Therapeutic Advances in Endocrinology and Metabolism最新文献

{"title":"Association of insulin resistance-related indicators with cardiovascular disease and cardiovascular disease mortality in individuals with MASLD: a population-based study.","authors":"Xiwen Yang, Wei Peng","doi":"10.1177/20420188261435033","DOIUrl":"10.1177/20420188261435033","url":null,"abstract":"<p><strong>Background: </strong>Limited studies have explored the relationship between surrogate markers of insulin resistance (IR) with both cardiovascular disease (CVD) risk and CVD mortality in individuals with metabolic dysfunction-associated fatty liver disease (MASLD). This study aimed to assess the associations of various IR surrogates with CVD risk and mortality and to identify effective predictors of cardiovascular outcomes in this population.</p><p><strong>Design: </strong>This study constituted a population-based cross-sectional investigation, utilizing data derived from six cycles of the National Health and Nutrition Examination Survey (NHANES) spanning from 2005 to 2016. The data were linked to the NHANES public-use linked mortality files up to December 31, 2019, to facilitate follow-up on CVD mortality. Following predefined exclusion criteria, participants diagnosed with MASLD were identified and incorporated into the study. The research assessed the associations between surrogate markers of IR and both the prevalence of CVD and CVD mortality.</p><p><strong>Methods: </strong>The primary outcome of this study was the incidence of CVD in individuals with MASLD, and the secondary outcome was CVD mortality. Weighted multivariate logistic regression was utilized to examine the relationship between surrogate markers of IR with total CVD and other subtypes. Weighted multivariate Cox regression and Kaplan-Meier analysis were used to examine the relationship between surrogate markers of IR and CVD mortality. Restricted cubic spline (RCS) was used to explore potential nonlinear relationships. Receiver operating characteristics (ROC) and calibration curves were plotted to evaluate the discriminability and accuracy of IR surrogate markers in predicting CVD risk. Furthermore, mediation analysis was conducted to determine whether surrogate markers of liver fibrosis play a mediating role in the association of surrogate markers of IR with the risk of total CVD and other subtypes.</p><p><strong>Results: </strong>This study suggests that in the fully adjusted model, estimated glucose disposal rate (eGDR) was significantly negatively correlated with total CVD, congestive heart failure (CHF), heart attack (HA), and CVD mortality. Metabolic score for IR and triglyceride-glucose-body mass index were significantly positively correlated with CVD mortality, total CVD, and CHF. eGDR was best correlated with total CVD (odds ratio (OR) = 0.40, 95% confidence interval (CI): 0.25, 0.63), CHF (OR = 0.15, 95% CI: 0.06, 0.38), and HA (OR = 0.40, 95% CI: 0.22, 0.71). Weighted multivariate Cox regression indicated that for each unit increase in eGDR, the risk of CVD mortality decreased by 27%. RCS analysis showed that all surrogate markers of IR were linearly related to CVD and CVD mortality (<i>P</i>-nonlinear relationship >0.05). In addition, the ROC curve showed that eGDR had a more robust diagnostic efficacy than other IR markers, and eGDR had a higher accuracy i","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"17 ","pages":"20420188261435033"},"PeriodicalIF":4.6,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147593903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The WATCH-DM integer-based risk score identifies risk of all-cause mortality in patients with type 2 diabetes: a retrospective cohort study.","authors":"Chin-Sung Kuo, Nai-Rong Kuo, Po-Hsun Huang, Chii-Min Hwu","doi":"10.1177/20420188261431021","DOIUrl":"10.1177/20420188261431021","url":null,"abstract":"<p><strong>Background: </strong>The WATCH-DM integer-based risk score (WATCH-DM(i)) was originally developed and validated to predict heart failure (HF) hospitalization risk in patients with type 2 diabetes mellitus (T2DM). However, its potential association with all-cause mortality in patients without HF remains unclear.</p><p><strong>Objectives: </strong>This study aimed to evaluate the prognostic utility of the WATCH-DM(i) score for all-cause mortality in a real-world outpatient cohort of T2DM patients without known HF.</p><p><strong>Design: </strong>This was a retrospective observational cohort study with national mortality registry linkage performed at a single center.</p><p><strong>Methods: </strong>We analyzed data from 449 adults with T2DM enrolled in a hospital-based cohort between 2016 and 2022. The WATCH-DM(i) score was calculated according to the original published integer-based model reported by Segar et al., using clinical and laboratory parameters. Patients were stratified into four risk groups based on their score. All-cause mortality data were obtained via national linkage. Cox regression models, Kaplan-Meier survival analysis, landmark analysis, and time-dependent receiver operating characteristic curves were used to assess mortality risk.