Sleep and Breathing最新文献

{"title":"Asthma and sleep disordered breathing in the pediatric adenotonsillectomy trial for snoring study.","authors":"Po-Yang Tsou, Seyni Gueye-Ndiaye, Krysta Lynn Gorman, Ariel Williamson, Sally Ibrahim, Scott Weber, David Zopf, Fauziya Hassan, Cristina Baldassari, Carlos Sendon, Rui Wang, Susan Redline, Dongdong Li, Kristie R Ross","doi":"10.1007/s11325-024-03210-1","DOIUrl":"10.1007/s11325-024-03210-1","url":null,"abstract":"<p><strong>Purpose: </strong>Although asthma is common in children with sleep-disordered breathing (SDB), it is unclear whether and to what extent asthma is associated with SDB-related outcomes. Our objectives are to describe risk factors for asthma among children with mild SDB (mSDB) and assess the association between asthma and the severity of sleep-related outcomes.</p><p><strong>Methods: </strong>Cross-sectional analyses were conducted for children aged 3-12.9 years with mSDB enrolled in Pediatric Adenotonsillectomy for Snoring Children Study. Sleep-related outcomes included SDB symptoms (Pediatric Sleep Questionnaire-Sleep-Related Breathing Disorder scale (PSQ-SRBD)), SDB-specific quality of life (OSA-18), sleepiness (modified Epworth Sleepiness Score) and polysomnographic and actigraphic measures. Asthma was defined by caregiver-reported diagnosis with current asthma symptoms and medication use, or a Composite Asthma Severity Index (CASI) score ≥ 4. Asthma was further categorized into mild (CASI < 4) and moderate-to-severe (CASI ≥ 4). Regression analyses were conducted to identify asthma risk factors and estimate the associations between mild and moderate-to-severe asthma with sleep-related outcomes.</p><p><strong>Results: </strong>The sample included 425 children (20.3%-Black, 17.4%-Hispanic; 51.7%-female). The prevalence of asthma was 19.1% (7.1% moderate-to-severe, 12.0% mild). Environmental tobacco smoke exposure and markers of atopy were associated with asthma in multivariable-adjusted analyses. Moderate-to-severe asthma was associated with increased OSA symptoms measured by PSQ-SRBD (adjusted effect estimate for moderate-to-severe vs. no asthma ( <math><mover><mi>β</mi> <mo>^</mo></mover> </math> _adj; 95%CI): 0.08; 0.01, 0.15)) and decreased quality of life measured by OSA-18 ( <math><mover><mi>β</mi> <mo>^</mo></mover> </math> _adj; 95%CI: 7.5; 1.20, 13.82)), and a small increase in the arousal index ( <math><mover><mi>β</mi> <mo>^</mo></mover> </math> _adj; 95%CI: 0.80; 0.09, 1.51)).</p><p><strong>Conclusion: </strong>Moderate-to-severe asthma was associated with worse QoL and greater SDB symptoms among children with mSDB. The co-occurrence of common risk factors for mSDB and asthma and worse symptoms and quality of life in children with both conditions support coordinated strategies for prevention and co-management of both disorders.</p><p><strong>Clinical trial: </strong>Pediatric Adenotonsillectomy for Snoring (PATS), NCT02562040, https://clinicaltrials.gov/study/NCT02562040.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"46"},"PeriodicalIF":2.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing sleep metrics in stroke survivors: a comparison between objective and subjective measures.","authors":"Temmy L T Lo, Ian C H Leung, Lydia L W Leung, Paul P Y Chan, Rainbow T H Ho","doi":"10.1007/s11325-024-03212-z","DOIUrl":"10.1007/s11325-024-03212-z","url":null,"abstract":"<p><strong>Introduction: </strong>Stroke survivors are at risk of sleep disturbance, which can be reflected in discrepancies between objective and subjective sleep measures. Given there are limited studies on this phenomenon and using portable monitoring devices is more convenient for stroke survivors to monitor their sleep, this study aimed to compare objectively measured (Belun Ring) and subjectively reported (sleep diary) sleep metrics (total sleep time (TST) and wakefulness after sleep onset (WASO)) in stroke survivors.</p><p><strong>Methods: </strong>In this cross-sectional study, thirty-five participants wore a ring-shaped pulse oximeter (Belun Ring) and kept a sleep diary for three consecutive nights in one week. The effects of various factors on TST and WASO were analyzed by linear mixed models. Systematic bias between two measures was examined by the Bland-Altman analysis.