal performance analysis of PCM-integrated structures using the resistance-capacitance model: Experiments and numerics","authors":"Inzamam Ahmad , Ravinder kumar , Uddipta Ghosh , Atul Bhargav , Rachid Bennacer , Mohammed El Ganaoui","doi":"10.1016/j.tsep.2024.103019","DOIUrl":"10.1016/j.tsep.2024.103019","url":null,"abstract":"<div><div>While holding significant potential to reduce cooling energy requirements in buildings, the incorporation of phase-change materials in building envelopes requires information regarding their diurnal and seasonal behaviour through high-fidelity simulations. However, utilizing short-term simulations and experimentation using state-of-the-art models for such a complex configuration does not accurately represent the true heat transfer dynamics of the building. To address this lacuna, we present a physics-based, low computational cost, experimentally and numerically validated resistance–capacitance (<em>RC</em>) model specifically tailored for PCM-encapsulated structures, designed for long-term simulations. The validation of this model is conducted through in-house experiments. Additionally, we support the credibility of our <em>RC</em> model by subjecting it to validation through 3D numerical simulations, emphasizing its precision and reliability. Then, we use the validated model to optimize the thermal properties of concrete roofs in hot and dry climates, taking a specific instance of a city in Western India for various geometric configurations as an illustrative example. We find that a PCM with a phase change temperature between 37 and 42 °C can reduce the peak ceiling temperature by up to 10 °C and the peak energy ingress by a factor of 2 or more, in a typical roof element subjected to the prevailing climatic conditions during peak summer. This shows the time constant of the modified roof is effective in delaying and damping the imposed solar insolation. We make specific recommendations on the selection and geometry optimization of PCM-incorporated roof elements.</div></div>","PeriodicalId":23062,"journal":{"name":"Thermal Science and Engineering Progress","volume":"56 ","pages":"Article 103019"},"PeriodicalIF":5.1,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermal performance analysis of a novel letter-type fin liquid cooling plate based on the field synergy principle and the second law of thermodynamics 基于场协同原理和热力学第二定律的新型字母型鳍片液体冷却板的热性能分析

IF 5.1 3区工程技术

Thermal Science and Engineering Progress Pub Date : 2024-11-02 DOI: 10.1016/j.tsep.2024.103027

Furen Zhang, Jiahui Tao, Huan Gou, Xuejiang Huang

{"title":"Thermal performance analysis of a novel letter-type fin liquid cooling plate based on the field synergy principle and the second law of thermodynamics","authors":"Furen Zhang, Jiahui Tao, Huan Gou, Xuejiang Huang","doi":"10.1016/j.tsep.2024.103027","DOIUrl":"10.1016/j.tsep.2024.103027","url":null,"abstract":"<div><div>In order to expand more forms of liquid-cooled plate fin construction, based on the traditional geometric fins and letter-type fins, a new idea of constructing a new type of letter-type fins by the geometric expansion method is proposed, and then a fin structure design with better heat transfer performance than the traditional geometric fins is explored. Firstly, the validity of the CFD model and method is verified by heat dissipation experiments. On this basis, the flow behavior and heat transfer performance of 6 letter-type fin structures at different Reynolds numbers are numerically investigated, and the synergism and thermal irreversibility of the flow and temperature fields are discussed and analyzed. According to the findings, the field synergy of the new letter-shaped fins is more significant and effectively reduced the irreversibility of heat transfer. In addition, the combined thermal performance analysis shows that the combined heat performance of C-type fins is better when the Reynolds number range is between 49.85–199.4 (HTPF = 1.098–1.57), and the combined thermal performance of T-type fins is better when the Reynolds number range is 249.25–398.8 (HTPF = 1.03–1.07). Secondly, in order to improve the liquid-cooled plate’s heat performance the paper discussed and optimizes the combination mode of C- and T-type letter fins. To further improve the liquid-cooled plate’s thermal performance, on the basis of the optimal combination of fins, we discuss the effect of fin break distance on the liquid-cooled plate’s thermal performance. Finally, secondary fins are introduced to further optimize the liquid-cooled plate’s thermal performance. It is found that a reasonable setting of secondary fins can effectively reduce the pressure drop of the liquid cooling plate and improve the comprehensive heat dissipation performance (18.71 %∼32.09 %).</div></div>","PeriodicalId":23062,"journal":{"name":"Thermal Science and Engineering Progress","volume":"56 ","pages":"Article 103027"},"PeriodicalIF":5.1,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multi-scale modeling approach for predicting and mitigating thermal runaway in electric vehicle batteries 预测和缓解电动汽车电池热失控的多尺度建模方法

