The Lancet

Immediate versus staged complete revascularisation during index admission in patients with ST-segment elevation myocardial infarction and multivessel disease (OPTION–STEMI): a multicentre, non-inferiority, open-label, randomised trial

Pub Date : 2025-08-31 DOI: 10.1016/s0140-6736(25)01529-6 Min Chul Kim, Joon Ho Ahn, Dae Young Hyun, Yongwhan Lim, Kyung Hoon Cho, Seung Hun Lee, Seongho Park, Seok Oh, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Jang Hyun Cho, Sang-Rok Lee, Dong Oh Kang, Jin-Yong Hwang, Young Jin Youn, Jung-Hee Lee, Young-Hoon Jeong, Jong-Hwa Ahn, Youngkeun Ahn

Paclitaxel in the lower limbs: harm outweighs the benefit

Pub Date : 2025-08-31 DOI: 10.1016/s0140-6736(25)01684-8 Konstantinos Katsanos, Stavros Spiliopoulos

Paclitaxel-coated versus uncoated devices for infrainguinal endovascular revascularisation in chronic limb-threatening ischaemia (SWEDEPAD 1): a multicentre, participant-masked, registry-based, randomised controlled trial

Pub Date : 2025-08-31 DOI: 10.1016/s0140-6736(25)01585-5 Mårten Falkenberg, Stefan James, Manne Andersson, Mattias Andersson, Martin Delle, Jan Engström, Torbjörn Fransson, Peter Gillgren, Anna Hilbertson, Tal M Hörer, Eva Jacobsson, Björn Kragsterman, Johan Lindbäck, Hans Lindgren, Karin Ludwigs, Stefan Mellander, Olle Nelzén, Robert Olin, Birgitta Sigvant, Per Skoog, Joakim Nordanstig