Sleep and Biological Rhythms最新文献

{"title":"Recommended sleep duration is associated with greater parasympathetic regulation in patients with hypertension.","authors":"Natsuki Nakayama, Yoshimi Moriwaki, Koji Tamakoshi, Makoto Hirai","doi":"10.1007/s41105-026-00656-6","DOIUrl":"10.1007/s41105-026-00656-6","url":null,"abstract":"<p><strong>Purpose: </strong>Sleep is a key component of biological rhythms, and autonomic regulation across the 24-hour cycle reflects circadian influences on cardiovascular control. Although reduced heart rate variability (HRV) is associated with adverse cardiovascular outcomes, the relationship between habitual sleep duration and parasympathetic function in patients with hypertension remains unclear. This study examined the association between sleep duration and autonomic activity, focusing on the high-frequency (HF) component of HRV as an indicator of parasympathetic regulation.</p><p><strong>Methods: </strong>Seventy-four patients with hypertension were classified into a short sleep (S) group (< 7 h, <i>n</i> = 28) and a recommended sleep (R) group (7-9 h, <i>n</i> = 46). Twenty-four-hour HRV was assessed using Holter electrocardiography, and the HF component was analyzed as an index of parasympathetic activity. Habitual physical activity was measured for one month using a waist-worn monitor, from which physical activity-related energy expenditure (PAEE), moderate-to-vigorous physical activity, and light physical activity were calculated.</p><p><strong>Results: </strong>The 24-hour HF component was significantly greater in the R group than in the S group (<i>p</i> = 0.039), even after adjustment for age, sex, dyslipidemia, β-blocker use, and PAEE. Similar but nonsignificant trends were observed during awake and sleep periods (<i>p</i> = 0.078 and 0.074, respectively).</p><p><strong>Conclusions: </strong>Achieving the recommended sleep duration was associated with greater parasympathetic activity, independent of habitual physical activity. These findings suggest that adequate sleep is an important behavioral factor for autonomic regulation and may be a relevant target for lifestyle guidance in patients with hypertension.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 4","pages":"461-466"},"PeriodicalIF":2.0,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective exploratory study of sleep spindles as an adjunctive diagnostic marker for narcolepsy type 1: a comparison with insufficient sleep syndrome.","authors":"Yuuki Hyodo, Hiroshi Hiejima, Takao Kato, Satoshi Mizuki, Minoru Takii, Haruka Yokoyama, Yuuki Fujii, Touma Koura, Nozomu Kotorii, Mitsunari Habukawa, Naohisa Uchimura, Motohiro Ozone","doi":"10.1007/s41105-026-00657-5","DOIUrl":"10.1007/s41105-026-00657-5","url":null,"abstract":"<p><strong>Purpose: </strong>Narcolepsy type 1 (NT1) and insufficient sleep syndrome (ISS) both present with excessive daytime sleepiness (EDS) and may fulfill the diagnostic criteria on the multiple sleep latency test (MSLT); therefore, differential diagnosis is often difficult. This study examined whether sleep spindle (SS) indices obtained from overnight polysomnography (PSG) performed before the MSLT are useful for distinguishing NT1 from ISS with false-positive MSLT findings.</p><p><strong>Methods: </strong>We retrospectively analyzed 23 patients aged 10-30 years (14 with NT1 and 9 with ISS) who underwent PSG and MSLT at Kurume University Hospital between January 2015 and December 2023. Diagnoses were established according to the International Classification of Sleep Disorders, 3rd Edition. SS density, duration, and amplitude were quantified from C3/C4 derivations using (1) visual scoring and (2) automated detection. Group comparisons were performed using the Mann-Whitney U test. Receiver operating characteristic (ROC) analysis was used to evaluate discriminatory performance for variables showing significant between-group differences.</p><p><strong>Results: </strong>Visual scoring showed no significant between-group differences in SS indices. Automated detection identified significant between-group differences in two fast SS indices derived from C3: duration during stage N2 and density during non-rapid eye movement sleep. No significant differences were found in C4 or in slow or unclassified SS. ROC analysis of C3 fast SS duration during stage N2 showed moderate discriminatory performance, with an area under the curve of 0.754. At the optimal cutoff value of 996.77 ms, sensitivity was 85.7% and specificity was 66.7%.</p><p><strong>Conclusions: </strong>Automated SS quantification identified between-group differences that were not apparent on visual scoring. This may reflect inclusion, by automated detection, of sigma-rich electroencephalographic activity not captured as SS by visual scoring. Quantitative evaluation of SS by automated detection from a single-night PSG may complement the MSLT and help distinguish NT1 from ISS in patients with EDS and false-positive MSLT findings.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 4","pages":"473-481"},"PeriodicalIF":2.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral and psychological factors associated with sleep-related symptoms and daytime sleepiness in Japanese Sports and Health Sciences undergraduates: a cross-sectional study.","authors":"Keita Suzuki, Maya Hagiwara, Yuki Matsumura, Satoru Nishida","doi":"10.1007/s41105-026-00654-8","DOIUrl":"10.1007/s41105-026-00654-8","url":null,"abstract":"<p><strong>Purpose: </strong>Sleep-related problems are common among Japanese university students. Students majoring in Sports and Health Sciences are generally more exposed to health-related education, yet those involved in extracurricular sports often maintain demanding routines that may constrain their sleep opportunity-potentially increasing their susceptibility to insufficient sleep. This study aimed to identify factors associated with sleep-related symptoms and excessive daytime sleepiness in Japanese undergraduate students majoring in Sports and Health Sciences.