IF 5.1 3区工程技术

Thermal Science and Engineering Progress Pub Date : 2024-11-02 DOI: 10.1016/j.tsep.2024.103029

V.S. Hemakumar , V.J. Chakravarthy , Srigitha Surendranath , Venkateswarlu Gundu , M. Ramkumar Prabhu , S Hari Chandra Prasad

{"title":"A multi-scale modeling approach for predicting and mitigating thermal runaway in electric vehicle batteries","authors":"V.S. Hemakumar , V.J. Chakravarthy , Srigitha Surendranath , Venkateswarlu Gundu , M. Ramkumar Prabhu , S Hari Chandra Prasad","doi":"10.1016/j.tsep.2024.103029","DOIUrl":"10.1016/j.tsep.2024.103029","url":null,"abstract":"<div><div>This study presents a unique multi-scale modelling technique for electric vehicle (EV) battery thermal runaway prediction models using electrochemical, thermal, and machine learning approaches. This modelling framework has illuminated the thermal runaway’s physical process and the race between heat production and dissipation at the cell, module, and pack levels.</div><div>Experimental evaluation has demonstrated solid predictive performance for each component. The modified pseudo-two-dimensional (P2D) electrochemical model has achieved high voltage prediction accuracy (mean absolute error: 8.5 mV), and the 3D thermal model has captured battery module temperatures with an average error of ± 1.5 °C.</div><div>The machine learning model has exhibited 96.8% accuracy, excellent classification precision, and an 18.3-minute early warning time. It was also demonstrated that the integrated multi-scale model outperformed standalone single-scale models with 15% higher prediction accuracy and 32% higher average early warning time.</div><div>Based on these findings, adaptive cooling techniques, unique charge/discharge procedures, and early isolation methods were created. Simulations showed that these mitigation techniques decreased thermal runaway occurrence by 78% and severity by 93%. Despite its high computing cost, this technique might improve EV battery safety, guide battery pack design, and accelerate EV adoption, which would cut carbon emissions.</div></div>","PeriodicalId":23062,"journal":{"name":"Thermal Science and Engineering Progress","volume":"56 ","pages":"Article 103029"},"PeriodicalIF":5.1,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental study on stable combustion of pulverized coal stream in a confined small space with air jet 密闭狭小空间内煤粉流喷气稳定燃烧实验研究

IF 5.1 3区工程技术

Thermal Science and Engineering Progress Pub Date : 2024-11-02 DOI: 10.1016/j.tsep.2024.103028

Lizhi Meng, Xiaoju Han, Zuodong Liu, Guojia Yao, Hong Tang, Lingfang Sun

{"title":"Experimental study on stable combustion of pulverized coal stream in a confined small space with air jet","authors":"Lizhi Meng, Xiaoju Han, Zuodong Liu, Guojia Yao, Hong Tang, Lingfang Sun","doi":"10.1016/j.tsep.2024.103028","DOIUrl":"10.1016/j.tsep.2024.103028","url":null,"abstract":"<div><div>Preheated pulverized coal self-sustaining stable combustion burners (PPSCBs) present a promising new avenue for advancing research on ultralow-load stable combustion and achieving ultralow NO<sub>x</sub> emissions in thermal power boilers. Self-sustaining ignition burners (SIBs) serve as a continuous ignition heat source for PPSCBs. The self-sustained combustion characteristics of SIBs play a crucial role in the stable operation of PPSCBs. The stable combustion barrel as a practical model for pulverized coal combustion within confined spaces is the crucial component for SIBs to achieve self-sustained combustion and is the focus of the study. In this study, three structural types of combustion barrels are designed, namely the single-stage air forward jet, single-stage air reverse jet, and three-stage air reverse jet. Relevant data are collected to analyze the effect of varying the combustion temperature on pulverized coal within these combustion barrels. The findings reveal that under various experimental conditions, thermal equilibrium is not established for the single-stage air forward jet structure. However, for the single-stage air reverse jet structure, thermal equilibrium durations of 433 s and 335 s are observed under two operating conditions. The three-stage air reverse jet structure demonstrates thermal equilibrium durations of 3158 s and 3408 s under two operating conditions, with the latter maintaining thermal equilibrium until the conclusion of the experiment. Therefore, the arrangement of the air reverse jet has significant effect on combustion stability. The results of this study offer valuable insights for the subsequent development of SIB technologies.</div></div>","PeriodicalId":23062,"journal":{"name":"Thermal Science and Engineering Progress","volume":"56 ","pages":"Article 103028"},"PeriodicalIF":5.1,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental study on the effect of Mongolian medicine warming acupuncture on proBDNF-tPA-BDNF balance in depression rats based on thermal imaging monitoring 基于热成像监测的蒙药温针灸对抑郁大鼠proBDNF-tPA-BDNF平衡影响的实验研究

