Therapeutic Advances in Urology最新文献

{"title":"Corrigendum to \"Endoscopic management of vesicourethral anastomotic stenosis after radical prostatectomy: Final outcomes defined by urethral patency and continence\".","authors":"","doi":"10.1177/17562872261494788","DOIUrl":"10.1177/17562872261494788","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1177/17562872261449901.].</p>","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"18 ","pages":"17562872261494788"},"PeriodicalIF":3.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13635647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic-assisted partial nephrectomy outcomes with airseal® versus conventional insufflation: A single tertiary center comparative study.","authors":"Bilal Alameddine, Baraa AlJardali, Oussama Nasrallah, Marwan Zein, Raja Khauli, Mohammad Bulbul, Rami Nasr, Sana Kalaji, Albert El Hajj","doi":"10.1177/17562872261485788","DOIUrl":"10.1177/17562872261485788","url":null,"abstract":"<p><strong>Background: </strong>The AirSeal® Intelligent Flow System (IFS) is a valveless insufflation system that provides stable pneumoperitoneum and continuous smoke evacuation. While its safety and efficacy have been demonstrated in urologic surgery, evidence regarding its impact on perioperative outcomes in robotic-assisted partial nephrectomy (RAPN) remains limited.</p><p><strong>Objectives: </strong>To compare perioperative outcomes, postoperative complications, and opioid use between RAPN performed with AirSeal® versus conventional insufflation.</p><p><strong>Design: </strong>Retrospective comparative study using a prospectively maintained single-center database.</p><p><strong>Methods: </strong>We analyzed 208 consecutive patients who underwent elective RAPN at a tertiary care center between 2013 and 2023. Patients were divided into two groups based on the insufflation system used: AirSeal® (n=86) and conventional insufflation (n=122). Baseline demographics, operative characteristics, and postoperative outcomes-including operative time, estimated blood loss, length of hospital stay, complications (Clavien-Dindo classification), trifecta achievement, renal function, and postoperative opioid use-were compared. Statistical analyses included chi-square tests, independent t-tests, and univariate linear regression.</p><p><strong>Results: </strong>Baseline demographic, functional, and oncologic characteristics were comparable between groups. Use of AirSeal® was associated with significantly shorter operative time (-30.83 minutes, p<0.001), reduced estimated blood loss (-81.42 cc, p=0.003), and shorter hospital stay (-1.09 days, p<0.001). There were no significant differences in postoperative complications, trifecta achievement, renal functional outcomes, or postoperative opioid use between the two groups.</p><p><strong>Conclusion: </strong>The use of AirSeal® in RAPN is associated with improved perioperative efficiency, including shorter operative time, reduced blood loss, and shorter hospitalization, without compromising safety or functional outcomes. Further prospective and multicenter studies are warranted to validate these findings and assess cost-effectiveness.</p>","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"18 ","pages":"17562872261485788"},"PeriodicalIF":3.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarker-guided selection of intravesical therapy in high-risk non-muscle invasive bladder cancer: A contemporary review.","authors":"Willian Ito, Isamu Tachibana","doi":"10.1177/17562872261485770","DOIUrl":"10.1177/17562872261485770","url":null,"abstract":"<p><p>High-risk non-muscle invasive bladder cancer poses therapeutic challenges, with significant rates of recurrence and progression with standard intravesical bacillus Calmette-Guérin (BCG) therapy. Current surveillance strategies lack accurate risk stratification models to predict individual treatment response and personalized treatment options. Simultaneously, there are no well-validated alternatives to replace the current gold-standard approach based on clinical and pathologic features. This review examines emerging biomarkers and advanced technologies with the potential to enhance patient selection and personalize intravesical therapy in HR-NMIBC. Artificial intelligence(AI)-driven histopathologic tools, such as the computer histological AI biomarker, have demonstrated the ability to identify non-responders to standard therapy using whole-slide digital pathology images. In parallel, radiomics-enhanced imaging has shown promise in assessing tumor biology and immune microenvironment features predictive of BCG responsiveness. Liquid biopsy, especially urine tumor DNA analysis, is now available in the arsenal to detect minimal residual disease, stratify recurrence risk, and predict treatment response even before clinical or radiographic evidence of recurrence. Tissue-based genomic profiling has also revealed molecular alterations associated with treatment resistance, though additional validation is needed. Together, these next-generation biomarkers may represent a pivotal shift toward precision oncology in bladder cancer and their incorporation into NMIBC future clinical guidelines is both anticipated and necessary.