International Journal of Hematology and Blood Disorders最新文献

{"title":"A Case Report on Osler -Weber Rendu Disease","authors":"Ameez S Khan, S. Salih","doi":"10.15226/ijhbd/4/1/00135","DOIUrl":"https://doi.org/10.15226/ijhbd/4/1/00135","url":null,"abstract":"Osler weber rendu disease, also known as hereditary hemorrhagic telengiectasia is a rare autosomal dominant genetic disorder that leads to abnormal blood vessel formation in skin, mucous membrane and in organs such as lungs, liver and brain. A 68 year old postmenopausal lady was admitted to our hospital following multiple episodes of hematemesis and malena for past 5 days. Upper GI endoscopy revealed multiple telengiectasia with active spurting, gastric polyp. Patient was treated with 1 unit of PRBC transfusion for anemia, Inj.Tranexamic acid 500 mg IV tid, Inj. Ondanseteron 4 mg IV for hematemesis. Tab. Thalidomide 100 mg hs have been given for treating hereditary hemorrhagic telengiectasia. The treatment is only palliative, with no consensus on the best treatment option. It is essential to promote control of the disease as long as possible.","PeriodicalId":225199,"journal":{"name":"International Journal of Hematology and Blood Disorders","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115890460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Darbepoetin alfa in anemic dogs with Chronic Kidney Disease – a review of 21 cases","authors":"G.R.Baranidharan, P. Ramesh, M. Chandrasekar, D. Sumathi, B. Thilagar, K. Jeyaraja, M. Jayathangaraj","doi":"10.15226/ijhbd/4/1/00134","DOIUrl":"https://doi.org/10.15226/ijhbd/4/1/00134","url":null,"abstract":"Anemia due to Chronic Kidney Disease (CKD) represents a major portion of hemodynamic imbalance in dogs. Although the pathogenesis of the anemia in CKD is multifactorial, decreased production of erythropoietin by the diseased kidneys has been proven and the severity of anemia correlates positively with serum creatinine concentrations in affected dogs. Therapeutic whole and Packed Red Blood Cell transfusion has always been a main stay in practice. However, the unavailability of appropriate dog donors, blood typing modalities and occurrence of post transfusion reactions are the common hurdles encountered. Alternatively, Darbepoetin alfa, a hyperglycosylated synthetic recombinant erythropoietin which is commonly used in human patients with CKD induced anemia is used in recent canine practice. Unlike human transfusion medicine, not much of study has been documented in dogs in India. However anecdotally, darbepoetin is perceived to less likely form antibodies compared to erythropoietin. A study comprising of 21 dogs referred to Madras Veterinary College Teaching Hospital (MVCTH) with CKD (stage II, III & IV were 7, 9 & 5 respectively) of multifactorial etiology during the period of January to December 2017 was done. Injectable Darbepoetin was administered @0.5μg/kg subcutaneously once in a week for three weeks along with supplementation of Iron to achieve a medium hematocrit of 30%. Efficacy of Darbepoetin was evaluated by measuring pre and post therapeutic clinico pathological studies. Darbepoetin proved effective in increasing PCV, anemic crisis potentially in 66.7% of dogs. Hypertension, vomiting, melena, inappetance were common findings in affected dogs and coexistence of normocytic, normochromic progressive anemia which responds to Darbepoetin alfa therapy. Though expensive than Erythropoietin, Darbepoetin @0.5μg/kg s/c proved safe and effective in improving packed cell volume in CKD dogs as an alternative to packed RBC or whole blood transfusion. Further immunological, toxicological and clinical studies on Darbepoetin therapy is warranted in a large population in dogs. Keywords: Ckd; Azotemia; Anemia; Darbepoetin","PeriodicalId":225199,"journal":{"name":"International Journal of Hematology and Blood Disorders","volume":"519 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132306156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Normal Blood Oxygen Level interrelate with watching Horror Movies?","authors":"M. Qadir, M. Asif","doi":"10.15226/ijhbd/4/1/00133","DOIUrl":"https://doi.org/10.15226/ijhbd/4/1/00133","url":null,"abstract":"The objective of current study was to analyze any relation between the normal blood oxygen level and watching horror movies. There are numbers of scary movies accessible on internet. Some people love watching horror movies and some fear from them. During fear, we feel an increase in heartbeat, adrenaline hormone and increase intake of oxygen. To compensate with fear, our respiration rate rises. Hence, our blood oxygen level enhances.Peripheral oxygen saturation (SpO2) is avaluation of the oxygen saturation level generally gauged with the help of an oximeter instrument. It can be considered with pulse oximetry according to the given formulation:","PeriodicalId":225199,"journal":{"name":"International Journal of Hematology and Blood Disorders","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122829136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytomegalovirus Reactivation in Hematopoietic Stem cell Transplantation managed by Preemptive Treatment with lower dose