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The Brown University Psychopharmacology Update最新文献

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Despite adverse event risk, anti psychotic polypharmacy has continued to rise 尽管存在不良事件风险，抗精神病药物的使用仍在持续增加
The Brown University Psychopharmacology Update Pub Date : 2025-03-27 DOI: 10.1002/pu.31298
{"title":"Despite adverse event risk, anti psychotic polypharmacy has continued to rise","authors":"","doi":"10.1002/pu.31298","DOIUrl":"https://doi.org/10.1002/pu.31298","url":null,"abstract":"<p>Concurrent use of two or more anti­psychotics has continued to increase over the past 50 years despite its association with a higher risk of adverse events, a systematic review and meta-analysis has found. In comparison with anti­psychotic monotherapy, polypharmacy was associated with higher risk of adverse outcomes such as relapse and psychiatric hospitalization. Results of the review and meta-analysis were published online Nov. 12, 2024, in <i>Lancet Psychiatry</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 5","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychotropic-induced weight gain and telomere length 精神药物引起的体重增加和端粒长度
The Brown University Psychopharmacology Update Pub Date : 2025-03-27 DOI: 10.1002/pu.31299
Y. W. Francis Lam Pharm.D., FCCP
{"title":"Psychotropic-induced weight gain and telomere length","authors":"Y. W. Francis Lam Pharm.D., FCCP","doi":"10.1002/pu.31299","DOIUrl":"https://doi.org/10.1002/pu.31299","url":null,"abstract":"<p>Research suggests that shortening of telomeres, protective cap-like structures at the ends of chromosomes, as well as inflammation, are associated with decreased cellular lifespan, and as such have been implicated in several age-related medical conditions (Gavia-García et al., 2021). A meta-analysis has reported an association between shorter telomere length and several psychiatric conditions, including anxiety, bipolar disorder, depression, post-traumatic stress disorder, and psychosis (Darrow et al., 2016).</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 5","pages":"2-3"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The frustrating disconnect between genetics and psychopharmacology 遗传学和精神药理学之间令人沮丧的脱节
The Brown University Psychopharmacology Update Pub Date : 2025-03-27 DOI: 10.1002/pu.31302
Lawrence H. Price M.D.
{"title":"The frustrating disconnect between genetics and psychopharmacology","authors":"Lawrence H. Price M.D.","doi":"10.1002/pu.31302","DOIUrl":"https://doi.org/10.1002/pu.31302","url":null,"abstract":"<p>Numerous criteria are utilized in selecting articles for coverage in the <i>Update</i>, and those criteria have evolved over time along with the field of psychopharmacology itself. For example, we've been covering an increasing number of papers comparing pharmacotherapy with neuromodulation over the past few years, as more high-quality studies have begun to address that issue. In contrast, our overall coverage of papers examining pharmacokinetics has declined compared with the early years of the <i>Update</i> (although we continue to highlight that topic in our monthly Drug-Drug Interactions column), as the larger field has tended to move on from this issue.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 5","pages":"7-8"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cohort study suggests benefit of earlier initiation of clozapine 队列研究表明早期开始氯氮平的益处
The Brown University Psychopharmacology Update Pub Date : 2025-03-27 DOI: 10.1002/pu.31297
{"title":"Cohort study suggests benefit of earlier initiation of clozapine","authors":"","doi":"10.1002/pu.31297","DOIUrl":"https://doi.org/10.1002/pu.31297","url":null,"abstract":"<p>A population-based cohort study has found that among patients with first-episode schizophrenia who experienced a relapse, continuation of the same treatment or switching to a non-clozapine antipsychotic was not as effective as switching to clozapine in preventing a second relapse. The results call into question the recommendation in treatment guidelines to use clozapine only as third-line treatment. Study results were published in the February 2025 issue of <i>Lancet Psychiatry</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 5","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Xanomeline-trospium significantly improves cognition in acute schizophrenia Xanomeline-trospium可显著改善急性精神分裂症患者的认知能力
The Brown University Psychopharmacology Update Pub Date : 2025-03-03 DOI: 10.1002/pu.31284
{"title":"Xanomeline-trospium significantly improves cognition in acute schizophrenia","authors":"","doi":"10.1002/pu.31284","DOIUrl":"https://doi.org/10.1002/pu.31284","url":null,"abstract":"<p>The drug combining xanomeline and trospium chloride (Cobenfy®) significantly improved cognition relative to placebo in cognitively impaired adults with acute schizophrenia, a study based on data from two Phase 3 trials has found. Changes in cognition were not significantly correlated with changes in symptoms of schizophrenia, study investigators reported. Study results were published online Dec. 11, 2024, in the <i>American Journal of Psychiatry</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Depression study shows influence of patients' treatment expectancies 抑郁症研究显示患者治疗预期的影响
The Brown University Psychopharmacology Update Pub Date : 2025-03-03 DOI: 10.1002/pu.31291
{"title":"Depression study shows influence of patients' treatment expectancies","authors":"","doi":"10.1002/pu.31291","DOIUrl":"https://doi.org/10.1002/pu.31291","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study suggests value of including genetic testing in clozapine monitoring 研究提示基因检测在氯氮平监测中的价值
The Brown University Psychopharmacology Update Pub Date : 2025-03-03 DOI: 10.1002/pu.31290
{"title":"Study suggests value of including genetic testing in clozapine monitoring","authors":"","doi":"10.1002/pu.31290","DOIUrl":"https://doi.org/10.1002/pu.31290","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Varenicline shows best results for smokers with current or past depression 伐尼克兰对目前或过去患有抑郁症的吸烟者效果最好
The Brown University Psychopharmacology Update Pub Date : 2025-03-03 DOI: 10.1002/pu.31287
{"title":"Varenicline shows best results for smokers with current or past depression","authors":"","doi":"10.1002/pu.31287","DOIUrl":"https://doi.org/10.1002/pu.31287","url":null,"abstract":"<p>Among smokers with current or past major depressive disorder, varenicline offered the most favorable combination of efficacy and safety in an analysis of the approved treatment options for smoking cessation. None of the studied treatments resulted in an increased risk of neuropsychiatric adverse events in individuals with a depression history.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"3-4"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Olanzapine plus samidorphan shows long-term safety in patients with schizophrenia 奥氮平加萨米多芬在精神分裂症患者中显示长期安全性
The Brown University Psychopharmacology Update Pub Date : 2025-03-03 DOI: 10.1002/pu.31293
{"title":"Olanzapine plus samidorphan shows long-term safety in patients with schizophrenia","authors":"","doi":"10.1002/pu.31293","DOIUrl":"https://doi.org/10.1002/pu.31293","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nicotinic receptor modulator shows promise in PTSD treatment 尼古丁受体调节剂有望用于PTSD治疗
The Brown University Psychopharmacology Update Pub Date : 2025-03-03 DOI: 10.1002/pu.31294
{"title":"Nicotinic receptor modulator shows promise in PTSD treatment","authors":"","doi":"10.1002/pu.31294","DOIUrl":"https://doi.org/10.1002/pu.31294","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 4","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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