South Asian Journal of Cancer最新文献

{"title":"Acute Lymphoblastic Leukemia at Birth with KMT2A Gene Rearrangement","authors":"S. Jha, V. Vij, Pronamee Borah, N. Dayal, R. Naithani","doi":"10.1055/s-0043-1768700","DOIUrl":"https://doi.org/10.1055/s-0043-1768700","url":null,"abstract":"Congenital leukemia (CL) is defined as leukemia that is diagnosedwithin 28 days of birth and the causativemutation develops in utero.1Only 20% of CL are lymphoid in origin and usually are characterized by higher white blood cell count, high incidence of central nervous system (CNS) involvement, and strong association with KMT2A, a transcriptional coactivator, which is a positive global regulator of the gene transcription.2 A 34-year-old female delivered 2,680 g female baby at 38 weeks of gestation through normal vaginal delivery. Antenatal history of mother was not significant for any infection, drug, or radiation exposures. Child had a normal APGAR score at birth. Multiple blue, red, or purple firm nodules (blueberry lesions) over head, face, all limbs, and trunk were noted at birth (►Fig. 1). There were no dysmorphic facies. Liver and spleen were palpable 3 and 4 cm below costal margin, respectively. Her complete blood cell (CBC) on day 1 of birth revealed hemoglobin of 9.9 g/dL, total leucocyte counts of 59,900/cu.mm with 66% blasts, and platelet count of 30,000/cu.mm. Bone marrow aspiration done on day 2 of birth revealed 80% blasts. Flow cytometry analysis confirmed precursor B cell acute lymphoblastic leukemia (ALL). Cerebrospinal fluid examination revealed leucocytosis (50 cells/μL) with 83% blast. Cytogenetics revealed t(11, 19) with KMT2A gene rearrangement. She was started on intravenous hydration along with tablet allopurinol. She was started on Interfant 99 protocol on day 7 of birth. She developed fever with tachypnea on day 17 of life during neutropenic phase and succumbed on day 19 of life due to pneumonia and septic shock. CBC and peripheral blood smear of the mother did not show any evidence of leukemia. Both parents’ karyotypes performed to rule out germline mutations were normal. CL is known to be associated with Down syndrome, Noonan syndrome, and other ill-defined constitutional syndromes.3 ALL at early neonatal age is frequently associated","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44913374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E-Procurement of Medical Laboratory Equipment: Experiences from a Tertiary Care Oncology Center in India","authors":"N. Bansal, C. Singh, S. Sancheti, A. Gulia","doi":"10.1055/s-0043-1771443","DOIUrl":"https://doi.org/10.1055/s-0043-1771443","url":null,"abstract":"1Department of Transfusion Medicine, Homi Bhabha Cancer Hospital and Research Centre, Chandigarh, Punjab, India 2Department of Microbiology, Homi Bhabha Cancer Hospital and Research Centre, Chandigarh, Punjab, India 3Department of Oncopathology, Homi Bhabha Cancer Hospital and Research Centre, Chandigarh, Punjab, India 4Department of Surgical Oncology, Homi Bhabha Cancer Hospital and Research Centre, Chandigarh, Punjab, India","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49537620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psycho-oncology/Supportive Care in Head–Neck Cancers Patients Undergoing Radiation Therapy: A Randomized Controlled Trial","authors":"S. Sinha, S. Pandey, S. Salins, N. Salins, J. Deodhar, T. Gupta, S. Laskar, A. Budrukkar, M. Swain, Anuj Kumar, V. Murthy, S. Nair, D. Nair, P. Joshi, P. Chaturvedi, N. Menon, V. Patil, A. Joshi, V. Noronha, K. Prabhash, J. Agarwal","doi":"10.1055/s-0043-1771405","DOIUrl":"https://doi.org/10.1055/s-0043-1771405","url":null,"abstract":"Abstract Shwetabh Sinha An elevated level of distress is associated with poor health-related quality of life (QoL), decreased patient satisfaction, poor treatment compliance, and possible reduced survival. This randomized trial, conducted at a single center in India, enrolled head–neck cancer patients aged > 18 years who were undergoing curative intent radiation therapy, and had significant baseline distress as per the National Comprehensive Cancer Network distress thermometer (distress score ≥ 4). The patients were randomized into the Standard arm (STD), which involved routine assessment by the oncologist, or the Interventional arm (INV), where psycho-oncology/palliative/supportive care referral was done at baseline and every week during treatment. The study's primary endpoint was the proportion of patients having significant distress 6 months' posttreatment. A total of 212 patients were randomized ( n  = 108 STD, n  = 104 INV). At 6 months' post-treatment completion, 90 and 89 were evaluable in the STD and INV, respectively. The median distress score was 2 in both arms at this time point. There was no significant difference in the proportion of patients having significant distress in STD