The Lancet Oncology最新文献

{"title":"Impact of suboptimal cancer care in the Commonwealth: a scoping review and call to action","authors":"Stephane Thibodeau, Michael Yan, Bhawna Sirohi, Rifat Atun, Fabio Ynoe Moraes","doi":"10.1016/s1470-2045(25)00026-9","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00026-9","url":null,"abstract":"Cancer is a global health challenge, with considerable disparities in care and outcomes across regions. Up to half of health outcome disparities are driven by social determinants of health. Addressing these disparities has become a priority. The Commonwealth of Nations—an international association of 56 countries tied together by common language and historical heritage—has a focus on universal health coverage, yet cancer incidence rates are rising, especially in the low-income and middle-income country (LMIC) member nations, where cancers caused by communicable diseases, such as cervical cancer, are prevalent. Although high-income Commonwealth countries have better health coverage, LMICs are hindered by fewer resources, leading to preventable cases. In this scoping review, we characterise the cancer care inequities within the Commonwealth, and propose a framework to inform research and policy to improve outcomes across health systems.","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"US Clean Air in the firing line","authors":"","doi":"10.1016/s1470-2045(25)00294-3","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00294-3","url":null,"abstract":"No Abstract","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the complexity: reflections on the development of perioperative cancer treatments","authors":"Matea Zosso-Pavic, Francesco Pignatti, Anita Wolfer, Qiyu Li, Pierre Demolis, Ulrich-Peter Rohr, Olli Tenhunen","doi":"10.1016/s1470-2045(25)00217-7","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00217-7","url":null,"abstract":"No Abstract","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"European cancer workforce: under pressure","authors":"Wendy H Oldenmenger, Alexandra Eni, Norbert Couespel, Wim Ceelen, Beate Rau, Mirjam Crul","doi":"10.1016/s1470-2045(25)00196-2","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00196-2","url":null,"abstract":"No Abstract","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contributions of cancer treatment and genetic predisposition to risk of subsequent neoplasms in long-term survivors of childhood cancer: a report from the St Jude Lifetime Cohort and the Childhood Cancer Survivor Study","authors":"Achal Neupane, Qi Liu, Siddhant Taneja, Jennifer French, Matthew J Ehrhardt, Tara M Brinkman, Rachel Webster, Jun J Yang, Cindy Im, Lucie M Turcotte, Joseph P Neglia, M Monica Gramatges, Rebecca M Howell, Smita Bhatia, Kirsten K Ness, Melissa M Hudson, Gregory T Armstrong, Leslie L Robison, Yutaka Yasui, Yadav Sapkota","doi":"10.1016/s1470-2045(25)00157-3","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00157-3","url":null,"abstract":"<h3>Background</h3>Survivors of childhood cancer are at risk of subsequent neoplasms (SNs) associated with exposure to radiotherapy and chemotherapy, as well as with genetic predisposition. We aimed to estimate the relative contributions of these risk factors to the total SN burden in survivor populations.<h3>Methods</h3>We analysed data from two retrospectively constructed cohorts with ongoing recruitment and prospective follow-up: the St Jude Lifetime Cohort (SJLIFE; 4401 participants; NCT00760656) and the Childhood Cancer Survivor Study (CCSS; 7943 participants; NCT01120353). We used multivariable piecewise-exponential models to calculate attributable fractions to assess the contributions of radiotherapy and chemotherapy exposures, genetic predisposition (comparing the top two tertiles with the lowest tertile of polygenic risk scores [PRSs] where the tertile is from external general population corresponding to SN outcome) and lifestyle factors (physical activity, smoking, alcohol consumption, obesity, and diet) to incident of the first occurrences of SNs as the primary outcome.<h3>Findings</h3>The study was conducted between Jan 1, 2024, and Sept 30, 2024. Of the 12 344 survivors eligible for analysis, median attained age was 33·0 years (IQR 24·1–42·1) in SJLIFE and 36·0 years (29·5–43·6) in CCSS; 6127 (49·6%) were men and 6217 (50·4%) were women. Most patients were White (10 907 [88·4%]). The median follow-up from primary cancer diagnosis was 24·2 years (IQR 11·7–35·4) in SJLIFE (from Sept 13, 2007 to April 20, 2020) and 28·0 years (8·9–37·2) in CCSS (from Jan 1, 1975 to Dec 31, 2023). Cancer treatments and genetic risk jointly contributed to a substantial proportion of incident SN cases with attributable fractions ranging from 30% (95% CI 6–49; sarcoma) to 92% (89–94; meningioma). Higher exposure levels of radiotherapy contributed most, particularly in older (≥35 years; SJLIFE proportion of SNs 44·7% [95% CI 41·9–47·5]) compared with younger (&lt;35 years; 40·0% [37·1–43·3]) follow-up age periods. Elevated genetic risk based on the PRSs accounted for a notable proportion, ranging from 1% (95% CI 0–7; meningioma) to 52% (39–62; thyroid cancer), surpassing contributions of chemotherapies, ranging from 3% (1–6; SMNs) to 35% (19–49; sarcoma). Lifestyle factors contributed negligibly.