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The Brown University Psychopharmacology Update最新文献

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Buprenorphine following ketamine treatment enhances anti-suicidal effects 氯胺酮治疗后服用丁丙诺啡可增强抗自杀效果
The Brown University Psychopharmacology Update Pub Date : 2026-08-03 DOI: 10.1002/pu.31484
{"title":"Buprenorphine following ketamine treatment enhances anti-suicidal effects","authors":"","doi":"10.1002/pu.31484","DOIUrl":"https://doi.org/10.1002/pu.31484","url":null,"abstract":"<p>Patients with major depressive disorder (MDD) who received 4 weeks of buprenorphine treatment following a single infusion of ketamine experienced a significant reduction in suicidal ideation compared with ketamine plus placebo, a randomized, double-blind trial has found. No serious treatment-related adverse events were reported. Study results were published online May 19, 2026 in the <i>American Journal of Psychiatry</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 9","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148662143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-analysis finds ketamine infusions efficacious in treatment of depression 荟萃分析发现氯胺酮输注对治疗抑郁症有效
The Brown University Psychopharmacology Update Pub Date : 2026-08-03 DOI: 10.1002/pu.31487
{"title":"Meta-analysis finds ketamine infusions efficacious in treatment of depression","authors":"","doi":"10.1002/pu.31487","DOIUrl":"https://doi.org/10.1002/pu.31487","url":null,"abstract":"<p>A systematic review and meta-analysis encompassing 26 ran-domized controlled trials (RCTs) has concluded that both single and repeated infusions of ketamine significantly improve suicidality and depressive symptoms in patients with a major depressive episode. Most of the serious adverse events that were reported in the included trials were determined to be unrelated to study treatment.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148662144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approvals 批准
The Brown University Psychopharmacology Update Pub Date : 2026-08-03 DOI: 10.1002/pu.31492
{"title":"Approvals","authors":"","doi":"10.1002/pu.31492","DOIUrl":"https://doi.org/10.1002/pu.31492","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148662284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Semaglutide reduces drinking in adults with alcohol use disorder and obesity 西马鲁肽可减少患有酒精使用障碍和肥胖的成人饮酒
The Brown University Psychopharmacology Update Pub Date : 2026-06-28 DOI: 10.1002/pu.31472
{"title":"Semaglutide reduces drinking in adults with alcohol use disorder and obesity","authors":"","doi":"10.1002/pu.31472","DOIUrl":"https://doi.org/10.1002/pu.31472","url":null,"abstract":"<p>Weekly doses of semaglutide were more effective than placebo in reducing heavy drinking in patients with alcohol use disorder (AUD) and comorbid obesity, a 26-week trial has found. Semaglutide also resulted in improvement in several metabolic measures, including weight and body mass index (BMI). Study results were published online May 2, 2026 in <i>The Lancet</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 8","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study suggests some patients can successfully resume clozapine after neutropenia 研究表明，一些患者在中性粒细胞减少后可以成功地恢复氯氮平
The Brown University Psychopharmacology Update Pub Date : 2026-06-28 DOI: 10.1002/pu.31478
{"title":"Study suggests some patients can successfully resume clozapine after neutropenia","authors":"","doi":"10.1002/pu.31478","DOIUrl":"https://doi.org/10.1002/pu.31478","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustained methylphenidate treatment not linked to risk of psychotic disorder 持续的哌甲酯治疗与精神障碍的风险无关
The Brown University Psychopharmacology Update Pub Date : 2026-06-28 DOI: 10.1002/pu.31480
{"title":"Sustained methylphenidate treatment not linked to risk of psychotic disorder","authors":"","doi":"10.1002/pu.31480","DOIUrl":"https://doi.org/10.1002/pu.31480","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaporized mebufotenin leads to improvement in treatment-resistant depression 汽化甲布丁宁可改善难治性抑郁症
The Brown University Psychopharmacology Update Pub Date : 2026-06-28 DOI: 10.1002/pu.31471
{"title":"Vaporized mebufotenin leads to improvement in treatment-resistant depression","authors":"","doi":"10.1002/pu.31471","DOIUrl":"https://doi.org/10.1002/pu.31471","url":null,"abstract":"<p>An individualized one-day dosing regimen of a vaporized formulation of the psychedelic mebufotenin (5-methoxy-<i>N,N</i>-dimethyltryptamine; 5-MeO-DMT) was more effective than placebo in improving depressive symptoms in adults with treatment-resistant depression, a Phase 2b trial has found. No serious treatment-emergent adverse events were reported during the 7-day study. Results were published online March 2, 2026 in <i>JAMA Psychiatry</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 8","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of child outcomes supports safety of buprenorphine use in pregnancy 儿童结局研究支持丁丙诺啡在妊娠期使用的安全性
The Brown University Psychopharmacology Update Pub Date : 2026-06-28 DOI: 10.1002/pu.31479
{"title":"Study of child outcomes supports safety of buprenorphine use in pregnancy","authors":"","doi":"10.1002/pu.31479","DOIUrl":"https://doi.org/10.1002/pu.31479","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 8","pages":"7-8"},"PeriodicalIF":0.0,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel antipsychotic shows efficacy in Phase 2 schizophrenia trial 新型抗精神病药在ii期精神分裂症试验中显示疗效
The Brown University Psychopharmacology Update Pub Date : 2026-06-28 DOI: 10.1002/pu.31476
{"title":"Novel antipsychotic shows efficacy in Phase 2 schizophrenia trial","authors":"","doi":"10.1002/pu.31476","DOIUrl":"https://doi.org/10.1002/pu.31476","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 8","pages":"6-7"},"PeriodicalIF":0.0,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benzodiazepine use in pregnancy not linked to risk of psychiatric disorders in children 怀孕期间使用苯二氮卓类药物与儿童精神疾病风险无关
The Brown University Psychopharmacology Update Pub Date : 2026-06-28 DOI: 10.1002/pu.31477
{"title":"Benzodiazepine use in pregnancy not linked to risk of psychiatric disorders in children","authors":"","doi":"10.1002/pu.31477","DOIUrl":"https://doi.org/10.1002/pu.31477","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"37 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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