IF 5.1 3区工程技术

Thermal Science and Engineering Progress Pub Date : 2024-11-02 DOI: 10.1016/j.tsep.2024.103030

Runa A , Qinglin Bao , Rigenjiya Mu , Muqile Te , Yinchaoketu Sai , Rilebagen Hu , Rentuya Sa , Lengge Si , Gula A

{"title":"Experimental study on the effect of Mongolian medicine warming acupuncture on proBDNF-tPA-BDNF balance in depression rats based on thermal imaging monitoring","authors":"Runa A , Qinglin Bao , Rigenjiya Mu , Muqile Te , Yinchaoketu Sai , Rilebagen Hu , Rentuya Sa , Lengge Si , Gula A","doi":"10.1016/j.tsep.2024.103030","DOIUrl":"10.1016/j.tsep.2024.103030","url":null,"abstract":"<div><div>Depression is a kind of mental illness affecting the whole world. Its pathological mechanism is complex, involving neurobiological and psychosocial factors.The depression model rats were randomly divided into control group, warm acupuncture group and drug treatment group. In order to evaluate the local thermal effect of warm acupuncture and moxibustion, real-time temperature changes of rat forebrain were monitored by thermal imaging technology. After the experiment, immunohistochemistry and Western blot were used to detect the expression levels of tPA and BDNF in the forebrain of each group of rats, and the relationship between tPA and BDNF was analyzed. The results of thermal imaging monitoring showed that local forebrain temperature in warm acupuncture group was significantly increased compared with control group (p < 0.05). The ratio of tPA to BDNF was significantly improved in the warm acupuncture and moxibustion group, suggesting that warm acupuncture and moxibustion can effectively regulate the balance of TPA-BDNF. The experimental results based on thermal imaging monitoring suggest that warm acupuncture can improve the balance of TPA-BDNF in the forebrain of depressed rats by promoting the expression of BDNF and tPA in the forebrain, which may provide a new method and mechanism basis for the treatment of depression.</div></div>","PeriodicalId":23062,"journal":{"name":"Thermal Science and Engineering Progress","volume":"56 ","pages":"Article 103030"},"PeriodicalIF":5.1,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring heat exchange in space: Recent advances in two-phase fluid experiments in microgravity 探索太空中的热交换：微重力两相流体实验的最新进展

IF 5.1 3区工程技术

Thermal Science and Engineering Progress Pub Date : 2024-11-01 DOI: 10.1016/j.tsep.2024.103025

Glauco Nobrega , Inês Santos Afonso , Beatriz Cardoso , Reinaldo Rodrigues de Souza , Ana Moita , João Eduardo Ribeiro , Rui A. Lima

{"title":"Exploring heat exchange in space: Recent advances in two-phase fluid experiments in microgravity","authors":"Glauco Nobrega , Inês Santos Afonso , Beatriz Cardoso , Reinaldo Rodrigues de Souza , Ana Moita , João Eduardo Ribeiro , Rui A. Lima","doi":"10.1016/j.tsep.2024.103025","DOIUrl":"10.1016/j.tsep.2024.103025","url":null,"abstract":"<div><div>Thermal regulation has assumed a central role in space expeditions ever since the inception of Sputnik-1 in 1957. Throughout the years, numerous techniques have been developed to regulate temperatures in spacecraft and space habitats. Initially, passive systems like heat shields and thermal linings were employed, while newer missions embrace active cooling using fluids like ammonia and water. With significant advancements in lunar exploration, thermal management systems have been integrated to ensure effective heat protection and dissipation. Experiments carried out in drop towers, parabolic flights, sounding rockets, and aboard the International Space Station (ISS) have yielded valuable insights into the physics of fluids, pool boiling, boiling in two-phase flow, and cooling phenomena. However, conducting tests in microgravity conditions can lead to lower performances, and accurate numerical simulations remain a challenge. At present, various organizations are conducting research to drive progress in thermal management and enhance the technology of space devices. This review describes the most recent advances in two-phase fluid experiments in microgravity. Furthermore, the major challenges that persist in this field are presented and discussed, along with observations on trends and possibilities for the future of thermal control in space. This review attempts to be a relevant guide for future research and developments on thermal control in space.</div></div>","PeriodicalId":23062,"journal":{"name":"Thermal Science and Engineering Progress","volume":"56 ","pages":"Article 103025"},"PeriodicalIF":5.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of building thermal environment in industrial heritage landscape regeneration design simulation based on image visual visualization 基于图像可视化的工业遗产景观再生设计模拟优化建筑热环境

