Japanese Journal of Complementary and Alternative Medicine最新文献

{"title":"Dermatitis Successfully Cured by Intake of Coix-seed Reactive Derivatives (CRD): An Observational Study","authors":"N. Suzuki, H. Kyo, K. Uebaba, Shintaro Hashimoto","doi":"10.1625/jcam.17.55","DOIUrl":"https://doi.org/10.1625/jcam.17.55","url":null,"abstract":"","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114857628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Hand Eczema Cured by Intake of Coix-seed Reactive Derivatives (CRD)","authors":"N. Suzuki, H. Kyo, K. Uebaba, Shintaro Hashimoto","doi":"10.1625/jcam.17.65","DOIUrl":"https://doi.org/10.1625/jcam.17.65","url":null,"abstract":"","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114879128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two Cases of Plantar Keratosis Successfully Cured by Intake of Coix-seed Reactive Derivatives (CRD)","authors":"N. Suzuki, H. Kyo, K. Uebaba, Shintaro Hashimoto","doi":"10.1625/jcam.17.51","DOIUrl":"https://doi.org/10.1625/jcam.17.51","url":null,"abstract":"","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115960292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Effect of Porcine Placental Extract Ingestion on Symptoms of Late-onset Hypogonadism Syndrome in Middle-aged and Elderly Men","authors":"H. Kyo, M. Namiki, Tomoya Mimura, K. Uebaba, Tohru Hasegawa, N. Suzuki","doi":"10.1625/jcam.16.71","DOIUrl":"https://doi.org/10.1625/jcam.16.71","url":null,"abstract":"and the public . Purpose: An open-label, single-arm study was conducted to evaluate the effectiveness of porcine placental extract (PPE) ingestion to improve late-onset hypogonadism (LOH) syndrome symptoms. In addition, we reported the safety of continuous PPE ingestion in biochemistry tests. Materials and Methods: Test food containing PPE was given daily to healthy male subjects with an Aging Males’ Symptoms (AMS) score of ≥27, who were assessed as having LOH syndrome. AMS score, blood hormone level, and other parameters were measured before the start of PPE ingestion, Week 4, and Week 8. And adverse events that occurred during the ingestion period were accumulated. Results: Excluding one subject who withdrew from the study due to an adverse event unrelated to the test food, 14 subjects were included in the analysis. In terms of AMS score, no improvement was observed at Week 4, whereas a significant improvement was observed at Week 8. AMS scores were further categorized into three subscales (psychological, somatic, and sexual) and analyzed. The results showed a significant improvement from baseline in somatic scores at Week 8. Meanwhile, no significant change in sexual hormone levels was observed. At Week 8, improvements from baseline were observed in renal function and LDL cholesterol level. There were no adverse events related to the test food. Conclusion: The study demonstrated that 8-week PPE ingestion in middle-aged and elderly men can improve LOH syndrome symptoms while having little effect on sexual hormone secretion.","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"466 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115322887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation and Interpretation of 9 Body Constitution Scores of CCMQ-J by Seven Independent Questionnaires","authors":"Guang Shi, H. Kyo, Toshihiro Kawasaki, S. Kanaya, Mariko Sato, Saki Tokuda-Kakutani, Hiroshi Watanabe, N. Murayama, Minako Ohashi, Md. Altaf-Ul-Amin, N. Ono, Hiroki Tanaka, Satoshi Nakamura, K. Uebaba, N. Suzuki, Ming Huang","doi":"10.1625/jcam.16.79","DOIUrl":"https://doi.org/10.1625/jcam.16.79","url":null,"abstract":"In this study, we proposed an approach to interpret the classification of body constitution based on the Japanese Version of Constitution in Chinese Medicine Questionnaire (CCMQ-J) in terms of an augmented questionnaire combining seven independent questionnaires. The augmented questionnaire consists of 254 questions in terms of seven categories of attributes, which are the (i) basic information (BI), (ii) disease (DI), (iii) social factors (SO), (iv) mental factors (ME), (v) dietary habits (DH), (vi) sleeping state (SL), and (vii) sub-health (SH). The partial least square (PLS) regression has been adopted to model the correlations between the scores of body constitutions and the questions, and their results show that the body constitution can be represented by the linear combination of the questions substantially (correlation coefficients between the true and predicted constitutions are all above 0.7). Moreover, by using the crowdsourcing technique in data collection, a total of 851 samples (350 males and 