Tanzania Journal of Science最新文献

Modeling the Transmission Dynamics of Tuberculosis in Humans 结核病在人类中的传播动态建模

Tanzania Journal of Science Pub Date : 2024-05-03 DOI: 10.4314/tjs.v50i1.12

Farida Kisinda, Joshua A. Mwasunda, Mbwiga Aloni

{"title":"Modeling the Transmission Dynamics of Tuberculosis in Humans","authors":"Farida Kisinda, Joshua A. Mwasunda, Mbwiga Aloni","doi":"10.4314/tjs.v50i1.12","DOIUrl":"https://doi.org/10.4314/tjs.v50i1.12","url":null,"abstract":"Tuberculosis (TB) is a major threat to human health particularly in most of developing countries. In this article, we formulate and analyze a deterministic model for the transmission dynamics of pulmonary and extra-pulmonary tuberculosis. The next generation method is employed to find the basic reproduction number R0 which helps to determine whether TB clears or persists in the human population. Global stability of model equilibria is done through Lyapunov functions whereas the normalized forward sensitivity index method is adopted to determine parameters that drive tuberculosis. Analysis shows that both TB free and endemic equilibria exist. The TB free equilibrium is globally asymptotically stable whenever the basic reproduction number R0 < 1 whereas the endemic equilibrium is globally asymptotically stable whenever R0 > 1. Sensitivity analysis shows that the TB infection rate, the fraction of individuals who progress to pulmonary tuberculosis and its induced death drive TB. Numerical results indicate that when there are no interventions, susceptible humans decline significantly with time until when they are attracted to the steady state whereas latently infected, pulmonary and extra-pulmonary TB individuals increase until when they settle at the equilibrium states supporting the analytical results for existence of the endemic equilibrium. In light of these findings, we recommend treating humans infected with pulmonary TB who are carriers of the disease.","PeriodicalId":22207,"journal":{"name":"Tanzania Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activated Carbon Based on Borassus aethiopum Shells, Hulls, Kernels and Fruits for Removal of Phenol and 2-Chlorophenol from Water 活性炭去除水中苯酚和2-氯酚的研究

Tanzania Journal of Science Pub Date : 2023-10-27 DOI: 10.4314/tjs.v49i4.2

Ndatiye W. Ndatiye, Lupituko L. Mkayula, Grace A. Kinunda

{"title":"Activated Carbon Based on Borassus aethiopum Shells, Hulls, Kernels and Fruits for Removal of Phenol and 2-Chlorophenol from Water","authors":"Ndatiye W. Ndatiye, Lupituko L. Mkayula, Grace A. Kinunda","doi":"10.4314/tjs.v49i4.2","DOIUrl":"https://doi.org/10.4314/tjs.v49i4.2","url":null,"abstract":"This study aimed at developing activated carbons from Borassus aethiopum shells (BaS), hulls (BaH), kernels (BaK) and fruits (BaF) for removing phenol (Ph) and 2-chlorophenol (2-CP) from aqueous solution. The preparation of the activated carbons involved carbonization of the starting materials at 500 ºC followed by chemical activation at 600 ºC using 0.5 M H3PO4 acid. The prepared activated carbons were found to be mesoporous having pore sizes and surface areas in the range of 3.2 to 3.5 nm and 644 to 740 m2/g, respectively. Thermogravimetric analysis (TGA) thermograms showed that the prepared activated carbons can be applied in the batch solution with a temperature not greater than 500 ºC as above this temperature, the materials decompose. Adsorption experiments showed that the uptake of 100 mg/L of Ph and 2-CP from water is favourable using an adsorbent dose of 0.5 g and a contact time of 6 hours. On the other hand, the batch solution of pH 8 and 6 favoured the adsorption of Ph and 2-CP, respectively. Moreover, the adsorption of the aforementioned adsorbates strongly depended on their initial concentrations and temperature of the batch solution. Equilibrium adsorption isotherms fitted into both Langmuir and Freundlich isotherms, but the Freundlich adsorption model was found to have the highest regression value, hence the best fit.","PeriodicalId":22207,"journal":{"name":"Tanzania Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136318574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidiabetic Potential of Vitex mombassae Fruits Extract in Streptozotocin-Nicotinamide Induced Diabetic Wistar Rat Model 黄荆果实提取物对链脲佐菌素-烟酰胺致糖尿病Wistar大鼠模型的降糖作用

