{"title":"Effects of Dietary Fish Oil and/or Sake Lees on the Concentration of Serum Lipids and Anxiety Behavior in Rats","authors":"Yasue Hososyamada, Masako Yamada","doi":"10.1625/jcam.17.43","DOIUrl":"https://doi.org/10.1625/jcam.17.43","url":null,"abstract":"Effects of Dietary Fish Oil and/or Sake Lees on the Concentration of Serum Lipids and Anxiety Behavior in Rats Yasue HOSOSYAMADA, Masako YAMADA Department of Nutrition, Faculty of Health Care Sciences, Chiba Prefectural University of Health Sciences Department of Food and Nutrition, Faculty of Contemporary Human Life and Science, Tokyo Kasei Gakuin University Objectives: We studied the effects of fish oil and sake lees combined with a high fat diet in rats, and assessed serum lipids concentrations and anxiety behavior. Methods: Male Sprague-Dawley rats aged 5 weeks were fed a diet containing the Soybean oil (Control), Soybean oil + Sake lees (S), Fish oil (FO) or FO + Sake lees (FO+S) for 18days. The control diet contained a soybean oil component. It was measured the concentrations of serum lipids and anxiety behavior. Results: The concentration of serum cholesterol were significantly lower in the FO+S group than in the Control group. The concentration of serum triglyceride and free fatty acids were significantly lower in the FO group and the FO+S group than in the Control group. In anxiety behavior, the stay time in the zone of open arm were significantly higher in the S group than in the","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116804437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Complementary and Alternative Medicine for COVID-19 -We need to hurry to establish the system for outpatient prescription of Avigan-","authors":"N. Suzuki","doi":"10.1625/jcam.17.83","DOIUrl":"https://doi.org/10.1625/jcam.17.83","url":null,"abstract":"","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130151670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Keiichiro Sugimoto, Kazuya Nakagawa, Suguru Fujiwara, K. Sakano, Shukuko Ebihara
{"title":"Safety Assessment of Eucalyptus Leaf Extract Oral Consumption for 4 Weeks in Human Subjects: A Pilot Study","authors":"Keiichiro Sugimoto, Kazuya Nakagawa, Suguru Fujiwara, K. Sakano, Shukuko Ebihara","doi":"10.1625/jcam.17.24","DOIUrl":"https://doi.org/10.1625/jcam.17.24","url":null,"abstract":"Eucalyptus (Eucalyptus globulus Labill.) is an evergreen tree found worldwide. The aqueous ethanolic extract of the leaves (eucalyptus leaf extract; ELE) is used as a functional food, and its active constituents are generally polyphenols. Toxicity and mutagenicity of ELE have been previously assessed using rodents, and no adverse effects were observed. Although clinical trials of low-dose ELE ingestion have been conducted on humans, safety evaluation of high-dose ELE has not yet been conducted. We conducted an open-label clinical trial as a pilot study to assess the safety of excessive oral intake of ELE in Japanese adult men. A powdery preparation of ELE, commercially sold as Eucagrandin ® , was prepared using spray drying method and contained approximately 80% ELE. Test capsules were packed with the powdery ELE. Six male subjects (aged 47.3 ± 12.4 years, mean ± SD) orally consumed 2,592 mg of ELE per day for 4 consecutive weeks. The subjects were examined at the start of the intervention, 4 weeks after the start, and 2 weeks after the last intake of test capsules. adverse reported. the with the of ELE was denied in both events because one event was attributed to a bruise and the other, which was elevated CPK levels, was due to excessive exercise. No unusual changes related to ELE consumption were observed in physical examination and during medical interviews. Further, blood and urine tests were normal during the trial period. These results demonstrated that oral consumption of ELE at the indicated dose is safe for humans.","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124775763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Case Report -A case of COVID-19 treated with Gyokuheifusan-","authors":"N. Suzuki","doi":"10.1625/jcam.17.93","DOIUrl":"https://doi.org/10.1625/jcam.17.93","url":null,"abstract":"","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127164974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Excessive Consumption Test for the Safety of Black Sesame Extract","authors":"Y. Matsumoto, S. Abe, S. Koyanagi","doi":"10.1625/jcam.17.7","DOIUrl":"https://doi.org/10.1625/jcam.17.7","url":null,"abstract":"The The excessive consumption test for the safety of black sesame extract (BSE) was conducted. Eleven healthy adults (male 6,female 5) were orally administered 5 tablets/day of BSE for 4 weeks. There were no abnormal changes in blood and urinary analysis. In addition, no serious adverse effects were observed. These results indicate that the excessive dose of BSE is safe for healthy adults.","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124422094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Suzuki, H. Kyo, Hirotaka Okuwa-Hayashi, K. Uebaba, Shintaro Hashimoto