</p>","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"18 ","pages":"17562872261485770"},"PeriodicalIF":3.5,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13539006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-session robot-assisted removal of a retained ureteral stent with complex proximal and distal encrustation: A case report.","authors":"Maximo Alvarez, Cole Freedman, Emma Romero, Paul Kim, Alexis Garza, Harras Zaid","doi":"10.1177/17562872261485779","DOIUrl":"10.1177/17562872261485779","url":null,"abstract":"<p><p>Retained encrusted ureteral stents represent a complex urologic problem, particularly in patients with limited healthcare access. We present a 28-year-old undocumented female with a 10-month retained ureteral stent who developed massive right-sided encrustation, including a 3 cm proximal renal stone near the renal pelvis and a 5-6 cm bladder stone, classified as FECal Grade IV-V. A single-session combined approach consisting of robot-assisted cystolithotomy, intraoperative ureteroscopy with stent exchange, and robot-assisted pyelolithotomy was performed successfully. Intraoperative ureteroscopy between operative phases confirmed ureteral clearance and enabled immediate stent placement without repositioning delay. This case supports the use of combined robotic approaches for high-grade disease and illustrates how structural barriers drive late presentation and increased surgical complexity.</p>","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"18 ","pages":"17562872261485779"},"PeriodicalIF":3.5,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13539040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and postoperative outcomes of kidney stone surgery in HIV-positive patients: A retrospective cohort study.","authors":"Nannan Li, Zhiwang Tang, Ke Yang, Yanlin Li, Jinbo Chen, Meng Gao, Liang Deng","doi":"10.1177/17562872261485769","DOIUrl":"10.1177/17562872261485769","url":null,"abstract":"<p><strong>Background: </strong>People living with HIV (PLWH) are increasingly undergoing endourological procedures, including mini-percutaneous nephrolithotomy (mini-PCNL) and retrograde intrarenal surgery (RIRS), but comparative evidence on postoperative infectious outcomes is limited.</p><p><strong>Objectives: </strong>This study aims to compare short-term postoperative outcomes between PLWH and HIV-negative patients undergoing mini-PCNL or RIRS, focusing on postoperative urosepsis and exploring factors associated with urosepsis among PLWH.</p><p><strong>Design: </strong>A single-center, retrospective cohort study.</p><p><strong>Methods: </strong>Consecutive adult patients who underwent mini-PCNL or RIRS between July 2023 and January 2025 were grouped by HIV status. The primary outcome was postoperative urosepsis during the index hospitalization. Secondary outcomes included stone-free status and length of stay.</p><p><strong>Results: </strong>A total of 708 patients were included (70 PLWH and 638 HIV-negative). Postoperative urosepsis occurred in 8/70 (11.4%) PLWH and 45/638 (7.1%) HIV-negative patients, with no significant difference between groups (p=0.13). Stone-free status was achieved in 66/70 (94.3%) PLWH and 586/638 (91.8%) HIV-negative patients (p=0.48). Other outcomes, including total hospitalization time, postoperative hospital stay, and preoperative antibiotic exposure, did not differ significantly between groups (all p>0.05). Among PLWH, exploratory univariable analyses showed that female sex, positive preoperative urine culture, and clinically higher-risk HIV disease group (acute HIV infection or AIDS) were associated with higher odds of postoperative urosepsis. CD4+ T-cell count <400 cells/µL showed a higher but statistically non-significant estimated odds.</p><p><strong>Conclusion: </strong>Short-term postoperative outcomes following mini-PCNL or RIRS did not differ significantly between PLWH and HIV-negative patients. Exploratory univariable analyses suggested that female sex, positive preoperative urine culture, and clinically higher-risk HIV disease group were associated with postoperative urosepsis among PLWH. These findings should be interpreted cautiously because of the limited number of PLWH and urosepsis events.