IF 5.1 3区工程技术

Thermal Science and Engineering Progress Pub Date : 2024-11-01 DOI: 10.1016/j.tsep.2024.103024

Yuan Gao , Wonjun Chung

{"title":"Optimization of building thermal environment in industrial heritage landscape regeneration design simulation based on image visual visualization","authors":"Yuan Gao , Wonjun Chung","doi":"10.1016/j.tsep.2024.103024","DOIUrl":"10.1016/j.tsep.2024.103024","url":null,"abstract":"<div><div>With the increasing attention paid to the regeneration design of industrial heritage landscape, how to effectively improve the thermal energy environment in these areas has become a research hotspot. The thermal efficiency of buildings not only affects the energy consumption, but also relates to the comfort of users and the sustainable development of the region. This study aims to explore the optimization method of building thermal energy environment based on image visual visualization, so as to achieve efficient regeneration of industrial heritage landscape, and improve the thermal energy performance and environmental adaptability of buildings through scientific design and simulation means. Through the use of computer aided design (CAD) and building information modeling (BIM) techniques, combined with heat flow simulation and visual image analysis, a detailed thermal environment assessment is carried out for selected industrial heritage buildings. Through data collection and analysis, we take into account factors such as sunlight, ventilation and heat loss in the building to develop an optimization plan. The simulation results show that the energy consumption of buildings with optimized thermal environment design is significantly reduced and the indoor thermal comfort is greatly improved. Visual tools effectively help the design team identify problem areas and provide intuitive data support for all parties during the design process. The optimization method of building thermal energy environment based on image visual visualization provides a new idea for the regeneration design of industrial heritage landscape, which helps to realize the dual goals of protecting the historical value and meeting the needs of modern environmental protection.</div></div>","PeriodicalId":23062,"journal":{"name":"Thermal Science and Engineering Progress","volume":"56 ","pages":"Article 103024"},"PeriodicalIF":5.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermal study of hybrid-type cooling tower with finned tube radiator 带翅片管散热器的混合型冷却塔的热研究

IF 5.1 3区工程技术

Thermal Science and Engineering Progress Pub Date : 2024-10-31 DOI: 10.1016/j.tsep.2024.103023

I.N. Madyshev , V.V. Kharkov

{"title":"Thermal study of hybrid-type cooling tower with finned tube radiator","authors":"I.N. Madyshev , V.V. Kharkov","doi":"10.1016/j.tsep.2024.103023","DOIUrl":"10.1016/j.tsep.2024.103023","url":null,"abstract":"<div><div>High-capacity and efficient cooling of the circulating water is an urgent task for modern industrial enterprises. A hybrid cooling tower has been developed to cool the circulating water, which is cooled by flowing inside an internal tube radiator, the surface of which is constantly wetted with coolant. For intensifying heat transfer processes, the surface of the radiator tubes is provided with circular fins. The paper presents a validated mathematical model of the process of cooling the circulating water in the hybrid cooling tower with the finned radiator. The influence of the material and dimensions of the fins on the thermal characteristics of the hybrid cooling tower is evaluated. It was found that changing the fin material to copper can increase the heat rate and capacity by 65.5 to 71.5 %, depending on the average temperature of the wetting liquid. It was shown that by using copper fins 3.5 mm high and spaced at a pitch of 2 mm, it is possible to increase the heat rate and capacity of the hybrid cooling system up to 5 times compared to smooth tubes of the radiator under the same conditions. It was determined that the selection of rational fin dimensions of radiator tubes ensures almost complete alignment of the thermal resistances of the radiator walls, which can enhance the heat rate and capacity of the hybrid cooling tower.</div></div>","PeriodicalId":23062,"journal":{"name":"Thermal Science and Engineering Progress","volume":"56 ","pages":"Article 103023"},"PeriodicalIF":5.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Energy-economic analysis and optimization of a shell and tube heat exchanger using a multi-objective heat transfer search algorithm 利用多目标传热搜索算法对管壳式热交换器进行能源经济分析和优化

