The LancetPub Date : 2025-09-18DOI: 10.1016/s0140-6736(25)01805-7
Farhan M Asrar, Marco A Sieber, Carmen Possnig, Chiaki Mukai, Andrew R Morgan
{"title":"Physician astronauts advancing deep-space exploration","authors":"Farhan M Asrar, Marco A Sieber, Carmen Possnig, Chiaki Mukai, Andrew R Morgan","doi":"10.1016/s0140-6736(25)01805-7","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01805-7","url":null,"abstract":"No Abstract","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The LancetPub Date : 2025-09-18DOI: 10.1016/s0140-6736(25)01373-x
Bharat Khialani, Marco Frazzetto, George Touma, Bernardo Cortese
{"title":"Orbital atherectomy for stent implantation: the ECLIPSE trial","authors":"Bharat Khialani, Marco Frazzetto, George Touma, Bernardo Cortese","doi":"10.1016/s0140-6736(25)01373-x","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01373-x","url":null,"abstract":"No Abstract","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The LancetPub Date : 2025-09-18DOI: 10.1016/s0140-6736(25)01372-8
Uri Ladabaum, Robert E Schoen, Noel S Weiss
{"title":"Colonoscopy versus faecal immunochemical testing in COLONPREV","authors":"Uri Ladabaum, Robert E Schoen, Noel S Weiss","doi":"10.1016/s0140-6736(25)01372-8","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01372-8","url":null,"abstract":"No Abstract","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The LancetPub Date : 2025-09-18DOI: 10.1016/s0140-6736(25)01898-7
Richard Horton
{"title":"Offline: When even the best is not enough","authors":"Richard Horton","doi":"10.1016/s0140-6736(25)01898-7","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01898-7","url":null,"abstract":"No Abstract","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The LancetPub Date : 2025-09-18DOI: 10.1016/s0140-6736(25)01904-x
Saleyha Ahsan
{"title":"Doctors as witnesses of war","authors":"Saleyha Ahsan","doi":"10.1016/s0140-6736(25)01904-x","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01904-x","url":null,"abstract":"No Abstract","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The LancetPub Date : 2025-09-18DOI: 10.1016/s0140-6736(25)01206-1
Elizabeth Appleton, E Antonio Chiocca, Guy Ungerechts, Alan Melcher, Richard Vile
{"title":"Oncolytic viruses as anticancer agents: clinical progress and remaining challenges","authors":"Elizabeth Appleton, E Antonio Chiocca, Guy Ungerechts, Alan Melcher, Richard Vile","doi":"10.1016/s0140-6736(25)01206-1","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01206-1","url":null,"abstract":"Immunotherapy has transformed the treatment of cancer, yet many patients do not have response or lasting benefit. Strategies to overcome resistance remain of crucial importance. Oncolytic viruses offer a promising approach, with the unique ability to selectively replicate within (and to destroy) cancer cells, remodel the immunosuppressive tumour microenvironment, and stimulate antitumour immunity. Interest in the potential of oncolytic viruses has grown steadily over the past two decades, fuelled by advances in cancer immunology and viral engineering. However, clinical translation has not kept pace, and although a plethora of promising new constructs have entered clinical testing, several barriers continue to restrict widespread clinical implementation. This Therapeutics paper highlights key milestones in oncolytic virus clinical development, discusses the challenges that remain, and, through clinical reflection, considers how future research might be streamlined to achieve meaningful benefit for patients.","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"17 Suppl1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The LancetPub Date : 2025-09-18DOI: 10.1016/s0140-6736(25)01866-5
{"title":"Department of Error","authors":"","doi":"10.1016/s0140-6736(25)01866-5","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01866-5","url":null,"abstract":"<em>Nepogodiev D, Picciochi M, Ademuyiwa A, et al. Surgical health policy 2025–35: strengthening essential services for tomorrow's needs.</em> Lancet <em>2025; <strong>406:</strong> 860–80</em>—In figure 5 of this Health Policy, the x-axis labels for panel D should have read “Overall 30-day postoperative complication rate (%)” and the x-axis labels for panel E should have read “Number of 30-day postoperative complications”. These corrections have been made to the online version as of Sept 18, 2025.","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The LancetPub Date : 2025-09-18DOI: 10.1016/s0140-6736(25)01852-5
Éimhín Ansbro, Katy Cooper, Mahmoud Tharwat, Sylvia Kehlenbrink, Bhanu Pratap, Eiman Hag, Pablo Perel, Lars Brun Laarsen
{"title":"Non-communicable diseases in emergencies: time for action on converging crises","authors":"Éimhín Ansbro, Katy Cooper, Mahmoud Tharwat, Sylvia Kehlenbrink, Bhanu Pratap, Eiman Hag, Pablo Perel, Lars Brun Laarsen","doi":"10.1016/s0140-6736(25)01852-5","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01852-5","url":null,"abstract":"No Abstract","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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