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The neglect of melioidosis 忽视类鼻疽
The Lancet Pub Date : 2025-10-09 DOI: 10.1016/s0140-6736(25)02060-4
Sophie Cousins
{"title":"The neglect of melioidosis","authors":"Sophie Cousins","doi":"10.1016/s0140-6736(25)02060-4","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)02060-4","url":null,"abstract":"No Abstract","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rethinking induction of labour for LGA fetuses: the Big Baby trial LGA胎儿引产的再思考:大婴儿试验
The Lancet Pub Date : 2025-10-09 DOI: 10.1016/s0140-6736(25)01538-7
Guillaume Favre, Caroline Daelemans
{"title":"Rethinking induction of labour for LGA fetuses: the Big Baby trial","authors":"Guillaume Favre, Caroline Daelemans","doi":"10.1016/s0140-6736(25)01538-7","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01538-7","url":null,"abstract":"No Abstract","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"344 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of mpox in Angola conflates distinct timelines 对安哥拉麻疹的分析合并了不同的时间线
The Lancet Pub Date : 2025-10-09 DOI: 10.1016/s0140-6736(25)01202-4
Nicaise Ndembi, Kyeng Mercy, Morenike O Folayan, Salim S Abdool Karim
{"title":"Analysis of mpox in Angola conflates distinct timelines","authors":"Nicaise Ndembi, Kyeng Mercy, Morenike O Folayan, Salim S Abdool Karim","doi":"10.1016/s0140-6736(25)01202-4","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01202-4","url":null,"abstract":"No Abstract","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Offline: Food and health—the unacknowledged emergency 离线:食物和健康——未被承认的紧急情况
The Lancet Pub Date : 2025-10-09 DOI: 10.1016/s0140-6736(25)02052-5
Richard Horton
{"title":"Offline: Food and health—the unacknowledged emergency","authors":"Richard Horton","doi":"10.1016/s0140-6736(25)02052-5","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)02052-5","url":null,"abstract":"No Abstract","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The imperative for the global community to save the Paris Climate Agreement 国际社会必须挽救《巴黎气候协定》
The Lancet Pub Date : 2025-10-09 DOI: 10.1016/s0140-6736(25)01946-4
Shilu Tong, Hilary Bambrick, Jason Prior, Eric Lavigne, Kristie Ebi, Patrick L Kinney, Xiaoming Shi
{"title":"The imperative for the global community to save the Paris Climate Agreement","authors":"Shilu Tong, Hilary Bambrick, Jason Prior, Eric Lavigne, Kristie Ebi, Patrick L Kinney, Xiaoming Shi","doi":"10.1016/s0140-6736(25)01946-4","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01946-4","url":null,"abstract":"No Abstract","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sultiame once per day in obstructive sleep apnoea (FLOW): a multicentre, randomised, double-blind, placebo-controlled, dose-finding, phase 2 trial 阻塞性睡眠呼吸暂停(FLOW):一项多中心、随机、双盲、安慰剂对照、剂量测定的2期试验
The Lancet Pub Date : 2025-10-09 DOI: 10.1016/s0140-6736(25)01196-1
Winfried Randerath, Ludger Grote, Kaj Stenlöf, Ingo Fietze, Julia Chevts, Erik Buntinx, Javier Albares, Katrin Kuhn, Corinna Hansen, Andreas Völp, Jan Hedner
{"title":"Sultiame once per day in obstructive sleep apnoea (FLOW): a multicentre, randomised, double-blind, placebo-controlled, dose-finding, phase 2 trial","authors":"Winfried Randerath, Ludger Grote, Kaj Stenlöf, Ingo Fietze, Julia Chevts, Erik Buntinx, Javier Albares, Katrin Kuhn, Corinna Hansen, Andreas Völp, Jan Hedner","doi":"10.1016/s0140-6736(25)01196-1","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01196-1","url":null,"abstract":"<h3>Background</h3>Obstructive sleep apnoea (OSA) is highly prevalent but approved pharmacological treatment options are missing. Sultiame improves the ventilatory response and upper airway muscle activity by inhibiting carbonic anhydrase. This study aimed to prospectively assess the efficacy and safety of three dosages of sultiame in OSA.<h3>Methods</h3>This multicentre, randomised, parallel, double-blind, placebo-controlled, dose-finding, phase 2 trial was performed at 28 hospitals and community-based sites in five European countries. Adults (aged 18–75 years) with untreated, moderate to severe OSA and an Apnoea–Hypopnea Index (AHI) of ≥15 to ≤50 events per h were randomly assigned (1:1:1:1), using interactive response technology, to receive placebo or sultiame 100 mg, 200 mg, or 300 mg tablets of identical appearance once per day at bedtime for 15 weeks. Randomisation was stratified by baseline AHI3a. The primary outcome measure for efficacy was the relative change of AHI3a from baseline to week 15 (scheduled treatment end). All participants who were randomly assigned were included in the primary efficacy analysis using an estimands framework and in the safety analysis. This trial is registered with EudraCT (2021–002926–26) and <span><span>ClinicalTrials.gov</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> (<span><span>NCT05236842</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>) and is complete.