ACS Omega最新文献

{"title":"Estrogen Inhibits the Phenotypic Switching of Vascular Smooth Muscle Cells through ER-α/CREB in Aortic Dissection","authors":"Yuting Pu,&nbsp;Yang Zhou,&nbsp;Tuo Guo,&nbsp;Xiangping Chai* and Guifang Yang*,&nbsp;","doi":"10.1021/acsomega.4c1095510.1021/acsomega.4c10955","DOIUrl":"https://doi.org/10.1021/acsomega.4c10955https://doi.org/10.1021/acsomega.4c10955","url":null,"abstract":"<p ><b>Objective:</b> To examine the alterations in estrogen levels in patients with aortic dissection (AD) and its protective effect on AD patients through the inhibition of vascular smooth muscle cells (VSMCs) phenotypic switching via the ER-α/CREB pathway. <b>Methods:</b> Demographic data were collected to assess sex disparity in AD patients, and serum 17β-estradiol (E2) levels were measured using ELISA. Phenotypic switching markers were analyzed in aortic tissues from AD patients and controls. Bioinformatics analysis identified estrogen-related pathways, focusing on the ER-α/CREB axis, with expression levels confirmed via immunohistochemistry and Western blot. AD mouse models were developed in male and ovariectomized female mice, with the effects of E2 supplementation on AD progression and VSMCs phenotypic switching evaluated. An AD cellular model was also employed to verify these findings through targeted pathway inhibition. <b>Results:</b> AD prevalence was higher in males, with reduced serum E2 levels observed in both male and postmenopausal female patients. Ovariectomized female mice showed increased AD incidence, while E2 supplementation reduced AD progression by inhibiting the phenotypic switching of VSMCs. Downregulation of ER-α and p-CREB/CREB expression was observed in AD patients, and E2 enhanced ER-α expression and CREB phosphorylation, preventing VSMC phenotypic switching. E2 also promoted ER-α/CREB interaction, and silencing ER-α inhibited CREB phosphorylation, leading to increased VSMC phenotypic switching. <b>Conclusions:</b> Estrogen (E2) plays a crucial role in preventing AD by maintaining VSMCs synthetic phenotype through the ER-α/CREB signaling pathway, providing a protective effect against the development of AD.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"15256–15271 15256–15271"},"PeriodicalIF":3.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c10955","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural Characterization and Study of the Mixed-Ion Effect in K–Li Metaphosphate Glasses","authors":"Izabel Mateus Nogueira dos Santos,&nbsp;Flavio Augusto de Melo Marques,&nbsp;Adriana Marcela Nieto Munõz,&nbsp;Ana Candida Martins Rodrigues,&nbsp;José Fabian Schneider and Jefferson Esquina Tsuchida*,&nbsp;","doi":"10.1021/acsomega.5c0102710.1021/acsomega.5c01027","DOIUrl":"https://doi.org/10.1021/acsomega.5c01027https://doi.org/10.1021/acsomega.5c01027","url":null,"abstract":"<p >This study investigates potassium–lithium metaphosphate glasses using Differential Scanning Calorimetry, Complex Impedance Spectroscopy, Nuclear Magnetic Resonance, and Raman Spectroscopy to elucidate the structural mechanisms underlying the Mixed Ion Effect. Thermal analyses reveal a systematic decrease in the glass transition temperature with increasing potassium content, which is dictated not solely by ionic size mismatch but also by structural reorganization within the glass network. The redistribution of nonbridging oxygens and the reduction of phosphate cross-links contribute to this behavior. Impedance spectroscopy shows a pronounced nonlinear reduction in ionic conductivity, decreasing by over 6 orders of magnitude at room temperature for the intermediate composition. NMR analysis indicates a nearly linear evolution of ³¹<i>P</i> and ⁷<i>Li</i> chemical shifts and full width at half-maximum, confirming the absence of phase segregation. Raman spectroscopy reveals a consistent <i>PO</i>₂ symmetric mode shift, indicative of solid solution behavior and random cation mixing. These findings validate two key hypotheses of the Random Ion Distribution Model: the structural specificity of each cation site and their random distribution within the glass network, while also demonstrating that structural reorganization plays a critical role in modulating <i>T</i>_g.