The Lancet Neurology最新文献_第10页

Lessons from the Colombian kindred: rethinking Alzheimer's prevention 哥伦比亚同胞的教训：重新思考老年痴呆症的预防

The Lancet Neurology Pub Date : 2026-01-22 DOI: 10.1016/s1474-4422(25)00481-8

Juan Fortea, Jorge Llibre-Guerra, Antoinette O'Connor, Johannes Levin

引用次数: 0

Fighting Parkinson's disease: a neurologist–patient journey 对抗帕金森氏症：神经科医生与患者的旅程

The Lancet Neurology Pub Date : 2026-01-22 DOI: 10.1016/s1474-4422(25)00489-2

Tissa Wijeratne

引用次数: 0

The neurological fascination with mysteries and puzzles 神经学对神秘和谜题的迷恋

The Lancet Neurology Pub Date : 2026-01-22 DOI: 10.1016/s1474-4422(26)00002-5

Rui Araújo

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Epileptic activity in Alzheimer's disease: emerging insights and therapeutic implications 阿尔茨海默病的癫痫活动：新见解和治疗意义

The Lancet Neurology Pub Date : 2026-01-22 DOI: 10.1016/s1474-4422(25)00425-9

Keith Vossel, Emily L Johnson, Benjamin Cretin, Riki Matsumoto

{"title":"Epileptic activity in Alzheimer's disease: emerging insights and therapeutic implications","authors":"Keith Vossel, Emily L Johnson, Benjamin Cretin, Riki Matsumoto","doi":"10.1016/s1474-4422(25)00425-9","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00425-9","url":null,"abstract":"An estimated 60% of patients with Alzheimer's disease develop epilepsy or subclinical epileptiform activity over the course of the disease. New-onset seizures in cognitively healthy adults also increase the risk of developing dementia. Epileptic activity, including both seizures and subclinical epileptiform discharges, can hasten the onset of Alzheimer's disease and accelerate cognitive decline. Studies are investigating whether antiseizure medications could improve cognitive outcomes, particularly in patients with Alzheimer's disease with epileptic activity. Detection of epileptic activity in people with Alzheimer's disease requires high clinical vigilance and neurophysiological monitoring. Evaluation and treatment of late-onset epilepsy or Alzheimer's disease-associated epileptic activity should be informed by clinical advances. Epilepsy management is especially important in patients receiving anti-amyloid monoclonal antibodies, which can increase seizure risk. Recent insights support the concept of an epileptic subtype of Alzheimer's disease, position epileptic activity as a modifiable risk factor in Alzheimer's disease, highlight innovations for earlier identification of epileptic activity, and provide evidence supporting the need for early detection and targeted treatment across the stages of Alzheimer's disease.","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146021886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood pressure reduction and reperfusion therapy 降压和再灌注治疗

The Lancet Neurology Pub Date : 2026-01-21 DOI: 10.1016/s1474-4422(26)00003-7

Eva Mistry, Pooja Khatri

引用次数: 0

Reducing door-in-door-out time to improve stroke outcome 减少室内外时间以改善中风结果

The Lancet Neurology Pub Date : 2026-01-21 DOI: 10.1016/s1474-4422(25)00495-8

Bernard P L Chan

引用次数: 0

Early blood pressure management in acute ischaemic stroke before and after reperfusion treatment 急性缺血性脑卒中再灌注治疗前后的早期血压管理

The Lancet Neurology Pub Date : 2026-01-21 DOI: 10.1016/s1474-4422(25)00378-3

Lili Song, Yu Mao, Else Charlotte Sandset, Nyika D Kruyt, Paul J Nederkoorn, Xia Wang, Sonali R Gnanenthiran, Craig S Anderson

{"title":"Early blood pressure management in acute ischaemic stroke before and after reperfusion treatment","authors":"Lili Song, Yu Mao, Else Charlotte Sandset, Nyika D Kruyt, Paul J Nederkoorn, Xia Wang, Sonali R Gnanenthiran, Craig S Anderson","doi":"10.1016/s1474-4422(25)00378-3","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00378-3","url":null,"abstract":"<h3>Background</h3>Patients with acute ischaemic stroke often present with elevated blood pressure. Evidence has emerged that challenges the longstanding recommendation across clinical guidelines that blood pressure should be controlled to a systolic pressure of less than 185 mm Hg before initiating reperfusion therapy in these patients.<h3>Recent</h3>developments Major clinical trials (INTERACT4, MR-ASAP, and RIGHT-2) and an observational study (TRUTH) indicate that intensively lowering blood pressure before initiating reperfusion therapy for acute ischaemic stroke is associated with increased risk of death and disability. Similar evidence has reshaped our approach to blood pressure management in patients who receive successful endovascular thrombectomy for acute ischaemic stroke from large-vessel occlusion. The underlying mechanisms of cerebral ischaemia are likely to involve alterations in cerebral blood flow through collateral vessels and the microcirculation.<h3>Where</h3>next? Current evidence underscores the harms of more intensive lowering of blood pressure to a systolic target of less than 140 mm Hg both before and after reperfusion therapy for acute ischaemic stroke. Despite the challenges in obtaining the necessary randomised evidence, such efforts are now required to establish whether elevated blood pressure should be controlled at all with this disease or left to decrease naturally.","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146021922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jacques Lazerme's description of apoplexy 雅克·拉泽姆对中风的描述

The Lancet Neurology Pub Date : 2026-01-21 DOI: 10.1016/s1474-4422(25)00487-9

Antoine Dampierre, Marion Hendrickx, Emmanuel Drouin

引用次数: 0

Neuromuscular disorders in superhero lore 超级英雄爱情中的神经肌肉紊乱

The Lancet Neurology Pub Date : 2026-01-21 DOI: 10.1016/s1474-4422(25)00488-0

Stéphane Mathis, Gwendal Le Masson

引用次数: 0

A global call to strengthen neurological care for all 加强对所有人的神经保健的全球呼吁

The Lancet Neurology Pub Date : 2025-12-10 DOI: 10.1016/s1474-4422(25)00449-1

Sebastian F Winter, Neerja Chowdhary, Katrin Seeher, Tarun Dua

引用次数: 0