501 females between 20 and 85 years old) samples with diverse geographical backgrounds in Japan have been collected, from which new medical implications have been extracted through the discussion in a Traditional Chinese Medicine standpoint. This study serves as a crucial step for validating the philosophy of ancient Chinese medicine by the state-of-the-art information science techniques and facilitating the use of the CCMQ-J in public healthcare.","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124537071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-sectional Study on the Association between the Constitution in Chinese Medicine and the risk factors of Lifestyle Diseases","authors":"Saki Tokuda-Kakutani, Hiroki Tanaka, Satoshi Nakamura, N. Murayama, H. Kyo, K. Uebaba, N. Suzuki, S. Kanaya","doi":"10.1625/jcam.16.95","DOIUrl":"https://doi.org/10.1625/jcam.16.95","url":null,"abstract":"We examined the association of 9 types of the Constitution in Chinese Medicine and body mass index (BMI) and/or the energy intake, which are considered to relate with lifestyle diseases. We obtained data on the Constitution in Chinese Medicine Questionnaire, height, weight, a Food Frequency Questionnaire, age, and exercise habits from 729 subjects through the Internet. We performed multiple comparison tests on the BMIs, the energy intake or the adjusted energy intake for age, height, weight, and exercise habits between types of the Constitution in Chinese Medicine. In women, the BMIs were not significantly different between personality types of the Constitution in Chinese Medicine. In men, the BMI of the yang-deficiency group was significantly lower than the ones of the gentleness, qi-deficiency, or phlegm-dampness groups (p = 0.0098, 0.029, or 0.040, respectively). No significant relationship was found between energy intake or adjusted energy intake and types of the Constitution in Chinese Medicine in men or women. Further studies are required to determine whether the Constitution in Chinese Medicine are useful for reducing risk factors for lifestyle diseases.","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126102496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acne Vulgaris Successfully Cured by Intake of Coix-seed Reactive Derivatives (CRD): A Case-series Study","authors":"N. Suzuki, H. Kyo, K. Uebaba, Shintaro Hashimoto","doi":"10.1625/jcam.16.119","DOIUrl":"https://doi.org/10.1625/jcam.16.119","url":null,"abstract":"Acne Vulgaris Successfully Cured by Intake of Coix-seed Reactive Derivatives (CRD): A Case-series Study Nobutaka SUZUKI, Hoko KYO, Kazuo UEBABA, Shintaro HASHIMOTO 1 Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University Graduate School of Medical Science 2 Urata Clinic, Hospy Medical Association 3 Teikyo Heisei University 4 Daimyomachi skin Clinic To clarify the functions of Coix Reactive Derivatives(CRD), we observed 4 cases of refractory acne vulgaris (case 1. 20 years of age, male/ case 2. 46 years of age, female/ case 3. 20 years of age, male /case 4. 28 years of age, female) successfully cured by intake of CRD for several months. Although CRD intake seemed to be effective in all cases, further studies are needed to define the optimal dose and duration.","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130155456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Optimum Number of Groups on the Crowdsourcing Survey in Japanese People Interpreted by Physical Constitution Defined by CCMQ-J","authors":"Mariko Sato, Toshihiro Kawasaki, Ming Huang, H. Kyo, N. Ono, R. Eguchi, Md. Altaf-Ul-Amin, Saki Tokuda-Kakutani, Hiroshi Watanabe, N. Murayama, Satoshi Nakamura, Shiori Yamaguchi, Hiroki Tanaka, S. Kanaya, Yanbo Zhu, Zhaoyu Dai, Qi Wang, K. Uebaba, N. Suzuki","doi":"10.1625/jcam.16.105","DOIUrl":"https://doi.org/10.1625/jcam.16.105","url":null,"abstract":"Determination of Optimum Number of Groups on the Crowdsourcing Survey in Japanese People Interpreted by Physical Constitution Defined by CCMQ-J Mariko SATO, Toshihiro KAWASAKI, Ming HUANG, Hoko KYO , Naoaki ONO, Ryouhei EGUCHI, Md. Altaf-Ul-Amin, Saki TOKUDA-KAKUTANI, Hiroshi WATANABE, Norihito MURAYAMA, Satoshi NAKAMURA, Shiori YAMAGUCHI, Hiroki TANAKA, Shigehiko KANAYA,Yanbo ZHU, Zhaoyu DAI, Qi WANG, Kazuo UEBABA, Nobutaka SUZUKI Suntory Global Innovation Center Research Group Computational Systems Biology Lab., Graduate School of Science and Technology, Nara Institute of Science and Technology Department of Complementary and Alternative Medicine Clinical R&D, Kanazawa University Graduate School of Medical Science Data Science Center, Nara Institute of Science and Technology Augmented