Valganciclovir","authors":"E. Akyol, H. Sahin","doi":"10.15226/IJHBD/4/1/00132","DOIUrl":"https://doi.org/10.15226/IJHBD/4/1/00132","url":null,"abstract":"Objective: The aim of this study was to investigate risk factors for cytomegalovirus (CMV) infection, effect of viral reactivation on hematopoietic stem cell transplantation (HSCT) and efficacy of preemptive treatment using a lower dose valganciclovir for the first time. Material and Method: The data of 447 patients who underwent HSCT for malignant and non-malignant hematological disorders at a single center from September 2009 to December 2016 were retrospectively evaluated in this study. DNA levels of CMV were routinely tested two days per week for the first 24 months following HSCT, and in case of clinical suspicion after 24 months using the Quantitative Real-Time quantitative polymerase chain reaction (RT-PCR). Results: Ninety (54.2%) allogeneic transplant patients, and forty one (14.6%) autologous transplant patients had CMV reactivation. There was a statistically significant increase in CMV reactivation in the non-myeloablative (NMA) allogeneic transplant group compared to the myeloablative (MA) group at a value of 150-1000 copies/mL CMV-PCR (p= 0.002). Acute/chronic Graft Versus Host Disease (GVHD) were observed in 30 of allogeneic HSCT patients. 29 of these patients (96.6%) had CMV antigenemia. There was a significant association between the development of acute/ chronic GVHD, and CMV viremia (p= 0.001). The patients without CMV antigenemia had a higher incidence of mortality at first 100-day, and 365-day in allogeneic transplant group (p= 0.022, p= 0.024, respectively). The 5-year overall survival (OS) rate was 61% in the viremia group, and 62% in the non-viremia group. There was no statistically significant difference between the two groups in terms of 5-year OS (p= 0.551). In patients receiving a lower dose of 900 mg/day valganciclovir treatment due to viremia, CMV disease did not develop and no adverse effect that required the drug to be discontinued was observed. Conclusion: The results conducted that development of GVHD was associated with CMV viremia. Early and late mortality rate were higher in the patients without CMV antigenemia. However; CMV reactivation had no impact on patients’ survival post allogeneic and autologous HSCT. Also, this was the first study that conducted preemptive treatment approach in the CMV viremia using a lower dose valganciclovir is safe and effective in HSCT.","PeriodicalId":225199,"journal":{"name":"International Journal of Hematology and Blood Disorders","volume":"30 3 Suppl 7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131900443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory issues in cancer survivors patients: Mini-review","authors":"L. Mendoza","doi":"10.15226/2639-7986/2/3/00112","DOIUrl":"https://doi.org/10.15226/2639-7986/2/3/00112","url":null,"abstract":"With the recent success of modern cancer therapy, cancer can be curable,and in cases where cure cannot be achieved, it can be treated as a chronic disease. As a result,there are now more than 15.5 million Americans with a history of cancer were alive on January 1, 2016. By January 1, 2026, this number is projected to reach 20.3 million [1]. These estimates do not include carcinoma in situ for any cancer except urinary bladder and do not include basal cell or squamous cell skin cancers. The respiratory effects of cancer therapy are critically important to the overall health of cancer survivors due to higher incidence of pulmonary disease compared with the general population. Because these conditions can result in a high degree of morbidity and mortality, understanding how to improve the prevention, recognition, and treatment of pulmonary disease is an important medical priority.","PeriodicalId":225199,"journal":{"name":"International Journal of Hematology and Blood Disorders","volume":"284 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121059828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FDA approvals for mismatch repair deficiency in metastatic colorectal cancer and hepatocellular carcinoma: a next-generation oncology treatment based on biomarker expression","authors":"Luis Mendoza","doi":"10.15226/ijhbd/4/1/00131","DOIUrl":"https://doi.org/10.15226/ijhbd/4/1/00131","url":null,"abstract":"Colorectal, gastric and hepatocellular cancers have been traditionally considered to be poorly immunogenic; however, increasing evidence now suggests that these tumors are recognized by the immune system. Immune checkpoint blockade is showing promising clinical activity in multiple tumors including colorectal and non-colorectal. In fact, one of the most significant achievements witnessed in the field of immunotherapy has been the success of immune checkpoint inhibitors (CPIs) in microsatellite instability-high colorectal and non-colorectal tumors. For this reason, the US FDA has granted accelerated approval to Pembrolizumab and Nivolumab as monotherapies and Nivolumab plus Ipilimumab as combined therapy. These new findings open the door to a next-generation oncology treatment based on biomarker expression.","PeriodicalId":225199,"journal":{"name":"International