Combining topiramate with prolonged exposure therapy improves PTSD symptoms

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Abstract

Military veterans with comorbid post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) who received topiramate in combination with prolonged exposure therapy (PE) showed greater improvement in PTSD symptoms than those receiving PE alone, a new study has found. The combination treatment did not lead to significant improvement in alcohol use outcomes compared with PE alone. Study results were published online March 19, 2025, in the American Journal of Psychiatry.

托吡酯联合长期暴露治疗可改善PTSD症状
一项新的研究发现,患有创伤后应激障碍(PTSD)和酒精使用障碍(AUD)合并症的退伍军人接受托吡酯联合延长暴露治疗(PE)后,PTSD症状的改善程度比单独接受PE的退伍军人更大。与单独使用PE相比,联合治疗没有导致酒精使用结果的显着改善。研究结果于2025年3月19日在线发表在《美国精神病学杂志》上。
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