South Asian Journal of Cancer最新文献

{"title":"Retinoblastoma: Poster-Child Tumor of the Low-Middle Income Countries (LMICs)!!!","authors":"Subramaniam Ramanathan, Kalasekhar Vijayasekharan","doi":"10.1055/s-0042-1759848","DOIUrl":"https://doi.org/10.1055/s-0042-1759848","url":null,"abstract":"The adage that ’the place of one’s birth dictates the outcome of one’s cancer’ chimeswell in no cancer better thanpediatric retinoblastoma. Survival outcomes of retinoblastoma (Rb) approaches 100% in high-income countries (HICs), whereas in low-middle income countries (LMICs), which harbor 80% of global retinoblastoma burden, the survival is strikingly dismal.1 Late diagnosis due to cultural or socioeconomic barriers, lack of information at primary care level, poor referral to oncology units secondary to deficient health care system, lack of a retinoblastoma program with multidisciplinary approach, infrastructure and fragmented care are attributed to poor outcomes in a LMIC setting. Irony abounds as retinoblastoma is one of those rare pediatric tumors where implementation of a simple screening program can lead to both preservation of both globe and life. In this issue, Tan RJD et al. from Northern Luzon in Philippines2 report the profile and outcomes of 47 children (53 eyes) with RB, who were offered upfront surgical enucleation/exenteration due to lack of globe salvage options in the hospital. Extraocular RB patients received adjuvant chemotherapy. The mean age of diagnosis for unilateral RB was about 2 years and the mean delay in diagnosis from symptom onsetwasabout10months.Morethan50%of thesepatientshad advanced disease and four/fifths of the eyes were enucleated. Overall survival among the whole cohort was around 50% and none among themwith extra-ocular Rb survived. HazarikaMet al. from India3 report the outcomes of 189RB patients from a tertiary cancer care center, where the median age of presentation was 14 months and the median time to reach thehospital fromsymptomonsetwasonly 49days. Twothird of the patients received computerized tomography(CT) for staging workup. Three-fourth of these patients had advanced intraocular disease, and a third had evidence of extraocular disease at presentation. One-fifth of RB refused treatment and an equal percentage underwent globe salvage. External beam RT and cryotherapy were the focal therapy modality mainly used for globe salvage in these patients. RB affects children between a narrow age range and has a clear natural history, making it an ideal candidate for screening. Given that RB occurs at an age where routine visits to the pediatrician are more common and a definite relationship between early diagnosis and enhanced prognosis for eye salvage and patient survival, screening programs involving pediatricians and relevantmembers of the community (school teachers, community health workers) should be developed. Routine screening for red eye reflex in babies presenting to pediatricians is recommended by the American academy of pediatrics for early detection of Rb.4 However, in a developing country scenario, Chantada et al suggested the key for eradication of extraocular Rb is related more to the possibility of a country’s health care system granting egalitarian access to health care for young mothers and ","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"11 4","pages":"279-280"},"PeriodicalIF":0.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/47/6c/10-1055-s-0042-1759848.PMC9902104.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10689664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonbilharzial Squamous Cell Bladder Cancer: An Indian Experience.","authors":"Saket Mittal,&nbsp;Kanuj Malik,&nbsp;Anand Raja","doi":"10.1055/s-0042-1754338","DOIUrl":"https://doi.org/10.1055/s-0042-1754338","url":null,"abstract":"<p><p>Anand Raja<b>Background</b>  Squamous cell carcinoma represents the second most common histological type of bladder cancer. Nonbilharzial squamous cell carcinomas of bladder are rare histological variant with limited experience. <b>Objective</b>  We aimed to review our experience to determine various treatment patterns and survival outcomes for this malignancy. <b>Methods</b>  Data from patients treated at our center from 1995 to 2016 was collected from patient records and analyzed. Clinicopathological variables, treatment patterns, and follow-up data were extracted. <b>Results</b>  A total of 32 patients were included in the study with a median age of 55.5 years. Hematuria was the most common presentation. Overall, 16 patients underwent radical cystectomy, 8 underwent definitive radiotherapy (RT), 4 received palliative RT, and 4 patients defaulted for any treatment. Surgery conferred better survival rates as compared with RT (31.9 vs. 7.45 months). In the surgical group, only pathological TNM staging was a significant prognostic factor. <b>Conclusion</b>  In localized nonbilharzial squamous cell bladder cancer, radical cystectomy with bilateral pelvic node dissection appears to be treatment modality of choice. Larger series are needed to validate the role of other perioperative modalities.