Therapeutic Advances in Urology最新文献

{"title":"Expanded PCR panel for uropathogen identification and treatment recommendations in urinary tract infections.","authors":"Lindsey Leech, Christopher Bigley, Marshall Chew, Ashley Crawford, JeanAnn Vawter, Manish P Patel","doi":"10.1177/17562872251342421","DOIUrl":"10.1177/17562872251342421","url":null,"abstract":"<p><strong>Background: </strong>Urinary tract infections (UTI) are common and costly, but standard urine culture (SUC) diagnostic tests have significant limitations. Emerging molecular techniques like multiplex polymerase chain reaction (PCR) offer rapid simultaneous detection of uropathogens and antimicrobial resistance (AMR) genes allowing timely targeted therapy.</p><p><strong>Objectives: </strong>To compare the performance of Urine-ID™ test, an expanded multiplex PCR panel designed to detect 26 uropathogens and 49 AMR markers against SUC for pathogen detection in individuals with suspected complicated UTI.</p><p><strong>Design and methods: </strong>A total of 56 urine specimens from individuals aged 50 and older, who exhibited UTI symptoms and failed previous therapy based on SUC results, were retrospectively analyzed using Urine-ID^™ using the TaqMan^® OpenArray plates on the QuantStudio 12K Flex Real-Time PCR System. Results of simultaneously collected PCR and SUC were compared at patient follow-ups.</p><p><strong>Results: </strong>Of the 56 suspected UTI cases, SUC failed to detect pathogens in 19.64% (<i>N</i> = 11/56) of the specimens while PCR yielded negative results in 7.14% (<i>N</i> = 4/56) of cases. SUC identified a specific organism in 50% (<i>N</i> = 28/56) while PCR detected at least one uropathogen in 92.86% (<i>N</i> = 52/56) of specimens. Data also revealed that a nonspecific result, \"Mixed urogenital flora\" (MUG), was the most frequent outcome (<i>N</i> = 18/45) obtained with SUC among positive samples. While SUC identified a single pathogen in 92.80% (<i>N</i> = 26/28) of positive specimens, PCR detected additional co-infecting uropathogens in 71.20% (<i>N</i> = 37/52) of positive samples. Of the 18 MUG and 11 negative samples using SUC, PCR identified treatable pathogens in 13 and 7 samples, respectively.</p><p><strong>Conclusion: </strong>These results highlight the effectiveness of expanded real-time PCR panels for quickly and accurately identifying uropathogens, surpassing traditional SUC sensitivity. Adopting these advanced molecular techniques, particularly in suspected complicated UTI cases, improves diagnosis efficiency, leading to faster pathogen identification and treatment, ultimately reducing patient morbidity.</p>","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"17 ","pages":"17562872251342421"},"PeriodicalIF":2.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"5-Year results of robotic female AUS implantation: our single-center series of 42 patients.","authors":"Alexandre Dubois, Claire Richard, Camille Haudebert, Juan Penafiel, Caroline Voiry, Magali Jezequel, Emmanuelle Samson, Lucas Freton, Andrea Manunta, Juliette Hascoet, Benoit Peyronnet","doi":"10.1177/17562872251342699","DOIUrl":"10.1177/17562872251342699","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, several preliminary reports have suggested that the robot-assisted approach may decrease the surgical morbidity of artificial urinary sphincter (AUS) implantation in female patients with stress urinary incontinence (SUI). However, for now, only short-term outcomes have been reported. The present study aimed to report the 5-year outcomes of robot-assisted AUS implantation in female patients.</p><p><strong>Patients and methods: </strong>All female patients who underwent a robot-assisted AUS implantation between January 2014 and September 2019 at a single academic center were included in a retrospective study. All robot-assisted female AUS implantations performed after September 2019 were excluded to ensure a 5-year minimum follow-up duration. The indication for AUS implantation was SUI due to intrinsic sphincter deficiency. The primary endpoint was the explantation-free survival and revision-free survival.</p><p><strong>Results: </strong>Forty-two patients were included. The median age was 66 years (28-84), and 83.8% of the patients had a history of previous anti-incontinence procedure. After a median follow-up of 64 months (16-110), 8 patients were lost to follow-up before the 5-year time point. The 5-year estimated revision-free survival was 89.2 and the 5-year estimated explantation-free survival was 88%. Five AUS explantations were needed (11.9%), and six revisions were required (14.3%). The median time to explantation was 14 months. Four explantations (80%) occurred within the first 18 months, and all of them within the first 27 months. Thirty patients (71.42%) had a complete or improved continence with a complete continence rate of 59.52% and an improved continence rate of 11.9%. There were 10 intraoperative complications (23.8%): 5 bladder injuries and 5 vaginal injuries. Thirteen patients had postoperative complications (30.9%), but only two were Clavien grade ⩾3.