The Scientific World Journal最新文献

{"title":"Effect of Charcoal on the Quality of Vermicompost Produced With Water Hyacinth and Cow Manure.","authors":"Solomon Girmay Berhe, Ali Seid, Berhanu Abraha Tsegay, Shinjiro Sato, Getahun Yemata Lule","doi":"10.1155/tswj/1086347","DOIUrl":"10.1155/tswj/1086347","url":null,"abstract":"<p><p>The significance of water hyacinth (<i>Pontederia crassipes</i> (C. Mart.) Solms (Pontederiaceae) vermicomposting lies in its ability to effectively manage its invasiveness while also improving soil fertility and supporting sustainable agricultural practices. This study evaluates the effects of charcoal addition on the composting followed by the vermicomposting of water hyacinth (WH) and cow manure, focusing on the growth, reproduction, and survival of <i>Eisenia fetida</i> earthworms and the quality of the resulting vermicompost. The treatments included WH and cow manure (2:1) with 7.5% charcoal (T1), 5% charcoal (T2), and without charcoal (T3). Composting (30 days) followed by vermicomposting (60 days) was conducted in a controlled greenhouse environment. Samples were collected biweekly to analyze temperature, moisture, pH, electrical conductivity, total nitrogen, total available phosphorous, and total potassium contents, vermicompost yield, and earthworm growth parameters throughout the process. Results showed that T1 and T2 significantly improved earthworm weight (8.23-16.0%), number of earthworms (65.0-69.0%), cocoon production (37.0-49.0%), and hatchling count (49.0-77.6%), compared to T3 (control). Also, T1 and T2 increased pH (4.30-5.75%), total nitrogen (53.6-62.5%), total available phosphorus (61.6-117%), and total potassium (47.5-71.3%) and reduced electrical conductivity (9.91%), total organic carbon (17.9-42.1%), carbon: nitrogen ratio (46.5-64.4%), and vermicompost mass (22.0-28.3%) at the end of the vermicomposting period, compared to T3. Moreover, T1 and T2 exhibited significantly higher lettuce seed germination (92.4-93.5%), germination index (76.2-80.4%), shoot elongation (46.0-92.5%), and root elongation (9.00-15.0%), compared to T3. However, in most of the results, there was no significant difference between T1 and T2. This finding suggests that the use of T2 (5.00%) charcoal addition enhances vermicompost quality to optimal maturity and stability.</p>","PeriodicalId":22985,"journal":{"name":"The Scientific World Journal","volume":"2025 ","pages":"1086347"},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal Parasitic Infection: Prevalence and Associated Risk Factors at Delgi Primary Hospital, Northwest Ethiopia.","authors":"Tarekegn Addis, Tilahun Yohannes","doi":"10.1155/tswj/8787678","DOIUrl":"10.1155/tswj/8787678","url":null,"abstract":"<p><p>Intestinal parasitic infections (IPIs) are among the leading causes of mortality and morbidity in developing nations such as Ethiopia. Determining epidemiological information of IPI is crucial for effective public health planning and intervention. The present study is aimed at assessing the prevalence and associated risk factors of human IPIs at Delgi Primary Hospital, Central Gondar Zone, Northwest Ethiopia. An institutional-based cross-sectional study was conducted from March to May 2023. A stool specimen was collected from 404 selected participants and examined microscopically for the presence of developmental stages of the intestinal parasites. A structured questionnaire was used to obtain information regarding the sociodemographic and associated risk factors. Data were analyzed using SPSS Version 23, and a crude odd ratio was calculated to verify and measure the possible association between IPIs and potential risk factors. A <i>p</i> value < 0.05 was taken as statistically significant. The overall prevalence of IPIs was 47.20%. Six species of intestinal parasites were identified: <i>Entamoeba histolytica/dispar</i> (16.8%) was the most predominant parasite, followed by <i>Giardia lamblia</i> (9.9%), <i>Ascaris lumbricoides</i> (8.1%), Hookworm species (7.6%), <i>Schistosoma mansoni</i> (4.2%), and <i>Hymenolepis nana</i> (0.5%). Furthermore, double and triple parasitic infections were observed in 10.39% and 0.49% of the study participants, respectively. Not having a habit of handwashing after toilet (AOR = 2.048, CI = 0.694, 3.583, <i>p</i> = 0.001), the habit of eating unwashed vegetables (<i>AOR</i> = 3.046, <i>CI</i> = 0.685, 5.596, <i>p</i> = 0.016), and presence of dirt matter under the nail (<i>AOR</i> = 2.939, <i>CI</i> = 0.621, 4.418, <i>p</i> = 0.001) were found to be significantly associated risk factors. This study showed that IPIs remained a public health concern in the study area. Therefore, regular provision of health education on personal hygiene and sanitation is recommended to prevent and control IPIs in the study area.