South Asian Journal of Cancer最新文献

{"title":"Retrospective Outcome Analysis of Allogenic Bone Graft","authors":"Vikas Maheshwari, Mohit Dhingra, Divyansh Sharma, Aditya K. S. Gowda, Arun Kurmi, Surabhi Das","doi":"10.1055/s-0043-1772775","DOIUrl":"https://doi.org/10.1055/s-0043-1772775","url":null,"abstract":"Bone bank has become an essential requirement for centers that perform tumor and reconstructive surgeries. It provides allogenic bone procured from cadavers as well as live donors in the form of surgical residues. Thus, we conducted a retrospective observational study on recipients who underwent various reconstructive procedures using fresh frozen allograft obtsined from the live donors through surgical residues in a newly established bone bank. The outcomes of cases operated where allogenic bone grafts were used between January 2018 and November 2020 were analyzed in terms of infection and time taken for the grafts to incorporate, allowing weight-bearing in the lower limbs. A total of 223 grafts were obtained as surgical residues from replacement surgeries and traumatic amputations performed on non-salvageable limbs. Out of these, 70 grafts were transplanted into eligible recipients, who were followed up for at least one year. Among the 70 recipients, 15 were lost to follow-up. The outcome data of the remaining 55 recipients was tabulated, including infections (early, delayed and late) and the achievement of weight-bearing milestones when transplanted in lower limbs. Out of the 55 cases, allografts were used alone in 20 cases, while in 35 cases, they were augmented by implants or cement. Two cases (3.6%) experienced acute infections, and another two cases (3.6%) had chronic infection. The mean time for weight-bearing was found to be 7 months when used alone and 3.5 months when augmented with cement or an implant. Additionally, five patients did not show complete integration of the graft. The results of using allogenic bone graft are quite encouraging, suggesting their potential as biological adjuvants in reconstructive surgeries.","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135534544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurvedic Doctors Cannot Prescribe Allopathic Medicines-National Consumer Dispute Redressal Commission Judgement.","authors":"Purvish M Parikh","doi":"10.1055/s-0043-1772678","DOIUrl":"https://doi.org/10.1055/s-0043-1772678","url":null,"abstract":"<p><p>Purvish M. ParikhWe describe the facts of the matter and the court's decision in a case of an Ayurveda, Yoga & Naturopathy, Unani, Siddha, and Homeopathy (AYUSH) doctor being found guilty of deficiency of service by prescribing allopathic medicines that were associated with known complications. The case details include the allegation, the defense, and the court's judgement. Details of the concerned acts, circulars, and regulations, as well as court case laws, are described. The regulations allow AYUSH doctors to prescribe allopathic medicines under certain circumstances, which were not adhered to in this case.</p>","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"12 2","pages":"100-103"},"PeriodicalIF":0.5,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134649761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical Clinical Consensus Guidelines for the Management of Cancer Associated Anemia in Low- and Middle-Income Countries.","authors":"Purvish Mahendra Parikh, Shyam Aggarwal, Ghanashyam Biswas, Seema Gulia, Vivek Agarwala, Maheboob Basade, P N Mohapatra, Krishna Muddu Vamshi, Arun Warrier, Krishna Prasad, Partha Roy, M V Chandrakant, Hemant Malhotra, Sachin Hingmire, Davinder Paul, Vashista Maniar, Alok Gupta, Soumya S Panda, Aseem Samar, Nitesh Rohatgi, Satya Dattatreya, Manjunath Krishnamurthy, Raja Thirumalairaj","doi":"10.1055/s-0043-1771445","DOIUrl":"10.1055/s-0043-1771445","url":null,"abstract":"<p><p>Purvish M. ParikhCancer-associated anemia (CAA) remains a major unmet need that compromises overall survival (OS) and quality of life (QoL). Currently, available guidelines do not take into consideration the unique challenges in low- and middle-income countries (LMIC). Our CAA patients have to battle preexisting impaired nutritional status, depleted body iron stores, financial limitations, and difficulty in having easily accessible affordable healthcare. Hence, we fulfilled the need of guidelines for LMIC. A group of subject experts were put together, given background literature, met in a face-to-face discussion, voted using Delphi process, and finally agreed on the contents of this guideline document. As many as 50% of cancer patients will have significant anemia (hemoglobin < 10 g/dL) at initial diagnosis. It is most commonly seen with gastrointestinal malignancies, head and neck cancers, and acute leukemias. The hemoglobin falls further after initiation of cancer directed therapy, due to chemotherapy itself or heightened nutritional deficiency. Its evaluation should include tests for complete blood count, red blood cell morphology, reticulocyte count, Coombs test, and levels of vitamin B12 and folic acid. Iron status should be monitored using test to measure serum iron, total iron binding capacity, transferring saturation, and serum ferritin levels. A minimum of 50% of cancer patients with anemia require iron supplements. The preferred mode of therapy is with intravenous (IV) iron using ferric carboxymaltose (FCM). Most patients respond satisfactorily to single dose of 1000 mg. It is also safe and does not require use of a test dose. Significant anemia is found in at least half of all cancer patients in India, South Asian Association for Regional Cooperation region, and other LMIC countries. Its awareness among healthcare professionals will prevent it from remaining undiagnosed (in up to 70% of all cancer patients) and adversely affecting OS and QoL. The benefits of treating them with IV iron therapy are quick replenishment of iron stores, hemoglobin returning to normal, better QoL, and avoiding risk of infections/reactions with blood transfusions. Many publications have proven the value of single-dose FCM in such clinical situations. CAA has been proven to be an independent prognostic factor that adversely affects both QoL and OS in cancer patients. Use of FCM as single IV dose of 1000 mg is safe and effective in the majority of patients with CAA.