The Indian journal of child health最新文献_第4页

Demystifying Renal Tubular Disorders in children : A simplified approach 儿童肾小管疾病的诊断:一种简化的方法

The Indian journal of child health Pub Date : 2022-12-28 DOI: 10.32677/ijch.v9i12.3725

Sharma Shobha, Kalra Suprita

引用次数: 0

Clinical Uses of Fructooligosaccharides for Gastrointestinal health in the Pediatric Population 低聚果糖对儿童胃肠道健康的临床应用

The Indian journal of child health Pub Date : 2022-12-25 DOI: 10.32677/ijch.v9i12.3769

Femitha Pournami, Ghazi Sharique Ahmad, Nayankumar Rameshchandra Kalawadia, Ravishankar Kanithi, Samik Hazra, Satyen Kanhiyalal Hemrajani, Shrish Bhatnagar, Preethi Rahul

引用次数: 0

Clinical predictors of hypoxemia in patients of acute lower respiratory tract infections: A hospital-based study 急性下呼吸道感染患者低氧血症的临床预测因素:一项基于医院的研究

The Indian journal of child health Pub Date : 2022-12-14 DOI: 10.32677/ijch.v9i11.3474

Mansi Arora, P. Rai, P. Prasad

{"title":"Clinical predictors of hypoxemia in patients of acute lower respiratory tract infections: A hospital-based study","authors":"Mansi Arora, P. Rai, P. Prasad","doi":"10.32677/ijch.v9i11.3474","DOIUrl":"https://doi.org/10.32677/ijch.v9i11.3474","url":null,"abstract":"Aim: The aim of this study was to study clinical predictors of hypoxemia in patients of acute lower respiratory infections in children.\u0000Materials and Methods: An observational prospective study was conducted for 8 months in the General Pediatric Ward and Pediatric Intensive Care Unit of Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, a tertiary care hospital in Rohilkhand region. This is a hospital-based study. All children admitted with acute lower respiratory tract infections between the age group of 1 month to 59 months of age and diagnosed with pneumonia and bronchiolitis were enrolled and oxygen saturation of patients was recorded and compared with arterial blood gas.\u0000Results: A total of 40 patients were enrolled in the study. More than 90% cases of pneumonia and bronchiolitis presented with difficulty in breathing followed by rapid breathing as the next most common symptom. The least common symptom was noisy breathing and pain in abdomen. The most common signs observed were tachypnea which was present in 100% cases of mild, moderate, and severe hypoxemia. Tachypnea (91%), pallor (89%) and nasal flaring (84%), crepitations (added sounds), and subcostal retractions had better sensitivity for detecting hypoxemia.\u0000Conclusion: It was observed that a combination of clinical signs and symptoms can be used to predict hypoxemia when facilities of pulse oximetry and arterial blood gas analysis are not available, especially in low-resource settings.","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82379665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of oral nutrition supplement on growth in preschool children – a systems physiology-based in silico analysis 口服营养补充剂对学龄前儿童生长发育的影响——基于系统生理学的硅分析

The Indian journal of child health Pub Date : 2022-12-13 DOI: 10.32677/ijch.v9i11.3696

Hari Nishanthi V, Ekta Chheda, Siranjeevi Gurumaani, Vani Gangwar, A. Saxena, K. Lomore, M. Marathe, Preethi Rahul, Venkatesh Kareenhalli