</p>","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"11 4","pages":"322-325"},"PeriodicalIF":0.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9d/a4/10-1055-s-0042-1754338.PMC9902085.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10689660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytogenetics and Molecular Genetics in Pediatric Acute Lymphoblastic Leukemia (ALL) and Its Correlation with Induction Outcomes.","authors":"Ajeitha Loganathan,&nbsp;Rishab Bharadwaj,&nbsp;Arathi Srinivasan,&nbsp;Julius Xavier Scott","doi":"10.1055/s-0042-1754337","DOIUrl":"https://doi.org/10.1055/s-0042-1754337","url":null,"abstract":"<p><p>Arathi Srinivasan<b>Aims</b>  The aim was to study cytogenetics and molecular genetic profile in pediatric B-acute lymphoblastic leukemia (ALL) and correlate it with induction outcomes. <b>Subjects and Methods</b>  A retrospective study of cytogenetics and molecular genetics of 98 children with B-cell ALL from January 2013 to May 2018 was done. Cytogenetics and molecular genetics were done in the bone marrow using multiplex reverse transcription polymerase chain reaction and G-banded karyotyping, respectively. Minimal residual disease (MRD) assessment was done at the end of induction by flowcytometry. <b>Results</b>  Of the 98 children, 83 (84.6%) had evaluable cytogenetics, with 11 (13.25%) being abnormal karyotypes. Of the 11 abnormal karyotypes, seven children (8.4%) had hyperdiploidy, one had hypodiploidy, and three had miscellaneous findings. In molecular genetics, TEL-AML1 (ETV6/RUNX1)[t(12;21)] was the most common fusion gene abnormality (12.2% [12/98]), followed by E2A-PBX1 [t(1;19)] (5%), BCR/ABL1 [t(9;22)] (3%), and MLL-AF4 [t(4;11)] (1%). All the 98 children attained morphologic remission at the end of induction. All children with hyperdiploidy (7/7) attained remission and MRD negativity, but one expired during maintenance chemotherapy of disseminated tuberculosis. The child with hypodiploidy was MRD-positive. Three (25%) children with t (12;21) were MRD-positive. All children with Ph + ALL, t(1:19), and t(4;11) were MRD-negative. Fifty-two children had no detected abnormalities, six of whom had MRD positivity (11.5%). <b>Conclusion</b>  Cytogenetic and molecular genetic subgrouping prognosticates ALL outcomes. Although 25% of TEL-AML + children had MRD positivity, larger studies are required to validate the same. End-of-induction MRD outcomes did not correlate with chromosomal aberrations.</p>","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"11 4","pages":"353-360"},"PeriodicalIF":0.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/27/10-1055-s-0042-1754337.PMC9902080.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10689662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indian Data on HER2 Fluorescence In Situ Hybridization in Invasive Breast Cancer with Immunohistochemically Equivocal Results As Per 2018 ASCO/CAP Guidelines.","authors":"B R Nagarjun,&nbsp;Biren Parikh,&nbsp;Manaswi Nareshkumar Patel,&nbsp;Pina J Trivedi,&nbsp;Dharmesh M Patel","doi":"10.1055/s-0042-1751052","DOIUrl":"https://doi.org/10.1055/s-0042-1751052","url":null,"abstract":"<p><p>Biren Parikh<b>Introduction</b>  Hormonal status and HER2 expression are valuable biomarkers and dictate the management of the patients diagnosed with invasive breast cancer (IBC). It is crucial to identify the patients who truly respond to anti-HER2 targeted therapy. Updated 2018 American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines has recommended certain modifications in HER2 interpretation by fluorescence in situ hybridization (FISH) with concomitant immunohistochemistry (IHC). <b>Objectives</b>  We aimed to evaluate HER2 FISH interpretation in IBC with equivocal IHC results as per 2018 ASCO/CAP recommendations and compare FISH results with hormonal receptor status. <b>Materials and Methods</b>  FISH results of 502 cases of IBC with equivocal IHC report between January 2016 to January 2022 were reviewed retrospectively. FISH results were categorized according to ASCO/CAP guidelines 2018 into five respective groups. <b>Results</b>  FISH testing in IHC equivocal cases showed 219 (43.6%) cases were classic amplified (positive) belonged to group 1, 217(43.2%) cases were classic nonamplified (negative) fell into group 5, 39 (7.8%) and 02 (0.4%) patients