Tanzania Journal of Science Pub Date : 2023-10-27 DOI: 10.4314/tjs.v49i4.1

Mussa B. Mbegeze, Joan J.E. Munissi, Flora Stephano, Ramadhani S.O. Nondo, Stephen S. Nyandoro

{"title":"Antidiabetic Potential of Vitex mombassae Fruits Extract in Streptozotocin-Nicotinamide Induced Diabetic Wistar Rat Model","authors":"Mussa B. Mbegeze, Joan J.E. Munissi, Flora Stephano, Ramadhani S.O. Nondo, Stephen S. Nyandoro","doi":"10.4314/tjs.v49i4.1","DOIUrl":"https://doi.org/10.4314/tjs.v49i4.1","url":null,"abstract":"Besides changes in life styles and improper dietary patterns, the rapidly increasing burden of diabetes mellitus type 2 is correlated with antidiabetic agents currently in clinical use, which are costly, less effective, and present undesirable side effects. Natural products from plants are promising alternative sources for developing more effective and cost friendly antidiabetic agents. This study therefore investigated the antidiabetic potential of Vitex mombassae fruits extract (VMFE) in streptozotocin-nicotinamide induced diabetic Wistar rat model. Oral acute toxicity test was conducted in male Wistar rat using up and down method by following OECD Guideline 423 (2002). No clinical signs of toxicity were observed at 300 and 2000 mg/kg body weight (b.w.) doses used in the assays. The LD50 value was estimated to be ˃ 2000 mg/kg b.w. In evaluation of antidiabetic activity, diabetic Wistar rats were administered with 100, 200 and 300 mg/kg b.w. of VMFE. VMFE resulting into significant lowering of the levels of fasting blood glucose (p < 0.05) and increased of level of high-density lipoprotein-cholesterol (HDL-C), levels of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein-cholesterol (LDL-C) were reduced significantly (p < 0.05). Therefore, this study provides scientific evidence for antidiabetic activities of V. mombassae fruits extracts, and validates its traditional use in the management of diabetes mellitus type 2.","PeriodicalId":22207,"journal":{"name":"Tanzania Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136318733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digitisation of Classical Exercise Practices with STACK: Management of Large Mathematics Classes in Higher Education Institutions 经典习题的STACK数字化:高等院校数学大班管理

Tanzania Journal of Science Pub Date : 2023-10-27 DOI: 10.4314/tjs.v49i4.13

Idrissa S. Amour, Fatuma Simba, Septimi Kitta, Abdi T. Abdalla

{"title":"Digitisation of Classical Exercise Practices with STACK: Management of Large Mathematics Classes in Higher Education Institutions","authors":"Idrissa S. Amour, Fatuma Simba, Septimi Kitta, Abdi T. Abdalla","doi":"10.4314/tjs.v49i4.13","DOIUrl":"https://doi.org/10.4314/tjs.v49i4.13","url":null,"abstract":"Management of large classes’ tutorials is a known problem in Mathematics. Engineering mathematics classes enrol around 1000 students at the University of Dar es Salaam. For effective learning, each tutorial session should register not more than 40 students. This requires at least 25 sessions of tutorials per week, which may not be feasible due to both scarce human resources and venues. In this work, we developed online Mathematics exercises based on the System for Teaching and Assessment using Computer Algebra Kernel (STACK). About 300 STACK questions in linear algebra, calculus, complex numbers, and numerical analysis were constructed for weekly tutorials and quizzes. Students were given an unlimited number of attempts in tutorials and only one attempt for quizzes. The quality of the questions was analysed by examining their facility indices and discriminative efficiencies. Majority of the questions (87%) were within acceptable region. The questions, therefore, provided reasonable insight as appropriate alternative to classical practice. Competent authoring of STACK questions can improve the quality of teaching and learning of Mathematics and save scarce human and material resources required to serve large classes. This can also address the issue of running online programmes in Mathematics and computational subjects to support distance learning.","PeriodicalId":22207,"journal":{"name":"Tanzania Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136318572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scientific Landscape on Phthalates Biodegradation Research: A Bibliometric and Scientometric Study 邻苯二甲酸酯生物降解研究的科学景观:文献计量学和科学计量学研究