</p>","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"12 2","pages":"93-99"},"PeriodicalIF":0.6,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134649762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Human Papillomavirus on Survival, Inflammation, and Immune Function in Patients with Cervical Cancer Undergoing Surgery","authors":"Hui Hua, Xiaoyong Lei, Jia Yu, Xinxin Zhang","doi":"10.1055/s-0043-1774709","DOIUrl":"https://doi.org/10.1055/s-0043-1774709","url":null,"abstract":"No studies have examined the impact of human papillomavirus (HPV)-16 and HPV-18 on survival, inflammation biomarkers, and immune function in early-stage cervical cancer patients undergoing surgery. Patients diagnosed with early-stage cervical cancer were screened for high-risk HPV prior to surgery. The influence of HPV infection on survival, inflammatory markers, and immune function was investigated. Findings revealed that patients in the HPV-18 positive subgroup exhibited poorer disease-free survival (DFS) and elevated levels of interleukin-6 and C-reactive protein, along with decreased CD4+ T cells compared to patients who tested negative for HPV-18. Notably, early-stage cervical cancer patients with HPV-18 infection experienced worse DFS, heightened inflammatory markers, and compromised immune function.","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135825918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation and Pilot Validation of Hindi, Marathi, and Bangla Translation of Quality-of-Life EORTC Radiation Proctitis Module (PRT-20) for Routine Clinical Use","authors":"Revathy Krishnamurthy, Rahul Krishnatry, Devankshi Rane, Purva Pawar, Debanjan Chakraborty, Utpal Gaikwad, Suman Ghosh, Aasma Siddiqui, Debanjali Datta, Akanksha Anup, Sayan Das, Shivakumar Gudi, Reena Engineer","doi":"10.1055/s-0043-1771442","DOIUrl":"https://doi.org/10.1055/s-0043-1771442","url":null,"abstract":"The aim of this study was to translate and validate the European Organization for Research and Treatment for Cancer (EORTC) “Radiation Proctitis” (PRT-20) module in Hindi, Marathi, and Bangla languages. The EORTC PRT-20 was translated into Hindi, Marathi, and Bangla using EORTC guidelines. Two separate translators first translated the original questionnaire into the three regional languages, following which a reconciled forward translation was compiled. This reconciled version in each language was then back-translated into English by two other translators. This back-translated version was then compared with the original the EORTC questionnaire for correctness, and the preliminary questionnaires were formed in all three languages. The EORTC translation unit approved the questionnaires. The preliminary questionnaires were administered to 30 patients (10 for each language) diagnosed with rectal or anal canal cancer who had received pelvic radiotherapy and were at risk of developing PRT. None of the patients had seen the questionnaire before. After filling out the questionnaire, each patient was interviewed for difficulty in answering, confusion, understanding, or if any of the questions were upsetting and if patients would have asked the question differently. No changes were suggested for Marathi and Bangla translations. Two modifications were suggested in the Hindi translation, which was then retested in five patients and finalized. All the suggestions were incorporated into the preliminary questionnaires, which were sent back to the EORTC for final approval. After reviewing the entire report of pilot testing for the translated quality-of-life questionaire-PRT-20 in three languages, it was approved by the EORTC translation unit. The translated questionnaires were reliable, with Cronbach α values of 0.767, 0.799, and 0.898 for Hindi, Marathi, and Bangla, respectively. The Hindi, Marathi, and Bangla translations of PRT-20 have been approved by the EORTC and can be used in routine clinical practice.","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135878278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Recurrent Unresectable Oral Cancer with Sequential Targeted Therapy, Surgery, and Metronomic Chemotherapy","authors":"Diksha Dinker, A. Pai, Keshava Rajan, Naveena A. N. Kumar","doi":"10.1055/s-0043-1773793","DOIUrl":"https://doi.org/10.1055/s-0043-1773793","url":null,"abstract":"Abstract Naveena A.N. Kumar A high incidence of locoregional recurrences in oral cavity cancers remains the biggest challenge leading to treatment failures post-surgery and radiotherapy. Our case report elaborates on one such recurrence pattern and the juxtaposition of various modalities applied to successfully not only eradicate the tumor but also to keep the recurrence at bay.","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48473765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the Other Side of the Table.","authors":"Venkata Pradeep Babu Koyyala","doi":"10.1055/s-0043-1773794","DOIUrl":"10.1055/s-0043-1773794","url":null,"abstract":"","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":"1 