</p><p><strong>Results: </strong>Over a median follow-up of 61 months, 39 patients (8.7%) died. Each 1-point increase in the WATCH-DM(i) score was associated with a 29% higher risk of all-cause mortality (HR: 1.287, 95% CI: 1.151-1.439, <i>p</i> < 0.001). Higher risk groups showed progressively greater mortality, especially after 24 months. The score demonstrated good discrimination for 5-year mortality (C-index: 0.751). Metformin use was independently associated with lower mortality risk (HR: 0.410, <i>p</i> = 0.019).</p><p><strong>Conclusion: </strong>The WATCH-DM(i) score is a robust prognostic marker of 5-year all-cause mortality in T2DM patients without HF and may serve as a practical tool for risk stratification in outpatient settings.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"17 ","pages":"20420188261431021"},"PeriodicalIF":4.6,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147514958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid function alterations after radiofrequency ablation in benign thyroid nodule management.","authors":"Yi-Han Chen, Pi-Ling Chiang, Cheng-Kang Wang, An-Ni Lin, Yen-Hsiang Chang, Chen-Kai Chou, Wei-Che Lin","doi":"10.1177/20420188261432727","DOIUrl":"10.1177/20420188261432727","url":null,"abstract":"<p><strong>Background: </strong>Radiofrequency ablation (RFA) has gained recognition as a highly effective treatment for benign thyroid nodules (BTNs). However, post-procedural thyroid function changes have been reported.</p><p><strong>Objectives: </strong>This study specifically focuses on the potential link between changes in thyroid function and the volume reduction ratio (VRR) of treated nodules. Additionally, it seeks to evaluate whether fluctuations in thyroid function at mid-term follow-up can serve as early indicators for the development of long-term hypothyroidism following RFA.</p><p><strong>Design: </strong>Retrospective cohort study.</p><p><strong>Methods: </strong>In this study, 50 euthyroid individuals (mean age = 47.1 years; 43 females, 7 males) with a total of 72 BTNs (median volume = 4.61 mL) undergoing RFA were evaluated. Comprehensive assessments, including clinical examinations, ultrasound imaging, and blood tests, were conducted at specific intervals (pre-RFA, and at 6 months, 12 months, and annually post-RFA).</p><p><strong>Results: </strong>The mean follow-up period was 22.3 months. Both medium-term and long-term follow-ups revealed significant reductions in triiodothyronine (T3) levels (<i>p</i> = 0.010, <i>p</i> = 0.036) and elevations in thyroid-stimulating hormone (TSH) levels (<i>p</i> < 0.001, <i>p</i> = 0.006) compared to baseline measurements. A negative correlation was found between medium-term T3 levels and long-term VRR (<i>r</i> = -0.475, <i>p</i> = 0.001). Furthermore, patients with lower T3 levels during medium-term follow-up demonstrated a significantly higher long-term VRR compared to those with higher T3 levels (0.89 vs 0.77, <i>p</i> = 0.030).</p><p><strong>Conclusion: </strong>Following RFA, notable alterations in thyroid function were observed, without meeting the criteria of hypothyroidism. Additionally, a lower mid-term T3 level may be indicative of a better VRR during long-term follow-up.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"17 ","pages":"20420188261432727"},"PeriodicalIF":4.6,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress-induced hyperglycemia ratio and gestational diabetes mellitus: a cross-sectional study based on NHANES database.","authors":"Yina Piao, Mengxia Jin","doi":"10.1177/20420188261431025","DOIUrl":"10.1177/20420188261431025","url":null,"abstract":"<p><strong>Background: </strong>Stress-induced hyperglycemia ratio (SHR) has shown strong correlations with diabetes risk. However, its relationship with gestational diabetes mellitus (GDM) remains an area of limited research.</p><p><strong>Objective: </strong>Based on the National Health and Nutrition Examination Survey (NHANES) database, this cross-sectional study aims to explore the association between SHR and GDM.</p><p><strong>Methods: </strong>The study included 461 pregnant women from NHANES between 1999 and 2016. Logistic regression analysis was performed to investigate the relation between SHR and GDM, as well as the weighted tertiles of SHR. Stratified and subgroup analyses assessed the association between SHR and GDM. Restricted cubic splines (RCS) delineated the nonlinear relationship between SHR and GDM. Moreover, a two-segment linear regression model was employed to test the threshold effect of SHR on GDM. Stratified analysis was conducted by stratifying by months of pregnancy.