versus INV (9 vs. 15.6%, p  = 0.20). There was an improvement in any symptom measured by the Edmonton Symptom Assessment Score (pain, tiredness, drowsiness, nausea, lack of appetite) and the QoL for the entire cohort with no statistically significant difference between arms for symptoms, QoL, or survival endpoints. Psycho-oncology and palliative/supportive care referral did not impact distress, symptom burden, QoL, or survival at 6 months' posttreatment completion significantly in this randomized trial. Clinical Trial Registry of India Registration number:  CTRI/2016/01/006549.","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48077920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melanotic Neuroectodermal Tumor of Infancy: A Case Report and Literature Review","authors":"Manu Coimbatore Balakrishnan, Sauradeep Das, Zareen A. Lynrah, J. Mishra, P. Kalita, Prachurya Tamuli","doi":"10.1055/s-0043-1771446","DOIUrl":"https://doi.org/10.1055/s-0043-1771446","url":null,"abstract":"Abstract Manu Coimbatore Balakrishnan Melanotic neuroectodermal tumor of infancy (MNTI), first described almost a century back, is of neural crest origin, locally aggressive, a rare biphasic neoplasm of infancy with a slightly higher male preponderance. In the last 100 years since the first description of MNTI, only around 500 cases have been described from 32 countries. We present a 7-month-old female child with 3 × 2 cm hard swelling in the oral cavity and right-side facial region for 3 months. Contrast-enhanced computed tomography scan and contrast-enhanced magnetic resonance imaging scan revealed a hypodense lesion of size 2.5 × 2 × 1.6 cm with relatively well-corticated walls. The lesion appeared to arise from the right maxillary alveolus with erosion of the floor of the maxillary sinus. A 7 × 5 mm tooth was visualized within the lesion. There was minimal enhancement in the postcontrast study. With the following provisional diagnoses—odontogenic keratocyst, dentigerous cyst, and unicystic ameloblastoma—the child underwent excision of the lesion. Intraoperatively, Hopkin's rigid endoscope 4 mm was used to ensure complete tumor removal in the maxillary sinus. Histopathological and immunohistochemistry examination resulted in the diagnosis of MNTI. On 1-year follow-up, the child did not show any signs of recurrence. A high index of suspicion, early diagnosis, and timely treatment are needed to diagnose such a rare tumor, to avoid morbidity, and to plan effective management when an infant presents with facial swelling. It should be complemented with close follow-up to identify recurrence early. Use of endoscope whenever feasible is encouraged by the authors to ensure adequate tumor removal.","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41800698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telangiectatic Osteosarcoma—A Single-Center Experience","authors":"G. Narayanan, Sugeeth M. Thambi, J. Kattoor, Bhaskar Subin Sugath, S. Nair","doi":"10.1055/s-0043-1771386","DOIUrl":"https://doi.org/10.1055/s-0043-1771386","url":null,"abstract":"Abstract Geetha Narayanan Telangiectatic osteosarcoma is an uncommon subtype of osteosarcoma accounting for less than 4% of all cases of osteosarcoma. It is characterized by distinctive radiographic, pathologic features, and prognostic implications. Radiologically and microscopically, it mimics aneurysmal bone cyst. The objective of this study was to study the clinical profile and treatment outcome of patients with telangiectatic osteosarcoma. Thirteen patients were diagnosed with telangiectatic osteosarcoma in the department of medical oncology at a tertiary cancer center in India during a 12-year period. All patients were above 15 years of age. The median age at presentation was 20 years, males were predominant, and the commonest sites of involvement were lower end of femur and upper end of humerus. Ten patients underwent treatment that consisted of neoadjuvant and/or adjuvant chemotherapy with ifosfamide, doxorubicin, cisplatin regimen and limb sparing surgery or amputation. Currently, eight out of ten patients are alive in remission at a median follow-up of 50 months with survival ranging from 18 to 138 months.","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45881908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor-Induced Osteomalacia: A Case Report of Rare Disease and Literature review","authors":"Shivam Bansal, V. Maheshwari, Bishwa Bandhu Niraula, A. Regmi, K. Sridharan, M. Dhingra","doi":"10.1055/s-0043-1768681","DOIUrl":"https://doi.org/10.1055/s-0043-1768681","url":null,"abstract":"Abstract Shivam Bansal Mohit Dhingra Background  Oncogenic osteomalacia term used for tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome of abnormal phosphate metabolism secondary to ectopic endocrine tumors. The diagnosis often becomes difficult due to rarity of occurrence