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Comment on: “Sport-Specific Impact Loading is Associated with Bone Mineral Density in Athletes: Implications for Relative Energy Deficiency in Sport (REDs) Assessment” 评论:“运动特异性冲击负荷与运动员骨密度有关:运动中相对能量缺乏(red)评估的含义”
IF 9.8 1区 医学
Sports Medicine Pub Date : 2026-09-23 DOI: 10.1007/s40279-026-02537-x
Nizhou Jiang,Yanchao Zhang,Lei Li
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引用次数: 0
Response to Comment on: “Sport-Specific Impact Loading is Associated with Bone Mineral Density in Athletes: Implications for Relative Energy Deficiency in Sport (REDs) Assessment” 对“运动特异性冲击负荷与运动员骨密度有关:运动中相对能量缺乏(red)评估的含义”评论的回应
IF 9.8 1区 医学
Sports Medicine Pub Date : 2026-09-23 DOI: 10.1007/s40279-026-02536-y
Trent Stellingwerff,Ming-Chang Tsai,Walter T. P. McCluskey,Louise M. Burke,Matthew D. Fliss,Kathryn E. Ackerman,Ida A. Heikura
{"title":"Response to Comment on: “Sport-Specific Impact Loading is Associated with Bone Mineral Density in Athletes: Implications for Relative Energy Deficiency in Sport (REDs) Assessment”","authors":"Trent Stellingwerff,Ming-Chang Tsai,Walter T. P. McCluskey,Louise M. Burke,Matthew D. Fliss,Kathryn E. Ackerman,Ida A. Heikura","doi":"10.1007/s40279-026-02536-y","DOIUrl":"https://doi.org/10.1007/s40279-026-02536-y","url":null,"abstract":"","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":"6 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision Prevention for Health: The Global Alliance Framework for the Promotion of Physical Activity. 精准预防促进健康:促进身体活动全球联盟框架。
IF 11 1区 医学
Sports Medicine Pub Date : 2026-09-21 DOI: 10.1007/s40279-026-02495-4
Jürgen M Steinacker, Willem van Mechelen, Lars Engebretsen, Evert Verhagen, Mats Börjesson, Marcela González-Gross, Mark R Hutchinson, Petra Zupet, Herbert Löllgen, Dina C Janse van Rensburg, Norbert Bachl, Sergio Migliorini, Pieter D'Hooghe, Christian Schneider, Jiao Jiao, Ka Ki Wong, Jeroen Swart, Leigh Gordon, Victoria Badtieva, Borja Muniz-Pardos, Tony Lei Shi, Li Xiangchen, Feng Qiang, Guoping Li, Minhao Xie, Xia Zhang, Uğur Erdener, Federica Fagnani, Fabio Pigozzi, Chiara Fossati, Luigi Di Luigi, Francisco Arroyo, Jean-François Kaux, Camille Tooth, Shulin Cheng, Xiuqiang Wang, Emin Ergen, Bülent Ülkar, Frederic Dutheil, Ruediger Reer, Theodora Papadopoulou, Clea Papaellina, Demitri Constantinou, Jason Constantinou, Merling Phaswana, Mamosilo Lichaba, Philippe Gradidge, Mandisa Simamane, Georgia Torres, Natalia Neophytou, Elelwani D Nevhufumba, Bernhard Schwaab, José Antonio Casajús Mallen, Martin Halle, Martine Duclos, Daniel Neunhaeuserer, Andrea Ermolao, Francesca Battista, Federica Duregon, Julio Motta-Pensabene, Yiannis Koutedakis, Lena Tepohl, Wilhelm Bloch, Nicolaas P Pronk, Anastasia Fischer, Lisset Pantoja-Arévalo, Ana V Cintrón, Adewale S Adebero, Jill Borresen, Johannes Zwerver, Diana M Ramos-Caballero, Erica M Mancera-Soto, Pedro Manonelles, Benedict Tan, Ingrid Burrowes, Carl Ward, Kim R Quimby, Christina Howitt, Robert Clive Landis, Hans Hauner, Mikio Hiura, Luz Divina De La Cruz Lastre, Gunnar Treff, Fotini Tsofliou, José Kawazoe Lazzoli, Umutcan Kayıkçı, Mourad Ghrairi, Vincent Onywera, Robert Ojiambo, Robert Sallis, Sophia Papamichalopoulos, Maher Zahar, Christine Joisten, Bernd Wolfarth, Sandra Rozenstoka, Hashel Al Tunaiji, Kiera Wason, Felix Drummond, Wolfgang Schobersberger, Vahur Ööpik, Eve Unt, Anna Jegier, Stéphane Doutreleau, Seung Hoon Han, Jörg F Debatin, Nils Schumacher, Luís B Sardinha, Lenka Dienstbach-Wech, Tuba Melekoğlu, Sheng Zeng, Maurizio Casasco, Kristy Howells, Eva-Maria Klinkisch, James Bilzon, Gregory Heath, Thomas Horstmann, Eduardo H De Rose, Nick Webborn, Klaus-Michael Braumann, Li Jing, Xiao Xu, Elizabeth Moxley, Yi Zheng, Alison V September, Malcolm Collins, Olena Andrieieva, Svitlana Drozdovska, Andreas Michael Nieß, Rikke Helene Moe, Carolin Knoke, Silvano Zanuso, Francesco Zanatta, Veronika Všetíčková, Spyridon Zormpas, Christoforos D Giannaki, Brian P Carson, Matthew P Herring, Ciara McCormack, Marco Vecchiato, Thomas Yvert, Makro Korenjak, Benjamin Billet, Andréia Lópes Azevedo, Naama Constantini, Sigmund Loland, Aaron Leigh Baggish, Luis Monteiro, Nuray Yazihan, Yannis P Pitsiladis