{"title":"Effect of oral nutrition supplement on growth in preschool children – a systems physiology-based in silico analysis","authors":"Hari Nishanthi V, Ekta Chheda, Siranjeevi Gurumaani, Vani Gangwar, A. Saxena, K. Lomore, M. Marathe, Preethi Rahul, Venkatesh Kareenhalli","doi":"10.32677/ijch.v9i11.3696","DOIUrl":"https://doi.org/10.32677/ijch.v9i11.3696","url":null,"abstract":"Introduction: Optimum nutrition is the cornerstone of child growth and development. Childhood is a period of rapid growth and development. Children of preschool age have higher nutritional needs and are often at risk of nutrient deficiencies.\u0000Objective: The present study was designed to evaluate the effect of an oral nutritional supplement (ONS) on growth parameters in a representative population.\u0000Methods: We used the systems-biology-based mathematical model for child growth to analyze the effect of ONS on growth in a representative in silico population of preschool children. The analysis included changes in average growth velocities of weight, height, muscle mass, fat mass, fat-free mass, and bone mass. We used meta-data analysis for evaluating the absorption of micronutrients present in the ONS that affects growth in preschool children.\u0000Results: The results of the analysis showed one serving of ONS in milk/day improved the weight gain velocity by 1.7 times in preschool children. The linear growth was 1.04 times higher than the control. The absorption of micronutrients such as iron, vitamin K, calcium, and magnesium was higher in the ONS group.\u0000Conclusions: This study indicates that the ONS containing macro and micronutrients, docosahexaenoic acid (DHA), and prebiotics can potentiate growth and development in preschool children. It provides micronutrients that can be readily absorbed which are essential for other vital functions in the body.","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90078836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early life antibiotic exposure and inflammatory bowel disease 早期抗生素暴露与炎症性肠病

The Indian journal of child health Pub Date : 2022-12-07 DOI: 10.32677/ijch.v9i11.3741

Rashmi Agrawal, Amit Agrawal, J. Jacson

{"title":"Early life antibiotic exposure and inflammatory bowel disease","authors":"Rashmi Agrawal, Amit Agrawal, J. Jacson","doi":"10.32677/ijch.v9i11.3741","DOIUrl":"https://doi.org/10.32677/ijch.v9i11.3741","url":null,"abstract":"Inflammatory bowel disease (IBD) is known to affect millions of people worldwide and is primarily caused due to abnormal due to abnormal immune responses to intestinal microbes. IBD is primarily categorized under two main types – ulcerative colitis and Crohn’s disease. Although the cause of IBD is still an unsolved puzzle, its development can be attributed to the presence of various risk factors including antibiotic use. The intestinal immune system is the point of genesis of IBD and anything that creates an imbalance can trigger IBD. Alterations in the gut microbiota can lead to reduced microbial populations and lead a chronic inflammation state. Antibiotics may influence microbial maturity and can hamper the formation of a strong immune system. This makes an individual vulnerable to the threat of infections and subsequent development of a chronic inflammation state. Studies have implicated that the use of antibiotics during pregnancy, antepartum, and among neonates is associated with the development of IBD. Adequate development of the microbial niche takes place within the first 2 years of life and extensive administration of antibiotics during this period can pose a significant risk for the development of IBD. Animal studies have also documented the role of in utero antibiotic exposure during the antepartum period and the subsequent risk of developing IBD in the offspring. This review summarizes the role of antibiotic exposure during pregnancy and infancy in the development of IBD.","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90208379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal purpura fulminans: A rare, life-threatening, and rapidly progressing disorder of coagulation 新生儿暴发性紫癜:一种罕见的、危及生命的、进展迅速的凝血疾病

The Indian journal of child health Pub Date : 2022-09-25 DOI: 10.32677/ijch.v9i9.3588

