{"title":"Association between sleep disorders and osteoporosis in the elderly at high altitude in China.","authors":"Chun Feng","doi":"10.1007/s41105-025-00579-8","DOIUrl":null,"url":null,"abstract":"<p><p>Sleep disorders and osteoporosis frequently co-occur in the elderly, especially among those living at high altitudes. This study aimed to investigate the association between sleep disorders and osteoporosis among elderly residents of high-altitude regions in China. We conducted a cross-sectional analysis from January 2021 to January 2023, enrolling 160 elderly participants aged 60 years and older from high-altitude areas. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI), and osteoporosis was diagnosed using dual-energy X-ray absorptiometry (DEXA). Demographic data, blood parameters, and pulmonary artery pressure were collected. Statistical analyses included descriptive statistics, correlation analysis, and logistic regression to determine the independent association between sleep disorders and osteoporosis, adjusting for potential confounders. Osteoporosis was prevalent in 65% of the participants, with 75% of those also having sleep disorders. A significant negative correlation was found between sleep quality and bone density (ρ = -0.65, P < 0.001), suggesting a positive relationship between the severity of sleep disorders and the risk of osteoporosis. Multivariate logistic regression analysis revealed a significant association between sleep disorders and the presence of osteoporosis (OR = 1.67, 95% CI: 1.20-2.20, P = 0.001). Subgroup analyses showed stronger associations in females (OR = 2.20, 95% CI: 1.50-3.20, P < 0.001) and participants aged over 70 years (OR = 2.00, 95% CI: 1.30-3.10, P = 0.002). Significant correlations were also observed in participants with oxygen saturation below 85% (OR = 2.50, 95% CI: 1.60-3.90, P < 0.001) and those with elevated pulmonary artery pressure (OR = 2.80, 95% CI: 1.80-4.30, P < 0.001). Sleep disorders are significantly associated with osteoporosis in the elderly at high altitudes, with physiological variables in this environment potentially exacerbating this relationship.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"23 3","pages":"313-318"},"PeriodicalIF":1.3000,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173966/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sleep and Biological Rhythms","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s41105-025-00579-8","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Sleep disorders and osteoporosis frequently co-occur in the elderly, especially among those living at high altitudes. This study aimed to investigate the association between sleep disorders and osteoporosis among elderly residents of high-altitude regions in China. We conducted a cross-sectional analysis from January 2021 to January 2023, enrolling 160 elderly participants aged 60 years and older from high-altitude areas. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI), and osteoporosis was diagnosed using dual-energy X-ray absorptiometry (DEXA). Demographic data, blood parameters, and pulmonary artery pressure were collected. Statistical analyses included descriptive statistics, correlation analysis, and logistic regression to determine the independent association between sleep disorders and osteoporosis, adjusting for potential confounders. Osteoporosis was prevalent in 65% of the participants, with 75% of those also having sleep disorders. A significant negative correlation was found between sleep quality and bone density (ρ = -0.65, P < 0.001), suggesting a positive relationship between the severity of sleep disorders and the risk of osteoporosis. Multivariate logistic regression analysis revealed a significant association between sleep disorders and the presence of osteoporosis (OR = 1.67, 95% CI: 1.20-2.20, P = 0.001). Subgroup analyses showed stronger associations in females (OR = 2.20, 95% CI: 1.50-3.20, P < 0.001) and participants aged over 70 years (OR = 2.00, 95% CI: 1.30-3.10, P = 0.002). Significant correlations were also observed in participants with oxygen saturation below 85% (OR = 2.50, 95% CI: 1.60-3.90, P < 0.001) and those with elevated pulmonary artery pressure (OR = 2.80, 95% CI: 1.80-4.30, P < 0.001). Sleep disorders are significantly associated with osteoporosis in the elderly at high altitudes, with physiological variables in this environment potentially exacerbating this relationship.
睡眠障碍和骨质疏松症经常同时发生在老年人中,特别是生活在高海拔地区的老年人。本研究旨在探讨中国高海拔地区老年居民睡眠障碍与骨质疏松症的关系。我们从2021年1月至2023年1月进行了横断面分析,招募了160名来自高海拔地区的60岁及以上的老年人。采用匹兹堡睡眠质量指数(PSQI)评估睡眠质量,采用双能x线吸收仪(DEXA)诊断骨质疏松症。收集人口统计数据、血液参数和肺动脉压。统计分析包括描述性统计、相关分析和逻辑回归,以确定睡眠障碍和骨质疏松症之间的独立关联,并调整潜在的混杂因素。65%的参与者普遍患有骨质疏松症,其中75%的人还患有睡眠障碍。睡眠质量与骨密度呈显著负相关(ρ = -0.65, P
期刊介绍:
Sleep and Biological Rhythms is a quarterly peer-reviewed publication dealing with medical treatments relating to sleep. The journal publishies original articles, short papers, commentaries and the occasional reviews. In scope the journal covers mechanisms of sleep and wakefullness from the ranging perspectives of basic science, medicine, dentistry, pharmacology, psychology, engineering, public health and related branches of the social sciences