The BMJ Pub Date : 2025-07-31 DOI: 10.1136/bmj.r1595

Helen Salisbury

引用次数: 0

No time to waste—we need to start cancer clinical trials faster 没有时间可以浪费了——我们需要更快地开始癌症临床试验

The BMJ Pub Date : 2025-07-31 DOI: 10.1136/bmj.r1598

Ellie Jones, Catherine Elliott, Charles Swanton

{"title":"No time to waste—we need to start cancer clinical trials faster","authors":"Ellie Jones, Catherine Elliott, Charles Swanton","doi":"10.1136/bmj.r1598","DOIUrl":"https://doi.org/10.1136/bmj.r1598","url":null,"abstract":"Cancer clinical trials in the UK are at a critical juncture. They face significant systemic pressures within the NHS and regulatory pathways that threaten efficiency and timeliness. Both commercial and non-commercial trials are vital for advancing cancer treatment and improving patient outcomes. However, non-commercial trials, which are key to tackling rare and hard-to-treat cancers and treatments with limited commercial interest (eg, radiotherapy and surgery), must not be left behind. Clinical trials have been instrumental in the substantial progress made in cancer care over the past 50 years. They have led to a doubling of cancer survival rates and groundbreaking diagnostics and treatments.1 The UK, with its world class research infrastructure and NHS, has been at the forefront of these advances. That position is, however, undermined by delays and inefficiencies in the current system that threaten to hinder this progress.23 The set-up of clinical trials in the UK is a disproportionately complex process involving multiple regulatory approvals, the setting up of contracts between sponsors and partners, and the need to work across numerous NHS sites. Cancer trials, in particular, often require specialised infrastructure such as radiology, pharmacy, and pathology. These challenges are compounded by constraints on resources within the NHS, leading to considerable delays in trial initiation.456 While both commercial and non-commercial trials are affected, the latter—often funded by charities and public institutions—recruit the majority of patients in the UK7 and therefore are the main route for patient access to trial treatments. Accelerating set-up times for these trials is critical. The importance of non-commercial trials cannot be overstated. They investigate …","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Doctor unemployment crisis: moving to New Zealand, living on unemployment benefits, and competing with thousands for roles. 医生失业危机：搬到新西兰，靠失业救济金生活，与成千上万的人竞争职位。

The BMJ Pub Date : 2025-07-31 DOI: 10.1136/bmj.r1608

Ella Hubbard

引用次数: 0

Upending women’s health 颠覆妇女健康

The BMJ Pub Date : 2025-07-31 DOI: 10.1136/bmj.r1605

Jocalyn Clark

引用次数: 0

Physician associate courses suspended by multiple universities after Leng review. 医师副学士课程经冷评后被多所大学暂停。

The BMJ Pub Date : 2025-07-31 DOI: 10.1136/bmj.r1612

Kate Bowie

引用次数: 0

NHS 10 year plan: another lost decade for women’s health 国民保健服务十年计划：妇女健康又一个失去的十年

The BMJ Pub Date : 2025-07-31 DOI: 10.1136/bmj.r1600

Marina Politis, Rachel Hulme, Kate Womersley, Edward Mullins

{"title":"NHS 10 year plan: another lost decade for women’s health","authors":"Marina Politis, Rachel Hulme, Kate Womersley, Edward Mullins","doi":"10.1136/bmj.r1600","DOIUrl":"https://doi.org/10.1136/bmj.r1600","url":null,"abstract":"Modernisation without equity risks deepening health inequalities The NHS 10 year plan promises radical and aspirational transformations in healthcare delivery, but it risks recreating and perpetuating structural bias and data gaps in the health system.1 A plan that is “fit for the future” can’t simply modernise or relocate the tools of healthcare delivery but must examine who the NHS is designed to benefit and who it continues to leave behind. The plan resigns women’s health to reproductive health; of its eight specific mentions of women, half relate to reproductive and maternal health. Although these areas are essential, the plan neglects women’s broader health needs and is silent on current gaps in sex and gender data, with the 2022 women’s health strategy also sidelined.2 The plan’s cursory treatment of women’s health reflects an ongoing male default in health research and delivery and echoes a wider failure to integrate sex and gender disaggregated evidence into clinical practice.34 These oversights lead to inequalities in outcomes by sex and gender across specialties from cardiovascular and neurological diseases to psychiatric and musculoskeletal conditions.5 A major pillar of the plan is its proposal to shift care from the hospital to the community. This …","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CDC: Susan Monarez first non-physician to head agency in 70 years. 美国疾病控制与预防中心：苏珊·莫纳雷斯70年来首位非内科医生担任该机构负责人。

