Xiao Yu, Chengxia Kan, Kexin Zhang, Xiaofei Zhang, Jiayi Ren, Jinyan Chen, Yuqun Wang, Yang Zhang, Guangdong Zhang, Xiaodong Sun
{"title":"55岁及以上成人2型糖尿病的全球流行病学和负担：1990年至2021年的见解","authors":"Xiao Yu, Chengxia Kan, Kexin Zhang, Xiaofei Zhang, Jiayi Ren, Jinyan Chen, Yuqun Wang, Yang Zhang, Guangdong Zhang, Xiaodong Sun","doi":"10.1177/20420188251362011","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) poses a growing global health challenge, particularly among individuals aged 55 years and above, placing significant pressure on healthcare systems.</p><p><strong>Objectives: </strong>This study aims to assess long-term trends in T2DM burden and its risk factors in this demographic from 1990 to 2021.</p><p><strong>Design: </strong>We conducted a retrospective analysis of T2DM based on the latest 2021 Global Burden of Disease (GBD) database.</p><p><strong>Methods: </strong>Utilizing data from the 2021 GBD Study, we analyzed T2DM incidence, prevalence, and disability-adjusted life years (DALYs) among individuals aged ⩾55 years, stratified by sex and age group. An autoregressive integrated moving average model was applied to forecast trends for 2022-2036.</p><p><strong>Results: </strong>In 2021, there were 9,179,347 (95% uncertainty interval (UI), 7,905,452-10,626,325) T2DM cases among those aged 55 years and above. From 1990 to 2021, global incidence increased from 409.06 (95% UI, 349.86-477.48) to 617.73 (95% UI, 532.00-715.10) per 100,000 population; diabetes-related mortality rose from 81.55 (95% UI, 76.57-85.44) to 96.19 (95% UI, 88.62-102.11) per 100,000, and DALYs climbed from 2562.71 (95% UI, 2293.81-2926.77) to 3552.41 (95% UI, 3041.94-4200.97) per 100,000. The highest mortality increase was in low-middle sociodemographic index (SDI) regions, while high SDI regions saw declines. Eastern Europe reported the highest incidence rate among 21 regions, at 1218.43 per 100,000 (95% UI, 1083.02-1370.82). Environmental, occupational, and behavioral risks were major contributors to diabetes-related mortality in this age group. Projections estimate T2DM cases will rise from 9.3 million in 2022 to 12.3 million by 2036.</p><p><strong>Conclusion: </strong>The global burden of diabetes in adults aged ⩾55 years has risen substantially from 1990 to 2021. As the population continues to age, urgent action is needed to address this growing disease burden.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"16 ","pages":"20420188251362011"},"PeriodicalIF":4.6000,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336403/pdf/","citationCount":"0","resultStr":"{\"title\":\"Global epidemiology and burden of type 2 diabetes in adults aged 55 and older: insights from 1990 to 2021.\",\"authors\":\"Xiao Yu, Chengxia Kan, Kexin Zhang, Xiaofei Zhang, Jiayi Ren, Jinyan Chen, Yuqun Wang, Yang Zhang, Guangdong Zhang, Xiaodong Sun\",\"doi\":\"10.1177/20420188251362011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) poses a growing global health challenge, particularly among individuals aged 55 years and above, placing significant pressure on healthcare systems.</p><p><strong>Objectives: </strong>This study aims to assess long-term trends in T2DM burden and its risk factors in this demographic from 1990 to 2021.</p><p><strong>Design: </strong>We conducted a retrospective analysis of T2DM based on the latest 2021 Global Burden of Disease (GBD) database.</p><p><strong>Methods: </strong>Utilizing data from the 2021 GBD Study, we analyzed T2DM incidence, prevalence, and disability-adjusted life years (DALYs) among individuals aged ⩾55 years, stratified by sex and age group. An autoregressive integrated moving average model was applied to forecast trends for 2022-2036.</p><p><strong>Results: </strong>In 2021, there were 9,179,347 (95% uncertainty interval (UI), 7,905,452-10,626,325) T2DM cases among those aged 55 years and above. From 1990 to 2021, global incidence increased from 409.06 (95% UI, 349.86-477.48) to 617.73 (95% UI, 532.00-715.10) per 100,000 population; diabetes-related mortality rose from 81.55 (95% UI, 76.57-85.44) to 96.19 (95% UI, 88.62-102.11) per 100,000, and DALYs climbed from 2562.71 (95% UI, 2293.81-2926.77) to 3552.41 (95% UI, 3041.94-4200.97) per 100,000. The highest mortality increase was in low-middle sociodemographic index (SDI) regions, while high SDI regions saw declines. Eastern Europe reported the highest incidence rate among 21 regions, at 1218.43 per 100,000 (95% UI, 1083.02-1370.82). Environmental, occupational, and behavioral risks were major contributors to diabetes-related mortality in this age group. Projections estimate T2DM cases will rise from 9.3 million in 2022 to 12.3 million by 2036.</p><p><strong>Conclusion: </strong>The global burden of diabetes in adults aged ⩾55 years has risen substantially from 1990 to 2021. As the population continues to age, urgent action is needed to address this growing disease burden.</p>\",\"PeriodicalId\":22998,\"journal\":{\"name\":\"Therapeutic Advances in Endocrinology and Metabolism\",\"volume\":\"16 \",\"pages\":\"20420188251362011\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2025-08-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336403/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Therapeutic Advances in Endocrinology and Metabolism\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/20420188251362011\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic Advances in Endocrinology and Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/20420188251362011","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Global epidemiology and burden of type 2 diabetes in adults aged 55 and older: insights from 1990 to 2021.
Background: Type 2 diabetes mellitus (T2DM) poses a growing global health challenge, particularly among individuals aged 55 years and above, placing significant pressure on healthcare systems.
Objectives: This study aims to assess long-term trends in T2DM burden and its risk factors in this demographic from 1990 to 2021.
Design: We conducted a retrospective analysis of T2DM based on the latest 2021 Global Burden of Disease (GBD) database.
Methods: Utilizing data from the 2021 GBD Study, we analyzed T2DM incidence, prevalence, and disability-adjusted life years (DALYs) among individuals aged ⩾55 years, stratified by sex and age group. An autoregressive integrated moving average model was applied to forecast trends for 2022-2036.
Results: In 2021, there were 9,179,347 (95% uncertainty interval (UI), 7,905,452-10,626,325) T2DM cases among those aged 55 years and above. From 1990 to 2021, global incidence increased from 409.06 (95% UI, 349.86-477.48) to 617.73 (95% UI, 532.00-715.10) per 100,000 population; diabetes-related mortality rose from 81.55 (95% UI, 76.57-85.44) to 96.19 (95% UI, 88.62-102.11) per 100,000, and DALYs climbed from 2562.71 (95% UI, 2293.81-2926.77) to 3552.41 (95% UI, 3041.94-4200.97) per 100,000. The highest mortality increase was in low-middle sociodemographic index (SDI) regions, while high SDI regions saw declines. Eastern Europe reported the highest incidence rate among 21 regions, at 1218.43 per 100,000 (95% UI, 1083.02-1370.82). Environmental, occupational, and behavioral risks were major contributors to diabetes-related mortality in this age group. Projections estimate T2DM cases will rise from 9.3 million in 2022 to 12.3 million by 2036.
Conclusion: The global burden of diabetes in adults aged ⩾55 years has risen substantially from 1990 to 2021. As the population continues to age, urgent action is needed to address this growing disease burden.
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