{"title":"Cancer drug discovery at warp speed: can AI deliver?","authors":"","doi":"10.1016/s1470-2045(25)00431-0","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00431-0","url":null,"abstract":"No Abstract","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"42 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Norbert Galldiks, Philipp Lohmann, Mariam Aboian, Ramon F Barajas, William G Breen, Jana Ivanidze, Derek R Johnson, Timothy J Kaufmann, Michelle M Kim, Maximilian J Mair, Giuseppe Minniti, Michael Müther, Ali Nabavizadeh, Joshua D Palmer, Roberta Rudà, Marion Smits, Nelleke Tolboom, Sophie E M Veldhuijzen van Zanten, Michael C Veronesi, Jan-Michael Werner, Nathalie L Albert
{"title":"Update to the RANO working group and EANO recommendations for the clinical use of PET imaging in gliomas","authors":"Norbert Galldiks, Philipp Lohmann, Mariam Aboian, Ramon F Barajas, William G Breen, Jana Ivanidze, Derek R Johnson, Timothy J Kaufmann, Michelle M Kim, Maximilian J Mair, Giuseppe Minniti, Michael Müther, Ali Nabavizadeh, Joshua D Palmer, Roberta Rudà, Marion Smits, Nelleke Tolboom, Sophie E M Veldhuijzen van Zanten, Michael C Veronesi, Jan-Michael Werner, Nathalie L Albert","doi":"10.1016/s1470-2045(25)00193-7","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00193-7","url":null,"abstract":"This Policy Review provides recommendations for the use of PET imaging in patients with gliomas and represents a joint effort of the Response Assessment in Neuro-Oncology (RANO) working group for PET and the European Association for Neuro-Oncology. The initial guideline was published in 2016, and summarised the previously established clinical benefit of PET with radiolabelled glucose and amino acid tracers in patients with gliomas. Since then, numerous additional studies have been published on this topic, focusing on differential diagnosis, prediction of molecular information, and prognostication. Further studies evaluated PET for biopsy guidance and delineation of glioma extent for local therapy planning, including resection and radiotherapy. In patients undergoing treatment, PET was studied for the assessment of response to local and systemic treatments and PET-based standardised response criteria (PET RANO 1.0) were proposed. In this Policy Review, the updated recommendations are based on evidence generated from studies that validated PET findings by histomolecular findings or clinical course. This guideline further underscores the previously reported clinical value of PET imaging and the superiority of amino acid PET over glucose PET, providing a framework for the use of PET in the management of patients with gliomas. The guideline also underscores the scarcity of class 1 evidence showing that incorporating PET imaging into clinical workflows improves patient outcomes, highlighting priority areas for future clinical studies designed to address this gap.","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patricia Mae G Santos, Manisha Dubey, Haley Simpson, Arthur S Hong, Aman Narayan, Sonia Persaud, Katherine Feldman, Emily Anderson, Jennifer Santos, Melina Smith, Monica F Bryant, Joanna F Doran, Mylin A Torres, Lilia Cervantes, K Robin Yabroff, Fumiko Chino
{"title":"Access to cancer care for undocumented immigrants in the USA","authors":"Patricia Mae G Santos, Manisha Dubey, Haley Simpson, Arthur S Hong, Aman Narayan, Sonia Persaud, Katherine Feldman, Emily Anderson, Jennifer Santos, Melina Smith, Monica F Bryant, Joanna F Doran, Mylin A Torres, Lilia Cervantes, K Robin Yabroff, Fumiko Chino","doi":"10.1016/s1470-2045(25)00207-4","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00207-4","url":null,"abstract":"Undocumented immigrants face substantial barriers to affordable health-care coverage in the USA. For people with cancer, federal restrictions on publicly funded health insurance pose serious downstream consequences, including delayed diagnosis, scarce treatment options, and worse health outcomes. In this Policy Review, we examine mechanisms through which undocumented immigrants access cancer care in the USA, focusing on Emergency Medicaid, Medicaid-equivalent plans, and Marketplace-based strategies. We evaluate the strengths and limitations of these approaches, highlighting how each can shape access to cancer prevention, diagnosis, treatment, and follow-up care. We offer insights in regard to the 2025 US presidential administration for states that seek to protect or expand access to cancer care for undocumented immigrants in a challenging sociopolitical climate. The goal of this Policy Review is to guide the creation of innovative policy solutions to mitigate geographical disparities in the hope of improving cancer outcomes for this underserved population.","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Epithelioid sarcoma presenting as a progressively enlarging wound","authors":"Yu-Ting Tsai, Jui Lan, Yi-Chien Yang","doi":"10.1016/s1470-2045(25)00378-x","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00378-x","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Contributors</h2>All authors contributed substantially to the collection of data and drafting of this manuscript, and approved the final version. Written informed consent to publication was obtained.</section></section><section><section><h2>Declaration of interests</h2>We declare no competing interests.</section></section>","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}