{"title":"Precision Prevention for Health: The Global Alliance Framework for the Promotion of Physical Activity.","authors":"Jürgen M Steinacker, Willem van Mechelen, Lars Engebretsen, Evert Verhagen, Mats Börjesson, Marcela González-Gross, Mark R Hutchinson, Petra Zupet, Herbert Löllgen, Dina C Janse van Rensburg, Norbert Bachl, Sergio Migliorini, Pieter D'Hooghe, Christian Schneider, Jiao Jiao, Ka Ki Wong, Jeroen Swart, Leigh Gordon, Victoria Badtieva, Borja Muniz-Pardos, Tony Lei Shi, Li Xiangchen, Feng Qiang, Guoping Li, Minhao Xie, Xia Zhang, Uğur Erdener, Federica Fagnani, Fabio Pigozzi, Chiara Fossati, Luigi Di Luigi, Francisco Arroyo, Jean-François Kaux, Camille Tooth, Shulin Cheng, Xiuqiang Wang, Emin Ergen, Bülent Ülkar, Frederic Dutheil, Ruediger Reer, Theodora Papadopoulou, Clea Papaellina, Demitri Constantinou, Jason Constantinou, Merling Phaswana, Mamosilo Lichaba, Philippe Gradidge, Mandisa Simamane, Georgia Torres, Natalia Neophytou, Elelwani D Nevhufumba, Bernhard Schwaab, José Antonio Casajús Mallen, Martin Halle, Martine Duclos, Daniel Neunhaeuserer, Andrea Ermolao, Francesca Battista, Federica Duregon, Julio Motta-Pensabene, Yiannis Koutedakis, Lena Tepohl, Wilhelm Bloch, Nicolaas P Pronk, Anastasia Fischer, Lisset Pantoja-Arévalo, Ana V Cintrón, Adewale S Adebero, Jill Borresen, Johannes Zwerver, Diana M Ramos-Caballero, Erica M Mancera-Soto, Pedro Manonelles, Benedict Tan, Ingrid Burrowes, Carl Ward, Kim R Quimby, Christina Howitt, Robert Clive Landis, Hans Hauner, Mikio Hiura, Luz Divina De La Cruz Lastre, Gunnar Treff, Fotini Tsofliou, José Kawazoe Lazzoli, Umutcan Kayıkçı, Mourad Ghrairi, Vincent Onywera, Robert Ojiambo, Robert Sallis, Sophia Papamichalopoulos, Maher Zahar, Christine Joisten, Bernd Wolfarth, Sandra Rozenstoka, Hashel Al Tunaiji, Kiera Wason, Felix Drummond, Wolfgang Schobersberger, Vahur Ööpik, Eve Unt, Anna Jegier, Stéphane Doutreleau, Seung Hoon Han, Jörg F Debatin, Nils Schumacher, Luís B Sardinha, Lenka Dienstbach-Wech, Tuba Melekoğlu, Sheng Zeng, Maurizio Casasco, Kristy Howells, Eva-Maria Klinkisch, James Bilzon, Gregory Heath, Thomas Horstmann, Eduardo H De Rose, Nick Webborn, Klaus-Michael Braumann, Li Jing, Xiao Xu, Elizabeth Moxley, Yi Zheng, Alison V September, Malcolm Collins, Olena Andrieieva, Svitlana Drozdovska, Andreas Michael Nieß, Rikke Helene Moe, Carolin Knoke, Silvano Zanuso, Francesco Zanatta, Veronika Všetíčková, Spyridon Zormpas, Christoforos D Giannaki, Brian P Carson, Matthew P Herring, Ciara McCormack, Marco Vecchiato, Thomas Yvert, Makro Korenjak, Benjamin Billet, Andréia Lópes Azevedo, Naama Constantini, Sigmund Loland, Aaron Leigh Baggish, Luis Monteiro, Nuray Yazihan, Yannis P Pitsiladis","doi":"10.1007/s40279-026-02495-4","DOIUrl":"https://doi.org/10.1007/s40279-026-02495-4","url":null,"abstract":"<p><p>This conceptual, implementation-oriented paper proposes a framework for precision prevention centred on physical activity promotion and early risk mitigation, aiming to support a shift from reactive disease management toward proactive prevention. The proposed framework focuses on the early identification of risk trajectories by integrating biological, environmental, and social determinants of health through systems thinking, multi-omics technologies, digital health, and behavioural science. It aims to inform tailored, context-sensitive interventions that will help to mitigate chronic non-communicable diseases (NCDs), while supporting lifelong resilience. Within this framework, physical activity is positioned as the central, modifiable anchor behaviour through which personalised prevention strategies may be operationalised. Building on the 2025 Hamburg Declaration and the Global Alliance