</p><p><strong>Results: </strong>TST and WASO were significantly affected by measures (p <.001), but not night. TST was significantly lower and WASO was significantly higher in the Belun Ring than in the sleep diary (p <.05). Age was the only covariate that had a significant effect on WASO (p <.05). The Bland-Altman analysis demonstrated positive bias in TST (29.55%; 95% CI [16.57%, 42.53%]) and negative bias in WASO (-117.35%; 95% CI [-137.65%, -97.06%]). Proportional bias was exhibited in WASO only (r =.31, p <.05).</p><p><strong>Conclusion: </strong>The findings revealed discrepancies between objective and subjective sleep measures in stroke survivors. It is recommended that objective measures be included when assessing and monitoring their sleep conditions.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"45"},"PeriodicalIF":2.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific impact of obstructive sleep apnea on peripheral blood mononuclear cells.","authors":"Joshua M Bock, Soumya Vungarala, Sreeja Sompalli, Prachi Singh, Kevin D Pavelko, Richard B Kennedy, Virend K Somers","doi":"10.1007/s11325-024-03201-2","DOIUrl":"10.1007/s11325-024-03201-2","url":null,"abstract":"<p><strong>Purpose: </strong>Experimental sleep disruption in healthy adults is more deleterious to immune function in females relative to males; however, it remains unknown if this translates to patients with obstructive sleep apnea (OSA). Thus, this study explored sex differences in peripheral blood mononuclear cells (PBMCs) from patients with untreated OSA.</p><p><strong>Methods: </strong>Participants completed sleep studies to identify the presence of OSA via the apnea-hypopnea index (AHI). PBMCs were isolated, cryopreserved, and batch phenotyped via mass cytometry.</p><p><strong>Results: </strong>Females with (n = 6, AHI = 25.9 ± 21.4 events/hr, age = 37 ± 14yrs, BMI = 30.5 ± 7.4 kg/m²) and without (n = 9, AHI = 2.6 ± 1.6 events/hr, age = 35 ± 10yrs, BMI = 29.2 ± 6.3 kg/m²) OSA were compared to males with (n = 7, AHI = 13.7 ± 8.5 events/hr, age = 33 ± 11yrs, BMI = 30.0 ± 4.8 kg/m²) and without (n = 7, AHI = 2.6 ± 1.6 events/hr, age = 33 ± 10yrs, BMI = 28.9 ± 3.8 kg/m²) OSA. No significant group-by-sex interactions were observed in CD3 T cells (p = 0.273), CD8 T cells (p = 0.656), B cells (p = 0.190), monocytes (p = 0.638), nor granulocytes (p = 0.267) expressed as a percent of their respective parent population. While the percentage of total NK cells did not differ between groups (group-by-sex p = 0.822), females with OSA had fewer CD57^- (42.4 ± 14.7 vs. 62.4 ± 10.4%) and more CD57⁺ (57.6 ± 14.7 vs. 37.6 ± 10.4%) NK cells than females without OSA (p < 0.050). No differences in CD57^- (53.6 ± 18.1 vs. 44.9 ± 16.8%) and CD57⁺ (46.4 ± 18.1 vs. 55.2 ± 19.8%) NK cells were observed between males (p = 0.283). Tregs were more prevalent in females with vs. females without OSA (2.17 ± 0.64 vs. 1.31 ± 0.41%, p = 0.006) with no difference between males (1.55 ± 0.50 vs. 1.71 ± 0.71%, p = 0.601).</p><p><strong>Conclusions: </strong>Our data suggest that OSA increases the prevalence of cytotoxic NK cells and Tregs in females. The causes and downstream effects of these changes remain undetermined.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"44"},"PeriodicalIF":2.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of pillow height on neck muscle activity: a pilot study.","authors":"Rui Jiao, Wenwu Xiao, Mingjun Wang, Shufang Yu, Hai Li","doi":"10.1007/s11325-024-03219-6","DOIUrl":"https://doi.org/10.1007/s11325-024-03219-6","url":null,"abstract":"<p><strong>Purpose: </strong>Muscle relaxation in the neck during sleep is crucial for achieving quality sleep, and varying pillow heights can significantly influence the myoelectric activity of the neck muscles. This study aims to investigate the effects of different pillow heights on neck muscle activity, with the goal of providing evidence-based recommendations for pillow selection.</p><p><strong>Methods: </strong>A total of 15 asymptomatic participants in this study, aged 18 to 30, were assigned to three groups based on pillow height: height 1 (0.5*Shoulder width), height 2 (1.0*Shoulder width), and height 3 (1.5*Shoulder width). Electromyography (EMG) was employed to measure muscle activity in the sternocleidomastoid and trapezius muscles during lateral sleeping positions. Sleep comfort was evaluated using a 100 mm visual analog scale (VAS). Statistical analysis was conducted using ANOVA to assess the differences in muscle activity and comfort levels across the various pillow heights.