1","pages":"309-310"},"PeriodicalIF":0.5,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41434424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD20-Negative Primary Bone Marrow Large B Cell Lymphoma: A Report of Two Cases with Review of Literature","authors":"A. Jaiswal, Aastha Gupta, M. Dixit, Govind R. Patel, S. Mohanty","doi":"10.1055/s-0043-1768707","DOIUrl":"https://doi.org/10.1055/s-0043-1768707","url":null,"abstract":"Abstract Aastha Gupta We describe diagnostic and therapeutic challenges in this rare entity of CD20-negative B cell lymphomas. They comprise only 1 to 2% of all B cell lymphoma with four subcategories. However, with an increasing understanding of these cases, novel entities have been recognized. Workup, treatment, and follow-up of two CD20-negative B cell lymphoma cases, including a novel entity, have been described. A novel case of triple expresser CD20-negative B cell lymphoma and plasmablastic lymphoma has been diagnosed. The absence of CD20 leads to the abolishment of the targeted drug (rituximab) from the treatment regimen. These cases render the importance of extensive immunohistochemistry and fluorescence in situ hybridization workup for diagnosis of this rare entity. Treatment also remains a challenge as immunotherapy with CD20-targeted drugs cannot be given.","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48064464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Intraosseous Synovial Sarcoma: Experience from a Tertiary Cancer Center","authors":"Vishnu Ramanujan, S. Soma, Chandrakumar Krishnan, Kanuj Malik, V. Radhakrishnan, A. Raja","doi":"10.1055/s-0042-1757551","DOIUrl":"https://doi.org/10.1055/s-0042-1757551","url":null,"abstract":"Abstract Anand Raja Introduction  Primary intraosseous synovial sarcoma (PISS) is a rare cancer of the bone, with few reported cases across literature. Data from our institute reveals seven indigenous cases. This study aims to evaluate these PISS diagnoses, and to further investigate any histopathological findings and prognostic factors associated with patient survival. Materials and Methods Data from patients diagnosed with PISS at the institute were obtained from January 1995 to December 2016, in the form of a retrospective study. Patient demographics, pathology locations, histological findings, surgical margins, and treatment modalities were audited as variables that can impact patient survival. Results This research identified seven cases which fulfilled the diagnostic criteria and were subsequently classified as PISS of the bone. There were five men and two women among the cases, with ages ranging from 16 to 46 years, with a mean of 29.6 years. The study found that the lower limb was the most affected site in PISS, followed by the pelvis. Limb salvage was performed in six patients and one patient underwent amputation. Of these patients, six received adjuvant chemotherapy and four received adjuvant radiation as per institution guidelines. The study found that the 5-year disease-free and overall survival rate was 80 and 61%, respectively. Conclusion PISS is a rare malignancy with limited cases in literature, and hence, there is no evidence for a standardized management protocol. The survival rates were similar between soft tissue and intraosseous synovial sarcoma among the case series.","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43033337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance Imaging Spectrum of Cauda Equina and Conus Lymphoma: Keys to Unravel the Differential Diagnosis with a Review of the Literature","authors":"Deb K. Boruah, Pallavi Gogoi, Bidyut B. Gogoi, K. Sarma, G. Sarma, Karuna Hazarika, Augstine A., H. Ahmed","doi":"10.1055/s-0043-1771406","DOIUrl":"https://doi.org/10.1055/s-0043-1771406","url":null,"abstract":"Abstract Deb K. Boruah Central nervous system lymphoma is not an uncommon condition, but spinal lymphoma with isolated involvement of the conus medullaris and cauda equina is a rare entity. Our study aims to evaluate the various magnetic resonance imaging (MRI) features of cauda equina and conus lymphoma. This retrospective study was carried out on nine patients with histopathologically proven cauda equina and conus lymphoma, who were presented at a tertiary care hospital between January 2018 and June 2020. All patients underwent lumbar spine MRI scans using a 1.5 Tesla MR scanner. The clinical data and different MRI findings were analyzed with an independent sample t -test and paired-samples t -test. Among the nine patients with cauda equina and conus lymphoma, three had primary lymphoma and six had secondary lymphoma. Six patients (66.7%) showed a diffuse pattern of involvement of cauda equina and conus medullaris, while three patients (33.3%) showed a focal pattern. T2-weighted imaging (T2WI) hypo to isointense signal intensity lesions were observed in six patients (66.7%) and T2WI iso to slight hyperintensities in three patients (33.3%). Diffuse sheet-like thickening and postcontrast enhancement of the thickened cauda equina nerve roots were observed in two patients of primary and one patient with secondary lymphoma. The diagnosis of cauda equina and conus lymphoma especially primary lymphoma is challenging and requires a high index of clinical suspicion as distinguishing this entity from similar conditions is difficult solely on MRI. Early diagnosis of this entity is important for early institution of treatment for increasing the chances of survival and improvement of symptoms.","PeriodicalId":22053,"journal":{"name":"South Asian Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47396566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}