for the Promotion of Physical Activity's (GA@PA) mission, this conceptual paper proposes a multidimensional model, combining personalised strategies for physical activity, nutrition, sleep, and mental health with contextual environmental adaptations. By bringing together stakeholders across multiple sectors, including healthcare, education, urban planning, sport organisations, industry, and community groups, GA@PA aims to strengthen global collaboration and to accelerate the implementation of evidence-based strategies for physical activity promotion. Emerging technologies, including digital twins, wearable biosensors and artificial intelligence (AI)-driven analytics, are discussed as potential enabling tools for real-time monitoring and for providing input for adaptive interventions, while mobile health platforms may extend access to underserved populations. Rather than providing prescriptive solutions, the paper outlines key implementation fundamentals. These include technological infrastructure with interoperable biosensors and AI aligned with prevailing ethical frameworks such as the AI Act and UNESCO recommendations; interdisciplinary research on resilience and outlier populations; policy and education reform, including routine assessment of physical activity as a vital sign within healthcare encounters; and cross-sector collaboration spanning urban design to sport-for-development initiatives such as the International Olympic Committee (IOC)'s Olympism365. Sports organisations may support broader participation through sport-for-all programmes. The framework emphasises equity, cultural adaptation, and community co-design as critical features for scalability across diverse global contexts, highlighting the role of sport, fitness, and public health partnerships in creating a context where healthy choices become accessible and sustainable. Overall, this conceptual paper outlines a practice-informed framework proposing precision prevention as an evolving and testable implementation framework for supporting sustainable and equitable prevention systems. By inte","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Resistance Training on Muscle Hypertrophy in Children and Adolescents: A Systematic Review and Meta-Analysis. 阻力训练对儿童和青少年肌肉肥大的影响:一项系统综述和荟萃分析。
IF 11 1区 医学
Sports Medicine Pub Date : 2026-09-17 DOI: 10.1007/s40279-026-02499-0
Yannik Komm, Linda Zeiler, Steffen Held, Paul Comfort, Avery Faigenbaum, Stephan Geisler, Claudia Augste
{"title":"Effects of Resistance Training on Muscle Hypertrophy in Children and Adolescents: A Systematic Review and Meta-Analysis.","authors":"Yannik Komm, Linda Zeiler, Steffen Held, Paul Comfort, Avery Faigenbaum, Stephan Geisler, Claudia Augste","doi":"10.1007/s40279-026-02499-0","DOIUrl":"https://doi.org/10.1007/s40279-026-02499-0","url":null,"abstract":"<p><strong>Background: </strong>Resistance training is considered safe and beneficial for young individuals, yet the extent to which it results in morphological adaptations before, during and after puberty remains unclear.</p><p><strong>Objective: </strong>The aim of this review was to quantify the effects of resistance training on muscle hypertrophy in children and adolescents and to examine whether the effects differ by maturational stage, sex, and hypertrophy-oriented design of the resistance training program.</p><p><strong>Methods: </strong>PubMed, Scopus, Web of Science and Google Scholar were searched in April 2025. Randomized and non-randomized controlled studies in participants younger than 18 years of age were eligible when hypertrophy was assessed with direct imaging or indirect instrumented methods. Subgroup analyses were conducted by maturational status, sex and the hypertrophy-oriented design of the resistance training program. Effect sizes (Cohen's d) with 95% confidence intervals were pooled using a random-effects model with heterogeneity quantified via the I<sup>2</sup> statistic. Risk of bias was assessed with RoB 2 and ROBINS-I and methodological quality with the PEDro scale. The review was preregistered on PROSPERO (CRD420251025605). The hypertrophy suitability of the resistance training protocols was evaluated using established hypertrophy guidelines.