</p><p><strong>Results: </strong>The muscle activation levels revealed that both the sternocleidomastoid and trapezius muscle exhibited the lowest EMG activity in the height 2 (p < 0.001). In contrast, the sternocleidomastoid muscle recorded the highest activation, demonstrating significantly greater average electromyography (AEMG) and integrated electromyography (iEMG) at height 1 (p < 0.001). Meanwhile, the trapezius muscle showed the highest AEMG at height 3 (p < 0.001). Additionally, height 2 was identified as the most comfortable option when compared to height 1 and 3 (p < 0.001).</p><p><strong>Conclusions: </strong>This study concludes that varying pillow heights are linked to neck muscle activity and sleep comfort. These findings underscore the importance of an appropriate pillow height to maintain a healthy cervical spine and promote restful sleep.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"40"},"PeriodicalIF":2.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In memoriam Michael Breitenbach.","authors":"Nikolaus Netzer, Mark Rinnerthaler","doi":"10.1007/s11325-024-03213-y","DOIUrl":"https://doi.org/10.1007/s11325-024-03213-y","url":null,"abstract":"","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"39"},"PeriodicalIF":2.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring sociodemographic moderators of the association between sleep duration and self-rated health.","authors":"Olatokunbo Osibogun","doi":"10.1007/s11325-024-03199-7","DOIUrl":"https://doi.org/10.1007/s11325-024-03199-7","url":null,"abstract":"<p><strong>Objective: </strong>This study examined the association of sleep duration with self-rated health (SRH) and if age, sex, and race/ethnicity modifies this association.</p><p><strong>Methods: </strong>This was a cross-sectional analysis of 396,455 adults who were aged ≥ 18 years in the 2020 Behavioral Risk Factor Surveillance System. Sleep duration was categorized into three: short (< 7 h), normal (7-9 h; reference), and long (> 9 h). SRH was dichotomized into suboptimal (fair/poor; reference) and optimal (excellent/very good/good). Logistic regression models were employed to investigate the association and assess interactions of age, sex, and race/ethnicity with sleep duration.</p><p><strong>Results: </strong>Short (adjusted odds ratio: 0.70 [95% confidence interval 0.66-0.74]) and long (0.65 [0.58-0.73]) sleep duration was associated with decreased odds of optimal SRH. There was a significant interaction between age and sleep duration (p = 0.029). The association between short sleep duration and SRH was strongest in the youngest age (18-24; 0.59 [0.47-0.74]), while 35-44 (0.57 [0.39-0.82] had the strongest association for long sleep duration with SRH. No significant interactions were found for sex (p = 0.314) or race/ethnicity (p = 0.930).</p><p><strong>Conclusion: </strong>Short and long sleep duration are associated with decreased odds of optimal SRH among US adults. Prioritizing sleep hygiene across all ages may improve SRH.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"42"},"PeriodicalIF":2.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep quality and risk of obstructive sleep apnea among breast cancer survivors with and without lymphedema.","authors":"Masood Soltanipur, Hossein Yarmohammadi, Fereshteh Abbasvandi, Ali Montazeri, Zahra Sheikhi","doi":"10.1007/s11325-024-03223-w","DOIUrl":"https://doi.org/10.1007/s11325-024-03223-w","url":null,"abstract":"<p><strong>Purpose: </strong>Breast cancer survivors (BCSs) tend to have sleep disturbances such as obstructive sleep apnea (OSA). However, limited evidence exists on the role of breast cancer-related lymphedema (BCRL) in sleep disturbances and OSA. Therefore, this study aimed to investigate the quality of sleep (QoS) and OSA risk among women with and without BCRL.