Tanzania Journal of Science Pub Date : 2023-10-27 DOI: 10.4314/tjs.v49i4.6

Sai Ngassa, Cyprian Mpinda, Kessy F. Kilulya, Rose Masalu

{"title":"Scientific Landscape on Phthalates Biodegradation Research: A Bibliometric and Scientometric Study","authors":"Sai Ngassa, Cyprian Mpinda, Kessy F. Kilulya, Rose Masalu","doi":"10.4314/tjs.v49i4.6","DOIUrl":"https://doi.org/10.4314/tjs.v49i4.6","url":null,"abstract":"This study investigated the scientific landscape of research on phthalate esters biodegradation using the Web of Science database up to 2022. The collected data were analysed using bibliometric and scientometric tools. A total of 863 scholarly documents published between 1975 and 2022 in 266 journals were selected for analysis. The analysis revealed a growth rate of 6.9% in the research field, with an average document age of 10.8 years. The trend in phthalate biodegradation research showed a steady increase in citations until 1997, followed by a slight decrease until 2005, but experienced renewed interest in 2006 and significant growth in 2016. Chemosphere was identified as the prominent journal, and China had the most publications (417) followed by India (78), while Africa had the least productivity, with South Africa contributing the highest number of publications (9). Thematic evolution in the field focused on understanding the mechanisms of phthalate breakdown through microbial enzymes like hydrolases, while revealing changing patterns with the current research focus being \"microbial community\" and \"metabolism\" as indicated by strongest burstiness strengths. The study sheds light on the scientific landscape of phthalate biodegradation research, highlighting research gaps and suggesting potential research policy improvements such as enhancing funding and capacity building in biodegradation research in Africa.","PeriodicalId":22207,"journal":{"name":"Tanzania Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136318573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical Constituents of Cissus oliveri growing in Pwani Region, Tanzania 坦桑尼亚Pwani地区山羊草的植物化学成分

Tanzania Journal of Science Pub Date : 2023-10-27 DOI: 10.4314/tjs.v49i4.8

Fadhili S. Estomini, Stephen I. Nnungu, Amelia S. Buriyo

{"title":"Phytochemical Constituents of Cissus oliveri growing in Pwani Region, Tanzania","authors":"Fadhili S. Estomini, Stephen I. Nnungu, Amelia S. Buriyo","doi":"10.4314/tjs.v49i4.8","DOIUrl":"https://doi.org/10.4314/tjs.v49i4.8","url":null,"abstract":"Cissus oliveri (Engl.) Gilg ex Engl. is among the plant species of the family Vitaceae widely used in traditional medicine for management of different ailments. This study aimed at assessing the phytochemicals of C. oliveri parts in order to provide scientific validation for its use as a therapeutic agent. Qualitative analysis of water and ethanolic extracts was conducted by using standard methods and the results revealed that all the parts possess alkaloids, flavonoids, phenols and tannins. Similarly, glycosides and saponins were only present in leaf and root. Quantitative analysis performed by gravimetric and spectrophotometric methods showed that all parts contain alkaloids, phenol, and tannins in large quantities. The largest amount was found in leaf for alkaloids (6.47 ± 0.41 mg/g DW) and phenols (4.85 ± 0.90 mg/g DW) compared to stem and root. Alkaloid content was higher in root than in stem (P < 0.01), whereas phenol content was the same in root and stem (p > 0.05). Further, there was no significant difference in tannins content among all the plant parts assessed. The presence and quantities of active phytochemicals in C. oliveri call for further investigations on the bioactivities of the extracts and isolated chemical constituents for potential pharmacological applications.","PeriodicalId":22207,"journal":{"name":"Tanzania Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136318724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Habitat Use and Diet Composition of the Common Eland (Tragelaphus oryx) in Ngorongoro Conservation Area, Tanzania 坦桑尼亚恩戈罗恩戈罗保护区羚羊的生境利用和饮食组成