{"title":"Effect of Coix-seed Reactive Derivatives(CRD) on Cold Sensitivity of Female Hands and Feet: A Randomized Controlled Trial","authors":"N. Suzuki, H. Kyo, Hirotaka Okuwa-Hayashi, K. Uebaba, Shintaro Hashimoto","doi":"10.1625/jcam.17.33","DOIUrl":"https://doi.org/10.1625/jcam.17.33","url":null,"abstract":"","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122327479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Frontline Chinese Herbal Medicine: the Use of Sanyao Sanfang against COVID-19","authors":"心範 謝, 理 山本","doi":"10.1625/jcam.17.73","DOIUrl":"https://doi.org/10.1625/jcam.17.73","url":null,"abstract":"The rapid spread of COVID-19, which was first reported in Wuhan, China, gave unprecedented impacts to the people around the globe. Since no current established treatments nor medications are available, medical professionals are longing for the effective tools to fight against COVID-19. The true value of Chinese herbal medicine can be seen under such tough circumstances. The effects of Sanyao Sanfang, containing various naturally occurring phytochemicals were reported from the epicenter of COVID-19 in China. The distinctive feature of the Sanyao Sanfang is its ability to strengthen vitality of the body and improved resistance against invasive attacks by viruses and microbes. It also promotes activation of the immune system and its recovery to healthy status. It is obvious that the comprehensive effects of the Sanyao Sanfang do not stem from a single substance. Further studies are warranted for clarification of the mechanism and the role of other raw materials, as well as for the improvement of its formulation, efficacy and safety.","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126569638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of Phenolic Compounds in Coix-seed Reactive Derivatives(CRD) by Using Liquid Chromatography/Mass Spectrometry(LC-MS)","authors":"N. Suzuki, M. Takino, Hirotaka Okuwa-Hayashi","doi":"10.1625/jcam.17.11","DOIUrl":"https://doi.org/10.1625/jcam.17.11","url":null,"abstract":"Analysis of Phenolic Compounds in Coix-seed Reactive Derivatives(CRD) by Using Liquid Chromatography/Mass Spectrometry(LC-MS) Nobutaka SUZUKI, Masahiko TAKINO , Hirotaka OKUWA-HAYASHI 3 1 Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University Graduate School of Medical Science 2 Agilent Technologies Japan, Ltd. 3 Faculty of Food Culture, Kurashiki Sakuyo University To clarify the functions of Coix-seed Reactive Derivatives(CRD), we analyzed 13 kinds of phenolic compounds and coixol(an alkaloid) in CRD powder by using Liquid Chromatography/Mass Spectrometry(LC-MS).The following are the results: p -Coumaric acid 275.0 (μg/g), p -Hydroxybenzaldehyde 50.2 (μg/g), Caffeic acid 36.9 (μg/g), Protocatechuic acid 31.9 (μg/g), Ferulic acid 27.1 (μg/g), Quercetin 16.2 (μg/g), Syringaldehyde 12.1 (μg/g), Chlorogenic acid 11.3 (μg/g), Naringenin 11.1 (μg/g), Vanillin 9.2 (μg/g), trans -Coniferylaldehyde 9.1 (μg/g), Tricin 0.7 (μg/g), Luteolin 0.5 (μg/g) and Coixol(6-Methoxy-2-benzoxazolinone) 5.5 (μg/g). CRD is composed of many substances other than these phenoic compounds. Therefore, further studies are needed to understand the various clinical features associated with CRD intake.","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126216827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Complementary and Alternative Medicine for COVID-19 -Kampo medicine-","authors":"N. Suzuki","doi":"10.1625/jcam.17.91","DOIUrl":"https://doi.org/10.1625/jcam.17.91","url":null,"abstract":"","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123511826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Melinjo Seed Extract","authors":"N. Suzuki","doi":"10.1625/jcam.17.1","DOIUrl":"https://doi.org/10.1625/jcam.17.1","url":null,"abstract":"","PeriodicalId":224142,"journal":{"name":"Japanese Journal of Complementary and Alternative Medicine","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134062257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}