S. Rudrappa, Thanuja B, Chandana N S

{"title":"Neonatal purpura fulminans: A rare, life-threatening, and rapidly progressing disorder of coagulation","authors":"S. Rudrappa, Thanuja B, Chandana N S","doi":"10.32677/ijch.v9i9.3588","DOIUrl":"https://doi.org/10.32677/ijch.v9i9.3588","url":null,"abstract":"Background: Neonatal purpura fulminans (NPF) is a life-threatening rare disease, which can be caused by deficiencies of protein C or protein S in a congenital or acquired manner. It is characterized by thrombosis of microvasculature, peri-vascular hemorrhage, and disseminated intravascular coagulation (DIC) occurring in the neonatal period. Clinical Description: A term female baby presented at 40 h of life with multiple purpuric rashes over the left foot which over 1 day extended until the knee. Over the next 3 days, there was rapid progression to involve extensive areas of necrosis with gangrene of toes of left foot, both forearms, bilateral temporal areas, peri-orbital regions, and left ear, in addition to multiple hemorrhagic blebs. Management and Outcome: Investigations showed anemia and thrombocytopenia with normal leucocyte count. DIC was suspected (INR 2), sepsis screen was negative, and fresh frozen plasma (FFP) was transfused 8th hourly. Arterial and venous Doppler was normal and blood culture showed no growth. Suspecting NPF, protein C, protein S, and anti-thrombin levels were sent, which showed a low protein C and protein S value. Mutations involving factor V Leiden, prothrombin gene, and MTHFR gene were not detected. The baby was started on low molecular weight heparin and, FFP and platelet concentrate replacement were continued, but she succumbed to the illness. Conclusion: NPF is a rare life-threatening entity that is fatal without prompt recognition of the condition. Therefore, it is necessary to recognize it early and initiate treatment.","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76442180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of stunting and determinants of growth failure in children with Type 1 diabetes 1型糖尿病儿童发育迟缓的患病率和生长衰竭的决定因素

The Indian journal of child health Pub Date : 2022-09-24 DOI: 10.32677/ijch.v9i9.3635

S. Bhor, C. Oza, A. Khadilkar, Dipali Ladkat, K. Gondhalekar, V. Khadilkar

{"title":"Prevalence of stunting and determinants of growth failure in children with Type 1 diabetes","authors":"S. Bhor, C. Oza, A. Khadilkar, Dipali Ladkat, K. Gondhalekar, V. Khadilkar","doi":"10.32677/ijch.v9i9.3635","DOIUrl":"https://doi.org/10.32677/ijch.v9i9.3635","url":null,"abstract":"Objectives: India is home to the highest number of prevalent cases of Type-1 diabetes (T1D) in children. There is scarcity of data on the growth failure of children with diabetes, especially those having complications and comorbidities, thus, we conducted this study with the objective to determine the prevalence and predictors of stunting in children with T1D. Methods: This cross-sectional study included 350 children and adolescents aged 1–18 years with T1D. Demographic data, anthropometry, diet, sexual maturity rating, and biochemical measurements were performed using standard protocols. Short stature was defined as height for age Z-score <−2. p<0.05 was considered statistically significant. Results: We report a 15.7% prevalence of stunting in our cohort of children with T1D. Stunted children had higher cholesterol, lower hemoglobin, lower mid-parental height Z-scores, and higher urinary albumin creatinine ratio. Binary logistic regression revealed that pre-existing comorbidities, compromised renal function, longer disease duration, and short mid-parental height were significant predictors of stunting. Conclusion: A little under one-sixth of children with T1D had short stature. Monitoring growth in these patients, especially in subjects with short parents, prolonged duration of diabetes, existing comorbidities, and deteriorating renal function are critical.","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77763486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pediatric cough as a symptom: Tips for management 小儿咳嗽作为一种症状:处理技巧

The Indian journal of child health Pub Date : 2022-09-17 DOI: 10.32677/ijch.v9i9.3362

S. Bavdekar, A. Vora, Sonali Karekar

引用次数: 1

Efficacy of inhaled salbutamol therapy through nebulizer versus mdi with spacer in children with acute asthmatic attack and short-term course 雾化吸入沙丁胺醇与间隔剂吸入沙丁胺醇治疗儿童急性哮喘发作及短期病程的疗效比较

The Indian journal of child health Pub Date : 2022-08-31 DOI: 10.32677/ijch.v9i8.3433

