South Asian Journal of Cancer最新文献

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Clinical Outcomes of Uterine Body Cancers Treated in a Tertiary Cancer Center. 某三级肿瘤中心治疗子宫体癌的临床效果。
IF 0.5
South Asian Journal of Cancer Pub Date : 2023-01-01 DOI: 10.1055/s-0042-1757550
K Muthulingeshkumar, Jagadesan Pandjatcharam, Latha Chaturvedula
{"title":"Clinical Outcomes of Uterine Body Cancers Treated in a Tertiary Cancer Center.","authors":"K Muthulingeshkumar,&nbsp;Jagadesan Pandjatcharam,&nbsp;Latha Chaturvedula","doi":"10.1055/s-0042-1757550","DOIUrl":"https://doi.org/10.1055/s-0042-1757550","url":null,"abstract":"<p><p>K. Muthulingeshkumar<b>Objectives</b>  This article reports the clinical outcomes of uterine body cancers in South Indian population. The primary outcome of our study was overall survival (OS). The secondary outcomes were disease-free survival (DFS), patterns of recurrence, toxicities of radiation treatment, and the association of patient, disease, and treatment characteristics with survival and recurrence. <b>Materials and Methods</b>  Records of the patients diagnosed as malignancy in uterus and treated with surgery alone or with adjuvant treatment from January 2013 to December 2017 were retrieved after Institute Ethics Committee approval. Demographic, surgical, histopathology, and adjuvant treatment details were retrieved. Patients of endometrial adenocarcinoma were stratified according to the European Society of Medical Oncology/European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology consensus for analysis and overall outcomes irrespective of histology were also analyzed. <b>Statistical Analysis</b>  For the survival analysis, Kaplan-Meier survival estimator was used. Cox regression was used to test the significance of association of factors with outcomes in terms of hazard ratio (HR). <b>Results</b>  A total of 178 patient records were retrieved. The median follow-up of all patients was 30 months (0.5-81 months). The median age of the population was 55 years. Most common histology was endometrioid type of adenocarcinoma (89%), sarcomas comprised only 4%. The mean OS of all patients was 68 months ( <i>n</i>  = 178), median was not reached. Five-year OS was 79 %. Five-year OS rates observed in low, intermediate, high-intermediate, and high-risk were 91, 88, 75, and 81.5%, respectively. The mean DFS was 65 months, median not reached. The 5-year DFS was 76%. The 5-year DFS rates observed were 82, 95, 80, and 81.5% for low, intermediate, high-intermediate, and high-risk, respectively. Univariate analysis using Cox regression showed increase in hazard for death in case of node positivity, HR 3.96 ( <i>p</i> 0.033). The HR for disease recurrence was 0.35 ( <i>p</i>  = 0.042) in patients who had received adjuvant radiation therapy. No other factors had any significant impact on death or disease recurrence. <b>Conclusion</b>  The survival outcomes in terms of DFS and OS were comparable with other Indian and Western data reported in the published literature.</p>","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"12 1","pages":"87-92"},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/73/05/10-1055-s-0042-1757550.PMC9970755.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9368926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cervical Cancer HPV Vaccination and Bhutan. 宫颈癌HPV疫苗接种与不丹。
IF 0.5
South Asian Journal of Cancer Pub Date : 2023-01-01 DOI: 10.1055/s-0043-1764220
Sachin Hingmire, Ugyen Tshomo, Tashi Dendrup, Amol Patel, Purvish Parikh
{"title":"Cervical Cancer HPV Vaccination and Bhutan.","authors":"Sachin Hingmire,&nbsp;Ugyen Tshomo,&nbsp;Tashi Dendrup,&nbsp;Amol Patel,&nbsp;Purvish Parikh","doi":"10.1055/s-0043-1764220","DOIUrl":"https://doi.org/10.1055/s-0043-1764220","url":null,"abstract":"1Department of Medical Oncology, Deenanath Mangeshkar Hospital, Pune, Maharashtra, India 2Department of Gynecology and Surgical Oncology, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan 3Department of Medical Oncology, INHS Asvini, Colaba, Mumbai, Maharashtra, India 4Department of Clinical Hematology, Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, Rajasthan, India","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"12 1","pages":"41-43"},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/73/92/10-1055-s-0043-1764220.PMC9970746.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9368933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Gender Parity in Healthcare: A Chronicle of Escalating Success Rate of Female Radiation Oncologists in India. 医疗保健中的性别平等:印度女性放射肿瘤学家成功率上升的编年史