were in group 2 (negative) and group 3 (positive), and 25 (5.0%) cases were in group 4 (negative). About 52.1 and 49.3% of cases with estrogen receptor and progesterone receptor positivity were reported as HER2 positive. Among 502 cases, 25 equivocal cases according to the 2013 guidelines were redefined as HER2 negative and 02 (0.4%) cases reported positive were classified negative as per updated 2018 guidelines. <b>Conclusion</b>  Revised 2018 guidelines is helpful in accurate identification of HER2 status and in avoiding targeted therapy in unwarranted cases. Updated 2018 guidelines has removed equivocal HER2-FISH category that has eliminated management dilemma in these cases. Only long-term clinical follow-up will establish the validity of the updated guidelines.</p>","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"11 4","pages":"281-286"},"PeriodicalIF":0.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/94/10-1055-s-0042-1751052.PMC9902087.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10681646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"End-of-Treatment FDG PET-CT (EOT-PET) in Patients with Post-Chemotherapy Masses for Seminoma: Can We Avoid Further Intervention?","authors":"Anjana Joel,&nbsp;Ashish Singh,&nbsp;Julie Hepzibah,&nbsp;Antony Devasia,&nbsp;Santosh Kumar,&nbsp;Birla Roy Gnanamuthu,&nbsp;Anuradha Chandramohan,&nbsp;Arun Jacob Philip George,&nbsp;Nirmal Thampi John,&nbsp;Bijesh Yadav,&nbsp;Ajoy Oommen John,&nbsp;Josh Thomas Georgy,&nbsp;Subhashini John,&nbsp;Raju Titus Chacko","doi":"10.1055/s-0041-1735480","DOIUrl":"https://doi.org/10.1055/s-0041-1735480","url":null,"abstract":"<p><p>Anjana Joel<b>Context</b>  Patients with seminoma present with advanced disease. End-of-treatment (EOT) positron emission tomography-computed tomography (PET-CT) is done to assess response and direct management of post-chemotherapy residual masses. <b>Purpose</b>  This article assesses the utility of EOT PET-CT in the management of post-chemotherapy residual lymph nodal masses seminoma. <b>Materials and Methods</b>  We analyzed all patients with seminoma who underwent an EOT PET-CT from January 2015 to January 2020 at our center and calculated the positive predictive value (PPV) and negative predictive value (NPV) of EOT PET-CT in the entire cohort of patients and among subgroups. <b>Results</b>  A total of 34 male patients underwent EOT PET-CT. Fourteen (41.2%) were stratified as good risk and 20 (58.8%) as intermediate risk. The median follow-up was 23 months (interquartile range: 9.75-53 months). In 23 patients there were residual masses of size more than 3 cm at the EOT PET scan. EOT PET was positive as per the SEMPET criteria in 18 (78%) out of 23 patients. None underwent retroperitoneal lymph node dissection. All four who underwent image-guided biopsy, showed only necrosis on pathology. One patient with positive mediastinal node (standardized uptake value 13.6) had granulomatous inflammation. There was no relapse or progression during this period of follow-up. The NPV for EOT PET-CT for the entire cohort, > 3 cm, and > 6 weeks cutoff were 100%, respectively. The PPV for EOT PET-CT for the entire cohort, > 3 cm residual mass, and > 6 weeks cutoff were 8.7, 11.11, and 6.67%, respectively. <b>Conclusion</b>  EOT PET-CT has a low PPV and high NPV in predicting viable tumor in post-chemotherapy residual masses among patients with seminomatous germ cell tumors. If required, EOT PET positivity can be confirmed by a biopsy or reassessed with a repeat PET-CT imaging to document persistent disease prior to further intervention.</p>","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"11 4","pages":"315-321"},"PeriodicalIF":0.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/90/11/10-1055-s-0041-1735480.PMC9902077.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10681650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis of Liposarcoma Patients in Modern ERA: Single-Center Experience.","authors":"Metin Demir,&nbsp;Denizcan Güven,&nbsp;Burak Yasin Aktaş,&nbsp;Gürkan Güner,&nbsp;Oktay Halit Aktepe,&nbsp;Hakan Taban,&nbsp;Yusuf Karakaş,&nbsp;Sadettin Kılıçkap,&nbsp;Ayşe Kars,&nbsp;Alev Türker,&nbsp;Ömer Dizdar","doi":"10.1055/s-0042-1755467","DOIUrl":"https://doi.org/10.1055/s-0042-1755467","url":null,"abstract":"<p><p><b>Objective</b>  Liposarcomas are relatively rare tumors. Prognostic and predictive factors and treatment options are limited. We herein presented our 10-year experience with liposarcomas. <b>Materials and Methods</b>  Adult patients with liposarcoma treated between 2005 and 2015 in our center were included. Demographic and clinicopathologic features of patients were retrieved from patient files. <b>Statistical Analyses</b>  