</p><p><strong>Results: </strong>Twenty-three studies with a total of 1443 participants were included. Overall, compared with passive controls, resistance training induced a small increase in muscle mass (Cohen's d = 0.22 95% CI 0.06-0.37), while compared with active controls, the effects were notably greater (Cohen's d =  0.61, 95% CI 0.03-1.20). Subgroup analyses revealed trivial-to-small hypertrophy across maturational stages when compared with passive controls (prepubertal Cohen's d = 0.16, 95% CI - 0.04 to 0.36; peripubertal Cohen's d =  0.30, 95% CI 0.01-0.58 postpubertal Cohen's d = 0.01, 95% CI - 0.31 to 0.33). Compared with active controls, subgroup differences by maturational stage were statistically significant (p =  0.0227), with postpubertal participants showing a large and significant effect (Cohen's d = 1.50, 95% CI 0.46-2.54) compared with smaller, non-significant effects in peripubertal and prepubertal participants. Compared with active controls, hypertrophy was large in males (Cohen's d =  1.26, 95% CI 0.29-2.22), trivial in females (Cohen's d =  - 0.12, 95% CI - 1.05-0.81) and trivial in mixed samples (Cohen's d = 0.04, 95% CI - 0.08 to 0.17). Compared with passive controls, changes were trivial in males (Cohen's d =  0.11, 95% CI - 0.12-0.34), small in females (Cohen's d = 0.20, 95% CI - 0.07 to 0.46) and small in mixed samples (Cohen's d =  0.39, 95% CI -  0.01 to 0.78).</p><p><strong>Conclusion: </strong>Resistance training induces small hypertrophy compared with passive controls and larger effects compared with active controls. The hypertrophic adaptations o","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence-Based Insights for the Development and Talent Promotion of Young Athletes in a National Sports Context. 国家体育背景下青年运动员发展和人才提升的循证见解。
IF 11 1区 医学
Sports Medicine Pub Date : 2026-09-13 DOI: 10.1007/s40279-026-02535-z
Tommy R Lundberg, John Lind, Joseph Baker, Erik Lundkvist, Alex Lascu, Kathryn Johnston, Jean Côté, Job Fransen, Andreas Ivarsson
{"title":"Evidence-Based Insights for the Development and Talent Promotion of Young Athletes in a National Sports Context.","authors":"Tommy R Lundberg, John Lind, Joseph Baker, Erik Lundkvist, Alex Lascu, Kathryn Johnston, Jean Côté, Job Fransen, Andreas Ivarsson","doi":"10.1007/s40279-026-02535-z","DOIUrl":"https://doi.org/10.1007/s40279-026-02535-z","url":null,"abstract":"<p><p>The development of young athletes continues to be a key concern for sports organizations, coaches and policy makers. In Sweden, the public debate on the balance between early talent promotion programs and more inclusive, long-term athlete development models has recently intensified. This discussion reflects the general global tensions within youth sport systems between high performance ambitions and the goal of lifelong sport, as well as other societal goals related to sport. Taking the Swedish context as a starting point, this perspective article explores the challenges and opportunities in integrating early talent promotion with sustainable athlete development frameworks. While the Swedish case provides the empirical context, the findings and recommendations presented are intended to inform broader international and national debates. We argue that evidence-based youth sport systems can support both elite performance and broader participation goals simultaneously. We propose a nuanced, evidence-based approach that recognizes the complexity of youth athlete development and the importance of aligning scientific evidence with local cultural and organizational contexts. The focus is on creating sport environments that support athlete well-being, intrinsic motivation and diverse opportunities for participation. Rather than prescribing a one-size-fits-all solution, this article highlights principles to help national federations and clubs design systems that promote both elite performance and broad participation. Ultimately, sustainable athlete development requires contextual governance, continuous evaluation and a commitment to promoting both performance goals and the wider benefits of sport.