IF 0.5
South Asian Journal of Cancer Pub Date : 2022-12-31 eCollection Date: 2023-10-01 DOI: 10.1055/s-0042-1756631
Biplab Sarkar, Anirudh Pradhan
{"title":"Gender Parity in Healthcare: A Chronicle of Escalating Success Rate of Female Radiation Oncologists in India.","authors":"Biplab Sarkar, Anirudh Pradhan","doi":"10.1055/s-0042-1756631","DOIUrl":"10.1055/s-0042-1756631","url":null,"abstract":"<p><p>Biplab Sarkar<b>Objectives</b>  This editorial describes the growth pattern of female radiation oncologists (FRO) in India and the prediction of gender equality through a mathematical formulation. <b>Materials and Methods</b>  Among the countries in South Asia, India has the largest population of radiation oncologists (RO), a total of 3,763: 1,286 female and 2,477 male radiation oncologists (MROs), and they are registered with the Association of Radiation Oncologists of India (AROI). The data were analyzed to find the differential and cumulative growth pattern of the FROs and MROs and predict gender equality in radiation oncology. The cumulative growth rate indicates the total number of FROs and MROs by end of every year. Differential growth rate indicates the differential increase in the number of FROs and MROs for a particular year. Annual cumulative and differential growth patterns were plotted as a function of the time, and an analytical functional form was fitted to predict the future growth pattern and achievement of gender equality. <b>Results</b>  AROI registration of FROs and MROs for 2013-2020 were as follows: FRO: MRO 2013-54: 102, 2014-99: 162, 2015-77: 148; 2016-86: 143, 2017-110: 110, 2018-116: 151, 2019-121: 152, 2020 (October)-129: 110. Differential growth pattern between 2013 and 2020 with the average incremental growth rate for FROs and MROs were 12.7 ± 14.8% and 2.1 ± 32.0%. Differential growth rate FRO fits in a power-law exponent 58.6 ×(Power0.3695), where MRO growth pattern showed a saturation [4.7ln(×) + 128.5] . Gender parity among Indian radiation oncologists is likely to be achieved by end of 2027. <b>Conclusions</b>  The present density of FRO in India 34.1% is high compared to developed countries such as the United States (≈26%). It is a big leap for the Indian radiation oncology society tending toward gender parity.</p>","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"1 1","pages":"311-313"},"PeriodicalIF":0.5,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10733059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41476517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is Optimal Cytoreduction Post Neoadjuvant Chemotherapy the Only Prognostic Factor in Advanced Ovarian Cancer? 新辅助化疗后最佳细胞减少是晚期癌症唯一的预后因素吗?
IF 0.6
South Asian Journal of Cancer Pub Date : 2022-12-30 eCollection Date: 2022-07-01 DOI: 10.1055/s-0042-1755291
Pravesh Dhiman, P P Bapsy, C N Patil, Renu Raghupathi
{"title":"Is Optimal Cytoreduction Post Neoadjuvant Chemotherapy the Only Prognostic Factor in Advanced Ovarian Cancer?","authors":"Pravesh Dhiman, P P Bapsy, C N Patil, Renu Raghupathi","doi":"10.1055/s-0042-1755291","DOIUrl":"10.1055/s-0042-1755291","url":null,"abstract":"<p><p>Pravesh Dhiman, DNB (Medical Oncology).<b>Background</b>  Epithelial ovarian cancer (EOC) is one of the leading causes of cancer-related death in women. Approximately 70% of patients with EOC are diagnosed in advanced stage [The International Federation of Gynecology and Obstetrics(FIGO stage III and IV)] with an expected 5-year survival rate of 30%. Numerous studies have shown that survival with neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) is noninferior to primary debulking surgery followed by chemotherapy. <b>Materials and Methods</b>  In this retroprospective observational study, 50 patients with advanced ovarian cancer, diagnosed from January 2012 to January 2015, were included and followed-up till January 2017. Correlation of