</p><p><strong>Methods: </strong>The quality of life (QoL) was evaluated using the SF-12 and EORTC-QLQ C-30 questionnaires, while their sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. The STOP-bang questionnaire (SBQ) was utilized to quantify OSA risk. Sleepiness was assessed using the Epworth Sleepiness Scale (ESS). Also, neck and waist circumference and the excessive volume in the affected limb were measured using a tape measure. The statistical analyses were performed using the SPSS 21.0 software.</p><p><strong>Results: </strong>Seventy-one women with BCRL and 84 BCS without lymphedema were included. The comparison of PSQI, SBQ, ESS, SF-12, and EORTC QLQ-C30 questionnaires exhibited no significant difference between these two groups. The overnight snoring and average neck circumference were significantly higher in the BCRL group than in the control. The BCRL stage significantly correlated with neck circumference and SBQ total score. Additionally, the mean volume difference indicated a significant correlation with the ESS total score and both physical and mental summary components of the SF-12 questionnaire.</p><p><strong>Conclusion: </strong>The prevalence of sleep disturbances among BCSs with and without BCRL is high. Women with advanced stages of BCRL might be at high risk for OSA. Therefore clinical evaluation of BMI, neck circumference, and, snoring overnight should be emphasized among this population.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"41"},"PeriodicalIF":2.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exogenous H₂S targeting PI3K/AKT/mTOR pathway alleviates chronic intermittent hypoxia-induced myocardial damage through inhibiting oxidative stress and enhancing autophagy.","authors":"Xiao-Bin Zheng, Chao Wang, Ming Zhang, Bing-Qi Yao, Hai-Yan Wu, Shu-Xian Hou","doi":"10.1007/s11325-024-03216-9","DOIUrl":"https://doi.org/10.1007/s11325-024-03216-9","url":null,"abstract":"<p><strong>Aims: </strong>Hydrogen sulfide (H₂S) is a novel gas signaling molecule that has been researched in several physiological and pathological conditions, indicating that strategies targeting H₂S may provide clinical benefits in diseases such as chronic cardiomyopathy. Here, we reveal the effect of H₂S on chronic intermittent hypoxia (CIH)-related myocardial damage and its mechanistic relevance to phosphoinositol-3 kinase (PI3K).</p><p><strong>Materials: </strong>Mice were subjected to a 4-week CIH process to induce myocardial damage, which was accompanied by daily administration of NaHS (a H₂S donor) and LY294002 (an inhibitor of PI3K). Changes in heart function were evaluated via echocardiography. Histological examination was applied to assess heart tissue lesions. Myocardial apoptosis was detected by TUNEL staining and apoptosis-associated protein expression. Furthermore, the effects of NaHS on autophagy and the PI3K/AKT/mTOR pathway were investigated. Finally, the level of inflammation is also affected by related proteins.</p><p><strong>Key findings: </strong>The CIH group presented increased myocardial dysfunction and heart tissue lesions. Echocardiography and histological analysis revealed that, compared with control mice, CIH-treated mice presented significantly more severe left ventricular remodeling and decreased myocardial contractile function. In addition, the apoptosis index and oxidative markers were significantly elevated in the CIH group compared with those in the control group. The autophagy marker Beclin-1 was decreased, while p62 was elevated by CIH treatment. H₂S supplementation with NaHS significantly improved cardiac function and alleviated fibrosis, oxidative stress, and apoptosis but upregulated autophagy in CIH mice, and these effects were also observed in animals that underwent only PI3K blockade. Furthermore, PI3K/AKT pathway-mediated inhibition of the mammalian target of rapamycin (mTOR) pathway, the Nrf2/HO-1 pathway and proinflammatory NF-κB activity were shown to play a role in the therapeutic effect of NaHS after CIH stimulation.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"43"},"PeriodicalIF":2.