</p><p><strong>Results: </strong>Among the 461 eligible women included in the study, SHR was a critical risk factor for GDM. Higher SHR values were associated with an elevated likelihood of developing GDM after accounting for other variables (OR: 1.77, 95% CI: 1.37-2.28, <i>p</i> < 0.001). This relationship was maintained across different SHR levels when analyzed in tertiles (<i>p</i> < 0.05). Further subgroup analyses based on education level and alcohol consumption status showed a consistent positive correlation between SHR and GDM risk in each group. A nonlinear relationship between SHR and GDM risk was confirmed by RCS. Threshold effect analysis further revealed a significant positive association between SHR and GDM when SHR was ≤ 15.75, whereas no significant association was observed beyond this threshold. The results of stratified analysis showed a significant positive correlation between SHR and GDM from 1 to 5 months of pregnancy (OR = 2.16, 95% CI: 1.12-4.16, <i>p</i> = 0.026). However, no significant SHR-GDM association was observed from 6 to 10 months of pregnancy.</p><p><strong>Conclusion: </strong>SHR is significantly positively correlated with an increased risk of GDM in early pregnancy. These results highlight the potential utility of SHR as a clinical marker for early identification and intervention in GDM risk cases.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"17 ","pages":"20420188261431025"},"PeriodicalIF":4.6,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147514879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When an OS update becomes a hypoglycemia trigger: a \"software change safety case\" for CGM ecosystems.","authors":"Mulavagili Vijayasimha, Mulavagili Srikanth","doi":"10.1177/20420188261435029","DOIUrl":"10.1177/20420188261435029","url":null,"abstract":"","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"17 ","pages":"20420188261435029"},"PeriodicalIF":4.6,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in the prevalence of metabolic syndrome among Jordanian adults following COVID-19.","authors":"Islam Al-Shami, Buthaina Alkhatib, Lana Agraib, Asem Taher Shawabkeh","doi":"10.1177/20420188261431012","DOIUrl":"10.1177/20420188261431012","url":null,"abstract":"<p><strong>Background: </strong>Several negative outcomes have been documented post-COVID-19 pandemic, including many cardiometabolic abnormalities associated with metabolic syndrome (MetS).</p><p><strong>Objectives: </strong>The study aims to evaluate the prevalence of MetS among Jordanian adults post-COVID-19 and compare these results with previous findings.</p><p><strong>Design: </strong>A cross-sectional study.</p><p><strong>Methods: </strong>A total of 5188 adults of both sexes (age >18 years) were recruited. Body weight, height, waist circumference (WC), fasting plasma glucose, high-density lipoprotein cholesterol (HDL-C), triglycerides, and blood pressure were measured.</p><p><strong>Results: </strong>The crude prevalence of MetS, using both the International Diabetes Federation (IDF) and the Adult Treatment Panel III (ATP III) diagnostic criteria, was 42.9% (32.5% in males and 46.9% in females). There was no change in the crude prevalence of MetS among the total population between 2017 (48.2% and 44.1%) and 2024 (48.1% and 45.0%) by IDF and ATP III criteria, respectively (<i>p</i> > 0.05). In comparison, the age-standardized prevalences were 44.6% (95% CI 43.3%-45.9%) for ATP III and 47.7% (95% CI 46.4%-49.0%) for IDF. The main contributing factors for MetS, according to ATP III, were low HDL-C (65.4%) and enlarged WC (60.4%). However, according to IDF criteria, enlarged WC (76.9%) was followed by low HDL-C (65.4%).</p><p><strong>Conclusion: </strong>Although the crude prevalence of MetS stayed relatively stable before and after COVID-19, age-standardized data show a noticeable upward trend, pointing to an increasing cardiometabolic burden. These findings highlight the urgent need for wide-ranging, population-level strategies that emphasize lifestyle modifications, screening, and early intervention to address metabolic risks.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"17 ","pages":"20420188261431012"},"PeriodicalIF":4.6,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147514996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of DNA methylation predicted leptin to all-cause, cancer, and cardiovascular mortality among US adults aged 50 years and older: findings from NHANES 1999-2002.","authors":"Yuxin Fan, Li Ding, Junhe Wang, Qi Li, Hua Shu, Shaofang Tang, Baoping Wang, Gang Hu, Yun Shen, Ming Liu","doi":"10.1177/20420188261426713","DOIUrl":"10.1177/20420188261426713","url":null,"abstract":"<p><strong>Background: </strong>Epigenetic biomarkers may provide novel insights into long-term health risk. DNA methylation (DNAm) predicted leptin has been proposed as an epigenetic proxy related to metabolic regulation, but its association with mortality remains underexplored.