</p><p><strong>Conclusion: </strong>The 5-year outcomes of robot-assisted AUS implantation seem to confirm the promising short-term outcomes that have been reported so far, although revision rates increased with time, which warrants further investigation.</p>","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"17 ","pages":"17562872251342699"},"PeriodicalIF":2.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What's new in paediatric urology? crossroads of pediatric surgery and adult urology.","authors":"Kiarash Taghavi","doi":"10.1177/17562872251343668","DOIUrl":"10.1177/17562872251343668","url":null,"abstract":"","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"17 ","pages":"17562872251343668"},"PeriodicalIF":2.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of holmium laser enucleation of the prostate in men with a history of prostatitis: a retrospective study.","authors":"Meera Bhanu Ganesh, Perry Xu, Nicholas Dean, Kyle Tsai, Jamie Michael, Alyssa McDonald, Devyn Taylor Coskey, Nabila Khondakar, Allaa Fadl-Alla, Amy Elizabeth Krambeck","doi":"10.1177/17562872251338430","DOIUrl":"10.1177/17562872251338430","url":null,"abstract":"<p><strong>Background: </strong>Prostatitis can be challenging to treat. In refractory cases, prostatitis can be treated surgically with transurethral resection.</p><p><strong>Objectives: </strong>To examine the safety and efficacy of holmium laser enucleation of the prostate (HoLEP) as treatment in patients with prostatitis.</p><p><strong>Design and methods: </strong>Patients who underwent HoLEP at a single center between January 2021 and August 2023 were retrospectively reviewed. Preoperative, intraoperative, and postoperative parameters were collected and analyzed. Patients with an ICD-10 diagnosis of prostatitis were identified and contacted postoperatively to evaluate for recurrent symptoms. Statistical significance was defined as <i>p</i> < 0.05.</p><p><strong>Results: </strong>We identified 918 patients, of whom 26 (2.8%) had a diagnosis of prostatitis. There were no differences in baseline characteristics between patients with and without prostatitis. Patients with prostatitis were less likely to have a history of a neurologic disorder (<i>p</i> = 0.035), less likely to be catheter-dependent (<i>p</i> = 0.005), and less likely to have a preoperative positive urine culture (<i>p</i> = 0.040). There were no significant differences in intraoperative and postoperative parameters between the two groups. There were 23/26 (88.5%) patients with follow-up. There were no episodes of recurrent prostatitis and one episode of UTI after surgery, with a mean follow-up of 19.39 months (range: 7.45-30.19, SD: 7.38).</p><p><strong>Conclusion: </strong>Prostatitis patients undergoing HoLEP had comparable safety and efficacy profiles to those who did not have prostatitis. On follow-up, 100% of patients with prostatitis did not experience recurrent prostatitis, suggesting that HoLEP may have a role in the management of prostatitis in the presence of benign prostatic enlargement.</p>","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"17 ","pages":"17562872251338430"},"PeriodicalIF":2.6,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the surgical robot in gender-affirming surgery: a scoping review.","authors":"Karen M Doersch, Lily Kong, Christodoulos Kaoutzanis, Ty Higuchi","doi":"10.1177/17562872251336639","DOIUrl":"https://doi.org/10.1177/17562872251336639","url":null,"abstract":"<p><strong>Background: </strong>Gender-affirming surgery is a growing field to address gender dysphoria, which is an increasingly recognized condition. The surgical robot is an excellent tool for performing some gender-affirming procedures and has been utilized extensively in both feminizing and masculinizing surgery.</p><p><strong>Objectives: </strong>To provide an overview for the use of the surgical robot in gender-affirming surgeries.</p><p><strong>Design: </strong>This is a scoping review.</p><p><strong>Methods: </strong>A literature search was conducted by the authors via PubMed and Google Scholar.</p><p><strong>Results: </strong>The ability of the robot to operate within the pelvis makes it an excellent platform for performing colpectomy with colpocleisis, hysterectomy, and vaginoplasty. A variety of grafts and flaps are amenable to robotic employment in the setting of gender-affirming surgeries. Finally, many revisions can be performed via the robotic approach, regardless of the approach of a patient's primary surgery.</p><p><strong>Conclusion: </strong>The surgical robot is a useful tool for performing gender-affirming surgeries, including primary surgeries and revisions. Future research will continue to define roles for the robot in the setting of gender-affirming surgery, improve outcomes, and develop novel techniques.