Sleep and Biological Rhythms最新文献

{"title":"Craniofacial features in positional obstructive sleep apnea: insights from quantitative facial photography.","authors":"Yasuhiro Tomita, Takatoshi Kasai","doi":"10.1007/s41105-026-00649-5","DOIUrl":"https://doi.org/10.1007/s41105-026-00649-5","url":null,"abstract":"","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 2","pages":"155-156"},"PeriodicalIF":1.3,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147676686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between chronic rhinosinusitis and obstructive sleep apnea: evidence from systematic review, meta-analysis, and Mendelian Randomization.","authors":"Jing-Hao Zhai, Lu-Lu Zhu, Shu-Qing Chen, Xian Jian, Chao Chen","doi":"10.1007/s41105-026-00641-z","DOIUrl":"https://doi.org/10.1007/s41105-026-00641-z","url":null,"abstract":"<p><strong>Background: </strong>Obstructive sleep apnea (OSA) and chronic rhinosinusitis (CRS) are common conditions that impair quality of life and are linked to adverse health outcomes. Evidence on their bidirectional association remains inconsistent. This study aimed to investigate the OSA-CRS relationship through systematic review, meta-analysis, and Mendelian Randomization (MR).</p><p><strong>Methods: </strong>We systematically reviewed 14 observational studies (30,509 participants) following PRISMA and MOOSE guidelines. Meta-analyses were performed in Stata 15.0 and Review Manager 5.4 to estimate pooled prevalence and risk ratios. Bidirectional two-sample MR used GWAS summary data, analyzed in R (v4.2.0) with the TwoSampleMR package; IVW was the primary method, complemented by MR-Egger and leave-one-out analyses to assess pleiotropy and robustness.</p><p><strong>Results: </strong>Observational studies indicate a bidirectional association between CRS and OSA, with CRS patients showing an increased risk of OSA, and OSA patients having a higher risk of developing CRS. Mendelian Randomization analysis, however, supports a unidirectional causal relationship, showing that CRS causally increases the risk of OSA, whereas there is no significant causal effect of OSA on CRS. Specifically, the meta-analysis revealed a 20% prevalence of OSA among CRS patients (95% CI: 19-21%) and an elevated risk of OSA in this group (OR = 1.14, 95% CI: 1.08-1.20). Patients with OSA exhibited a 5.8-fold higher risk of developing CRS (OR = 5.79, 95% CI: 1.61-20.80). Mendelian Randomization analysis confirmed the causal effect of CRS on OSA (IVW OR = 1.11, 95% CI: 1.03-1.20, <i>p</i> = 0.008), while the reverse direction showed no significant association (OR = 1.0, 95% CI: 0.9-1.1).</p><p><strong>Conclusion: </strong>Research data indicate bidirectional associations between OSA and CRS, but MR supports only a causal effect of CRS on OSA. These findings identify CRS as a modifiable risk factor for OSA, supporting targeted OSA screening in CRS populations.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s41105-026-00641-z.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 2","pages":"183-194"},"PeriodicalIF":1.3,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147676549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of electromagnetic fields on circadian rhythms: molecular and physiological insights.","authors":"Hadja Fatima Tbahriti, Meriem Benbernou, Abhijeet Satani, Maksim Rebezov, Rekha Arcot, Muthu Thiruvengadam, Mohammad Ali Shariati","doi":"10.1007/s41105-026-00643-x","DOIUrl":"https://doi.org/10.1007/s41105-026-00643-x","url":null,"abstract":"<p><strong>Purpose: </strong>Electromagnetic fields (EMFs) are ubiquitous in modern environments, raising concerns about their potential influence on circadian rhythms and human health. This systematic review examines the biological mechanisms underlying EMF-circadian interactions to inform evidence-based public health policies.</p><p><strong>Methods: </strong>Following PRISMA 2020 guidelines, we systematically searched PubMed/MEDLINE, Web of Science, Scopus, and EMBASE for peer-reviewed studies published between 2010 and 2024. From 892 initial records, 55 studies met inclusion criteria after rigorous screening, comprising 22 in vitro studies, 21 animal studies, and 12 human studies.</p><p><strong>Results: </strong>EMF exposure can affect circadian regulation through multiple pathways including clock gene expression alterations, melatonin disruption, and cellular signaling modulation. The most robust evidence involves melatonin suppression (88% of high-quality animal studies) and sleep architecture changes. However, evidence quality varied considerably, with only 27% of studies meeting high methodological standards. Critical limitations include inadequate sham controls in 48% of animal studies, incomplete EMF exposure characterization in 33% of investigations, and minimal high-quality human research. The magnitude of melatonin suppression (20-50%) is substantially lower than light-induced effects (> 90%), raising questions about clinical significance. Translation from cellular effects to systemic circadian disruption remains incompletely established.</p><p><strong>Conclusion: </strong>While EMFs can influence molecular and cellular circadian components, whether typical environmental exposures produce clinically meaningful circadian disruption in humans remains uncertain. The findings highlight critical evidence gaps and underscore the need for well-controlled studies with standardized protocols, rigorous designs, and comprehensive circadian assessment to clarify public health implications of chronic EMF exposure.