</p>","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimising Exercise Prescription: A Meta-Analysis Examining the Dose Response of Exercise Duration on Cardiorespiratory Fitness Following HIIT and MICT. 优化运动处方:一项检验HIIT和MICT后运动时间对心肺健康剂量反应的荟萃分析。
IF 11 1区 医学
Sports Medicine Pub Date : 2026-09-12 DOI: 10.1007/s40279-026-02528-y
Felipe Mattioni Maturana, Nur Hidayah Asilah Zadon, Matthew Cocks, Andreas M Nieß, Dick H J Thijssen, Ellen Adele Dawson
{"title":"Optimising Exercise Prescription: A Meta-Analysis Examining the Dose Response of Exercise Duration on Cardiorespiratory Fitness Following HIIT and MICT.","authors":"Felipe Mattioni Maturana, Nur Hidayah Asilah Zadon, Matthew Cocks, Andreas M Nieß, Dick H J Thijssen, Ellen Adele Dawson","doi":"10.1007/s40279-026-02528-y","DOIUrl":"https://doi.org/10.1007/s40279-026-02528-y","url":null,"abstract":"<p><strong>Background: </strong>High-intensity interval training (HIIT) is often promoted as a time-efficient alternative to moderate-intensity continuous training (MICT) for improving cardiorespiratory fitness, yet the duration of HIIT sessions varies considerably across studies.</p><p><strong>Objective: </strong>We aimed to characterise the dose-response relationship between exercise session duration and the improvement in cardiorespiratory fitness for HIIT and MICT.</p><p><strong>Methods: </strong>A dose-response meta-analysis of randomised controlled trials comparing exercise duration in HIIT and MICT, following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines and registered in PROSPERO (CRD42022335590). Effect sizes were calculated using a random-effects meta-analysis. The primary outcome was maximal oxygen uptake (VO<sub>2max</sub>). Secondary outcomes included blood pressure, lipid profiles, glucose metabolism markers and body composition measures. A one-stage random-effects dose-response meta-analysis was performed to examine the relationship between exercise duration and adaptations. We searched PubMed and Google Scholar; eligibility criteria for selecting studies were randomised controlled trials in humans, published in English and exercise interventions lasting at least 4 weeks.</p><p><strong>Results: </strong>We identified 69 randomised controlled trials (2387 participants). High-intensity interval training elicited greater improvements in VO<sub>2max</sub> than MICT (d = 0.38, 95% confidence interval 0.27-0.49, p < 0.001). High-intensity interval training demonstrated a non-linear dose-response relationship between exercise session duration and VO<sub>2max</sub>, with 80% of maximal effect (changes in VO<sub>2max</sub> = 3.45 mL/kg/min) achieved with only ~11 min/session (95% confidence interval 9.5-40.2). Moderate-intensity interval training showed a linear dose-response relationship between exercise session duration and VO<sub>2max</sub>, requiring ~52 min/session to achieve 80% of the maximal observed effect (95% confidence interval 30.4-55.8). The dose-response relationship was consistent across populations. High-intensity interval training and MICT had comparable effects in improving cardiometabolic risk factors.</p><p><strong>Conclusions: </strong>High-intensity interval training demonstrated a non-linear dose response, with 80% of maximal effect on VO<sub>2max</sub> in ~11 min/session, whilst MICT required four to five times longer to reach similar responses. The different types of training had comparable effects on cardiometabolic risk factors.</p>","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Clenbuterol on Body Composition and Strength Following Resistance Training, Detraining, and Retraining in Healthy Adults: A Randomized Controlled Trial. 盐酸克仑特罗对健康成人阻力训练、去训练和再训练后身体成分和力量的影响:一项随机对照试验