</p><p><strong>Objectives: </strong>To examine the association between DNAm-predicted leptin levels and all-cause, cardiovascular, and cancer mortality among US adults using The National Health and Nutrition Examination Survey (NHANES) data.</p><p><strong>Design: </strong>Population-based cohort analysis with linkage to the National Death Index.</p><p><strong>Methods: </strong>We analyzed 2531 participants from NHANES 1999-2002 with available DNAm-predicted leptin derived from whole-blood methylation profiles. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality outcomes across quartiles of DNAm-predicted leptin, with sequential adjustment for potential confounders. Subgroup and sensitivity analyses were performed to evaluate robustness.</p><p><strong>Results: </strong>Over a mean follow-up of 17.1 years, 1360 deaths occurred. DNAm-predicted leptin showed a J-shaped association with all-cause mortality. In fully adjusted models, HRs for all-cause mortality were 1.28 (95% CI: 1.00-1.62) for Quartile 1, 1.00 (reference) for Quartile 2, 1.32 (95% CI: 1.01-1.73) for Quartile 3, and 1.35 (95% CI: 1.11-1.64) for Quartile 4. After full adjustment, DNAm-predicted leptin was not statistically significantly associated with cancer mortality, while cardiovascular mortality risk was higher in Quartile 4 compared with Quartile 2.</p><p><strong>Conclusion: </strong>DNAm-predicted leptin was associated with all-cause mortality in a J-shaped pattern, with elevated risk at both lower and higher levels. Associations with cancer mortality were not statistically significant after adjustment, and evidence for cardiovascular mortality was limited to the highest quartile. Larger studies are needed to validate these findings and clarify cause-specific associations.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"17 ","pages":"20420188261426713"},"PeriodicalIF":4.6,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity indices as predictors of metabolic syndrome: 1-year findings from a Peruvian cohort of private educational institution workers.","authors":"Vicente A Benites-Zapata, Daniel Fernandez-Guzman, Percy Herrera-Añazco, Enrique Moncada-Mapelli, Diego Urrunaga-Pastor, Carlos J Toro-Huamanchumo","doi":"10.1177/20420188261428781","DOIUrl":"10.1177/20420188261428781","url":null,"abstract":"<p><strong>Background: </strong>Metabolic syndrome (MetS) is a common condition marked by abdominal obesity, insulin resistance, hypertension, and hyperlipidemia. It has significant health and economic impacts, highlighting the need for early predictive markers.</p><p><strong>Objective: </strong>To compare the prognostic performance of various obesity indices in the 1-year incidence of MetS among adult employees of a private educational institution.</p><p><strong>Design: </strong>Cohort study.</p><p><strong>Methods: </strong>A prospective cohort study was conducted using data from adults employed at a private educational institution in Lima, Peru. Participants were enrolled in 2019 and followed for 1 year to monitor anthropometric and biochemical parameters. The outcome was the development of MetS at the end of follow-up, defined according to the criteria of the Latin American Diabetes Association. Receiver operating characteristic curves were plotted, and the area under the curve (AUC) with 95% confidence intervals (CI) was calculated to assess the predictive utility of each index for MetS after 1 year.</p><p><strong>Results: </strong>Of the 792 adults initially enrolled, 475 were included in the final analysis after exclusions and loss to follow-up. Their average age was 38.4 years, and 54.3% were women. The overall incidence of MetS was 7.4%, with 12% for males and 4% for females. The highest AUC values for predicting MetS were observed for the body mass index (AUC: 0.88; 95% CI: 0.84-0.92), waist-to-height ratio (WHtR; AUC: 0.89; 95% CI: 0.85-0.92), abdominal volume index (AVI; AUC: 0.89; 95% CI: 0.86-0.92), and body roundness index (BRI; AUC: 0.89; 95% CI: 0.85-0.92). In sex-stratified analyses, results were consistent for males. Among females, the body adiposity index also showed good discrimination (AUC: 0.91; 95% CI: 0.83-1.00). The wide 95% CI reflects the small number of incident MetS cases among women (<i>n</i> = 10) and should be interpreted with caution.</p><p><strong>Conclusion: </strong>In conclusion, the incidence of MetS after 1 year of follow-up was 7.4%, with a higher rate among males. The WHtR, BRI, and AVI were the most useful anthropometric indices for predicting MetS.