<h3>Interpretation</h3>Cancer treatments and genetic predisposition are primary contributors to the risk of SNs in childhood cancer survivors, and lifestyle factors seem to have a minimal effect. These results highlight the crucial need to consider both treatment history and genetic factors in developing effective risk assessment and surveillance strategies for this vulnerable population.<h3>Funding</h3>US National Institutes of Health and the American Lebanese Syrian Associated Charities.","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition in head and neck cancer care: a roadmap and call for research","authors":"Xin Chen, Brooke Beilman, Heather D Gibbs, Jessica L Hamilton, Nathan Parker, Andrés M Bur, Jimmy J Caudell, Gregory N Gan, Jill M Hamilton-Reeves, Heather S L Jim, Kedar Kirtane, Chris Lominska, Sylvia L Crowder, Anna E Arthur","doi":"10.1016/s1470-2045(25)00087-7","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00087-7","url":null,"abstract":"Survivors of head and neck cancer have complex nutritional and supportive care needs. These needs result from the tumour's proximity to organs essential for normal eating function and the intensive treatment targeting those organs. Despite the crucial role of nutrition and supportive care in head and neck cancer, research and funding are lacking compared with other cancer types. This Review was compiled and written by a team of multidisciplinary medical professionals. Topics include poor access to medical nutrition therapy (MNT), MNT reimbursement policies, long-term survivorship care needs, percutaneous endoscopic gastrostomy tube placement, nutrition literacy, psychological services, speech–language pathology care, and concomitant physical activity. The goal of this work is to define current issues in research and practice, advocate for the expansion of head and neck cancer funding opportunities, and raise awareness of head and neck cancer supportive care needs and challenges. This work provides a roadmap for health-care professionals, researchers, policy makers, and funding agencies to prioritise nutrition in head and neck cancer care, with the overarching goal of improving treatment outcomes and quality of life.","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to Lancet Oncol 2025; 26: 559–70","authors":"","doi":"10.1016/s1470-2045(25)00273-6","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00273-6","url":null,"abstract":"<em>Lou E, Choudhry MS, Starr TK, et al. Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial.</em> Lancet Oncol <em>2025; <strong>26:</strong> 559–70</em>—In this Article, several appendix citations referred to the incorrect page and have been updated, and a corrected appendix file has been uploaded. Additionally, minor typographical errors have been amended. These changes have been made to the online version of the Article, as of May 28, 2025.","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary granulocytic sarcoma of the breast","authors":"Yali Le, Xiaoyan Leng","doi":"10.1016/s1470-2045(25)00269-4","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00269-4","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Contributors</h2>XL was responsible for data collection and figure preparation. YL undertook the literature search, conducted data analysis, interpreted the data, and drafted the manuscript.</section></section><section><section><h2>Declaration of interests</h2>We declare no competing interests.</section></section>","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causes of subsequent neoplasms after childhood cancer","authors":"Claudia E Kuehni, Nicolas Waespe, Ben D Spycher","doi":"10.1016/s1470-2045(25)00227-x","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00227-x","url":null,"abstract":"No Abstract","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ICGC-ARGO precision medicine: an update on immunotherapy response in metastatic head and neck squamous cell carcinoma","authors":"Riccardo Nocini, Claudio Luchini, Andrea Mafficini, Luca Tondulli, Consuelo D'Ambrosio, Andrew V Biankin, Raffaella Casolino, Aldo Scarpa, Michele Milella, Rita T Lawlor","doi":"10.1016/s1470-2045(25)00064-6","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00064-6","url":null,"abstract":"No Abstract","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}