Outcomes in terms of disease-free survival (DFS) and overall survival (OS) were assessed along with potential prognostic factors using Kaplan-Meier analyses. <b>Results</b>  A total of 88 patients were included. The median age was 52. Rates of well-differentiated (WDLS), dedifferentiated (DDLS), myxoid (MLS), and pleomorphic liposarcomas (PLS) were 42, 9.1, 37.5, and 4.5%, respectively. Only 10% of patients had high-grade tumors and 93% had localized disease. Ninety-six percent of patients ( <i>n</i>  = 84) underwent surgery. Adjuvant chemotherapy was delivered to 16 patients. The most common regimen was ifosfamide-doxorubicin. Recurrences were observed in 30 patients, 21 had local, and 9 had distant metastasis. Five-year DFS of patients with the localized disease was 68%. All patients with PLS had relapses and those had the highest distant relapse rates among all subtypes. Multivariate analysis showed T stage and grade were associated with DFS. Five-year OS of the entire population was 68%. Five-year OS was 79, 76, 50, and 0% in WDLS, MLS, DDLS, and PLS, respectively ( <i>p</i>  = 0.002). <b>Conclusion</b>  Management of liposarcomas is still challenging. Surgery is the mainstay of treatment. Novel effective therapies are needed, particularly in advanced disease settings.</p>","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"11 4","pages":"287-292"},"PeriodicalIF":0.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/8f/10-1055-s-0042-1755467.PMC9902100.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10681651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Modified Killian's Method in the Evaluation of Hypopharyngeal and Supraglottic Cancers.","authors":"Priyanka Schilling Amar,&nbsp;Kamran Asif Syed,&nbsp;Rajiv C Michael","doi":"10.1055/s-0042-1754375","DOIUrl":"https://doi.org/10.1055/s-0042-1754375","url":null,"abstract":"<p><p>Priyanka Schilling Amar<b>Objectives</b>  Hypopharyngeal cancer is one of the upper aerodigestive tract malignancies with the poorest prognosis. The aim of this study was to assess the role of modified Killian's (MK) method in routine, outpatient-based flexible laryngoscopy to improve visualization and assess the extent of supraglottic and hypopharyngeal cancers. <b>Materials and Methods</b>  An observational study was conducted in a tertiary hospital in India where fifty consecutive patients who presented to the outpatient clinic with suspected hypopharyngeal and supraglottic malignancy underwent a conventional laryngoscopy as well as MK method. The site and extent of the tumor on endoscopy were recorded and the videos were graded independently by two investigators on Murono's scale from 1 to 5. A subset of these patients who underwent direct laryngoscopy under general anesthesia was also scored with the above scale. The scores were compared to check the accuracy of flexible laryngoscopy with the MK method in staging cancer. <b>Statistical Analysis</b>  Descriptive statistics were given using mean (standard deviation [SD]) for continuous variables and frequency (percentage) for categorical variables. The difference between the mean scores was analyzed using the paired-t test. The agreement between the scales and the observer, that is, the inter- and intraobserver agreement, was presented with concordance rate and Kappa weighted analysis. <b>Results</b>  In this study, the mean scores of the Murono's scale grading of the conventional method, MK method, and direct laryngoscopy were 1.42 (SD: 0.64), 2.94 (SD: 0.95), and 4.30 (SD: 1.49), respectively, which showed significant improvement in scores with MK method. In addition, the subset analysis demonstrated a significant agreement between direct laryngoscopy and MK method. <b>Conclusion</b>  The MK method is a good diagnostic test and a valuable adjunct to diagnostic flexible laryngoscopy in the evaluation and staging of hypopharyngeal and supraglottic cancers.</p>","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"11 4","pages":"332-335"},"PeriodicalIF":0.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/de/88/10-1055-s-0042-1754375.PMC9902103.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10689663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to: Prognostic Factors for Survival in Patients with Carcinoma Endometrium.","authors":"Aparna Mullangath Prakasan,&nbsp;Minolin Dhas,&nbsp;Krishnapillai M Jagathnathkrishna,&nbsp;Aswin Kumar,&nbsp;Susan Mathews,&nbsp;John Joseph,&nbsp;Suchetha Sambasivan,&nbsp;Francis V James","doi":"10.1055/s-0043-1764147","DOIUrl":"https://doi.org/10.1055/s-0043-1764147","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1055/s-0041-1735563.].</p>","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"11 4","pages":"e1"},"PeriodicalIF":0.