The Lancet Oncology最新文献

{"title":"Interpretation of constitutional cancer predisposition gene variants in 14 765 individuals in the 100 000 Genomes Project cancer arm: a retrospective cohort analysis","authors":"James Whitworth, Valerie Yawen Wang, Daniella Black, Helen Ruth Davies, Andrea Degasperi, Diana Prepelita, Serena Nik-Zainal","doi":"10.1016/s1470-2045(25)00766-1","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00766-1","url":null,"abstract":"Cancer predisposition due to constitutional (germline) genetic variants in high-risk or moderate-risk cancer predisposition genes presents clinical opportunities for risk mitigation. Focusing genetic testing only on patients who are most likely to be positive for germline variants might enhance the clinical utility of positive results, but this approach could fail to assess the rate and pattern of such variants in patients with cancer overall. We aimed to assess the frequency and nature of constitutional variants in cancer predisposition genes in patients with cancer in the UK health-care system.","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The promise of telesurgery in oncology","authors":"The Lancet Oncology","doi":"10.1016/s1470-2045(26)00134-8","DOIUrl":"https://doi.org/10.1016/s1470-2045(26)00134-8","url":null,"abstract":"","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147587102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From reliability to implementable toxicity policy in PRO-informed CTCAE","authors":"Jiale Chen, Xiaoyuan Xu","doi":"10.1016/s1470-2045(26)00074-4","DOIUrl":"https://doi.org/10.1016/s1470-2045(26)00074-4","url":null,"abstract":"","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"121 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147587111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Principles of cytoreductive surgery for primary and metastatic peritoneal malignancies—the PSOGI–ESGO–ISSPP Lyon consensus","authors":"Aditi Bhatt MCh, Artem Stepanyan MD, Ahmed Al-Niaimi MD, Donal Brennan MB PhD, Joel Baumgartner MD, Naoual Bakrin PhD, Dennis Chi MD, Marcello Deraco PhD, Gwenael Ferron PhD, Christina Fotopoulou PhD, Vahan Kepenekian PhD, Shigeki Kusamura PhD, Vincent Lavoue PhD, Brendan Moran MD, François Planchamp MSc, Alvaro Arjona-Sanchez PhD, Jalid Sehouli MD, Vivek Sukumar MCh, Kiran Turaga MD, Laurent Villeneuve PhD, Kurt Van Der Speeten PhD, Willemien Van Driel PhD, Ane Gerda Zahl Eriksson MD, Ignacio Zapardiel PhD, Olivier Glehen PhD","doi":"10.1016/s1470-2045(26)00052-5","DOIUrl":"https://doi.org/10.1016/s1470-2045(26)00052-5","url":null,"abstract":"Complete macroscopic resection is the key objective of cytoreductive surgery for peritoneal malignancy. However, heterogeneity in terminology and operative technique persists across centres and between surgical and gynaecological disciplines. This study sought to establish international consensus on the nomenclature of cytoreductive surgery procedures, key technical principles of peritonectomy procedures and visceral resections, and management of regional lymph nodes in the context of peritoneal malignancy. A modified Delphi process was undertaken involving 148 surgical and gynaecological oncologists across six continents. Cytoreductive surgery was endorsed as the preferred term for potentially curative surgery for peritoneal malignancy. Agreement was reached on core principles guiding peritonectomy, including the extent of peritoneal resection around tumour deposits. For visceral resections, the panel favoured a conservative, tumour biology-informed strategy that considers disease distribution and patient-specific factors. The group recommended selective removal of clinically enlarged nodes only. This global consensus defines foundational principles for cytoreductive surgery in patients with peritoneal malignancy and provides standardised terminology and operative guidance that can be integrated into routine surgical practice across various surgical oncology disciplines. Adoption of these recommendations has the potential to reduce variability in cytoreductive surgery techniques, facilitate comparison between studies by increasing standardisation, and facilitate the design and conduct of high-quality surgical trials in peritoneal malignancy.","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147587112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ALND after neoadjuvant chemotherapy: a call for caution","authors":"Fady Sourial, Sushil Beriwal, Colin E Champ","doi":"10.1016/s1470-2045(26)00023-9","DOIUrl":"https://doi.org/10.1016/s1470-2045(26)00023-9","url":null,"abstract":"","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147587114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to Lancet Oncol 2026; 27: 413","authors":"","doi":"10.1016/s1470-2045(26)00136-1","DOIUrl":"https://doi.org/10.1016/s1470-2045(26)00136-1","url":null,"abstract":"","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"121 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147587100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New subcutaneous nodules and joint pain in a patient with pancreatic cancer","authors":"An-Ting Zhan MMed, Yong Wang MMed, Rui Gao MMed, Shi-Fang Wan MMed, Ting Lin MBBS, Prof Jian-Yong Fan MD","doi":"10.1016/s1470-2045(26)00082-3","DOIUrl":"https://doi.org/10.1016/s1470-2045(26)00082-3","url":null,"abstract":"","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147587109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ALND after neoadjuvant chemotherapy: a call for caution – Authors' reply","authors":"Giacomo Montagna, Monica Morrow, Walter P Weber","doi":"10.1016/s1470-2045(26)00121-x","DOIUrl":"https://doi.org/10.1016/s1470-2045(26)00121-x","url":null,"abstract":"","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147587104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[177Lu]Lu-PSMA-617 in combination with pembrolizumab for treatment of metastatic castration resistant prostate cancer (PRINCE): a single-arm, phase 1b/2 study","authors":"Prof Shahneen Sandhu MBBS, Prof Anthony M Joshua PhD, Prof Louise Emmett MD, Mathias Bressel MSc, Angelyn Anton MBBS, Lavinia Spain MBBS, Prof Lisa G Horvath PhD, Anupama Pasam MSc, Sofie H Tolmeijer PhD, Timothy J Akhurst MBBS, Ramin Alipour MD, Patricia Banks MBBS, James P Buteau MD, Erin Cassidy PGCert, Megan Crumbaker PhD, Nattakorn Dhiantravan MBBS, Wen Xu MBBS, Joanna Chan PhD, Nadia Hitchen MD, Mark Scalzo BAppSc, Aravind S Ravi Kumar MBBS, Grace Kong MBBS, Roslyn Wallace MBBS, Narelle Williams MPH, Prof Scott Williams MD, Prof Nicole M Haynes PhD, Prof Paul Neeson PhD, Alexander W Wyatt DPhil, Prof Rodney J Hicks MBBS, Prof Michael S Hofman MBBS","doi":"10.1016/s1470-2045(26)00017-3","DOIUrl":"https://doi.org/10.1016/s1470-2045(26)00017-3","url":null,"abstract":"Lutetium-177 [<ce:sup loc=\"post\">177</ce:sup>Lu]-prostate-specific membrane antigen (PSMA)-617 improves overall survival and progression-free survival in metastatic castration resistant prostate cancer (mCRPC), whereas immune checkpoint inhibitors (ICIs) have limited activity. Preclinical evidence suggests radioligand therapy might induce immunogenic cell death that can be enhanced with ICIs. This study evaluates the activity and adverse event profile associated with multiple doses of [<ce:sup loc=\"post\">177</ce:sup>Lu]Lu-PSMA-617 with pembrolizumab.","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147587115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond monotherapy: chemotherapy-free strategies in first-line advanced non-small-cell lung cancer","authors":"Teresa Gorría, Laura Mezquita","doi":"10.1016/s1470-2045(26)00110-5","DOIUrl":"https://doi.org/10.1016/s1470-2045(26)00110-5","url":null,"abstract":"","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147587107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}