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential impact of new remodelling intrapharynegal OSA surgery on sleep architecture: a preliminary investigation.","authors":"Antonio Moffa, Lucrezia Giorgi, Domiziana Nardelli, Francesco Iafrati, Giannicola Iannella, Rodolfo Lugo, Peter M Baptista, Claudio Vicini, Manuele Casale","doi":"10.1007/s11325-024-03222-x","DOIUrl":"https://doi.org/10.1007/s11325-024-03222-x","url":null,"abstract":"<p><strong>Purpose: </strong>Patients with Obstructive Sleep Apnea (OSA) often experience poor sleep quality and excessive daytime sleepiness, which significantly affect their daily lives. Among the therapeutic options, Barbed Pharyngoplasty (BP) is widely used, showing an overall improvement in the primary efficacy parameters. However, the impact of this surgical intervention on sleep architecture remains unclear. The purpose of this study is to assess potential changes in sleep architecture in patients with moderate to severe OSA who have successfully undergone BP.</p><p><strong>Methods: </strong>Adult patients affected by moderate-severe OSA who underwent Alianza BP were enrolled. Each patient underwent polysomnography preoperatively and six months postoperatively, using the WatchPAT device for consistent data acquisition.</p><p><strong>Results: </strong>This study enrolled 27 patients. Although not statistically significant, improvements were observed in Total Sleep Time (TST), Sleep Efficiency, REM, light, and deep sleep, significant improvements were noted in the Apnea-Hypopnea Index (AHI), Oxygen Desaturation Index (ODI), Respiratory Disturbance Index (RDI), and Epworth Sleepiness Scale (ESS). Positive correlations were found between AHI improvement and changes in light sleep and negative correlations with deep sleep. ODI and RDI improvement correlated positively with light sleep and negatively with deep and REM sleep. No correlations were found between these indices and TST and sleep efficiency.</p><p><strong>Conclusion: </strong>A noteworthy correlation was found between AHI improvement and changes in sleep stages. Increased AHI gain and surgical success were associated with improved deep sleep and reduced light sleep, even though REM sleep remained relatively unchanged. Indeed, BP could be a valid surgical option for improving sleep architecture, by promoting better sleep quality.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 1","pages":"38"},"PeriodicalIF":2.1,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of snoring on the risk of stroke in patients with diabetes mellitus.","authors":"Eujene Jung, U Chul Ju, Hyun Ho Ryu, Hyun Lee Kim","doi":"10.1007/s11325-024-03131-z","DOIUrl":"10.1007/s11325-024-03131-z","url":null,"abstract":"<p><strong>Background: </strong>The impact of snoring and diabetes on stroke risk is unclear. This study examined the association between snoring and stroke risk and how it varies with diabetes mellitus (DM) status.</p><p><strong>Methods: </strong>This research was conducted as a prospective cohort study. A total of 4,352 subjects were included in the analysis, with a mean follow-up time of 13.7 years. The study used snoring history obtained through interviews as the primary exposure variable and DM as the secondary exposure variable. The main outcome measured was the occurrence of stroke. Cox regression analysis was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Additionally, a joint test was conducted to evaluate the combined effect of snoring and diabetes on the occurrence of stroke.</p><p><strong>Results: </strong>In our study of 4,352 subjects, 1,135 (26.1%) had a history of snoring, 233 (5.4%) had diabetes mellitus, and over the 18-year observation period, there were 168 cases of new-onset stroke. Snoring was not associated with an increased risk of stroke (HR: 0.95, 95% CI [0.68-1.33]), but DM significantly elevated the risk of stroke (3.02 [1.96-4.65]). In the interaction analysis of snoring and DM status on stroke risk, snoring was a significant risk factor for stroke only in the population with DM (2.89 [1.07-7.60]). Compared to non-snoring and non-DM, the multivariate HRs for stroke were 1.09 (0.76-1.57) for snoring and non-DM, 1.64 (0.83-2.82) for non-snoring and DM, and 2.95 (1.42-5.45) for snoring and DM.</p><p><strong>Conclusion: </strong>Diabetes mellitus was associated with an increased risk of stroke, while a history of snoring was not. In a sub analysis, snoring appeared to be associated with an increased risk of stroke among subjects with diabetes mellitus.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":" ","pages":"2675-2682"},"PeriodicalIF":4.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}