Demystifying Renal Tubular Disorders in children : A simplified approach

Sharma Shobha, Kalra Suprita 
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引用次数: 0

Abstract

Renal tubular disorders essentially include all disorders of the highly specialized channels of the renal tubular system, from the proximal convoluted tubule to the cortical and medullary collecting ducts. This tubular system is responsible for reabsorption of 99% of glomerular ultrafiltrate, which contains a large amount of fluid (approximately 180 L/day) as well as most electrolytes and many metabolites such as glucose (G), amino acids, bicarbonate (HCO3-), phosphate (PO4 3-), and low-molecular-weight proteins and is essential for maintaining fluid, electrolyte, and acid–base balance. In this review, we will briefly discuss when to suspect a renal tubular disorder, a simplified algorithm for evaluation, and specific mutations of a few common disorders.
儿童肾小管疾病的诊断:一种简化的方法
肾小管疾病基本上包括肾小管系统高度特化通道的所有疾病,从近曲小管到皮质和髓质集管。这个管状系统负责99%的肾小球超滤液的重吸收,其中包含大量的液体(约180升/天),以及大多数电解质和许多代谢物,如葡萄糖(G)、氨基酸、碳酸氢盐(HCO3-)、磷酸盐(PO4 3-)和低分子量蛋白质,对维持液体、电解质和酸碱平衡至关重要。在这篇综述中,我们将简要讨论何时怀疑肾小管疾病,一种简化的评估算法,以及一些常见疾病的特定突变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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