Journal of Hematology and Blood Disorders","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130380830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary Hyperferritinaemia-Cataract Syndrome Classical presentation for differential diagnosis","authors":"F. Farhan, F. Al‐Refaie, Suki Sankaralingham","doi":"10.15226/2639-7986/3/3/00129","DOIUrl":"https://doi.org/10.15226/2639-7986/3/3/00129","url":null,"abstract":"","PeriodicalId":225199,"journal":{"name":"International Journal of Hematology and Blood Disorders","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134535222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythropoietin Response in Patients with Anaemia of Chronic Disorders","authors":"Tinuade O. Piwuna, C. Ukoli, Alani S Akanmu","doi":"10.15226/2639-7986/3/3/00130","DOIUrl":"https://doi.org/10.15226/2639-7986/3/3/00130","url":null,"abstract":"Chronic disease conditions characterized by infection and intense inflammatory response abound in Sub-Saharan Africa and are very often complicated by anemia. Erythropoietin (EPO) is up regulated in response to anemic conditions. In Nigeria there is a dearth of public literature describing Anemia of Chronic Disease (ACD) and Erythropoietin levels in chronic diseases. The aim of the study was to determine the appropriateness of erythropoietin response to anemia observed in chronic disease.","PeriodicalId":225199,"journal":{"name":"International Journal of Hematology and Blood Disorders","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131045562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular manifestations of sickle cell disease in heterozygous subjects: Senegalese experience","authors":"A. Ka, E. Ba, A. Wane, A. Sow, J. Diagne, de Medeiros Me, H. Kane, M. Dieng, G MouenBengue, Ndiaye Jmm, S. Sow, M. Nguer, Ndoye Roth Pa, P. Ndiaye","doi":"10.15226/2639-7986/3/3/00128","DOIUrl":"https://doi.org/10.15226/2639-7986/3/3/00128","url":null,"abstract":"Sickle cell disease is a genetic disease with autosomal recessive transmission due to the presence in the red blood cell of abnormal hemoglobin called hemoglobin S. It would be the most widespread hemoglobinopathy in the world affecting nearly 120 million people according to the WHO. This disease is very frequent in Africa south of Sahara, where in Senegal it affects almost 10% of the population. It is responsible for polymorphic clinical manifestations, in particular ophthalmologic. However, the latter are very little described by the literature in our country. We report our experience of ocular lesions found in heterozygous sickle cell subjects monitored in our department.","PeriodicalId":225199,"journal":{"name":"International Journal of Hematology and Blood Disorders","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125886582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Impact of Alcohol Consumption on Some Haematological Variables among Alcohol Consumers in Jos Metropolis, Nigeria","authors":"M. Lugos, Bitrus N. Lekshak, Changjul L. Singnap, U. Polit, Benedict H Mangs","doi":"10.15226/2639-7986/3/3/00127","DOIUrl":"https://doi.org/10.15226/2639-7986/3/3/00127","url":null,"abstract":"Ethanol is contained in alcoholic beverages, which are produced by the process of fermentation of grains, fruits, and other sources of sugar. The effect of alcohol consumption among youths and adults resulting to escalating crime rate in the society has generated great concern. The impact of alcohol consumption on haematological variables has not been well documented in Jos metropolis. The study sought to establish whether alcohol consumption has any effect on the haematological status of individuals or not. Following informed consent, we determined haematocrit values by the microhaematocrit method, haemoglobin (Hb) concentration by cyanmethaemoglobin technique, total and differential white blood cell counts (WBC), malaria parasite as well as microscopic blood film reporting of 124 alcohol consumers and 53 non-consumers as a control. SPSS version 23 was used to compare mean values between alcohol consumers and the control group (student t-test), while associations of blood film report were determined by chi-square. Results showed a significantly higher total lymphocytes count among alcohol consumers compared to nonalcohol consumers (48.28±12.98 v 41.91±11.59; p=0.002). Also, the blood film reporting revealed a significantly higher percentages of macrocytes (p=0.001), microcytes (p=0.020), hypochromia (p=0.001), polychromasia (p=0.013), rouleaux formation (p=0.004) and atypical lymphocytes (p=0.011) and malaria parasitaemia (p=0.001) among alcohol consumers compared to the control group. Anisocytosis and hypochromia, which are essential characteristic features of anaemia, have been shown to associate with alcohol consumption. The implication is that excessive alcohol intake may impact adversely on haematological variables, and particularly constitute an increased risk of developing anaemia.","PeriodicalId":225199,"journal":{"name":"International Journal of Hematology and Blood Disorders","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126685634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}