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"15646–15653 15646–15653"},"PeriodicalIF":3.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.5c01027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of 3D Extrusion-Printed Particle-Containing Hydrogels for Osteogenic Differentiation","authors":"Stephanie E. Doyle,&nbsp;Deirdre Winrow,&nbsp;Fiona Buckley,&nbsp;Elin Pernevik,&nbsp;Martin Johnson,&nbsp;Kerry Thompson,&nbsp;Linda Howard and Cynthia M. Coleman*,&nbsp;","doi":"10.1021/acsomega.4c1051510.1021/acsomega.4c10515","DOIUrl":"https://doi.org/10.1021/acsomega.4c10515https://doi.org/10.1021/acsomega.4c10515","url":null,"abstract":"<p >There is a continued increase in demand for novel bone grafting substitutes to reduce reliance on and address challenges associated with allograft and autograft bone grafts. Current synthetic bone grafting substitutes exhibit low mechanical strength and bioactivity, which has inspired the development of novel grafting materials. Accelerating the translation of new bone graft substitutes requires workflows for high-throughput fabrication and analysis of particle-containing models. This study utilized 3D sacrificial printing for the fabrication of reproducible, cellular scaffolds containing tricalcium phosphate (TCP), hydroxyapatite (HA), or natural coral particles. High-throughput analysis of the cellular scaffolds included quantifying cell metabolism, viability, and calcium consumption, as well as nondestructive analysis of collagen accumulation and destructive methods for assessing cell number and morphological changes. Both particle- and non-particle-containing inks sustained cell metabolism with low and decreasing cell death for 7 days post-printing. Collagen staining, scanning electron microscopy imaging, and calcium and collagen quantification suggested that, under osteogenic induction conditions, cells migrated to the surface of the scaffolds and formed a sheet of cells and a collagen-containing extracellular matrix, thereby indicating osteogenic differentiation. The workflow described herein enables the creation of <i>in vitro</i> models to study the osteogenic nature of new bone grafting substitute materials. High-throughput printing combined with non-destructive screening techniques resulted in reduced time, resources, and associated costs and could be applicable to a broader range of cell types.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"15036–15051 15036–15051"},"PeriodicalIF":3.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c10515","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Precursors on Trimetallic Ruthenium-Based Catalysts Supported on γ-Al2O3 Pellets for Low-Temperature Ammonia Decomposition","authors":"Christopher J. Koch,&nbsp;Jennifer Naglic,&nbsp;Logan Kearney,&nbsp;Daniel Clairmonte,&nbsp;Binod Rai,&nbsp;Jochen Lauterbach,&nbsp;Lucas M. Angelette and Tyler Guin*,&nbsp;","doi":"10.1021/acsomega.4c0996810.1021/acsomega.4c09968","DOIUrl":"https://doi.org/10.1021/acsomega.4c09968https://doi.org/10.1021/acsomega.4c09968","url":null,"abstract":"<p >Ammonia is a promising candidate as a liquid hydrogen energy storage medium, but it requires catalytic decomposition (ammonia cracking) to regenerate hydrogen. Recently developed trimetallic ruthenium–potassium-promoter (RuKM) ammonia decomposition catalysts have exceptionally low ammonia decomposition temperatures, able to perform the decomposition as low as 250 °C, which is significantly lower than other known catalysts that require temperatures above 500 °C. However, the effects of the RuKM precursor on the catalytic activity have not been investigated. We report the observed differences of 3% ruthenium/12% potassium/1% yttrium (RuKY) catalysts on γ-alumina synthesized from chloride-, nitrate-, and acetate-based precursors. Catalysts synthesized from chloride-based precursors demonstrated the lowest ammonia decomposition catalytic activity at lower reaction temperatures. In contrast, those synthesized from nitrate-based precursors demonstrated the highest yield, despite similar metal loading. This