</p>","PeriodicalId":22985,"journal":{"name":"The Scientific World Journal","volume":"2025 ","pages":"8787678"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroethanolic Extract of <i>Salvia officinalis</i> L. Leaves Improves Memory and Alleviates Neuroinflammation in ICR Mice.","authors":"Bernard Sefah, Yolanda Ashie, Newman Osafo, Priscilla Kolibea Mante","doi":"10.1155/tswj/2198542","DOIUrl":"10.1155/tswj/2198542","url":null,"abstract":"<p><p>Neurodegenerative disorders are known to be commonly associated with neuroinflammation. Plants with antioxidant and anti-inflammatory properties hold prospect in alleviating neuroinflammation. One such plant with documented anti-inflammatory and antioxidant potential is <i>Salvia officinalis</i> L. This study looked at effects of the hydroethanolic leaf extract of <i>S. officinalis</i> L. on lipopolysaccharide (LPS)-induced neuroinflammation and associated memory impairment using an ICR mouse model. Assessment of the phytochemical constituents in <i>S. officinalis</i> L. and its acute toxicity was conducted. Mice were treated with <i>S. officinalis</i> L. extract (30, 100, and 300 mg/kg) after LPS administration. Object recognition and elevated plus maze tests were employed to assess neuroinflammation-induced behavioral changes. Brain samples were taken to determine the levels of TNF-<i>α</i> and conduct histopathological analysis. The hydroethanolic extract of <i>S. officinalis</i> L. was found to contain alkaloids, glycoside, tannins, flavonoids, and coumarins and exhibited no observable acute toxicity. The extract showed the presence of eicosatrienoic acid, methyl ester, and phenanthrene derivatives. The extract improved memory and cognitive performance but had no significant effect on brain tissue TNF-<i>α</i> expression. <i>S. officinalis</i> L. treatment in mice with neuroinflammation also resulted in reduced mononuclear infiltration and gliosis and reduced apoptotic and necrotic neurons as well as no observable brain lesions. <i>S. officinalis</i> L. holds promising pharmacological activity at reducing neuroinflammation and its associated cognitive impairment.</p>","PeriodicalId":22985,"journal":{"name":"The Scientific World Journal","volume":"2025 ","pages":"2198542"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Compliance: The Role of Self-Efficacy in Foot Care and Self-Management Among Patients With Type 1 Diabetes.","authors":"Mohamad Amir Sadeghi, Afsaneh Raiesifar, Sanaz Aazami","doi":"10.1155/tswj/8848211","DOIUrl":"10.1155/tswj/8848211","url":null,"abstract":"<p><p><b>Background:</b> Effective self-management behaviors are crucial for diabetes management. This study examines the mediating role of self-efficacy in the relationship between compliance dimensions and self-management activities in patients with Type 1 diabetes. <b>Methods:</b> The current study explores a baseline analysis from a randomized controlled trial but the intervention's effectiveness is not reported here; the analysis focuses on elucidating potential mediating factors at baseline. The study investigated the relationships between seven compliance dimensions (treatment effort, intention, adaptability, integration, adherence, commitment, and indecisiveness) and six self-management activities (diet, exercise, smoking cessation, blood sugar monitoring, and foot care) through the potential mechanism of self-efficacy. <b>Results:</b> The analysis revealed an indirect association between three compliance dimensions (treatment effort, intention, and commitment) and foot care behavior, mediated by self-efficacy. Additionally, self-efficacy was identified as an indirect mechanism influencing the association between commitment and adaptability with dietary behaviors. <b>Conclusions:</b> This study highlights the importance of self-efficacy in promoting self-management behaviors in chronic conditions. By targeting specific compliance dimensions that influence self-efficacy, healthcare professionals can potentially improve patient self-management. <b>Trial Registration:</b> Iranian Registry of Clinical Trials number: IRCT20221029056335N1.