{"title":"Peripheral electrical stimulation for premature ejaculation: a systematic review of clinical studies.","authors":"Fateme Tahmasbi, Alireza Rahimi-Mamaghani, Farzin Soleimanzadeh, Omid Sedigh, Sarvin Sanaie, Mohsen Mohammad-Rahimi","doi":"10.1177/17562872251382317","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Premature ejaculation (PE) is a common sexual disorder characterized by a lack of voluntary control over ejaculation. Current treatments often fail to produce consistently satisfactory outcomes. Peripheral electrical stimulation (PES) is an emerging neuromodulation technique that applies electrical currents to targeted body areas and has shown promise across various conditions.</p><p><strong>Objectives: </strong>Although the use of PES for PE is relatively underexplored, this study aimed to synthesize existing research to better understand its potential as a treatment option.</p><p><strong>Design: </strong>Systematic review.</p><p><strong>Data sources and methods: </strong>A systematic search was conducted in PubMed, Embase, Scopus, Web of Science, and Google Scholar using relevant keywords. Studies were included if they investigated PES as a treatment for PE and reported outcomes such as intravaginal ejaculatory latency time (IELT) or other clinical measures.</p><p><strong>Results: </strong>Ten studies met the eligibility criteria. Due to the limited number and heterogeneity of studies, a meta-analysis was not feasible, and a narrative synthesis was performed. Stimulation was applied transcutaneously in various ways, including at acupuncture points, the dorsal penile nerve, and the posterior tibial nerve. Protocols varied considerably, though commonly reported parameters included a pulse frequency of 20 Hz and a pulse width of 200 µs, typically administered in 30-min sessions. Some studies lacked detailed descriptions of stimulation settings. Overall, the studies demonstrated a positive trend in favor of PES for prolonging IELT, and no consistent or significant adverse events were reported.</p><p><strong>Conclusion: </strong>The findings suggest that PES may be a promising adjunctive therapy for men with PE by prolonging IELT. Further high-quality research using validated patient-reported outcomes is needed to clarify the impact of PES on perceived ejaculatory control and sexual satisfaction.</p><p><strong>Trial registration: </strong>The study protocol was prospectively registered in PROSPERO (ID: CRD42024551360).</p>","PeriodicalId":23010,"journal":{"name":"Therapeutic Advances in Urology","volume":"17 ","pages":"17562872251382317"},"PeriodicalIF":3.5000,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477390/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic Advances in Urology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/17562872251382317","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Premature ejaculation (PE) is a common sexual disorder characterized by a lack of voluntary control over ejaculation. Current treatments often fail to produce consistently satisfactory outcomes. Peripheral electrical stimulation (PES) is an emerging neuromodulation technique that applies electrical currents to targeted body areas and has shown promise across various conditions.
Objectives: Although the use of PES for PE is relatively underexplored, this study aimed to synthesize existing research to better understand its potential as a treatment option.
Design: Systematic review.
Data sources and methods: A systematic search was conducted in PubMed, Embase, Scopus, Web of Science, and Google Scholar using relevant keywords. Studies were included if they investigated PES as a treatment for PE and reported outcomes such as intravaginal ejaculatory latency time (IELT) or other clinical measures.
Results: Ten studies met the eligibility criteria. Due to the limited number and heterogeneity of studies, a meta-analysis was not feasible, and a narrative synthesis was performed. Stimulation was applied transcutaneously in various ways, including at acupuncture points, the dorsal penile nerve, and the posterior tibial nerve. Protocols varied considerably, though commonly reported parameters included a pulse frequency of 20 Hz and a pulse width of 200 µs, typically administered in 30-min sessions. Some studies lacked detailed descriptions of stimulation settings. Overall, the studies demonstrated a positive trend in favor of PES for prolonging IELT, and no consistent or significant adverse events were reported.
Conclusion: The findings suggest that PES may be a promising adjunctive therapy for men with PE by prolonging IELT. Further high-quality research using validated patient-reported outcomes is needed to clarify the impact of PES on perceived ejaculatory control and sexual satisfaction.
Trial registration: The study protocol was prospectively registered in PROSPERO (ID: CRD42024551360).
背景：早泄（PE）是一种常见的性功能障碍，其特征是缺乏对射精的自主控制。目前的治疗方法往往不能产生持续的令人满意的结果。外周电刺激（PES）是一种新兴的神经调节技术，它将电流应用于目标身体区域，并在各种情况下显示出前景。目的：尽管PES治疗PE的研究相对较少，但本研究旨在综合现有研究，以更好地了解其作为治疗选择的潜力。设计：系统回顾。数据来源和方法：系统检索PubMed、Embase、Scopus、Web of Science、谷歌Scholar等相关关键词。如果研究将PES作为PE的治疗方法，并报告了诸如阴道内射精潜伏期（雅思）或其他临床测量的结果，则纳入研究。结果：10项研究符合入选标准。由于研究的数量有限和异质性，meta分析是不可行的，并进行了叙述综合。刺激以各种方式经皮应用，包括穴位、阴茎背神经和胫后神经。方案差异很大，但通常报道的参数包括脉冲频率为20 Hz，脉冲宽度为200µs，通常为30分钟。一些研究缺乏对刺激环境的详细描述。总的来说，这些研究表明PES对延长雅思考试有积极的趋势，没有一致的或显著的不良事件报道。结论：研究结果表明，PES可能是一种有希望的辅助治疗，可以延长男性PE患者的雅思成绩。需要进一步的高质量研究，使用经过验证的患者报告的结果来阐明PES对射精控制和性满意度的影响。试验注册：研究方案在PROSPERO进行前瞻性注册（ID: CRD42024551360）。
期刊介绍：
Therapeutic Advances in Urology delivers the highest quality peer-reviewed articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of urology.
The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers in urology, providing a forum in print and online for publishing the highest quality articles in this area. The editors welcome articles of current interest across all areas of urology, including treatment of urological disorders, with a focus on emerging pharmacological therapies.
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