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Encephalitis: a growing global threat 脑炎：日益严重的全球威胁
The Lancet Neurology Pub Date : 2025-02-19 DOI: 10.1016/s1474-4422(25)00037-7
Ava Easton
{"title":"Encephalitis: a growing global threat","authors":"Ava Easton","doi":"10.1016/s1474-4422(25)00037-7","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00037-7","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An ethical framework to assess covert consciousness 评估隐性意识的伦理框架
The Lancet Neurology Pub Date : 2025-02-19 DOI: 10.1016/s1474-4422(24)00432-0
Michael J Young, Christof Koch, Jan Claassen, David Fischer, Charlène Aubinet, Olivia Gosseries, Daniel Kondziella, Mario Rosanova, Simone Sarasso, Silvia Casarotto, Marcello Massimini, Brian L Edlow
{"title":"An ethical framework to assess covert consciousness","authors":"Michael J Young, Christof Koch, Jan Claassen, David Fischer, Charlène Aubinet, Olivia Gosseries, Daniel Kondziella, Mario Rosanova, Simone Sarasso, Silvia Casarotto, Marcello Massimini, Brian L Edlow","doi":"10.1016/s1474-4422(24)00432-0","DOIUrl":"https://doi.org/10.1016/s1474-4422(24)00432-0","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Call for the creation of a European Parliament Intergroup on brain health 呼吁建立欧洲议会脑健康小组
The Lancet Neurology Pub Date : 2025-02-19 DOI: 10.1016/s1474-4422(25)00027-4
Claudio L A Bassetti, Stephanie Kramer, Frédéric Destrebecq, Suzanne L Dickson
{"title":"Call for the creation of a European Parliament Intergroup on brain health","authors":"Claudio L A Bassetti, Stephanie Kramer, Frédéric Destrebecq, Suzanne L Dickson","doi":"10.1016/s1474-4422(25)00027-4","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00027-4","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ATTeST trial in ataxia telangiectasia: some concerns 共济失调性毛细血管扩张的临床试验：一些问题
The Lancet Neurology Pub Date : 2025-02-19 DOI: 10.1016/s1474-4422(25)00025-0
Michèl A A P Willemsen, Nienke J H van Os, Nel Roeleveld, Corry M R Weemaes
{"title":"The ATTeST trial in ataxia telangiectasia: some concerns","authors":"Michèl A A P Willemsen, Nienke J H van Os, Nel Roeleveld, Corry M R Weemaes","doi":"10.1016/s1474-4422(25)00025-0","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00025-0","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A pivotal recognition of the burden of encephalitis 对脑炎负担的关键认识
The Lancet Neurology Pub Date : 2025-02-19 DOI: 10.1016/s1474-4422(25)00040-7
{"title":"A pivotal recognition of the burden of encephalitis","authors":"","doi":"10.1016/s1474-4422(25)00040-7","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00040-7","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amyloid-related iatrogenic atrophy of the brain: data transparency is an urgent safety priority – Authors' reply 淀粉样蛋白相关的医源性脑萎缩：数据透明是一个紧迫的安全优先事项-作者的答复
The Lancet Neurology Pub Date : 2025-02-19 DOI: 10.1016/s1474-4422(25)00030-4
Christopher R S Belder, Delphine Boche, James A R Nicoll, Zane Jaunmuktane, Henrik Zetterberg, Jonathan M Schott, Frederik Barkhof, Nick C Fox
{"title":"Amyloid-related iatrogenic atrophy of the brain: data transparency is an urgent safety priority – Authors' reply","authors":"Christopher R S Belder, Delphine Boche, James A R Nicoll, Zane Jaunmuktane, Henrik Zetterberg, Jonathan M Schott, Frederik Barkhof, Nick C Fox","doi":"10.1016/s1474-4422(25)00030-4","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00030-4","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ATTeST trial in ataxia telangiectasia: some concerns – Authors' response 共济失调性毛细血管扩张的试验：一些问题-作者的回应
The Lancet Neurology Pub Date : 2025-02-19 DOI: 10.1016/s1474-4422(25)00031-6
Biljana Horn, Maureen Roden, Dirk Thye
{"title":"The ATTeST trial in ataxia telangiectasia: some concerns – Authors' response","authors":"Biljana Horn, Maureen Roden, Dirk Thye","doi":"10.1016/s1474-4422(25)00031-6","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00031-6","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amyloid-related iatrogenic atrophy of the brain: data transparency is an urgent safety priority 淀粉样蛋白相关的医源性脑萎缩：数据透明是一个紧迫的安全优先事项
The Lancet Neurology Pub Date : 2025-02-19 DOI: 10.1016/s1474-4422(25)00029-8
Scott Ayton, Robert Howard, Madhav Thambisetty
{"title":"Amyloid-related iatrogenic atrophy of the brain: data transparency is an urgent safety priority","authors":"Scott Ayton, Robert Howard, Madhav Thambisetty","doi":"10.1016/s1474-4422(25)00029-8","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00029-8","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating the use of generative AI in peer review 引导生成式人工智能在同行评审中的使用
The Lancet Neurology Pub Date : 2025-02-19 DOI: 10.1016/s1474-4422(25)00041-9
Laura Hart
{"title":"Navigating the use of generative AI in peer review","authors":"Laura Hart","doi":"10.1016/s1474-4422(25)00041-9","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00041-9","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amyotrophic lateral sclerosis caused by hexanucleotide repeat expansions in C9orf72: from genetics to therapeutics 由C9orf72中六核苷酸重复扩增引起的肌萎缩性侧索硬化：从遗传学到治疗学
The Lancet Neurology Pub Date : 2025-02-19 DOI: 10.1016/s1474-4422(25)00026-2
Sarah Mizielinska, Guillaume M Hautbergue, Tania F Gendron, Marka van Blitterswijk, Orla Hardiman, John Ravits, Adrian M Isaacs, Rosa Rademakers
{"title":"Amyotrophic lateral sclerosis caused by hexanucleotide repeat expansions in C9orf72: from genetics to therapeutics","authors":"Sarah Mizielinska, Guillaume M Hautbergue, Tania F Gendron, Marka van Blitterswijk, Orla Hardiman, John Ravits, Adrian M Isaacs, Rosa Rademakers","doi":"10.1016/s1474-4422(25)00026-2","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00026-2","url":null,"abstract":"GGGGCC repeat expansions in <em>C9orf72</em> are a common genetic cause of amyotrophic lateral sclerosis in people of European ancestry; however, substantial variability in the penetrance of the mutation, age at disease onset, and clinical presentation can complicate diagnosis and prognosis. The repeat expansion is bidirectionally transcribed in the sense and antisense directions into repetitive RNAs and translated into dipeptide repeat proteins, and both accumulate in the cortex, cerebellum, and the spinal cord. Furthermore, neuropathological aggregates of phosphorylated TDP-43 are observed in motor cortex and other cortical regions, and in the spinal cord of patients at autopsy. <em>C9orf72</em> repeat expansions can also cause frontotemporal dementia. The GGGGCC repeat induces a complex interplay of loss-of-function and gain-of-function pathological mechanisms. Clinical trials using antisense oligonucleotides to target the GGGGCC repeat RNA have not been successful, potentially because they only target a single gain-of-function mechanism. Novel therapeutic approaches targeting the DNA repeat expansion, multiple repeat-derived RNA species, or downstream targets of TDP-43 dysfunction are, however, on the horizon, together with the development of diagnostic and prognostic biomarkers.","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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