</p>","PeriodicalId":22985,"journal":{"name":"The Scientific World Journal","volume":"2025 ","pages":"8848211"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Potential of Agro-Nanotechnology in African Agriculture: A Path to Sustainable Development-Systematic Review.","authors":"Yohannes Gelaye","doi":"10.1155/tswj/9073364","DOIUrl":"10.1155/tswj/9073364","url":null,"abstract":"<p><p>Agro-nanotechnology-the application of nanotechnology in agriculture-holds immense promise for addressing main challenges in African agriculture and promoting sustainable development. This review provides a comprehensive analysis of how agro-nanotechnology is being utilized across Africa, emphasizing its potential to revolutionize various aspects of agricultural practices on the continent. Firstly, the utilization of nanomaterials such as nanoparticles, nanofertilizers, and nanopesticides offers opportunities for enhancing nutrient management, improving soil health, and increasing crop productivity in diverse agroecosystems across Africa. Nanofertilizers, with their controlled release mechanisms, facilitate efficient nutrient uptake by plants, thereby reducing nutrient losses and enhancing fertilizer use efficiency, which is crucial for resource-constrained smallholder farmers. Nanopesticides suggest improved efficacy in pest and disease control, reducing environmental harm compared to traditional pesticides. Their targeted delivery also minimizes off-target effects, which is crucial for Africa's food security. Nanosensors also enable real-time monitoring of soil and crop health, enhancing precision agriculture. Nanotechnology in postharvest management reduces food losses and improves safety. However, its adoption requires careful consideration of socioeconomic and regulatory factors to ensure equitable access and environmental safety. Collaborative efforts involving policymakers, researchers, farmers, and other stakeholders are crucial for harnessing the benefits of agro-nanotechnology while addressing potential risks and concerns. In conclusion, the integration of agro-nanotechnology into African agriculture presents a transformative opportunity to enhance productivity, resilience, and sustainability, contributing to the continent's efforts toward achieving food security, economic development, and environmental conservation.</p>","PeriodicalId":22985,"journal":{"name":"The Scientific World Journal","volume":"2025 ","pages":"9073364"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solid Waste Generation Rate, Composition Analysis, and Proposed Management Plan: A Case Study of Main Market Centers of Bahir Dar City.","authors":"Amare Kassawe, Eshetu Getahun","doi":"10.1155/tswj/8504268","DOIUrl":"10.1155/tswj/8504268","url":null,"abstract":"<p><p>Effective municipal solid waste management is a critical aspect of urban development. This study investigated the waste generation rate, composition, and current solid waste management plan in Bahir Dar City, Ethiopia. A two-stage random sampling technique was implemented. Data collection involves onsite data collection, structured questionnaires, and semistructured interviews. The result indicated that retail trade emerges as the leading sector, generating nearly half of the total solid waste (49%), and the food service sector stands second. In terms of solid waste type, food waste constitutes a significant portion of the waste stream, with a daily generation of 10,817.51 kg. The paper and cardboard waste in the market centers were the second waste, accounting for 762.684 kg per day. The amount of plastic waste generated per day ranges from 157.946 to 493.253 kg, and because of its high volatile matter content (68.95%), it might be used to produce energy. Food waste and yard waste had a high moisture content of 63.25% and 40.14%, respectively, which makes them ideal for composting and biogas production. Among the seven study sites, Kebele 04 had a huge waste generation, which was 47% of the total waste generation, indicating a spatial disparity in waste production in the city. The results highlighted the immense potential for waste reuse and recycling, emphasizing the circular economic opportunities associated with sustainable waste management practices. The findings contribute valuable insights to urban planners and policymakers to implement sustainable solid waste management plans in the country.</p>","PeriodicalId":22985,"journal":{"name":"The Scientific World Journal","volume":"2025 ","pages":"8504268"},"PeriodicalIF":0.0,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shaping Ability of the ProTaper Gold and R-Motion Systems in Long-Oval Canals: A Microcomputed Tomography Study.","authors":"Marina da Cunha Isaltino, Wesley Viana de Sousa, Christianne Tavares Velozo Telles, Luiza de Almeida Souto Montenegro, Hugo Victor Dantas, Frederico Barbosa de Sousa, Diana Santana de Albuquerque","doi":"10.1155/tswj/5825229","DOIUrl":"https://doi.org/10.1155/tswj/5825229","url":null,"abstract":"<p><p><b>Objectives:</b>The aim of this study was to evaluate, by microcomputed tomography (micro-CT), the shaping ability and reduction