and deficient literature. The reconstruction following resection has its own technical difficulties, which are addressed in this article. Presentation of Case  A 39-year-old female presented with pain in bilateral lower limbs and difficulty in mobilizing. The patient had unexplained hypophosphatemia which was diagnosed due to tumor (arising ectopically in greater trochanter), inducing osteomalacia. She was managed successfully with excision of tumor and reconstruction. The biochemical parameters improved drastically within 5 days and fracture healed in 6 weeks' time. Conclusion  TIO is a debilitating disease with significant morbidity due to prolonged onset to diagnosis interval and difficulty in localizing the causative tumor. So thorough clinico-radiological and laboratory parameter correlation is a necessity. A rapid diagnosis followed by complete surgical excision, which remains the gold standard treatment modality that confers favorable prognosis in most patients, with strict vigilance for recurrence is required.","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42656932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of Serum Leptin, Adiponectin, and Malondialdehyde Levels in Tobacco-Induced Oral Squamous Cell Carcinoma: ELISA-Based Study","authors":"M. Kamboj, G. Sharma, A. Narwal, P. Gill, A. Devi, Jagveer Yadav","doi":"10.1055/s-0043-1768688","DOIUrl":"https://doi.org/10.1055/s-0043-1768688","url":null,"abstract":"Abstract Gitika Sharma Background  Tobacco, a harmful, addictive chemical is responsible for occurrence of oral cancer by triggering inflammation and lipid peroxidation. The aim of the present study is to explore if there exists any difference in serum levels of inflammatory biomarkers such as leptin, adiponectin, and lipid peroxidation marker malondialdehyde (MDA) and also its correlation with oxidative stress in cases of tobacco-induced oral squamous cell carcinoma (OSCC) as compared with tobacco users having no lesion. Materials and Methods  Enrolled participants in this study included a total of 84 subjects (all males and 28 in each group) inclusive of healthy individuals, tobacco users with no lesion, and oral cancer cases. Serum leptin, adiponectin, and MDA levels were measured via enzyme-linked immunosorbent assay method in all subjects. Results  A significant reduction in serum leptin and adiponectin levels in patients with OSCC was observed when compared with tobacco users with no lesions and healthy persons (control). For serum MDA, findings were comparable in control and tobacco consumers with no lesions groups but significantly higher in OSCC cases. The correlation between serum adiponectin, leptin, and MDA levels with body mass index (BMI) was highly significant. In addition, comparison of BMI with serum markers and histopathological grades of OSCC showed significant difference. Conclusion  These present study observations suggest that reduced adiponectin and leptin and elevated serum MDA could serve as valuable markers for both preventive and clinical intervention, and may deserve further investigation for the early diagnosis, treatment, and prognosis of OSCC.","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44977498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pretreatment Systemic Inflammatory Markers, Neutrophil Lymphocyte Ratio, and Platelet Lymphocyte Ratio as a Prognostic Factor in Cervical Cancer: A Retrospective Study","authors":"Sabyasachi Sarkar, Behjet Mirza, S. M. Das, D. Singh, Siddhartha Das","doi":"10.1055/s-0043-1768682","DOIUrl":"https://doi.org/10.1055/s-0043-1768682","url":null,"abstract":"Abstract Dharmendra Singh Inflammation has been recognized as a promoter of the neoplastic process initiation and progression. Neutrophilia, lymphocytopenia, and thrombocytosis are hallmarks of inflammatory reaction. The aim of this study is to find the correlation and prognostic value of pretreatment neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), with the recurrence in carcinoma cervix. Data of 208 biopsy-proven cases of squamous cell carcinoma cervix treated with definitive chemoradiotherapy were retrospectively analyzed. Neutrophil, lymphocyte, and platelet count at diagnosis were recorded and NLR and PLR were calculated. The cutoff value of NLR and PLR were calculated using receiver operator characteristics curve analysis. Correlation between locoregional recurrence (LRR) and NLR and PLR is evaluated. Median age of diagnosis is at 50 years. International Federation of Gynecology Obstetrics stage IIB was the most prevalent stage in this study. The NLR and PLR were statistically significantly affecting the LRR. The cutoff value of NLR was 2.45 with a sensitivity of 82.6% and specificity of 77.7%. The cutoff value for PLR was 140.6 with a sensitivity of 85.5% and specificity of 80.6%. On univariate regression analysis stage ( p  = 0.045), tumor grade ( p  = 0.001), addiction ( p  = 0.024), NLR ( p  < 0.001), and PLR ( p  < 0.001) were associated with LRR. Multivariate regression analysis showed that NLR ( p  = 0.005) risk group and PLR ( p  < 0.001) risk group are independent risk factors associated with LRR. Conclusion  High value of NLR and PLR correlate with poor prognosis in squamous cell carcinoma cervix. Hence, these biomarkers may be used as surrogates for tumor prognosis.","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45352918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histoplasma Infection in a Case of Multiple Myeloma Presenting as a Diagnostic Conundrum","authors":"Manasi C. Mundada, F. Ahmed, Bharat Potturu, Pavan Kumar","doi":"10.1055/s-0043-1761279","DOIUrl":"https://doi.org/10.1055/s-0043-1761279","url":null,"abstract":"Histoplasma is a common dimorphic fungus in the environ-ment. Infection by this fungus in an immunocompetent host might present with fl u-like symptoms or might be innocu-ous. However, in immunocompromised host, itcan cause any of the clinical subtypes: pulmonary, disseminated, or systemic disease. 1 Here we present a case of a patient of multiple myeloma who developed disseminated histoplasmosis post allogenic bone marrow transplant. A 45-year-old gentleman, a known case of pulmonary tuberculosis, who presented with back pain. The patient had taken complete course of ATT. Bone marrow examination showed80%plasmacells.Electrophoresisshowedthepresence of the M band, which was proven to be IgG kappa subtype by immuno fi xation studies. Serum-free light chain ratio was deranged. The patient received induction chemotherapy with bortezomib,lenalidomide,anddexamethasone;however,itdid not achieve complete remission, hence he was advised for autologous stem cell transplant. He underwent stem cell trans-plant,andwasonlenalidomidetherapyfor8months.However, his condition relapsed in 10 months and he was started on pomalidomide4mg withdexamethasonefor 6cycles,followed by single agent pomalidomide 2mg and was on follow-up. Presently, 3.5 years post-transplant, the patient came with persisting thrombocytopenia. Bone marrow showed hypercellular marrow and trephine biopsy showed single granuloma consisting of a few histiocytes with a single giant cell. PAS and GMS staining","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46367925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes and Prognostic Factors of Extensive Stage Small Cell Lung Cancer: A Retrospective Study","authors":"Veena Ps, Sajeed A., Geethi Mh, K. M. J. Krishna, Sivananadan Cd, A. S., Roshni S., Lijeesh Al","doi":"10.1055/s-0043-1768476","DOIUrl":"https://doi.org/10.1055/s-0043-1768476","url":null,"abstract":"Abstract Veena PS Introduction  Small cell lung cancer (SCLC) represents about 15% of all lung cancers. Extensive stage (ES) SCLC represents around 60% of diagnosed SCLC cancers. The median survival in untreated ES SCLC is 2 to 4 months and that of treated cases is 8 to 13 months. Aim and Objectives  This retrospective analysis aims to find out the clinical outcome of patients with ES SCLC and the prognostic factors affecting their survival. Methods  Details of patients registered in the department of radiation oncology from January 1, 2010 to September 30, 2019 were retrieved from the hospital records. This includes the demographic characteristics, treatment received, toxicity, and follow-up details. Results  Two-hundred eighty-three patients were included. Median age of presentation was 62 years. Around 97.5% of patients were men. Smokers constitute 94% of all cases. About 86.9% (246 patients) of cases were not alive at the end of the study period. The median estimated overall survival (OS) was 7 months ± 0.47 (95% confidence interval [CI]: 6.026–7.974) and progression-free survival (PFS) was 5 months ± 0.535 (95% CI: 3.952–6.048). Multivariate analysis showed that Eastern Cooperative Oncology Group performance status (ECOG PS), hyponatremia, number of chemotherapy cycles, consolidative radiotherapy (RT) and prophylactic cranial irradiation (PCI) were found to have prognostic effect on OS. Smoking, ECOG PS, number of chemotherapy cycles, consolidative RT, and PCI were found to have prognostic effects on PFS. Conclusion  There is a difference in OS and PFS patterns of ES SCLC patients among various Indian studies even though the available data is scarce. Our study shows that the OS and PFS of our study population are comparable to other South Indian studies available. PS, serum sodium level, number of chemotherapy cycles, consolidative RT, and PCI were found to be independent prognostic factors for survival of ES SCLC. The identification of these factors will help physicians to tailor treatment.","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48069589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}