</p>","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"17 ","pages":"17562872251336639"},"PeriodicalIF":2.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of clear cell renal cell carcinoma via a deep learning model with whole-slide images.","authors":"Weixing Jiang, Siyu Qi, Cancan Chen, Wenying Wang, Xi Chen","doi":"10.1177/17562872251333865","DOIUrl":"https://doi.org/10.1177/17562872251333865","url":null,"abstract":"<p><strong>Background: </strong>Traditional pathological diagnosis methods have limitations in terms of interobserver variability and the time consumption of evaluations. In this study, we explored the feasibility of using whole-slide images (WSIs) to establish a deep learning model for the diagnosis of clear cell renal cell carcinoma (ccRCC).</p><p><strong>Methods: </strong>We retrospectively collected pathological data from 95 patients with ccRCC from January 2023 to December 2023. All pathological slices conforming to the standards of the model were manually annotated first. The WSIs were preprocessed to extract the region of interest. The WSIs were divided into a training set and a test set, and the ratio of tumor slices to normal tissue slices in the training set to the test set was 3:1. Positive and negative samples were randomly extracted. Model training was based on a convolutional neural network (CNN) and a random forest model. The accuracy of the model was evaluated by generating a receiver operating characteristic (ROC) curve.</p><p><strong>Results: </strong>A total of 663 pathological slices from 95 patients with ccRCC were collected. The mean number of slices per patient was 7.6 ± 2.7 (range: 3-17), with 506 tumor slices and 157 normal tissue slices. There were 200 tumor slices and 74 normal slices in the training set, and a total of 200,870 small images were extracted. There were 250 tumor slices and 63 normal slices in the test set, and a total of 39,211 small images were extracted. According to the CNN model and random forest model trained with the training set, 11 pathological slices in the test set were identified as false normal slices, and six pathological slices were identified as false tumor slices. The total accuracy was 94.6% (296/313), the precision rate was 97.6% (239/245), and the recall rate was 95.6% (239/250). The generated probabilistic heatmaps were consistent with the manually annotated pathological images. The ROC curve results revealed that the area under curve (AUC) reached 0.9658 (95% confidence interval: 0.9603-0.9713), the specificity was 90.5%, and the sensitivity was 95.6%.</p><p><strong>Conclusion: </strong>The use of a deep learning method for the diagnosis of ccRCC is feasible. The ccRCC model established in this study achieved high accuracy. AI-based diagnostic methods for ccRCC may improve diagnostic efficiency.</p>","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"17 ","pages":"17562872251333865"},"PeriodicalIF":2.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quadrifecta during retrograde intrarenal surgery: suction, irrigation, intrarenal temperature and pressure: achieving best clinical outcomes - an overview from EAU Endourology.","authors":"Carlotta Nedbal, Vineet Gauhar, Steffi Kar Kei Yuen, Daniele Castellani, Thomas Herrmann, Olivier Traxer, Bhaskar Kumar Somani","doi":"10.1177/17562872251335268","DOIUrl":"https://doi.org/10.1177/17562872251335268","url":null,"abstract":"","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"17 ","pages":"17562872251335268"},"PeriodicalIF":2.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal cell cancer treatment: the Latin American Cooperative Oncology Group (LACOG) and the Latin American Renal Cancer Group (LARCG) surgery-focused consensus update.","authors":"Stênio de Cássio Zequi, Anderson de Oliveira Galvão, André Costa Matos, Gilberto Laurino Almeida, Marcelo Esteves Chaves Campos, Marcelo Langer Wroclawski, Thiago Camelo Mourão, Wagner Eduardo Matheus, Arie Carneiro, Augusto Modesto de Sousa Neto, Aurus Meneses, Breno Dauster, Daher Cezar Chade, Deusdedit Cortez Vieira da Silva Neto, Éder Silveira Brazão, Eduardo Café Cardoso Pinto, Eliney Faria, Felipe de Almeida E Paula, Felipe Lott, Fernando Korkes, Fernando Meyer, Francisco Hidelbrando Alves Mota Filho, Frederico Mascarenhas, Giuliano Betoni Guglielmetti, Guilherme Antônio Veloso Coaracy, Gustavo Cardoso Guimarães, Gustavo Franco Carvalhal, Jonatas Luiz Pereira, Leandro Koifman, Lucas Fornazieri, Lucas Nogueira, Lucas Teixeira Batista, Luciano Alves Favorito, Luiz Henrique Araújo, Marcos Lima de Oliveira Leal, Marcos Tobias-Machado, Mauricio Cordeiro, Mauricio Murce Rocha, Nilo Jorge Carvalho Leão Filho, Rafael Ribeiro Meduna, Renato Beluco Corradi, Ricardo de Lima Favaretto, Roberto