IF 11 1区 医学
Sports Medicine Pub Date : 2026-09-12 DOI: 10.1007/s40279-026-02522-4
Lukas Moesgaard, Sebastian Skov Uhrenholt, Søren Jessen, Rasmus Blak Hasgaard, Vibeke Backer, Yvette Dehnes, Jens Bangsbo, Morten Hostrup
{"title":"Effects of Clenbuterol on Body Composition and Strength Following Resistance Training, Detraining, and Retraining in Healthy Adults: A Randomized Controlled Trial.","authors":"Lukas Moesgaard, Sebastian Skov Uhrenholt, Søren Jessen, Rasmus Blak Hasgaard, Vibeke Backer, Yvette Dehnes, Jens Bangsbo, Morten Hostrup","doi":"10.1007/s40279-026-02522-4","DOIUrl":"https://doi.org/10.1007/s40279-026-02522-4","url":null,"abstract":"<p><strong>Background: </strong>Clenbuterol, a potent β<sub>2</sub>-adrenoceptor agonist, is commonly used off-label in conjunction with resistance training to increase muscle mass and decrease fat mass. However, the long-term effects on body composition and strength with use and following discontinuation of use remain unexplored.</p><p><strong>Objective: </strong>The aim of the study was to investigate the effects of clenbuterol on body composition and strength during a resistance training intervention, as well as the long-term effects of prior use of clenbuterol during detraining and subsequent retraining in healthy young men and women.</p><p><strong>Methods: </strong>This randomized, double-blinded, placebo-controlled trial was conducted at the University of Copenhagen, Denmark, between March 2023 and March 2025. Thirty-two healthy men (26 ± 3 years; mean ± SD; n = 16) and women (25 ± 5 years; n = 16) completed 8 weeks of resistance training with daily ingestion of clenbuterol (80 μg) (n = 16) or placebo (n = 16). This was followed by 16 weeks of detraining and another 8 weeks of resistance training. Before the intervention and after each training and detraining period, body composition was assessed by dual-energy X-ray absorptiometry (DXA) and strength was assessed by leg press and bench press 1-repetition maximum (1RM).</p><p><strong>Results: </strong>Clenbuterol increased gains in lean mass (+ 1.7 kg, p < 0.001) and 1RM bench press (+ 6 kg, p < 0.001) and leg press (+ 16 kg, p = 0.001) during 8 weeks of resistance training compared with placebo, with a more pronounced effect in males than females (lean mass: p = 0.003; 1RM bench press: p < 0.001), whereas the decrease in fat mass did not differ between clenbuterol and placebo (p = 0.614). Following cessation of clenbuterol, detraining decreased lean mass (p < 0.001), 1RM bench press (p < 0.001), and 1RM leg press (p = 0.026) to a greater extent in the clenbuterol group, such that initial changes in lean mass (p = 0.363) and 1RM bench press (p = 0.834) no longer differed from placebo, whereas 1RM leg press remained elevated in the clenbuterol group (p = 0.041). Retraining increased lean mass and 1RM leg press with no differences between the clenbuterol and placebo group (lean mass: p = 0.393; 1RM leg press: p = 0.662), whereas the increase in 1RM bench press was greater in the clenbuterol group (+ 3 kg, p = 0.047).</p><p><strong>Conclusion: </strong>Clenbuterol markedly augments training-induced gains in lean mass and strength. After discontinuation, prior clenbuterol exposure does not enhance retraining-induced lean mass gains, but some strength-related advantages persist.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier, NCT05692856.</p>","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Citius, Maius, Melius: Mitochondria and Endurance Performance. Citius, Maius, Melius:线粒体和耐力表现。
IF 11 1区 医学
Sports Medicine Pub Date : 2026-09-12 DOI: 10.1007/s40279-026-02530-4
Javier Botella, David J Bishop, Cesare Granata
