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The relevance of primary cilia in neurological disorders 原发性纤毛与神经系统疾病的相关性
The Lancet Neurology Pub Date : 2025-07-21 DOI: 10.1016/s1474-4422(25)00226-1
Valentina Serpieri, Fulvio D'Abrusco, Enza Maria Valente
{"title":"The relevance of primary cilia in neurological disorders","authors":"Valentina Serpieri, Fulvio D'Abrusco, Enza Maria Valente","doi":"10.1016/s1474-4422(25)00226-1","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00226-1","url":null,"abstract":"Primary cilia are ubiquitous organelles, which play essential roles in sensing and transducing cellular signals and in mediating key developmental pathways. Pathogenic variants in genes encoding for ciliary proteins give rise to a spectrum of disorders termed primary ciliopathies. The archetypal neurodevelopmental ciliopathy is Joubert syndrome. However, in the past decade, primary cilia have been implicated in several other neurological disorders, including neurodevelopmental disorders, malformations of cortical development, neurodegenerative disorders, and psychiatric disorders. Therapeutic approaches for cilia-related disorders are still scarce. Strategies based on gene therapy and antisense oligonucleotides show promising results, especially for the treatment of retinal ciliopathies, and are currently moving towards clinical translation. Other approaches based on drug repurposing or the use of small molecules, despite positive results in a variety of cellular and animal models, are still in the experimental stage.","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Over a decade of MR-guided focused ultrasound 十多年的核磁共振引导聚焦超声
The Lancet Neurology Pub Date : 2025-07-16 DOI: 10.1016/s1474-4422(25)00241-8
Alfonso Fasano, Andres M Lozano
{"title":"Over a decade of MR-guided focused ultrasound","authors":"Alfonso Fasano, Andres M Lozano","doi":"10.1016/s1474-4422(25)00241-8","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00241-8","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Updates to the ILAE seizure classification ILAE癫痫发作分类更新
The Lancet Neurology Pub Date : 2025-07-16 DOI: 10.1016/s1474-4422(25)00236-4
Nathalie Jette, Leah J Blank
{"title":"Updates to the ILAE seizure classification","authors":"Nathalie Jette, Leah J Blank","doi":"10.1016/s1474-4422(25)00236-4","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00236-4","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gait training after stroke: are physiotherapists overcautious? 中风后的步态训练：理疗师是否过于谨慎？
The Lancet Neurology Pub Date : 2025-07-16 DOI: 10.1016/s1474-4422(25)00242-x
Gert Kwakkel
{"title":"Gait training after stroke: are physiotherapists overcautious?","authors":"Gert Kwakkel","doi":"10.1016/s1474-4422(25)00242-x","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00242-x","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"676 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interpreting the evidence on gantenerumab for dominantly inherited Alzheimer's disease 解释gentenerumab治疗显性遗传性阿尔茨海默病的证据
The Lancet Neurology Pub Date : 2025-07-16 DOI: 10.1016/s1474-4422(25)00234-0
Sebastian Walsh, Robert Howard, Edo Richard, Richard Milne, Carol Brayne
{"title":"Interpreting the evidence on gantenerumab for dominantly inherited Alzheimer's disease","authors":"Sebastian Walsh, Robert Howard, Edo Richard, Richard Milne, Carol Brayne","doi":"10.1016/s1474-4422(25)00234-0","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00234-0","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When children diagnosed with Guillain-Barré syndrome do not recover 当被诊断患有格林-巴罗综合征的儿童无法康复时
The Lancet Neurology Pub Date : 2025-07-16 DOI: 10.1016/s1474-4422(25)00240-6
Marie-Claire Y de Wit, Bart C Jacobs
{"title":"When children diagnosed with Guillain-Barré syndrome do not recover","authors":"Marie-Claire Y de Wit, Bart C Jacobs","doi":"10.1016/s1474-4422(25)00240-6","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00240-6","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Superheroes come in all shapes and sizes 超级英雄有各种各样的形状和大小
The Lancet Neurology Pub Date : 2025-07-16 DOI: 10.1016/s1474-4422(25)00247-9
Jules Morgan
{"title":"Superheroes come in all shapes and sizes","authors":"Jules Morgan","doi":"10.1016/s1474-4422(25)00247-9","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00247-9","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interpreting the evidence on gantenerumab for dominantly inherited Alzheimer's disease 解释gentenerumab治疗显性遗传性阿尔茨海默病的证据
The Lancet Neurology Pub Date : 2025-07-16 DOI: 10.1016/s1474-4422(25)00235-2
Yangfan Cheng, Yang Zhang, Sirui Zhang, Huifang Shang
{"title":"Interpreting the evidence on gantenerumab for dominantly inherited Alzheimer's disease","authors":"Yangfan Cheng, Yang Zhang, Sirui Zhang, Huifang Shang","doi":"10.1016/s1474-4422(25)00235-2","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00235-2","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rethinking neuromodulation in stroke: lessons from TRANSPORT2 重新思考脑卒中中的神经调节：来自TRANSPORT2的经验教训
The Lancet Neurology Pub Date : 2025-07-16 DOI: 10.1016/s1474-4422(25)00231-5
Stéphane Perrey
{"title":"Rethinking neuromodulation in stroke: lessons from TRANSPORT2","authors":"Stéphane Perrey","doi":"10.1016/s1474-4422(25)00231-5","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00231-5","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional or hysterical? 功能正常还是歇斯底里？
The Lancet Neurology Pub Date : 2025-07-16 DOI: 10.1016/s1474-4422(25)00245-5
Mark Weatherall
{"title":"Functional or hysterical?","authors":"Mark Weatherall","doi":"10.1016/s1474-4422(25)00245-5","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00245-5","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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