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 2","pages":"195-214"},"PeriodicalIF":1.3,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147676697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restless legs syndrome in Japanese adolescents: closing a critical epidemiologic gap.","authors":"Yuichi Inoue","doi":"10.1007/s41105-026-00639-7","DOIUrl":"https://doi.org/10.1007/s41105-026-00639-7","url":null,"abstract":"","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 2","pages":"153-154"},"PeriodicalIF":1.3,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147676684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When pain encounters the biological clock: does it disrupt sleep architecture?","authors":"Renata K Carvalho, Tathiana A Alvarenga, Renata Mazaro-Costa, Sergio Tufik, Monica L Andersen","doi":"10.1007/s41105-026-00632-0","DOIUrl":"https://doi.org/10.1007/s41105-026-00632-0","url":null,"abstract":"","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 2","pages":"299-300"},"PeriodicalIF":1.3,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147676805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upper airway muscle activation in obstructive sleep apnea: a brief overview of emerging neuromodulatory and pharmacologic therapies.","authors":"Da-Been Lee, Jinkwan Kim, Suhng-Wook Kim, Dae-Wui Yoon","doi":"10.1007/s41105-026-00633-z","DOIUrl":"https://doi.org/10.1007/s41105-026-00633-z","url":null,"abstract":"<p><p>Obstructive sleep apnea (OSA) is a highly prevalent disorder associated with significant cardiovascular, metabolic, and cognitive consequences. Although continuous positive airway pressure (CPAP) therapy remains the gold standard, poor adherence rates ranging from 29 to 83% highlight the need for alternative strategies. Recent advances in the understanding of OSA pathophysiology, particularly the role of non-anatomical traits such as impaired neuromuscular control, ventilatory instability, and low arousal threshold, have led to the development of novel therapies targeting upper airway muscle activation. This review provides an overview of emerging non-CPAP approaches, including electrical stimulation, myofunctional therapy, and pharmacological interventions. Transcutaneous and hypoglossal nerve stimulation demonstrate clinically meaningful improvements in apnea severity and quality of life, especially in patients intolerant to CPAP and with favorable phenotypes such as low body mass index and moderate disease severity. Intraoral electrical stimulation shows potential in the management of primary snoring and mild OSA with good tolerability. Myofunctional therapy, consisting of oropharyngeal and tongue-strengthening exercises, has been shown to reduce the apnea-hypopnea index by up to 50% and may also improve CPAP adherence. Pharmacological approaches targeting noradrenergic, serotonergic, and cholinergic pathways have demonstrated short-term efficacy, although side effects limit widespread application. Collectively, these findings underscore the promise of phenotype-guided, personalized interventions. However, robust evidence from large-scale, long-term randomized controlled trials is required to establish the safety, efficacy, and cost-effectiveness of these emerging therapies in clinical practice.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 2","pages":"157-168"},"PeriodicalIF":1.3,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147676793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between metabolic dysfunction-associated steatotic liver disease and sleep disorders: an umbrella review.","authors":"Yuanfei Wang, Wanyi Ou, Ling Zhu","doi":"10.1007/s41105-026-00636-w","DOIUrl":"https://doi.org/10.1007/s41105-026-00636-w","url":null,"abstract":"<p><p>Umbrella review, also known as a systematic review of systematic reviews, is positioned at the apex of the evidence-based medicine pyramid and represents one of the highest levels of methodology for evidence synthesis. This umbrella review evaluates the current body of evidence linking sleep disorders with metabolic dysfunction-associated steatotic liver disease (MASLD), in light of growing indications that disturbances in sleep may play a role in the development and progression of MASLD. Following PRISMA framework, a systematic literature search was performed across five databases (PubMed, Web of Science, Embase, CNKI, and Wanfang Data) from inception to April 2025. Eligible studies examined the relationship between sleep disorders and MASLD. Twenty studies (seventeen quantitative, three qualitative) were included. Key findings revealed: (1) Short sleep duration and obstructive sleep apnea (OSA) were significantly associated with increased MASLD risk (<i>p</i> < 0.05), prolonged sleep was correlated with a low risk of MASLD; (2) OSA was linked to elevated liver enzyme levels and hepatic fibrosis; (3) No significant association existed between sleep quality and MASLD risk; (4) MASLD patients showed higher prevalence of excessive daytime sleepiness (<i>p</i> < 0.01) and napping habits compared to healthy controls; (5) Prolonged daytime napping predicted unfavorable MASLD outcomes. Sleep disorders, particularly short sleep duration and OSA, have been identified as risk factors for MASLD outcomes. While underlying mechanisms remain underexplored, future clinical studies are warranted to elucidate the specific mechanisms underlying the effects of sleep disturbances on MASLD pathogenesis.