A. Yadav, S. Gupta, Kawalpreet Chhabra, O. Chaurasiya, M. Shastri

{"title":"Efficacy of inhaled salbutamol therapy through nebulizer versus mdi with spacer in children with acute asthmatic attack and short-term course","authors":"A. Yadav, S. Gupta, Kawalpreet Chhabra, O. Chaurasiya, M. Shastri","doi":"10.32677/ijch.v9i8.3433","DOIUrl":"https://doi.org/10.32677/ijch.v9i8.3433","url":null,"abstract":"Introduction: Asthma is a common chronic disease in childhood and has been subject of studies for at least two decades, due to its increasing prevalence. The symptoms are persistent, recurrent, and entirely related to bronchial hyper-responsiveness to many environmental triggers. Nebulization and metered dose inhaler (MDI) are two available modalities of salbutamol administration in patients with acute asthmatic attack. Aim: The aim of the study was to compare the relative efficacy of nebulizer and MDI with spacer for the administration of salbutamol in the treatment of acute asthmatic attack. Materials and Methods: A randomized, prospective, and interventional study was conducted on 100 children aged 1–12 years with acute asthmatic attack at a tertiary care. The subjects were randomized into two groups for salbutamol administration. Group I was given salbutamol by nebulizer and Group II by MDI with spacer. Demographic data and detailed history was collected. Children were categorized into mild, moderate, and severe grade according to peak expiratory flow rate (PEFR) and pulmonary index (PI) score. Oxygen saturation, PEFR, and PI were monitored at 0, 20, 40, and 60 min of therapy. Other details such as duration of hospital stay and oxygen requirement were also noted. Results: One hundred children with male female ratio of 1.12:1 were included in the study. Highest incidence was seen in age group of 1–3 years (38%). Statistically significant change in PI and PEFR was noted with treatment in both the groups (p<0.05). On comparison between MDI and nebulizer group, no statistically significant difference was found (p>0.05). Conclusion: MDI with spacer is an effective alternative to nebulizer for the administration of salbutamol drug in acute asthmatic attack in pediatric patients.","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"166 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77868637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Galactosialidosis presenting as non-immune hydrops in a newborn: A case report 新生儿半乳糖唾液中毒表现为非免疫性水肿1例报告

The Indian journal of child health Pub Date : 2022-08-31 DOI: 10.32677/ijch.v9i8.3568

Anu Sharma, Radhika Sujatha, S. H, Krishna Neisseril, Akash G. Nair

{"title":"Galactosialidosis presenting as non-immune hydrops in a newborn: A case report","authors":"Anu Sharma, Radhika Sujatha, S. H, Krishna Neisseril, Akash G. Nair","doi":"10.32677/ijch.v9i8.3568","DOIUrl":"https://doi.org/10.32677/ijch.v9i8.3568","url":null,"abstract":"Galactosialidosis is a rare autosomal recessive lysosomal storage disorder (LSD). It results from defects in glycoprotein degradation due to mutation in a single gene, encoded by the protective protein cathepsin A, (CTSA), located on chromosome 20q13.12. Most cases of non-immune hydrops fetalis (NIHF) nowadays being recognized are due to cardiac, lymphatic dysplasia, and hematological disorders. Inborn errors of metabolism account for NIHF in 1.3% of patients. Among metabolic disorders, around 14 LSDs have been reported as being associated with NIHF and congenital ascites. In the present case, we report an early infantile form of galactosialidosis with a novel homozygous miss-sense mutation c.319 A>C (p. Ser107 Arg) in exon 3 of CTSA gene in a newborn who presented as non-immune hydrops. The baby also had coarse facies, wide anterior fontanelle, hypertelorism, bilateral congenital talipes equinovarus, hepatosplenomegaly, nephrocalcinosis, and disproportionately small limbs with metaphyseal irregularity. Gradually, he developed worsening cardiac functions and cardiomyopathy and succumbed to death on day 47 of life. Being an autosomal recessive disorder, it can recur in the next pregnancy and treatment is mainly supportive. Targeted prenatal diagnostics in subsequent pregnancies can help in early diagnosis.","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80630090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1