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"17 ","pages":"20420188261428781"},"PeriodicalIF":4.6,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of risk factors and establishment of a prediction model for latent autoimmune diabetes in adults.","authors":"Haiyan Yan, Jiarong Lv, Lingling Miao, Lei Shi","doi":"10.1177/20420188261423784","DOIUrl":"10.1177/20420188261423784","url":null,"abstract":"<p><strong>Background: </strong>Latent autoimmune diabetes in adults (LADA) is a form of diabetes that shares clinical features with type 2 diabetes mellitus (T2DM), often leading to misdiagnosis and delayed treatment. Early detection is critical to prevent the progression of the disease.</p><p><strong>Objectives: </strong>This study aims to analyze the risk factors of LADA and develop a predictive model to enhance early diagnosis.</p><p><strong>Design: </strong>A retrospective study was conducted on T2DM patients treated at our hospital between June 2019 and June 2024. The study focused on identifying risk factors for LADA and developing a predictive model.</p><p><strong>Data sources and methods: </strong>Clinical data of 728 patients (651 non-LADA, 77 LADA) were analyzed. LASSO regression was used for variable selection, followed by logistic regression to identify risk factors. The model's performance was assessed using the receiver operating characteristic curve and the Hosmer-Lemeshow test.</p><p><strong>Results: </strong>Significant differences were found between the non-LADA and LADA groups in terms of thyroid disease history, diabetic ketoacidosis, fasting plasma glucose (FPG), 2-hour postprandial glucose (2hPG), and glycated hemoglobin (HbA1c) levels (<i>p</i> < 0.05). Logistic regression identified thyroid disease history, FPG, 2hPG, and HbA1c as key risk factors for LADA. The model achieved an area under the curve of 0.907, with a sensitivity of 76.6% and specificity of 91.9%, indicating strong discrimination and robust calibration (<i>p</i> = 0.275).</p><p><strong>Conclusion: </strong>The predictive model based on thyroid disease history, FPG, 2hPG, and HbA1c demonstrates excellent predictive ability in our cohort for early identification of LADA, suggesting its potential to aid in timely intervention and improved patient outcomes.<i>Trial registration:</i> Not applicable.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"17 ","pages":"20420188261423784"},"PeriodicalIF":4.6,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of serum MKRN3 and DLK1 levels in precocious puberty: association with an MKRN3 pathogenic variant.","authors":"Esin Karakilic-Ozturan, Volkan Karaman, Asuman Gedikbaşı, Şükran Poyrazoğlu, Feyza Darendeliler, Zehra Oya Uyguner, Firdevs Baş","doi":"10.1177/20420188261424161","DOIUrl":"https://doi.org/10.1177/20420188261424161","url":null,"abstract":"<p><strong>Background: </strong>Loss-of-function alterations in <i>Makorin Ring Finger Protein 3</i> (<i>MKRN3</i>) and <i>Delta-like Non-Canonical Notch Ligand 1</i> (<i>DLK1</i>) genes are associated with familial central precocious puberty (CPP) and can result in reduced serum levels of these proteins.</p><p><strong>Objectives: </strong>This study aimed to evaluate the potential of serum MKRN3 and DLK1 levels for predicting genetic variants associated with CPP.</p><p><strong>Design: </strong>Retrospective study.</p><p><strong>Methods: </strong>This retrospective cross-sectional study included 26 girls with CPP: 11 receiving treatment (Group 1) and 15 not yet treated (Group 2). The control group consisted of 26 healthy girls. Serum MKRN3 and DLK1 levels were measured by ELISA, and <i>MKRN3</i> and <i>DLK1</i> genes were analyzed by Sanger sequencing.</p><p><strong>Results: </strong>A known pathogenic <i>MKRN3</i> gene variant (c.482dupC/p.(Ala162Glyfs*15)) was found in one patient with a notably low MKRN3 level of 0.127 ng/mL, consistent with paternal inheritance. Median MKRN3 and DLK1 levels were 1.32 (0.7) and 0.62 (0.4) ng/mL in Group 1, and 1.2 (0.6) and 0.62 (0.2) ng/mL in Group 2 (excluding the patient with the variant). No significant differences were observed between Group 1 and Group 2 (<i>p</i> = 0.279; <i>p</i> = 0.338). Control group median serum levels were 1.177 (0.76) ng/mL for MKRN3 and 0.67 (0.44) ng/mL for DLK1, with no significant differences from the CPP cohort (<i>p</i> = 0.917; <i>p</i> = 0.756).</p><p><strong>Conclusion: </strong>MKRN3 and DLK1 levels do not significantly differ between treated, untreated CPP patients, and healthy controls. Identifying a known <i>MKRN3</i> variant with low serum levels suggests serum measurements can help predict variants. Familial studies are recommended as these variants may be inherited even in isolated cases.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"17 ","pages":"20420188261424161"},"PeriodicalIF":4.6,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12924910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147277238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}