The Brown University Psychopharmacology Update最新文献

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Buprenorphine following ketamine treatment enhances anti-suicidal effects 氯胺酮治疗后服用丁丙诺啡可增强抗自杀效果
The Brown University Psychopharmacology Update Pub Date : 2026-08-03 DOI: 10.1002/pu.31484
{"title":"Buprenorphine following ketamine treatment enhances anti-suicidal effects","authors":"","doi":"10.1002/pu.31484","DOIUrl":"https://doi.org/10.1002/pu.31484","url":null,"abstract":"<p>Patients with major depressive disorder (MDD) who received 4 weeks of buprenorphine treatment following a single infusion of ketamine experienced a significant reduction in suicidal ideation compared with ketamine plus placebo, a randomized, double-blind trial has found. No serious treatment-related adverse events were reported. Study results were published online May 19, 2026 in the <i>American Journal of Psychiatry</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 9","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148662349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-analysis finds ketamine infusions efficacious in treatment of depression 荟萃分析发现氯胺酮输注对治疗抑郁症有效
The Brown University Psychopharmacology Update Pub Date : 2026-08-03 DOI: 10.1002/pu.31487
{"title":"Meta-analysis finds ketamine infusions efficacious in treatment of depression","authors":"","doi":"10.1002/pu.31487","DOIUrl":"https://doi.org/10.1002/pu.31487","url":null,"abstract":"<p>A systematic review and meta-analysis encompassing 26 ran-domized controlled trials (RCTs) has concluded that both single and repeated infusions of ketamine significantly improve suicidality and depressive symptoms in patients with a major depressive episode. Most of the serious adverse events that were reported in the included trials were determined to be unrelated to study treatment.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148662285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-analysis suggests need for personalized dosing in ADHD treatment 荟萃分析表明需要个性化的ADHD治疗剂量
The Brown University Psychopharmacology Update Pub Date : 2026-08-03 DOI: 10.1002/pu.31490
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引用次数: 0
Meta-analysis suggests need for personalized dosing in ADHD treatment 荟萃分析表明需要个性化的ADHD治疗剂量
The Brown University Psychopharmacology Update Pub Date : 2026-08-03 DOI: 10.1002/pu.31490
{"title":"Meta-analysis suggests need for personalized dosing in ADHD treatment","authors":"","doi":"10.1002/pu.31490","DOIUrl":"https://doi.org/10.1002/pu.31490","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148662126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trial suggests effectiveness of psilocybin for cocaine use disorder 试验表明裸盖菇素对可卡因使用障碍有效
The Brown University Psychopharmacology Update Pub Date : 2026-08-03 DOI: 10.1002/pu.31488
{"title":"Trial suggests effectiveness of psilocybin for cocaine use disorder","authors":"","doi":"10.1002/pu.31488","DOIUrl":"https://doi.org/10.1002/pu.31488","url":null,"abstract":"<p>Individuals with cocaine use disorder who received a single dose of psilocybin combined with psychotherapy showed greater reductions in cocaine use relative to active placebo with psychotherapy, a randomized trial has found. No serious adverse events were reported during the trial.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148662276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genotype-guided SSRI prescribing might have long-term benefit 基因型导向的SSRI处方可能具有长期效益
The Brown University Psychopharmacology Update Pub Date : 2026-08-03 DOI: 10.1002/pu.31489
{"title":"Genotype-guided SSRI prescribing might have long-term benefit","authors":"","doi":"10.1002/pu.31489","DOIUrl":"https://doi.org/10.1002/pu.31489","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 9","pages":"6-8"},"PeriodicalIF":0.0,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148662277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approvals 批准
The Brown University Psychopharmacology Update Pub Date : 2026-08-03 DOI: 10.1002/pu.31492
{"title":"Approvals","authors":"","doi":"10.1002/pu.31492","DOIUrl":"https://doi.org/10.1002/pu.31492","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148662280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overprescribing and the ‘mental health crisis’: will deprescribing make America healthy again? 过度处方和“心理健康危机”:减少处方会让美国人恢复健康吗?
The Brown University Psychopharmacology Update Pub Date : 2026-08-03 DOI: 10.1002/pu.31491
Lawrence H. Price M.D.
{"title":"Overprescribing and the ‘mental health crisis’: will deprescribing make America healthy again?","authors":"Lawrence H. Price M.D.","doi":"10.1002/pu.31491","DOIUrl":"https://doi.org/10.1002/pu.31491","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148662368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adjunctive antipsychotics for MDD differ in efficacy and acceptability 辅助抗精神病药物治疗重度抑郁症的疗效和可接受性不同
The Brown University Psychopharmacology Update Pub Date : 2026-08-03 DOI: 10.1002/pu.31485
{"title":"Adjunctive antipsychotics for MDD differ in efficacy and acceptability","authors":"","doi":"10.1002/pu.31485","DOIUrl":"https://doi.org/10.1002/pu.31485","url":null,"abstract":"<p>A systematic review and network meta-analysis has found considerable differences in efficacy and acceptability among atypical antipsychotics used as adjunctive treatment for major depressive disorder (MDD). Lumateperone had the greatest effect size for efficacy, and aripiprazole had the highest level of acceptability. Results of the systematic review and meta-analysis were published online May 6, 2026 in <i>JAMA Psychiatry</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 9","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148662274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New oral anticoagulants and related anxiety symptoms 新型口服抗凝剂及相关焦虑症状
The Brown University Psychopharmacology Update Pub Date : 2026-08-03 DOI: 10.1002/pu.31486
Y. W. Francis Lam Pharm.D., FCCP
{"title":"New oral anticoagulants and related anxiety symptoms","authors":"Y. W. Francis Lam Pharm.D., FCCP","doi":"10.1002/pu.31486","DOIUrl":"https://doi.org/10.1002/pu.31486","url":null,"abstract":"<p>Newer oral anticoagulants (NOACs), now most commonly referred to as direct oral anticoagulants (DOACs), have replaced warfarin in preventing clot formation and minimizing the risk of stroke in patients with atrial fibrillation. Unlike warfarin, which exerts its anticoagulant effect indirectly by inhibiting vitamin K metabolism, DOACs have a direct anticoagulant effect via inhibition of specific coagulation factors such as activated factor II (Iia, thrombin) or activated factor X (Xa). Not only are DOACs highly effective and convenient for patients, they also do not entail the close monitoring of pharmacologic effect required with warfarin. As a result, their use is included in clinical guidelines and favored by clinicians as first-line treatment.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148662275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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