The BMJ Pub Date : 2025-07-31 DOI: 10.1136/bmj.r1613

Janice Hopkins Tanne

引用次数: 0

Frontiers retracts over 100 articles after uncovering "peer review manipulation network". 在发现“同行评议操纵网络”后，前沿撤回了100多篇文章。

The BMJ Pub Date : 2025-07-31 DOI: 10.1136/bmj.r1604

Kate Bowie

引用次数: 0

Reimagining women’s health is a global imperative 重新构想妇女健康是一项全球性的当务之急

The BMJ Pub Date : 2025-07-30 DOI: 10.1136/bmj.r1537

Ru Cheng

{"title":"Reimagining women’s health is a global imperative","authors":"Ru Cheng","doi":"10.1136/bmj.r1537","DOIUrl":"https://doi.org/10.1136/bmj.r1537","url":null,"abstract":"The choices and investments we make to advance women’s health now will define our shared health and prosperity in the future Imagine a world where women and girls do not just survive—they thrive. A world where women live longer, healthier lives because of more rigorous and inclusive research and policies. Where health systems—from London to Nairobi to Jakarta—deliver female centred care, and where conditions that can be detrimental to women’s lives, such as endometriosis, autoimmune diseases, or pregnancy complications, are met with rapid research, timely diagnoses, and effective treatments. It is a world where the health of women, who comprise more than a half of the global population, is just health, not a niche issue. This world is achievable—if we invest in it now. Historically, women’s health in global settings has been under-researched and underfunded.1 The damaging consequences of this include maternal deaths from preventable causes; chronic diseases that go undiagnosed or poorly managed for years; and a lack of affordable, accessible tools that reflect women’s lived realities and preferences across their lifespans.23 We know the fundamental changes that are required in study design and systems to substantially improve women’s health. First, the data must be improved. In October 2023, the …","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reshaping research and development through women’s leadership 通过女性领导重塑研发

The BMJ Pub Date : 2025-07-30 DOI: 10.1136/bmj.r1556

Fara Ndiaye

{"title":"Reshaping research and development through women’s leadership","authors":"Fara Ndiaye","doi":"10.1136/bmj.r1556","DOIUrl":"https://doi.org/10.1136/bmj.r1556","url":null,"abstract":"To achieve equitable health systems women need to be the architects of innovation, not merely its recipients Across the world, women are the foundation of health systems. They serve as caregivers, nurses, frontline responders, and trusted community leaders. In Africa, this reality is even more pronounced. Women provide up to 75% of unpaid care and make up nearly 70% of the health and social workforce in many countries.1 Yet despite this central role in delivering care, women are largely excluded from the upstream processes that shape the health system. Women are strikingly under-represented in leadership and decision making roles in research and development and prioritisation of health funding, including in research institutions, regulatory agencies, national ethics committees, and ministries of health. As a result, the people most engaged in delivering health solutions are often absent from decisions about their design. Closing this leadership gap is a matter of equity as well as strategic necessity. Without women’s leadership, there is potential for bias in understanding and addressing the health needs of half the population, ranging from drug dosing protocols that ignore female physiology to diagnostic tools that overlook symptoms …","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"110 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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