IF 5.1 3区工程技术

Thermal Science and Engineering Progress Pub Date : 2024-10-30 DOI: 10.1016/j.tsep.2024.103021

Parth Prajapati , Bansi D. Raja , Vivek Patel , Hussam Jouhara

{"title":"Energy-economic analysis and optimization of a shell and tube heat exchanger using a multi-objective heat transfer search algorithm","authors":"Parth Prajapati , Bansi D. Raja , Vivek Patel , Hussam Jouhara","doi":"10.1016/j.tsep.2024.103021","DOIUrl":"10.1016/j.tsep.2024.103021","url":null,"abstract":"<div><div>This study presents the energy-economic analysis and optimization of a shell and tube heat exchanger. A water-water, segmental baffled shell and tube heat exchanger was designed using the Kern method and analysed by performing energy and economic modelling. The analysis is carried out considering the design variables on the shell side i.e. baffle cut, baffle spacing, shell diameter and tube side variables i.e. tube layout, tube outside diameter, number of tube passes and number of tubes. The multi-objective heat transfer search algorithm was used to optimize the heat exchanger for minimum total cost and maximum heat exchanger efficiency. Multiple optimal solutions were presented using the Pareto optimal curve. TOPSIS selection criteria was used to identify the optimum operating condition. Within the given bounds of the variables, the shell and tube heat exchanger can be operated at a minimum cost of 72,000 $/year resulting in 16.4 % efficiency, or, it can be operated at a maximum efficiency of 81.6 % with a total cost of 275,000 $/year. The scattered distribution of shell diameter, baffle spacing, number of tube passes and number of tubes between the lower and upper bound represent their substantial role in optimizing the heat exchanger performance. The number of tubes and tube passes showed the maximum variation in efficiency, while significantly less impact was observed when the tube layout was altered.</div></div>","PeriodicalId":23062,"journal":{"name":"Thermal Science and Engineering Progress","volume":"56 ","pages":"Article 103021"},"PeriodicalIF":5.1,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142571851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profiles of peripheral regulatory T cells forecasts the feasibility of steroid withdrawal after liver transplantation based on cellular thermal modeling 基于细胞热建模的外周调节性 T 细胞图谱预测肝移植后停用类固醇的可行性

IF 5.1 3区工程技术

Thermal Science and Engineering Progress Pub Date : 2024-10-30 DOI: 10.1016/j.tsep.2024.103022

Linhui Pan , Di Lu , Di Wang , Xiao Xu

{"title":"Profiles of peripheral regulatory T cells forecasts the feasibility of steroid withdrawal after liver transplantation based on cellular thermal modeling","authors":"Linhui Pan , Di Lu , Di Wang , Xiao Xu","doi":"10.1016/j.tsep.2024.103022","DOIUrl":"10.1016/j.tsep.2024.103022","url":null,"abstract":"<div><div>After liver transplantation, steroid therapy is often used to prevent rejection. However, long-term steroid use can lead to serious side effects, therefore, this study aimed to evaluate the feasibility of peripheral regulatory T cell profiles for steroid discontinuation after liver transplantation through cellular thermal modeling and real-time monitoring of intracellular thermodynamics. In this study, cellular thermal modeling techniques were used to simulate the thermodynamic characteristics of peripheral TREgs under different conditions. The dynamic changes of peripheral Treg in liver transplantation animal models were monitored by flow cytometry and molecular biology. Significant changes in peripheral Treg profiles were observed after initiation of steroid therapy, especially in the discontinuation group, and these changes were strongly associated with the restoration of immune homeostasis. Real-time monitoring of the thermodynamic data revealed that peripheral Treg activity showed a specific temperature dependence in the cellular thermal model. Cell thermal modeling combined with real-time monitoring of intracellular thermodynamics provides a new perspective for evaluating the feasibility of peripheral regulatory T cell profiles for steroid discontinuation after liver transplantation. Strengthening the dynamic monitoring of peripheral Treg spectrum provides an important basis for the formulation of personalized immunosuppression strategies, and improves the therapeutic effect and quality of life of liver transplant patients.</div></div>","PeriodicalId":23062,"journal":{"name":"Thermal Science and Engineering Progress","volume":"56 ","pages":"Article 103022"},"PeriodicalIF":5.1,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142571760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0