</p>","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"18 ","pages":"17562872261485769"},"PeriodicalIF":3.5,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative treatment for muscle invasive bladder cancer in the era of immunotherapy.","authors":"Cheyenne Williams, Yash Shah, Leilei Xia","doi":"10.1177/17562872261481954","DOIUrl":"10.1177/17562872261481954","url":null,"abstract":"<p><p>Muscle-invasive bladder cancer (MIBC) remains associated with high recurrence and mortality despite radical cystectomy and cisplatin-based neoadjuvant chemotherapy (NAC). For decades, perioperative therapy was defined by platinum-based regimens, which improve survival but are limited to fewer than half of patients due to comorbidities. Recent advances in the past year have redefined this landscape. Multiple pivotal phase III trials have demonstrated the efficacy of immune checkpoint inhibitors (ICIs) in both neoadjuvant and adjuvant settings. The phase III trials, KEYNOTE-905/EV-303 and KEYNOTE-B15/EV-304 have established perioperative enfortumab vedotin plus pembrolizumab as a new standard of care for neoadjuvant therapy. Parallel translational research has identified biomarkers that may refine patient selection and optimize therapy. PD-L1 expression, DNA damage repair gene alterations, molecular subtyping, and circulating tumor DNA (ctDNA) have all emerged as predictive and prognostic tools. Liquid biopsy approaches may guide adjuvant therapy decisions and facilitate real-time monitoring of minimal residual disease. This review synthesizes the evolving role of perioperative therapies in MIBC, from the historical reliance on cisplatin-based chemotherapy to the transformative integration of immunotherapy, ADCs, and biomarker-guided approaches. Together, these advances represent a significant progress in perioperative bladder cancer care, heralding a shift toward individualized, biomarker-driven strategies that promise improved survival and broader treatment applicability.</p>","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"18 ","pages":"17562872261481954"},"PeriodicalIF":3.5,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13522676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thulium fiber laser versus high-power holmium laser for renal stones: a systematic review and meta-analysis of high-quality studies.","authors":"Khi Yung Fong, Han Jie Lee, Pierre Yeap, Jingzeng Du, Alvin Wei Xiang Low, Tsung Wen Chong, Palaniappan Sundaram","doi":"10.1177/17562872261467267","DOIUrl":"10.1177/17562872261467267","url":null,"abstract":"<p><strong>Background: </strong>Thulium fiber laser (TFL) and high-power Holmium:Yttrium-Aluminum-Garnet laser (HPHL) are common laser modalities used in flexible ureteroscopy (F-URS). Existing comparisons are imperfect due to lack of randomization, use of obsolete low-power settings, and the recent advent of technologies such as flexible and navigable ureteral access sheaths (FANS).</p><p><strong>Objectives: </strong>To compare the safety and efficacy of TFL versus HPHL for F-URS in renal stones.</p><p><strong>Design: </strong>A PRISMA-compliant literature review was conducted on PubMed, EMBASE, Scopus and for randomized trials or propensity score-matched studies comparing TFL to HPHL in renal stones.</p><p><strong>Data sources and methods: </strong>Primary outcomes were study-defined stone-free rate (SFR), as well as 100% SFR (zero residual fragments). Secondary outcomes were total operation time, all complications, bleeding complications, postoperative fever, and reintervention. Random-effects meta-analyses were performed to generate risk ratios (RRs) or mean differences (MDs).</p><p><strong>Results: </strong>Eight studies (1290 patients) were shortlisted for analysis. Only one utilized FANS; three did not routinely use ureteral access sheaths. Between TFL and HPHL, there was no significant difference in study-reported SFR (RR = 1.17, 95% CI = 0.98-1.40, <i>p</i> = 0.07), 100% SFR (RR = 1.16, 95% CI = 0.90-1.50, <i>p</i> = 0.19), total operation time (MD -1.0 min, 95% CI = -8.8 to 6.8 min, <i>p</i> = 0.75), all complications (RR = 1.01, 95% CI = 0.54-1.87, <i>p</i> = 0.97), bleeding complications (RR = 0.59, 95%CI = 0.01-23.3, <i>p</i> = 0.60), postoperative fever (RR = 1.23, 95% CI = 0.68-2.24, <i>p</i> = 0.27), and reintervention (RR = 0.72, 95% CI = 0.38-1.34, <i>p</i> = 0.15).</p><p><strong>Conclusion: </strong>This meta-analysis of high-quality studies found no significant differences between HPHL and TFL in the trifecta of outcomes-SFR, complications, and reintervention-in F-URS for renal stones. Continued re-evaluation of this field remains a necessity as technological advancements such as FANS and novel lasers continue to emerge.</p>","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"18 ","pages":"17562872261467267"},"PeriodicalIF":3.5,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Anterior Transmembranous Posterior Urethral Bulbar (CATPUB) cuff placement: A novel surgical technique for AUS implantation after severe pelvic trauma - a retrospective cohort study.","authors":"Peter Rehder, Gennadi Tulchiner, Lukas Andrius Jelisejevas","doi":"10.1177/17562872261477670","DOIUrl":"https://doi.org/10.1177/17562872261477670","url":null,"abstract":"<p><strong>Background: </strong>Neurogenic urinary incontinence represents a major therapeutic challenge in patients with a history of severe pelvic trauma, where extensive scarring and distorted anatomy limit conventional surgical options. Despite its clinical relevance, published data on continence-preserving treatments for this subgroup remain scarce, and many patients are managed with permanent catheterization or urinary diversion.