</p><p><strong>Methods: </strong>A cross-sectional online survey was conducted from May to August 2024 among 3,284 students majoring in Sports and Health Sciences from four Japanese universities. Participants completed an anonymous questionnaire assessing sociodemographic characteristics, participation in extracurricular sports, lifestyle habits, psychological distress, exposure to health information, and sleep-related variables. Sleep-related symptoms and daytime sleepiness were assessed using validated scales. Multiple linear regression was used to examine associations between behavioral and psychological factors and sleep outcomes.</p><p><strong>Results: </strong>A total of 841 students responded (25.6%), with 813 included in the analysis. Among them, 42.2% exceeded the cutoff for sleep-related symptoms and 35.2% for excessive daytime sleepiness. Later weekday bedtimes, earlier wake-up times, and psychological distress were associated with more sleep-related symptoms. Additionally, later bedtimes, gaming device use after lights-out, participation in extracurricular sports, and psychological distress were associated with greater daytime sleepiness.</p><p><strong>Conclusions: </strong>These findings suggest that awareness not only of mental health and individual lifestyle behaviors but also of the scheduling constraints that limit sleep opportunity may be important for addressing sleep-related problems in this population.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s41105-026-00654-8.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 3","pages":"411-420"},"PeriodicalIF":2.0,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13304373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Non-constraining and non-contact monitoring of respiratory rate at awake and apnea and hypopnea during sleep using a millimeter wave radar.","authors":"Kazuo Chin, Shigeaki Okumura, Daisuke Endo, Kazuma Nagata, Tatsuya Ito, Kimihiko Murase, Hironobu Sunadome, Mamiko Hoshi, Hisato Hiranuma, Yutaka Kozu, Susumu Sato, Toyohiro Hirai, Yasuhiro Gon, Takuya Sakamoto, Hirofumi Taki, Toshiki Akahoshi","doi":"10.1007/s41105-026-00651-x","DOIUrl":"10.1007/s41105-026-00651-x","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1007/s41105-025-00612-w.].</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 3","pages":"431"},"PeriodicalIF":2.0,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13305231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Mitophagy protects renal tubular epithelial cells from intermittent hypoxia-induced injury via the HIF-1α/BNIP3 pathway.","authors":"Xiao-Bin Zhang, Qi-Feng Gan, Yu-Xin Guo, Li-Da Chen, Li-Qin Zhang, Ling Cai, Ya-Ting Yuan, Jing-Huang Cai, Xiang-Xin Chen","doi":"10.1007/s41105-026-00652-w","DOIUrl":"10.1007/s41105-026-00652-w","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1007/s41105-025-00625-5.].</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 3","pages":"433-435"},"PeriodicalIF":2.0,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13305083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How circadian misalignment matters-and when it does not: subjective sleep quality as the link between social time pressure and perceived stress.","authors":"Yoko Komada","doi":"10.1007/s41105-026-00653-9","DOIUrl":"10.1007/s41105-026-00653-9","url":null,"abstract":"","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 3","pages":"301-302"},"PeriodicalIF":2.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13305076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of sleep deprivation on interoception accuracy measured using a heartbeat-counting task.","authors":"Shoichi Asaoka, Ritsuko Nishimura, Shin Hiraga, Rino Sato, Riko Nakazawa, Taro Hirashima","doi":"10.1007/s41105-026-00648-6","DOIUrl":"10.1007/s41105-026-00648-6","url":null,"abstract":"<p><strong>Purpose: </strong>This study examined the impact of extended wakefulness on interoceptive accuracy and how individual differences in interoception related to subjective sleepiness.</p><p><strong>Methods: </strong>Twenty-four healthy university students participated in the study. Interoceptive accuracy was assessed using the heartbeat-counting task during daytime and midnight sessions.</p><p><strong>Results: </strong>Interoceptive accuracy did not differ significantly between the sleep conditions. However, subjective sleepiness was negatively correlated with interoceptive accuracy at midnight.</p><p><strong>Conclusions: </strong>Individual differences in interoceptive function may be associated with variability in perceived sleepiness under sleep pressure. These findings highlight the potential role of interoception in explaining why some individuals experience a mismatch between subjective and objective sleepiness.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 3","pages":"421-425"},"PeriodicalIF":2.