difference in reactivity is most apparent between 250 and 400 °C, as the conversion rates of the catalysts synthesized with chloride-free precursors are up to 50% greater than those synthesized with chloride precursors. The observed differences in catalytic activity were much less apparent above 450 °C. The observed activation energies of the catalysts were independent of the precursor utilized, despite the difference in catalytic activity, suggesting that the active site composition was the same for all catalysts. These results suggest a pathway to improved ammonia cracking catalysts by tailoring the precursor used in the synthesis.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"15243–15249 15243–15249"},"PeriodicalIF":3.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c09968","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between Different Activation Overvoltage Descriptions for Semiempirical Proton-Exchange Membrane Fuel Cell Models","authors":"Leonardo Fortuna Carneiro*,&nbsp;Nicolas Tadeu Domingues Fernandes,&nbsp;Esly Ferreira da Costa Junior and Tulio Matencio,&nbsp;","doi":"10.1021/acsomega.4c1160310.1021/acsomega.4c11603","DOIUrl":"https://doi.org/10.1021/acsomega.4c11603https://doi.org/10.1021/acsomega.4c11603","url":null,"abstract":"<p >Using parameter estimation along with semiempirical fuel cell models is a promising strategy to obtain simple yet accurate models for proton-exchange membrane fuel cells. This work compares a model using a common semiempirical description of the activation overvoltage with one based on an agglomerate model. The parameters are estimated by nonlinear regression and the resulting optimization problem is solved using a parallel implementation of the genetic algorithm. The results indicate that the model incorporating the agglomerate description offers parameters with more straightforward physical interpretations and achieves superior fits to the experimental polarization data, both for individual curve fitting and when multiple curves are fitted simultaneously. Moreover, an analysis of the overvoltages shows that it is more robust in modeling reactant depletion effects at high current densities, attesting to its ability to represent relevant phenomena reasonably. Thus, further usage of parameter estimation along with agglomerate models is recommended as a useful strategy to describe fuel cells with limited data availability.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"15381–15392 15381–15392"},"PeriodicalIF":3.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c11603","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Alkali and Permanganate Treatments on Terminalia catappa Leaf Fibers: Efficient Reinforcements to Be Used in Eco-Friendly Composites","authors":"S. Anne Kavitha,&nbsp;Krishna Priya Retnam*,&nbsp;Krishna Prakash Arunachalam*,&nbsp;Mohamed Abbas,&nbsp;Cecilia Bustos Ávila and Siva Avudaiappan*,&nbsp;","doi":"10.1021/acsomega.4c0271510.1021/acsomega.4c02715","DOIUrl":"https://doi.org/10.1021/acsomega.4c02715https://doi.org/10.1021/acsomega.4c02715","url":null,"abstract":"<p >Natural fiber-reinforced composites could be obtained by utilizing agricultural wastes, fallen leaves, or abandoned materials as reinforcements after their usage as a way to reduce environmental impacts such as to stop deforestation, i.e., cutting down of plants and trees for their fibers, and in waste management, which includes recyling of natural wastes and minimizing the use of nonbiodegradable synthetic composites by replacing it with their natural fiber counterparts. As an outcome, leaves from a <i>Terminalia catappa</i> (Tc) tree grown in the Kanyakumari district that falls off in large quantities throughout the winter are gathered and examined. The leaves are treated with NaOH and KMnO₄. In this investigation, all three powdered samples (raw, alkali treated, and permanganate treated Tc leaf fibers) are sent to chemical analysis, powder X-ray diffraction (p-XRD), Fourier transform infrared (FTIR) analysis, scanning electron microscopy (SEM), energy dispersive spectroscopy (EDAX), thermal analysis (TGA-DTA), and carbon hydrogen nitrogen sulfur (CHNS) analysis. The results of the research showed that the powdered Tc leaf samples had high levels of cellulose (≈ 50%), crystallinity index (≈ 50–65%), and crystallite size (≈ 3 nm). There are various vibrational bands associated with them. The rough surface of the raw and treated Tc powder samples and their particle size (≈ 50–100 μm), as revealed by the SEM images, might aid in good adherence with the matrix. According to EDAX and CHNS analyses, there is a high carbon content in all of the samples. The fibers have an activation energy (≈ 55–60 kJ/mol) and maximum temperature limit (≈ 500 °C) that are comparable to many other natural fibers. The density of Tc leaf fibers (≈ 0.2 g/cm³) is very low and so could be used in lightweight composite applications. The chemical treatments enhanced the qualities of Tc fibers to a certain extent. In various polymers, rubber, or concrete matrices where the inclusion of natural fiber reinforcement is desired, all three samples could function as potential reinforcements.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"14566–14580 14566–14580"},"PeriodicalIF":3.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c02715","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Four New Pyranones from the Sponge-Derived Fungus Aspergillus versicolor","authors":"Na Zhang,&nbsp;Jiali Wang,&nbsp;Jigang Jiang,&nbsp;Xianguo Rong,&nbsp;Liying Ma* and Desheng Liu*,&nbsp;","doi":"10.1021/acsomega.5c0134910.1021/acsomega.5c01349","DOIUrl":"https://doi.org/10.1021/acsomega.5c01349https://doi.org/10.1021/acsomega.5c01349","url":null,"abstract":"<p >Four novel pyranone derivatives were isolated from fungi associated with the marine sponge species <i>Aspergillus versicolor</i>. The planar structures of these compounds were elucidated through comprehensive spectroscopic techniques, including HRESIMS, UV, IR, and 1D and 2D NMR. The absolute configuration of compound <b>1</b> was determined via X-ray diffraction, while that of compound <b>3a</b> was determined using electronic circular dichroism (ECD) spectroscopy. Furthermore, all compounds were evaluated for their cytotoxic activity against human lung carcinoma cells (A549). At 30 μM, only compound <b>2</b> exhibited slight cytotoxic activity, with an inhibition rate of (46 ± 3.63)%, compared to doxorubicin (positive control, (86 ± 1.81)%). In DPPH free radical scavenging assays, compound <b>2</b> demonstrated a superior capacity than other derivatives, with a scavenging rate of (21.5 ± 3.03)% at 0.6 mg/mL, though still lower than vitamin C ((38.4 ± 2.96)%). Compounds <b>1</b>, <b>3a</b>, and <b>3b</b> exhibited diminished scavenging activities, with rates of (16.1 ± 1.32)%, (13.6 ± 1.60)%, and (15.2 ± 2.79)%, respectively.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"15725–15731 15725–15731"},"PeriodicalIF":3.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.5c01349","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of Gene Expression by Substrate Stiffness via Ubiquitination of Histone H2B by Ubiquitin-Conjugating Enzyme E2A/B","authors":"Mingwei Feng,&nbsp; and ,&nbsp;Fumihiko Nakamura*,&nbsp;","doi":"10.1021/acsomega.5c0245910.1021/acsomega.5c02459","DOIUrl":"https://doi.org/10.1021/acsomega.5c02459https://doi.org/10.1021/acsomega.5c02459","url":null,"abstract":"<p >Animal cells adapt to the stiffness of their environment through mechanotransduction, a process in which mechanical signals are converted into biochemical responses, influencing key cellular processes such as growth and differentiation. We identified ubiquitin-conjugating enzymes E2 A and B (UBE2A/B) as mechanosensitive proteins that translocate between the nucleus and cytoplasm depending on force and substrate stiffness. Here, we hypothesized that UBE2A/B nuclear translocation on stiff substrates triggers gene expression via UBE2A/B-mediated ubiquitination of histone H2B lysine 120 (H2BK120). Chromatin immunoprecipitation sequencing (ChIP-seq) revealed distinct DNA fragments bound to monoubiquitinated H2B in cells cultured on soft (0.2 kPa) versus stiff (64 kPa) substrates. We identified 2245 gene regions binding to ubiquitinated histones on stiff substrates and 294 on soft substrates and further integrated RNA-seq and UBE2A/B knockdown data to pinpoint 179 stiff-specific and 18 soft-specific genes. Among these, filamin C (FLNC), leucine zipper protein 1 (LUZP1), and glutamate-rich WD repeat-containing protein 1 (GRWD1) showed higher expression on stiff substrates, with GRWD1 known for its role in cancer progression through cell cycle and gene regulation. These findings highlight how substrate stiffness modulates gene expression via UBE2A/B-mediated H2B ubiquitination.