</p><p><strong>Objective: </strong>Our aim was to describe a novel technique for artificial urinary sphincter implantation using an alternative cuff placement strategy around the bladder outlet and to evaluate associated clinical outcomes.</p><p><strong>Design: </strong>Single-center retrospective cohort study evaluating feasibility, safety, and long-term outcomes of a novel surgical technique.</p><p><strong>Methods: </strong>We provide a standardized, step-by-step description of the novel operating technique and retrospectively analyzed 12 consecutive paraplegic male patients who underwent artificial urinary sphincter implantation using this approach. Demographic, functional, and patient-reported outcomes were assessed.</p><p><strong>Results: </strong>Twelve consecutive patients underwent successful implantation of an artificial urinary sphincter using the CATPUB (Combined Anterior Transmembranous Posterior Urethral Bulbar) technique between 2008 and 2025. No serious perioperative complications were observed during a follow-up of up to 15 years (median 35 months).</p><p><strong>Conclusions: </strong>CATPUB cuff placement provides a safe and effective continence-preserving option for male paraplegic patients with neurogenic urinary incontinence following severe pelvic trauma and may represent a valuable alternative when conventional bladder neck cuff placement is not feasible.</p>","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"18 ","pages":"17562872261477670"},"PeriodicalIF":3.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13490825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mind the pressure - Why does intrarenal pressure monitoring matter? Overview from EAU endourology.","authors":"D Fuligni, V Gauhar, Skk Yuen, A Tsaturyan, B K Somani","doi":"10.1177/17562872261473528","DOIUrl":"10.1177/17562872261473528","url":null,"abstract":"","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"18 ","pages":"17562872261473528"},"PeriodicalIF":3.5,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13462504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pelvic stone angle as a novel parameter for predicting stone-free rates after RIRS: A retrospective comparative analysis with established scoring systems-AUSET collaboration.","authors":"Yu-Hung Tung, Wei-Ming Li, Yung-Shun Juan, Hsin-Chih Yeh, Yen-Chun Wang, Hsiang-Ying Lee","doi":"10.1177/17562872261473181","DOIUrl":"10.1177/17562872261473181","url":null,"abstract":"<p><strong>Background: </strong>Several scoring systems have been developed to predict stone-free rates (SFR) after retrograde intrarenal surgery (RIRS), but their clinical utility remains limited. The pelvic stone angle (PSA) has recently been proposed as a novel anatomical parameter for evaluating lower pole stones.</p><p><strong>Objectives: </strong>To evaluate the predictive value of PSA for stone-free outcomes after RIRS and compare the performance of PSA-integrated scoring systems with existing nephrolithometric models.</p><p><strong>Design: </strong>Retrospective single-center cohort study.</p><p><strong>Methods: </strong>A total of 198 patients who underwent RIRS between April 2018 and October 2023 were retrospectively reviewed. Patients with lower pole stones were included. Preoperative non-contrast computed tomography was used to evaluate PSA, stone burden, and other anatomical parameters. Stone-free status was assessed one month postoperatively. Four scoring systems (MS-ReSC, R.I.R.S., RUSS, and T.O.HO.) were analyzed, with PSA replacing the conventional infundibulopelvic angle where applicable. Predictive performance was evaluated using area under the receiver operating characteristic curve (AUC).</p><p><strong>Results: </strong>The T.O.HO. score demonstrated the highest predictive performance for stone-free status with an AUC of 0.7080, followed by the R.I.R.S. score with PSA (0.6525), MS-ReSC (0.6147), and RUSS with PSA (0.6121). Among the evaluated models, only the T.O.HO. score showed a statistically significant improvement compared with RUSS (p = 0.0445). No statistically significant differences in overall accuracy were observed among the scoring systems. Lower pole stone burden, stone multiplicity, CT attenuation values, and multifocal stones were significantly associated with postoperative stone-free outcomes.</p><p><strong>Conclusion: </strong>PSA is a practical and reliable anatomical parameter for predicting stone-free outcomes after RIRS. Integration of PSA into existing scoring systems maintained comparable predictive performance and may improve reproducibility in modern endourological practice. Although the T.O.HO. score demonstrated the best overall performance, further large-scale prospective multicenter studies are required to validate PSA-based scoring systems.</p>","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"18 ","pages":"17562872261473181"},"PeriodicalIF":3.5,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13462620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}