of dentin thickness in mesial and distal surfaces of the ProTaper Gold (PTG; Dentsply Sirona, Ballaigues, Switzerland) and R-Motion (RM; FKG Dentaire, La Chaux-de-Fonds, Switzerland) systems in long-oval canals of lower incisors. <b>Materials and Methods:</b> Twenty long-oval lower incisors were selected, compared anatomically, and scanned by micro-CT (SkyScan 1172, Bruker Micro-CT, Kontich, Belgium). The teeth were divided into two groups (<i>n</i> = 10) according to instrumentation technique: PTG and RM. The following morphometric measurements were made on images recorded before and after preparation: volume, surface area, structure model index (SMI), unprepared walls, and dentin thickness parameters were calculated. The Shapiro-Wilk test and Student <i>t</i>-test were used for comparison of the data between the two groups at a significance level of 5%. <b>Results:</b> Significant differences were found in volume (127.60% vs. 69.22%) and reduction in dentin thickness on the distal surface of the root canal, with higher values for PTG compared to RM, respectively (<i>p</i> < 0.05). There was no significant difference in surface area (34.79% vs. 26.93%), SMI, and the percentage of unprepared areas (9.43% vs. 12.22%). <b>Conclusion:</b> Although GTP resulted in a greater reduction in dentin thickness on the distal surface and volume, there was no difference in the percentage of contact surface and unprepared areas between the two systems, confirming that neither technique was able to completely prepare the long-oval canals of the lower incisors. <b>Clinical Relevance:</b> Despite the technological advances in instruments launched on the market, exhibiting greater flexibility due to their metallurgical properties and short sequences, there is little scientific evidence regarding the new RM instrument, manufactured by FKG Dentaire, and its root canal modeling capacity.</p>","PeriodicalId":22985,"journal":{"name":"The Scientific World Journal","volume":"2025 ","pages":"5825229"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Patient Safety Culture Among Healthcare Professionals in Oman: A Cross-Sectional Study.","authors":"Zainab M Al-Zadjali, Heba Ibrahim Awadh, Moon Fai Chan, Sulaiman Dawood Al Sabei, Qamra S Al-Sariri, Ruhina Aimaq, Phiona Gimono, Yahya M Al-Farsi","doi":"10.1155/tswj/7398293","DOIUrl":"https://doi.org/10.1155/tswj/7398293","url":null,"abstract":"<p><p><b>Background:</b> Patient safety (PS) is a worldwide concern affecting countries at all health system stages. Three million people die each year worldwide due to medical errors and unsafe care. Medical malpractice cases have increased in the Sultanate of Oman, although the reasons for this increase are poorly understood, and there are not many studies on PS. <b>Aim:</b> This study is aimed at assessing PS culture among healthcare professionals in Oman's healthcare facilities. <b>Methods:</b> This cross-sectional study used a national PS culture database maintained by the Directorate General of Quality Assurance at the Ministry of Health. The data was collected using a validated hospital survey on PS culture tool with Cronbach's alpha of 0.87 in the English version which was distributed online to 1599 full-time healthcare professionals in Oman; the response rate was 99%. A stratified random sampling technique was used. The study examined the relationship between items using <i>t</i>-tests, chi-squared tests, regression, and odds ratio. <b>Results:</b> Out of the 1599 healthcare professionals who participated in the study, 16 were excluded and only 1583 healthcare professionals were included; the majority 842 (53.2%) were working in nonprimary healthcare (non-PHC). The global average proportion of reported adverse events' positive response rates (PRRs) was significantly higher in the PHC group compared to the non-PHC group (50.0% vs. 47.6%) (<i>p</i> < 0.04). Staffing (OR 1.55; 95% CI [1.24-1.93]), teamwork across units (OR 1.37; 95% CI [1.07-1.75]), and organizational learning (OR 1.26; 95% CI [1.02-1.57]) were significantly higher than other domains. The female group showed significantly higher PRR in \"staffing\" (OR 1.27; 95% CI [1.00-1.62]) (<i>p</i> < 0.05). Similarly, older age demonstrated higher PRR in \"nonpunitive response to errors\" (OR 1.28; 95% CI [1.05-1.57]) (<i>p</i> < 0.02), the nursing profession exhibited higher PRR in \"communication openness\" (OR 1.57; 95% CI [1.24-1.98]) (<i>p</i> < 0.001), and advanced work experience was significantly higher in \"management support\" (OR 1.30; 95% CI [1.07-1.60]) (<i>p</i> < 0.01). <b>Conclusion:</b> The study reports that primary healthcare professionals in Omani healthcare institutions have higher PRRs in critical PSC domains like teamwork, supervisor expectations, organizational learning, and staffing compared to non-PHC professionals. They also scored highest in communication openness and management support. The study suggests interventions focusing on staffing adequacy, teamwork, and communication strategies can enhance PS culture among healthcare professionals.