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b5/1b/10-1055-s-0043-1764147.PMC9966161.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10851813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Psychological Distress Among Indian Adolescents and Young Adults with Solid Cancer Using the National Comprehensive Cancer Network Distress Thermometer","authors":"S. Shrivastava, A. Elhence, Prutha Jinwala, Shashank Bansal, P. Chitalkar, Shweta Bhatnagar, R. Patidar, V. Asati, P. K. Reddy","doi":"10.1055/s-0042-1756184","DOIUrl":"https://doi.org/10.1055/s-0042-1756184","url":null,"abstract":"\u0000 Purpose The incidence of cancer has increased in India with a visible impact on the young population (aged 15–39 years). The present study aims to evaluate psychological distress among Indian adolescents and young adults (AYAs) with solid cancer using the National Comprehensive Cancer Network (NCCN) distress thermometer.\u0000 Methods The demographic and clinical characteristics of AYAs patients (age 15–39 years) with cancer were recorded. Assessment of psychological distress of patients using the NCCN distress thermometer was performed at three time points over a period of 3 months. Distress thermometer scale and a self-administered questionnaire in English and Hindi languages was handed over to participants at three time points: at treatment commencement (T1), at 1 month, and 3 months (T2 and T3, respectively) into therapy.\u0000 Results Of the 259 patients, 63% were women and 37% men; the median age was 34 years. In total, 71 (27%) were ≤ 24 years old and 188 (73%) were>24 years old. Bone sarcoma (39%) was common cancer in AYA patients aged ≤ 24 years and breast cancer (21%) in >24 years of age. The distress scores in both the groups were the highest at diagnosis (T1) followed by that measured at 1 (T2) and 3 months (T3) after diagnosis. The distress score in the age ≤ 24 years was the highest (6.7) at T1, followed by those measured at T2 (2.6) and T3 (1.1) and among age>24 years was the highest (6.6) at T1, followed by those measured at T2 (2.6) and T3 (1.2). Among AYA patients>24 years old, worry, nervousness, sadness, transportation, and sleep were the top five identified problems and in ≤ 24 years old, the top identified problems were worry, financial support, sleep, nervousness, and sadness.\u0000 Conclusion Adolescents and young adults experience some level of distress associated with the cancer diagnosis, effects of the disease, treatment regardless of the stage and various transitions throughout the trajectory of the disease. The distress thermometer is an easy and useful tool for the assessment of psychological distress in AYA cancers. Early identification of distress burden with the distress thermometer leads to effective interventions in patients with cancer which could improve outcomes including survival in AYAs with cancer in India.","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48203076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ear Keloids Treated with Postoperative Electrons: A Case Series","authors":"Pankaj Vats, A. Sarin, H. Mukundan, Kirti Tyagi, Deboleena Mukherjee, G. Vishwanath","doi":"10.1055/s-0042-1748911","DOIUrl":"https://doi.org/10.1055/s-0042-1748911","url":null,"abstract":"\u0000 Introduction Multiple modalities exist for treating keloids ranging from surgical, medical, chemotherapeutic, and radiation therapy. Different techniques of radiation therapy have been used to treat keloids as an adjuvant to surgical excision. With this case series, we report our experience of using electron beam radiation therapy in this setting.\u0000 Materials and Methods We retrospectively analyzed 16 ear keloids treated in 10 patients from January 2013 to October 2015 with surgical excision followed by electron beam to a dose of 10 Gy in two fractions over two consecutive days in immediate postoperative period. Patients were evaluated for recurrent lesions, cosmesis, and adverse effects.\u0000 Results With a median follow-up of 78 months (range: 67–100 months), recurrent lesion was seen in five cases; a local control rate of 68.75% was seen. Median recurrence-free period was 67 months (range: 12–100 months). Acceptable cosmesis was seen in all cases and no acute or chronic adverse effects were seen.\u0000 Conclusion The large follow-up period in our series establishes the role of electron beam radiation therapy in attaining long-term control in keloid patients. The lower total dose with higher dose per fraction used in our patients has acceptable control along with good cosmesis and absent adverse effects.","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47856800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}