Human Communication Lab.., Graduate School of Science and Technology, Nara Institute of Science and Technology School of Management, Beijing University of Chinese Medicine School of Chinese Medicine, Hong Kong, Baptist University School of Traditional Chinese Medicine, Beijing University of Chinese Medicine Teikyo Heisei University Chinese Medicine Questionnaire (CCMQ-J) consists of sixty independent questionnaires and 9 physical constitutions called subscales. One type is balanced constitution (i.e., gentleness), and the following eight types represent unbalanced constitution: Qi-deficiency constitution, Yang-deficiency constitution, Yin-deficiency constitution, Phlegm-dampness constitution, Damp-heat constitution, Stagnant Blood constitution, Stagnant Qi constitution, and Inherited Special constitution. In this study, we proposed to determine optimal number of groups in 851 participants recruited from crowdsourcing answered CCMQ-J questionnaire consisting of 60 questions. In the present study, we applied k-means clustering with gap statistics to the questionnaire data and the number of optimal groups was estimated by five. The five groups are mainly characterized by 3 subscales in CCMQ-J, i.e. (i) two subscales corresponding to Yang-deficiency and Qi-depress, (ii) three subscales corresponding to gentleness, Yang-deficiency and Qi-depress (iii) Yang-deficiency, (iv) gentleness, and (v) Qi-depress. In the crowdsourcing survey, two subscales, Yangdeficient and Qi-depress are the most frequently occurred in current Japanese people.","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133750865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Safety Test of the Intake of Coix-seed Reactive Derivatives (CRD) in Healthy Adult Volunteers","authors":"N. Suzuki, Hirotaka Okuwa-Hayashi, H. Kyo, K. Uebaba","doi":"10.1625/jcam.16.113","DOIUrl":"https://doi.org/10.1625/jcam.16.113","url":null,"abstract":"Objective: In this study, we evaluated the safety of intake of Coix-seed Reactive Derivatives (CRD) in healthy adult volunteers. Methods: Eight subjects (4 males and 4 females, ages 26.6 ± 4.7) consumed 2.0g CRD/day for 4weeks. We observed weight, vital signs(blood pressure, pulse, body temperature), complete blood count(red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, white blood cell count, and platelet count), hemogram, blood chemistry(Na, K, Cl, AST, ALT, γ -GTP, LDH, ALP, total protein, albumin, A/G, total bilirubin, urea nitrogen, creatinine, cholinesterase, total cholesterol, HDL cholesterol, LDL cholesterol, and neutral fats), coagulation examination (prothrombin time and partial prothrombin time), and urinalysis (sugar, protein, and occult blood in urine). Results: Although several laboratory data (MCHC, MCV and serum creatinine) changed slightly, all of these values were within normal range. Furthermore, no severe adverse effect was observed. Conclusion: These results suggest that CRD intake up to 2g/day is safe in healthy adults. Further study will be needed to define the safety of long-term administration of CRD.","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125445313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Capsaicin on Fat Accumulation in Rats with High Fat Diet and Alcohol","authors":"Yasue Hosoyamada, Masako Yamada","doi":"10.1625/JCAM.16.27","DOIUrl":"https://doi.org/10.1625/JCAM.16.27","url":null,"abstract":"Objectives: We studied the effects of capsaicin (CP) with high fat diets and alcohol (Alc）on the weight of accumulated fat and oxidative stress in rats. Methods: The Sprague-Dawley rats of 4weeks male were fed for 4 weeks with the experimental diets using high fat diet. The rats were divided Control group, CP group, Alc group and CP+Alc group. Alcohol was used as a drinking solution instead of water. The control group was fed without capsaicin. It was measured fat accumulation and oxidative stress in rats. Results: There was no different between each group with respect to the body weigt gain and total foods intake. The posterior abdominal wall fat weight, concentration of liver triglyceride and oxidative stress degree of the CP group and the CP+Alc group were lower significantly than those of the Control group, and those of the CP+Alc group was lower significantly than thoes of the Alc group. Conclusion: These results suggested that the high fat diets and alcohol diets containing the capsaicin appear to effectively decrease the fat accumulation and oxidative stress. The capsaicin were expected to prevent dyslipidemia.","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122385088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}