</p>","PeriodicalId":22985,"journal":{"name":"The Scientific World Journal","volume":"2025 ","pages":"7398293"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Engineering for Cereal Crop Yield Improvement and Disease Resistant Breeding.","authors":"Asaye Demelash Limenie, Mastewal Alehegn","doi":"10.1155/tswj/6743917","DOIUrl":"https://doi.org/10.1155/tswj/6743917","url":null,"abstract":"<p><p>Genetic engineering has revolutionized the field of agriculture, providing innovative solutions to enhance crop productivity and resilience against diseases. Among the various crops, cereals hold a pivotal position in global food security, feeding a significant portion of the world population. Genetic engineering, in cereal crop breeding, has opened new avenues for yield improvement and the development of disease-resistant varieties. Growing population and climate change, traditional breeding methods alone are insufficient to meet the increasing demand for food while ensuring sustainability. Genetic engineering offers a precise and efficient approach to introduce desirable traits into cereal crops, thereby improving yield and reducing the impact of diseases. One of the primary objectives of genetic engineering in cereal crops is to enhance yield potential. This can be achieved by modifying genes associated with key traits such as photosynthetic efficiency, stress tolerance, and nutrient use efficiency. For instance, genetic engineering can be used to increase the efficiency of light capture and conversion into biomass, thereby boosting yield. Disease resistance is another critical area where genetic engineering can make a significant impact. Pathogens and pests pose a constant threat to cereal crops, leading to significant yield losses. Genetic engineering techniques allow the introduction of genes encoding resistance to diseases, such as those from wild relatives or from other organisms. Here, evidence shows that the incorporation of <i>Bacillus thuringiensis</i> (<i>Bt</i>) genes into maize has effectively controlled corn borer infestations, reducing the need for chemical pesticides. This not only reduces yield losses but also minimizes the development of pathogen resistance to single-gene interventions.</p>","PeriodicalId":22985,"journal":{"name":"The Scientific World Journal","volume":"2025 ","pages":"6743917"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of the Prospective Effects of Methadone on Peripheral Neuropathic Pain in Diabetic Patients.","authors":"Javad Poursamimi","doi":"10.1155/tswj/8483881","DOIUrl":"https://doi.org/10.1155/tswj/8483881","url":null,"abstract":"<p><p>Peripheral neuropathic pain (PNP) is a significant complication for diabetic patients, often linked to poor glycemic control and elevated levels of glycosylated hemoglobin (HbA1c). High serum levels of cytokines, such as interleukin (IL)-6, and an increase in T-lymphocytes are crucial factors in developing neuropathic complications. Research suggests that substances like opiates and methadone can provide pain relief for these patients. This literature review is aimed at exploring the advantages and disadvantages of prescribing methadone to individuals with diabetes. We conducted a search of several databases, including PubMed, Google Scholar, Medline, Embase, Web of Science, and Scopus. We used keywords such as \"diabetes,\" \"neuropathic pain,\" \"methadone,\" \"opioids,\" \"inflammation,\" and \"neuroimmunomodulation.\" Ultimately, we identified 19 articles suitable for a more detailed examination. Studies have revealed that the visual analog scale (VAS) index and serum glucose levels decreased in patients who had taken low-dose methadone. Additionally, the production of N-chlorotaurine, a crucial component for innate immunity, was increased in these individuals. Methadone, in a dose-dependent manner, is accountable for increasing serum levels of tumor necrosis factor alpha (TNF-<i>α</i>), interleukin-1 beta (IL-1<i>β</i>), and interleukin-2 (IL-2) and a high number of monocyte CD14⁺. In conclusion, there were several advantages to taking methadone in a dose-dependent manner, compared to opioids.</p>","PeriodicalId":22985,"journal":{"name":"The Scientific World Journal","volume":"2025 ","pages":"8483881"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}