{"title":"Citius, Maius, Melius: Mitochondria and Endurance Performance.","authors":"Javier Botella, David J Bishop, Cesare Granata","doi":"10.1007/s40279-026-02530-4","DOIUrl":"https://doi.org/10.1007/s40279-026-02530-4","url":null,"abstract":"<p><p>Endurance performance relies on a range of physiological adaptations classified as central or peripheral depending on whether the remodeling occurs in the cardiovascular system or in the skeletal muscle, respectively. One of the goals of these adaptations is to enhance oxygen transport and its utilization by mitochondria to sustain ATP resynthesis. While a link between skeletal muscle mitochondrial characteristics and endurance performance may seem obvious, there is no consensus on whether mitochondrial characteristics are key determinants of endurance performance. In this narrative review, we examine cross-sectional, correlational, and intervention studies conducted in humans that support or challenge the role of mitochondria in endurance performance. Cross-section studies suggest that individuals with superior endurance performance exhibit greater mitochondrial content and respiratory function than those with lower fitness levels. Correlation studies have shown positive associations between multiple mitochondrial characteristics and markers of endurance performance. However, a lack of correlation between training-induced changes in mitochondrial characteristics and endurance performance has also been reported. Intervention studies indicate that changes in mitochondrial characteristics following training, phlebotomy, or detraining are often associated with changes in markers of endurance performance. Conversely, increasing oxygen delivery to the working muscle (i.e., via increasing oxygen concentration) has been shown to improve performance markers, suggesting these improvements are not limited by mitochondrial characteristics. In conclusion, while substantial evidence associates mitochondrial characteristics with endurance performance, this relationship is not universal; central factors display an equally strong influence independently of mitochondrial characteristics. We propose that enhanced mitochondrial characteristics represent an important and often necessary, but not sufficient, adaptation that is required to support endurance performance.</p>","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the Linear versus Non-Linear Repeated Sprint Training on Lower Limb Sports Performance Tasks in Team Sport Athletes: A Systematic Review and Meta-Analysis 线性与非线性重复短跑训练对团体运动运动员下肢运动表现任务的影响:系统回顾与meta分析
IF 9.8 1区 医学
Sports Medicine Pub Date : 2026-09-10 DOI: 10.1007/s40279-026-02468-7
Seyyed Hadi Asghari,Alexei Wong,Paul Comfort,Seyed Javad Mirghani,Naghme Asadi
{"title":"Comparison of the Linear versus Non-Linear Repeated Sprint Training on Lower Limb Sports Performance Tasks in Team Sport Athletes: A Systematic Review and Meta-Analysis","authors":"Seyyed Hadi Asghari,Alexei Wong,Paul Comfort,Seyed Javad Mirghani,Naghme Asadi","doi":"10.1007/s40279-026-02468-7","DOIUrl":"https://doi.org/10.1007/s40279-026-02468-7","url":null,"abstract":"","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":"20 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proprioception Training and Surrogate Outcomes: A Systematic Review of Definitions, Measures, and Effectiveness Claims 本体感觉训练和替代结果:定义、措施和有效性声明的系统回顾
IF 9.8 1区 医学
Sports Medicine Pub Date : 2026-09-05 DOI: 10.1007/s40279-026-02524-2
Robert Trybulski,Gracjan Olaniszyn,Yaroslav Svyshch,Andryi Vovkanych,Ireneusz Ryszkiel,Adam Meakins
{"title":"Proprioception Training and Surrogate Outcomes: A Systematic Review of Definitions, Measures, and Effectiveness Claims","authors":"Robert Trybulski,Gracjan Olaniszyn,Yaroslav Svyshch,Andryi Vovkanych,Ireneusz Ryszkiel,Adam Meakins","doi":"10.1007/s40279-026-02524-2","DOIUrl":"https://doi.org/10.1007/s40279-026-02524-2","url":null,"abstract":"","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":"10 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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