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13304425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associated factors of possible consultation behavior for obstructive sleep apnea among male Japanese workers: a retrospective analysis.","authors":"Toshiyuki Hirasawa, Yuta Takano, Hideaki Nakayama, Yuichi Inoue","doi":"10.1007/s41105-026-00647-7","DOIUrl":"10.1007/s41105-026-00647-7","url":null,"abstract":"<p><p>This study investigated factors associated with possible consultation behavior (PCB) for obstructive sleep apnea (OSA; together, PCB-OSA) among male Japanese workers to promote early intervention and treatment. Data from 20,063 male employees were retrospectively analyzed. PCB-OSA was identified by the presence of at least one of the following medical procedure codes in the medical claim records from April 1, 2018, to March 31, 2019: polysomnography, home sleep apnea test, or percutaneous arterial blood oxygen saturation with an OSA diagnosis. Binomial logistic regression was used to assess factors related to PCB-OSA and the initiation of continuous positive airway pressure treatment in both the overall cohort and the OSA risk groups, defined by our objective measure-based OSA risk scale. Age (odds ratio [OR] = 1.01, 95% confidence interval [CI] [1.00, 1.02]), hypertension (OR = 1.38, 95% CI [1.10, 1.74]), heart disease (OR = 2.17, 95% CI [1.31, 3.58]), subjective sleepiness (OR = 1.49, 95% CI [1.16, 1.92]), habitual snoring (OR = 1.41, 95% CI [1.12, 1.77]), and witnessed apnea (OR = 2.13, 95% CI [1.63, 2.80]) were significantly and positively associated with PCB-OSA. Meanwhile, blue-collar workers (OR = 0.65, 95% CI [0.51, 0.82]) were significantly and negatively associated with the behavior. In the OSA high-risk group, working 6 or more days per week (OR = 0.62, 95% CI [0.40, 0.96]) was significantly and negatively associated with PCB-OSA. The study population showed a low rate of PCB-OSA. Obesity was not associated with PCB-OSA, and blue-collar workers exhibited a negative association, highlighting the need for disease education in this population.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s41105-026-00647-7.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 3","pages":"399-410"},"PeriodicalIF":2.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13304032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between nonrestorative sleep and increased healthcare costs: a 6-year cohort study.","authors":"Shota Matsunaga, Mitsuhiro Sado, Yoshitaka Kaneita, Norio Sasaki, Katsutoshi Tanaka, Kenichi Kuriyama","doi":"10.1007/s41105-026-00642-y","DOIUrl":"10.1007/s41105-026-00642-y","url":null,"abstract":"<p><p>Nonrestorative sleep (NRS) refers to the subjective experience of not feeling refreshed after sleeping. Although associations between NRS and mental and physical health have been reported, their relationship with long-term healthcare costs has not been examined. This study investigated whether NRS is associated with increased long-term healthcare costs using a large-scale cohort dataset from Japan. We analyzed the annual health screening and medical claims data of 117,049 individuals enrolled in a health insurance association for civil engineering and construction workers. NRS was assessed in the 2018 health screening using a single item: \"Do you feel refreshed after a typical night's sleep?\" Annual healthcare costs were calculated using medical claims data from fiscal years (FY) 2018 to 2023. Mixed-effects models for repeated measures, including interaction terms, were used to examine the association between NRS and healthcare costs over time. Sex-stratified analyses were also performed. At baseline, 45.7% of participants reported NRS. From FY 2020 onward, healthcare costs were significantly higher in the NRS group than in the restorative sleep (RS) group. In FY 2023, the cost difference was JPY 18,468 (95% CI: 7,306 to 29,630). Interaction analysis revealed that the cost gap between the NRS and RS groups widened significantly over time. Similar trends were observed in the sex-stratified analysis. NRS is significantly associated with increased long-term healthcare costs, suggesting an important medical and economic impact. Screening for NRS during routine health checkups and providing early interventions may be beneficial in reducing healthcare costs.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 3","pages":"359-366"},"PeriodicalIF":2.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13305221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter microstructural alterations in chronic insomnia: an automated fiber quantification study linking diffusion changes to symptom severity.","authors":"Zhengwei Qu, Wenzheng Zhang, Maoyang Wang, Wen Li, Shengyan Miao, Chenyu Wang, Haizhu Xie, Jun Li, Xueyan Zhang","doi":"10.1007/s41105-026-00650-y","DOIUrl":"10.1007/s41105-026-00650-y","url":null,"abstract":"<p><strong>Purpose: </strong>Investigate white matter alterations in chronic insomnia (CI) using Automated Fiber Quantification (AFQ).</p><p><strong>Methods: </strong>Diffusion tensor imaging data from 49 CI patients and 27 healthy controls were profiled for fractional anisotropy (FA), axial/mean/radial diffusivity (AD/MD/RD) across 100 nodes of 18 tracts.</p><p><strong>Results: </strong>CI showed increased AD in bilateral anterior thalamic radiations, right inferior longitudinal fasciculus, right arcuate fasciculus; increased MD in bilateral anterior thalamic radiations, right corticospinal tract, forceps minor of the corpus callosum, and right inferior longitudinal fasciculus. Changes in specific segments correlated significantly with clinical scores.</p><p><strong>Conclusions: </strong>AFQ reveals fiber-specific abnormalities linked to clinical scores in CI.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 3","pages":"427-430"},"PeriodicalIF":2.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13304059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}