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s41105-026-00636-w.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 2","pages":"169-181"},"PeriodicalIF":1.3,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147676661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of daridorexant on sleep architecture in Japanese patients with insomnia disorder: analysis of a phase II randomized controlled trial.","authors":"Tomoko Yagi, Motohiro Ozone, Tetsuya Ioji, Kenta Murotani, Akinori Nishi, Naohisa Uchimura","doi":"10.1007/s41105-025-00628-2","DOIUrl":"https://doi.org/10.1007/s41105-025-00628-2","url":null,"abstract":"<p><p>While daridorexant, a dual orexin receptor antagonist (DORA), demonstrated dose-dependent improvements in sleep parameters in a Japanese Phase II trial, its effects on sleep architecture remain incompletely characterized. This secondary analysis examined daridorexant's effects on sleep fragmentation and architecture in Japanese patients with insomnia disorder. Forty-seven Japanese patients with insomnia (mean age 50.4 ± 8.0 years) underwent 10 nights of polysomnographic (PSG) recordings in a randomized protocol (baseline, placebo, daridorexant 10 mg, 25 mg, 50 mg; 2 nights each). Key parameters included latency to persistent sleep (LPS), total sleep time (TST), wake after sleep onset (WASO), sleep stage durations, and the number of persistent awakenings (NAW). The 8-hour recording was divided into quarters for temporal analysis. Dose-response trends were assessed using Jonckheere-Terpstra tests. Significant dose-response relationships were observed for LPS (<i>P</i> = 0.004), TST (<i>P</i> < 0.001), WASO (<i>P</i> < 0.001), and NAW (<i>P</i> = 0.004). Changes from baseline showed dose-dependent reductions in N1 time (<i>P</i> = 0.006) and increases in N2 (<i>P</i> = 0.049), N3 (<i>P</i> = 0.050), and REM sleep times (<i>P</i> < 0.001). Quartile analysis revealed a significant reduction in NAW in the first quarter with 50 mg (<i>P</i> = 0.012) and a significant increase in REM sleep in the first and fourth quarters with 25 mg and 50 mg (<i>P</i> < 0.05). Daridorexant dose-dependently improves sleep architecture by reducing fragmentation and enhancing deeper NREM and REM sleep. Temporal analysis demonstrated sustained effects throughout the night with REM sleep enhancement persisting through the final quarter. These findings suggest restoration of natural sleep architecture supporting daridorexant's potential as a comprehensive sleep-promoting agent.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s41105-025-00628-2.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 2","pages":"279-289"},"PeriodicalIF":1.3,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147676708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do seasonal variation shape insomnia? Integrating epidemiological reanalysis with social and clinical factors.","authors":"Yoko Komada","doi":"10.1007/s41105-026-00630-2","DOIUrl":"https://doi.org/10.1007/s41105-026-00630-2","url":null,"abstract":"","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 2","pages":"151-152"},"PeriodicalIF":1.3,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147676739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between nonrestorative sleep and persistent post-acute sequelae of COVID-19: a longitudinal study of recovery trajectories.","authors":"Megumi Hazumi, Mayumi Kataoka, Kentaro Usuda, Michi Miyake, Ayako Nakashita, Makiko Kitamura, Emi Okazaki, Takuya Yoshiike, Kentaro Matsui, Kenichi Kuriyama, Daisuke Nishi, Naoaki Kuroda","doi":"10.1007/s41105-025-00629-1","DOIUrl":"https://doi.org/10.1007/s41105-025-00629-1","url":null,"abstract":"<p><p>Nonrestorative sleep (NRS) may contribute to the persistence of post-acute sequelae of COVID-19 (PASC), but no longitudinal studies have investigated this relationship. This study examined the association between NRS and PASC persistence over one year.This was a one-year prospective cohort study conducted using an online survey. We conducted a one-year prospective cohort study through an online survey between September 2022 (Time 1, T1) and September 2023 (Time 2, T2). Eligible patients were adults aged 18 years or older who had experienced COVID-19 infection after February 2022 and were more than one month post-infection with at least one PASC symptom. NRS, difficulty initiating sleep (DIS), difficulty maintaining sleep (DMS), and early morning awaking (EMA) were evaluated at T1. PASC persistence was evaluated at T2. Relative risk ratio calculations with multiple imputations were performed to examine associations between sleep disturbances and PASC.Among 957 participants with PASC at baseline, 559 (58.4%) completed the follow-up assessment. NRS at T1 was associated with PASC persistence at T2 (Relative Risk = 1.33, 95% confidence interval = 1.08 - 1.64). In contrast, DIS, DMS, and EMA showed no significant associations with PASC persistence. Sensitivity analyses using different NRS thresholds yielded consistent trends. This study suggests that NRS may partly contribute to PASC persistence through a potentially distinct mechanism from DIS, DMS, and EMA.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 2","pages":"291-298"},"PeriodicalIF":1.3,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147676767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}