<h3>Findings</h3>Between Dec 2, 2021, and April 8, 2023, 535 patients were screened and 298 were randomly assigned to placebo (n=75), or sultiame 100 mg (n=74), 200 mg (n=74), or 300 mg (n=75). 240 patients completed 15 weeks of treatment. 220 (74%) of 298 participants were male and 78 (26%) were female. In the full analysis set, placebo-subtracted relative AHI3a adjusted means change at week 15 was –16·4% (95% CI –31·3 to –1·4; p=0·032), –30·2% (–45·4 to –15·1; p<0·0001), and 34·6% (–49·1 to –20·0; p<0·0001) for sultiame 100 mg, 200 mg, and 300 mg, respectively. The incidence of adverse events increased dose-dependently: 46 (61%) of 75 patients in the placebo group, 54 (73%) of 74 in the 100 mg group, 62 (84%) of 74 in the 200 mg group, and 68 (91%) of 75 in the 300 mg group. Events reported in more than 10% of patients in the placebo, 100 mg, 200 mg, or 300 mg groups were paraesthesia (seven [9%] of 75, 16 [22%] of 74, 32 [43%] of 74, 43 [57%] of 75), headache (six [8%], five [7%], 12 [16%], 11 [15%]), COVID-19 (three [4%], three [4%], six [8%], ten [13%]), and nasopharyngitis (nine [12%], three [4%], seven [9%], seven [9%]).<h3>Interpretation</h3>Sultiame caused consistent, dose-dependent improvements of OSA, nocturnal hypo","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From vibe coding to vibe caring: what clinicians can learn 从氛围编码到氛围关怀:临床医生可以学到什么
The Lancet Pub Date : 2025-10-09 DOI: 10.1016/s0140-6736(25)01807-0
Gwćnolć Abgrall, Zaineb Chelly Dagdia, Xavier Monnet, Karine Zeitouni, Anmol Arora
{"title":"From vibe coding to vibe caring: what clinicians can learn","authors":"Gwćnolć Abgrall, Zaineb Chelly Dagdia, Xavier Monnet, Karine Zeitouni, Anmol Arora","doi":"10.1016/s0140-6736(25)01807-0","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01807-0","url":null,"abstract":"No Abstract","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rethinking induction of labour for LGA fetuses: the Big Baby trial – Authors' reply LGA胎儿引产的再思考:大婴儿试验——作者回复
The Lancet Pub Date : 2025-10-09 DOI: 10.1016/s0140-6736(25)01741-6
Jason Gardosi, Siobhan Quenby
{"title":"Rethinking induction of labour for LGA fetuses: the Big Baby trial – Authors' reply","authors":"Jason Gardosi, Siobhan Quenby","doi":"10.1016/s0140-6736(25)01741-6","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01741-6","url":null,"abstract":"No Abstract","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parkinson's disease: emerging opportunities through global collaboration 帕金森氏症:全球合作带来的新机遇
The Lancet Pub Date : 2025-10-09 DOI: 10.1016/s0140-6736(25)01910-5
Andrew Singleton, Cornelis Blauwendraat, Huw R Morris, Alastair J Noyce, Christine Klein, Ignacio Mata, Njideka Okubadejo, Maria Teresa Periñan, Lana M Chahine
{"title":"Parkinson's disease: emerging opportunities through global collaboration","authors":"Andrew Singleton, Cornelis Blauwendraat, Huw R Morris, Alastair J Noyce, Christine Klein, Ignacio Mata, Njideka Okubadejo, Maria Teresa Periñan, Lana M Chahine","doi":"10.1016/s0140-6736(25)01910-5","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01910-5","url":null,"abstract":"No Abstract","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disability, equity, and social justice through the eyes of a physician | Grace Spence Green, To Exist As I Am: A Doctor's Notes on Recovery and Radical Acceptance, Wellcome Collection/Profile Books (2025), p. 224, £16·99 格蕾丝·斯宾塞·格林,医生眼中的残疾、公平和社会正义,《像我一样存在:一个医生关于康复和彻底接受的笔记》,惠康收藏/简介书(2025),第224页,16.99英镑
The Lancet Pub Date : 2025-10-09 DOI: 10.1016/s0140-6736(25)02026-4
James Broadbent
{"title":"Disability, equity, and social justice through the eyes of a physician | Grace Spence Green, To Exist As I Am: A Doctor's Notes on Recovery and Radical Acceptance, Wellcome Collection/Profile Books (2025), p. 224, £16·99","authors":"James Broadbent","doi":"10.1016/s0140-6736(25)02026-4","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)02026-4","url":null,"abstract":"No Abstract","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"204 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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