Machado, Rodolfo Borges Dos Reis, Roni de Carvalho Fernandes, Victor Espinheira Santos, Vladmir Pinheiro De Oliveira, Walter Henriques da Costa, Wilson F S Busato, Andrey Soares","doi":"10.1177/17562872241312581","DOIUrl":"https://doi.org/10.1177/17562872241312581","url":null,"abstract":"<p><p>Renal cell carcinoma (RCC) represents 2.2% of all malignancies worldwide; however, its mortality rate is not negligible. Surgery is the primary treatment for most nonadvanced cases, with its indications and techniques evolving over the years. To provide an update on RCC management in Brazil, focusing on surgery. The Latin American Cooperative Oncology Group-Genitourinary Section and the Latin American Renal Cancer Group gathered a panel of Brazilian urologists and clinical oncologists to vote on and discuss the best management of surgically resectable RCC. The experts compared the results with the literature and graded them according to the level of evidence. For small renal masses (SRMs; less than 4 cm), biopsy is indicated for specific/select cases, and when intervention is needed, partial nephrectomy should be prioritized. Radical nephrectomy and ablative techniques are exceptions for managing SRMs. Patients with small tumors (less than 3 cm), slow tumor growth, or a risk for surgery may benefit from active surveillance. Localized carcinoma up to 7 cm in diameter should be treated preferably with partial nephrectomy. Lymphadenectomy and adrenalectomy should be performed in locally advanced cases if involvement is suspected by imaging exams. Patients with venous tumor thrombi usually require surgical intervention depending on the extent of the thrombus. Neoadjuvant therapy should be considered for unresectable cases. Even in the era of targeted therapy, cytoreductive nephrectomy still has a role in metastatic disease. Metastasectomy is indicated for most patients with resectable disease. This consensus presents recommendations for surgical treatment of RCC based on expert opinions and evidence from the medical literature. Surgery remains the best curative option for nonadvanced cases, and it still has a role for select patients with metastatic disease.</p>","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"17 ","pages":"17562872241312581"},"PeriodicalIF":2.6,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in minimally invasive urology and uro-technology: current status, evolution and future prospects.","authors":"Bhaskar Somani","doi":"10.1177/17562872251329898","DOIUrl":"10.1177/17562872251329898","url":null,"abstract":"","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"17 ","pages":"17562872251329898"},"PeriodicalIF":2.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic reconstruction for benign upper urinary tract obstruction: a review of the current literature.","authors":"Rebeca Gonzalez Jauregui, Rohan G Bhalla, Karen Doersch, Brian J Flynn","doi":"10.1177/17562872251326785","DOIUrl":"10.1177/17562872251326785","url":null,"abstract":"<p><p>The field of reconstructive urology has seen a paradigm shift in the surgical approach for intra-abdominal cases, resulting in an increased preference for minimally invasive techniques. The introduction of the surgical robot has led to exponential growth in innovative approaches, reflecting the ongoing efforts to improve patient outcomes and address the limitations of open and laparoscopic surgery. This review article summarizes the knowledge gained in the last 10 years about adult robotic ureteral reconstruction. A non-systematic literature review was conducted on February 18, 2024 using Medline, PubMed, Web of Science, and Embase libraries. Studies published in English since 2014 reporting at least five robotic ureteral reconstructive cases for the management of benign ureteral obstruction in adults were included. A narrative review focusing on robotic ureteral reconstructive techniques, their associated success and complication rates, and how the robotic approach compares to open and laparoscopic reconstruction was performed. The current literature demonstrates increased utilization of the robotic platform in reconstructive urological procedures. Robotic surgery has been shown to be associated with shorter learning curves, lower surgeon fatigue, better visualization and equivalent results to those seen with laparoscopic surgery. While the literature is limited by a lack of comparative data, well-designed randomized controlled trials, and standardized criteria for defining and measuring success, this review demonstrates the safety, feasibility, and efficacy of robotic ureteral reconstruction for managing benign ureteral strictures, confirming it as a viable alternative to open and laparoscopic surgery.</p>","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"17 ","pages":"17562872251326785"},"PeriodicalIF":2.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}