NACT with patient profile, CA125 levels, clinicopathologic parameters, progression-free survival (PFS), and treatment response was studied. Statistical analysis was performed using log-rank test and Kaplan-Meir survival plots. <b>Results</b>  The extent of cytoreduction significantly correlated with PFS. The PFS was maximum in patients who had optimal cytoreduction (19 months) and 10 months in patients with suboptimal cytoreduction with <i>p</i> -value < 0.05. The survival was not significantly correlated with other parameters such as age, stage, preoperative CA125 levels, and ascites. <b>Conclusions</b>  The extent of cytoreduction following NACT in this study was associated with statistically significant PFS advantage in patients who were able to undergo optimal cytoreduction, but not significantly correlated to other factors such as age, stage, preoperative CA125 levels, and ascites. NACT followed by interval cytoreduction is an important modality affecting survival in advanced EOC. Further studies and longer follow-up are needed to demonstrate survival advantage over standard treatment.</p>","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"11 3","pages":"207-212"},"PeriodicalIF":0.6,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10289404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Driver Mutations in Lung Cancer-Mapping the Way Forward. 肺癌中的驱动突变--绘制前进之路。
IF 0.6
South Asian Journal of Cancer Pub Date : 2022-12-30 eCollection Date: 2022-07-01 DOI: 10.1055/s-0042-1758549
Arun Chandrasekharan
{"title":"Driver Mutations in Lung Cancer-Mapping the Way Forward.","authors":"Arun Chandrasekharan","doi":"10.1055/s-0042-1758549","DOIUrl":"10.1055/s-0042-1758549","url":null,"abstract":"","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"11 3","pages":"181-182"},"PeriodicalIF":0.6,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/48/10-1055-s-0042-1758549.PMC9803547.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10523384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual-Energy X-Ray Absorptiometry and Anthropometry for Assessment of Nutritional Status at Diagnosis in Children with Cancer: A Single-Center Experience from India. 双能x线吸收测量和人体测量用于评估癌症儿童诊断时的营养状况:来自印度的单中心经验。
IF 0.5
South Asian Journal of Cancer Pub Date : 2022-12-02 eCollection Date: 2022-04-01 DOI: 10.1055/s-0042-1757860
Soni Priyanka, Jain Sandeep, Kapoor Gauri, Vishwakarma Gayatri
{"title":"Dual-Energy X-Ray Absorptiometry and Anthropometry for Assessment of Nutritional Status at Diagnosis in Children with Cancer: A Single-Center Experience from India.","authors":"Soni Priyanka, Jain Sandeep, Kapoor Gauri, Vishwakarma Gayatri","doi":"10.1055/s-0042-1757860","DOIUrl":"10.1055/s-0042-1757860","url":null,"abstract":"<p><p>Gauri Kapoor<b>Background</b>  The survival of children with cancer has improved owing to advances in chemotherapy and better supportive care, and nutritional support is an important component of the latter especially in low- and middle-income countries like India. <b>Materials and Methods</b>  A prospective observational study of 137 newly diagnosed children with cancer aged less than 18 years was planned. Nutritional assessment was done using dual-energy X-ray absorptiometry (DXA), anthropometry, and serum albumin. Patients were followed for 3 months for assessment of treatment-related morbidity. <b>Results</b>  Lean body mass (LBM; DXA), mid-upper arm circumference (MUAC), and body mass index detected undernutrition in 44, 45, and 14% patients, respectively. Combination of arm anthropometry (MUAC and triceps skinfold thickness) with serum albumin categorized patients as adequately nourished (32%), moderately depleted (18%), and severely depleted (49%). Patients with hematological malignancy had a higher prevalence of undernutrition but there was no difference in morbidities between the undernourished and adequately nourished children by any parameter. Hypoalbuminemia observed in 25% patients was associated with significant chemotherapy delays ( <i>p</i> , 0.01) and interval admissions ( <i>p</i> , 0.03). Using LBM as a criterion, linear regression analysis revealed MUAC ( <i>R</i> <sup>2</sup>  = 0.681) as the best predictor of undernutrition with lowest standard error. <b>Conclusion</b>  Our study reports undernutrition among two-fifths of newly diagnosed patients of childhood cancer associated with high prevalence of sarcopenia and adiposity. These findings are of utmost clinical relevance in planning interventional strategies.</p>","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"11 2","pages":"164-171"},"PeriodicalIF":0.5,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10319522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Free Fibula Reconstruction for Bone Tumors Involving Humerus: Our Experience 游离腓骨重建治疗肱骨骨肿瘤的经验