Tanzania Journal of Science Pub Date : 2023-10-27 DOI: 10.4314/tjs.v49i4.9

Gregory A. Mtega, Cuthbert L. Nahonyo, Steven Temu, George Sangu, John Bukombe

{"title":"Habitat Use and Diet Composition of the Common Eland (Tragelaphus oryx) in Ngorongoro Conservation Area, Tanzania","authors":"Gregory A. Mtega, Cuthbert L. Nahonyo, Steven Temu, George Sangu, John Bukombe","doi":"10.4314/tjs.v49i4.9","DOIUrl":"https://doi.org/10.4314/tjs.v49i4.9","url":null,"abstract":"Ngorongoro Conservation Area (NCA) is renowned worldwide for its multiple land use where pastoralism and wildlife conservation co-exist. Thus, the NCA must meet a delicate balance of competing needs between livestock and wildlife. Currently the NCA is conducting resettlement program to facilitate pastoralists who are willing to move and resettle outside of the conservation area in order to reduce the number of people and livestocks in NCA. The common eland (Tragelaphus oryx) are among the large herbivore species found in the NCA that might be affected by possible competition between livestock and wildlife. The information on this species including habitat utilization and feeding ecology is limited. This study therefore, investigated the factors influencing habitat use and diet composition of the common eland (Tragelaphus oryx) in NCA. Data were collected along 82 pre-established transects using direct field survey. The study therefore assessed habitat use, distribution patterns, diet composition and conservation threats facing the common eland in NCA, The results indicated that the grassland habitat was mainly used by elands (> 85% in both dry and wet seasons), while other habitats were least used (< 15%). Eland diet composition varied significantly among plant species, with the animals most frequently feeding on Themeda triandra but rarely on Vachellia tortilis and Hibiscus aponeurus. The study concludes with recommendations for enhancement of grassland habitat management and reduced anthropogenic activities to enhance eland conservation in NCA.","PeriodicalId":22207,"journal":{"name":"Tanzania Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136318732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Zn and W Doping Levels on Properties of Thermochromic VO2-Based Thin Films Zn和W掺杂水平对热致变色vo2基薄膜性能的影响

Tanzania Journal of Science Pub Date : 2023-10-27 DOI: 10.4314/tjs.v49i4.3

Haji F. Haji, Margaret E. Samiji, Nuru R. Mlyuka

{"title":"Impact of Zn and W Doping Levels on Properties of Thermochromic VO2-Based Thin Films","authors":"Haji F. Haji, Margaret E. Samiji, Nuru R. Mlyuka","doi":"10.4314/tjs.v49i4.3","DOIUrl":"https://doi.org/10.4314/tjs.v49i4.3","url":null,"abstract":"DC magnetron sputtering at a substrate temperature of 425 °C was used to successfully deposit W/Zn-doped VO2 thin films on soda lime glass (SLG) substrates. The aim was to investigate the influence of Zn doping levels on the transition temperature ( ), luminous transmittance (Tlum) and solar transmittance modulation (ΔTsol) of VO2-based thin films. UV/VIS/NIR spectrometer, X-ray Diffraction (XRD), Atomic Force Microscope (AFM), and Rutherford Backscattering Spectroscopy (RBS) were used to characterise the thin films. It was revealed that W/Zn co-doped VO2 thin films with ~ 10.8 at.% Zn showed a luminous transmittance of ~ 40.4%, with excellent solar transmittance modulation of 10.2%. Furthermore, the transition temperature obtained for the Zn and W co-doped VO2 films with ~ 10.8 at.% Zn was lower at 23.1 °C compared to 25.6 °C and 26.8 °C for thin films with ~ 3.9 at.% Zn and ~ 2.8 at.% Zn, respectively. It was not possible to deposit the films with Zn doping level above 10.8 at.% due to some technical limitations. These findings indicate that thin films with a controlled proportion of Zn in the W/Zn co-doped VO2-based thin films have the potential to be employed for applications such as smart windows.","PeriodicalId":22207,"journal":{"name":"Tanzania Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136318575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Residual Feed Intake to Metrics of Tanganyika Shorthorn Zebu Cattle in Maswa and Misungwi Districts, Tanzania 坦桑尼亚Maswa和Misungwi地区坦噶尼喀短刺泽布牛剩余采食量与指标的关系