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"15799–15809 15799–15809"},"PeriodicalIF":3.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.5c02459","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significant Luminescence Enhancement of Ga-Doped WS2 Monolayers Grown by CVD","authors":"Shuai Zhang,&nbsp;Andre N. Barbosa*,&nbsp;Munique Eva Paiva de Araujo Monteiro de Barros,&nbsp;Alexandre Mello,&nbsp;Kevin Lizárraga,&nbsp;Pedro Paulo de Mello Venezuela and Fernando Lázaro Freire Jr.,&nbsp;","doi":"10.1021/acsomega.5c0106610.1021/acsomega.5c01066","DOIUrl":"https://doi.org/10.1021/acsomega.5c01066https://doi.org/10.1021/acsomega.5c01066","url":null,"abstract":"<p >Monolayer tungsten disulfide (WS₂) is a direct-band-gap semiconductor that has excellent luminescence properties, which are of great interest for optoelectronic applications. In this study, we investigated the effect of gallium (Ga) on WS₂ monolayers grown by chemical vapor deposition. Our results indicate that Ga-doped WS₂ exhibits a 3.6-fold increase in photoluminescence intensity for doped samples compared to pristine WS₂. To confirm the existence of Ga in the WS₂ structures, resonance Raman spectroscopy and X-ray photoelectron spectroscopy (XPS) were utilized as characterization methods. A redshift of the XPS spectrum was observed as well as an increase in the disorder-related Raman modes, which were attributed to the influence of Ga. XPS analysis and ab initio electronic structure calculations reveal the presence of substitutional Ga atoms as well as Ga atoms adsorbed on WS₂ surfaces.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"15663–15672 15663–15672"},"PeriodicalIF":3.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.5c01066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlling Oligomer Chain Length via Ultrasonic Pretreatment in Lactic Acid Polycondensation for Enhanced Poly(lactic acid) ROP","authors":"Nikmatuz Zahra,&nbsp;Endarto Yudo Wardhono,&nbsp;Hikmatun Ni’mah,&nbsp;Graecia Lugito and Tri Widjaja*,&nbsp;","doi":"10.1021/acsomega.4c0771210.1021/acsomega.4c07712","DOIUrl":"https://doi.org/10.1021/acsomega.4c07712https://doi.org/10.1021/acsomega.4c07712","url":null,"abstract":"<p >Controlling oligomer chain length in lactic acid (LA) polycondensation is crucial for producing good properties of poly(lactic acid) (PLA). This study explores the use of ultrasonic pretreatment to reduce the water content of LA, aiming to optimize the polycondensation process and enhance the quality of PLA through ring-opening polymerization (ROP). The methodology involved varying ultrasonic treatment time and power during LA pretreatment, followed by polycondensation at the optimized temperature. The study results indicate that ultrasonic pretreatment effectively reduces the water content in LA, with optimal conditions found at 90 min and 75 W, yielding the lowest water content. The polycondensation process, conducted at a gradual temperature of 150 °C followed by 180 °C, resulted in the highest yield of 92.75% and a molecular weight of 25,126 g/mol for the oligomers. Ultrasonic pretreatment enhances water removal efficiency, reduces byproduct formation, and increases oligomer reactivity, resulting in higher-purity oligomers and improved chain length control. During the ROP stage, oligomers prepared through ultrasonic pretreatment produced PLA with a higher molecular weight and crystallinity.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"14657–14665 14657–14665"},"PeriodicalIF":3.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c07712","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}