IF 0.5
South Asian Journal of Cancer Pub Date : 2022-11-22 DOI: 10.1055/s-0042-1757438
B. Borthakur, Sumanjit S. Boro, Ashutosh Sahewalla
{"title":"Free Fibula Reconstruction for Bone Tumors Involving Humerus: Our Experience","authors":"B. Borthakur, Sumanjit S. Boro, Ashutosh Sahewalla","doi":"10.1055/s-0042-1757438","DOIUrl":"https://doi.org/10.1055/s-0042-1757438","url":null,"abstract":"Abstract Ashutosh Sahewalla Background  Malignant primary bone tumors constitute only 0.2% of all malignancies in adults and approximately 5% of childhood malignancies. The humerus is a common site for malignancies like chondrosarcoma, osteosarcoma, Ewing sarcoma, and metastatic carcinomas. Management consists of multimodality treatment including chemotherapy, radiotherapy, and surgery depending on histology of the tumor and response to therapy. Reconstruction of humerus following oncological resection is a challenging procedure and the surgical options include endoprosthesis, plates, avascular bone grafts, and vascularized autologous bone using microvascular surgery. Materials and Methods  This was a single institutional, retrospective observational study conducted at a tertiary cancer center in Northeast India from June 2018 to March 2020. All the reconstructions were done with free fibular osseous flap. Postoperative outcome was measured with Musculoskeletal Tumor Society (MSTS) scoring. Data was collected from patient records and hospital online reporting system. All data were analyzed using Statistical Package for Social Sciences, version 21. Histograms were used for descriptive statistics; Spearman's correlation was run to determine the relationship between MSTS score and age. Rest of the data was checked with Mann–Whitney and Kruskal–Wallis test. A p -value less than 0.05 was considered as statistically significant at 5% level of significance. Results  Six patients were included in our study ( n  = 6), three of Ewing sarcoma and one each of osteosarcoma, angiosarcoma, and chondrosarcoma. Mean age was 21.7 ± 18.6 years; there was no flap necrosis in the series. One old lady developed nonunion and fracture at the native humerus in follow-up. At the end of 1 year the mean MSTS score of the series was 24.7/30. From data analysis a significant decrease in mean MSTS score was by 0.134 times ( p  = 0.035), been observed with increasing age. The correlation between gender and MSTS score ( p  = 0.325), type of tumor and MSTS score ( p  = 0.490), and location of the tumor and MSTS score ( p  = 0.351) was statistically not significant. Conclusion  Free vascularized fibular graft is an important option for bony reconstruction following tumor resection. In our small series we find it very effective for reconstruction of proximal humerus, particularly in younger patients, when microvascular expertise is present. Following a positive initial experience in humerus reconstruction with free fibular osseus flap a large study population will be considered in near future.","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44863677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large Symptomatic Sclerosing Pneumocytoma in a Young Male Smoker-A Rare and Deceptive Presentation. 年轻男性吸烟者的大症状性硬化性肺细胞瘤-一种罕见且具有欺骗性的表现。
IF 0.5
South Asian Journal of Cancer Pub Date : 2022-10-01 DOI: 10.1055/s-0042-1751029
Sunil Pasricha, Divya Bansal, Ullas Batra, Ankush Jajodia, Venkata Pradeep Babu Koyyala, Anurag Mehta