Tanzania Journal of Science Pub Date : 2023-10-27 DOI: 10.4314/tjs.v49i4.10

Godfrey L. Chasama, Fred D. Chibwana, Aloyce S. Hepelwa, Jestina V. Katandukila

{"title":"Association of Residual Feed Intake to Metrics of Tanganyika Shorthorn Zebu Cattle in Maswa and Misungwi Districts, Tanzania","authors":"Godfrey L. Chasama, Fred D. Chibwana, Aloyce S. Hepelwa, Jestina V. Katandukila","doi":"10.4314/tjs.v49i4.10","DOIUrl":"https://doi.org/10.4314/tjs.v49i4.10","url":null,"abstract":"Increasing competition for feed resources and greenhouse gases pollution have been compelling beef production systems to operate at higher feed utilization. These challenges imply the need to breed cattle for Residual Feed Intake (RFI) to lower feeding costs and enteric methane production per output. To explore relevant indicator traits of RFI, this study investigated the association of RFI to Tanganyika Shorthorn Zebu (TSZ) cattle metrics from the Misungwi and Maswa Districts of Tanzania, where Tarime and Sukuma ecotypes are common. A correlation study involving the fattening of twenty-eight TSZ bulls was conducted at Tanzania Livestock Research Institute -Mabuki. From the animals' body weight and feeding data, regression of daily feed intake on average daily gain and metabolic body weight was analyzed to estimate the animals' RFI. Subsequently, the correlation of RFI to metrics of belly, horn, hip, dewlap and body length was investigated. Residual Feed Intake and Belly Length (BeL) were highly positively correlated, while RFI and Dewlap Depth (DD) were moderately positively correlated. The results indicated prospects for using BeL and DD as indicator traits for RFI. Extensive studies are recommended to analyze the correlation of RFI to hump depth, ear length, muzzle circumference and kidney fat.","PeriodicalId":22207,"journal":{"name":"Tanzania Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136318728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anticancer Potential of the Leaf Extracts from the Selected Croton Species 巴豆叶提取物的抗癌潜力研究

Tanzania Journal of Science Pub Date : 2023-10-27 DOI: 10.4314/tjs.v49i4.11

Peter V. Fayyu, Joan J.E. Munissi, Stephen S. Nyandoro, Flora Stephano

{"title":"Anticancer Potential of the Leaf Extracts from the Selected Croton Species","authors":"Peter V. Fayyu, Joan J.E. Munissi, Stephen S. Nyandoro, Flora Stephano","doi":"10.4314/tjs.v49i4.11","DOIUrl":"https://doi.org/10.4314/tjs.v49i4.11","url":null,"abstract":"The reported investigations were aimed at establishing anticancer potential of the leaf extracts from Croton dictyophlebodes (CDE), C. kilwae (CKE) and C. longipedicellatus ssp austrotanzanicus (CLE). In vitro cytotoxicity assays of the extracts were performed against human laryngeal cancer cell line (HEp-2) and human breast cancer cell line (MCF-7), while in vivo toxicological studies were done using Swiss albino mice (Mus musculus) following the Organization for Economic Cooperation and Development guideline number 423 of 2001. Results for in vitro assays revealed that CDE and CLE induced cytotoxicity to MCF-7 and HEp-2 cell lines at EC50 values of 86 and 63 µg/mL, respectively, while CKE was inactive to HEp-2 cells at 100 µg/mL. For in vivo studies, mice were given calculated doses based on globally harmonized standards and monitored for 14 days to observe signs of toxicity. Haematological analysis was also carried out to obtain information on changes in blood conditions. The findings showed that LD50 for CKE and CDE were > 2000 mg/kg, while for CLE was 175 mg/kg body weight (b.w.). The oral administration of CDE and CKE did not reveal significant changes in haematological parameters of treated mice, while CLE provoked some. Thus, the studied extracts may be considered potential cancer remedies with safety pre-cautions that warrant further investigations.","PeriodicalId":22207,"journal":{"name":"Tanzania Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136318731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0