{"title":"Large Symptomatic Sclerosing Pneumocytoma in a Young Male Smoker-A Rare and Deceptive Presentation.","authors":"Sunil Pasricha,&nbsp;Divya Bansal,&nbsp;Ullas Batra,&nbsp;Ankush Jajodia,&nbsp;Venkata Pradeep Babu Koyyala,&nbsp;Anurag Mehta","doi":"10.1055/s-0042-1751029","DOIUrl":"https://doi.org/10.1055/s-0042-1751029","url":null,"abstract":"Pulmonary sclerosing pneumocyto__ma (PSP) is a rare pulmonary tumor that behaves in a benign fashion and has excellent prognosis. 1 The tumor was historically termed as sclerosing hemangioma by Liebow and Hubbell in 1956.","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"11 4","pages":"378-381"},"PeriodicalIF":0.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a4/f0/10-1055-s-0042-1751029.PMC9902086.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10681643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Once-a-Day Ceftriaxone-Amikacin Combination as Empiric Antibiotic Therapy to Enable Outpatient Management of Febrile Neutropenia in Children-16-Year Experience from a Single Institute. 每日一次头孢曲松-阿米卡星联合用药作为经验性抗生素治疗,使儿童发热性中性粒细胞减少症的门诊管理成为可能——来自单一研究所的16年经验。
IF 0.5
South Asian Journal of Cancer Pub Date : 2022-10-01 DOI: 10.1055/s-0042-1745834
Shailesh Kanvinde, Atul Mulay, Anand Deshpande, Chetan Deshmukh, Sampada Patwardhan
{"title":"Once-a-Day Ceftriaxone-Amikacin Combination as Empiric Antibiotic Therapy to Enable Outpatient Management of Febrile Neutropenia in Children-16-Year Experience from a Single Institute.","authors":"Shailesh Kanvinde,&nbsp;Atul Mulay,&nbsp;Anand Deshpande,&nbsp;Chetan Deshmukh,&nbsp;Sampada Patwardhan","doi":"10.1055/s-0042-1745834","DOIUrl":"https://doi.org/10.1055/s-0042-1745834","url":null,"abstract":"<p><p>Shailesh Kanvinde<b>Background</b>  To enable outpatient department (OPD) management of febrile neutropenia (FN), we used once-a-day (OD) ceftriaxone-amikacin (CFT-AMK) as empiric antibiotic therapy. Our experience over 16-year period is presented. <b>Methods</b>  This was a retrospective study conducted from January2002 to December2017. Inclusion criteria were <18 years of age, undergoing cancer chemotherapy, and having FN. Exclusion criteria were FN after palliative chemotherapy, bone marrow transplantation, or at diagnosis of malignancy. Empiric CFT-AMK was used in all, except those having respiratory distress, hypotension, altered sensorium, paralytic ileus, or clinical evidence of peritonitis. Admission criteria were age <1 year, acute myeloid leukemia (AML) chemotherapy, poor performance status, need for blood transfusions, convenience, insurance, or persistent fever >48 to 72 hours after CFT-AMK. Outcomes analyzed were response (defervescence within 48-72 hours), OPD management, antibiotic upgrade, and mortality. AML diagnosis, >7 days to absolute neutrophil count >0.5 × 10 <sup>9</sup> /L, poor performance status, and malignancy not in remission were considered high-risk FN criteria. <b>Results</b>  CFT-AMK was given in 877/952 (92.2%) FN episodes. Seventy-six percent had hematolymphoid malignancies. Response, antibiotic upgrade, and mortality were seen in 85.7 and 65.5% ( <i>p</i>  < 0.0001), 15 and 45.5% ( <i>p</i>  < 0.0001), and 0 and 2% ( <i>p</i>  = 0.003) of low- and high-risk patients, respectively. Treatment was started in OPD in 52%, of which 21.6% required subsequent admission. Of those initially admitted, early discharge (hospital stay < 5 days) was possible in 24.6%. Forty-one percent episodes were managed entirely on OPD. Overall, 80% of low-risk and 42% of high-risk episodes received treatment wholly or partially on OPD. <b>Conclusion</b>  Our results show empiric OD CFT-AMK allows OPD management for most of the low-risk and a proportion of high-risk FN following chemotherapy in children, without compromising clinical outcomes.</p>","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"11 4","pages":"370-377"},"PeriodicalIF":0.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8a/98/10-1055-s-0042-1745834.PMC9902091.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10689665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Factors for Survival in Patients with Carcinoma Endometrium. 影响子宫内膜癌患者生存的预后因素。
IF 0.5
South Asian Journal of Cancer Pub Date : 2022-10-01 DOI: 10.1055/s-0041-1735563
Aparna Mullangath Prakasan, Minolin Dhas, Krishnapillai M Jagathnathkrishna, Aswin Kumar, Susan Mathews, John Joseph, Suchetha Sambasivan, Francis V James
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