The potential impact of new remodelling intrapharynegal OSA surgery on sleep architecture: a preliminary investigation.

IF 2.1 4区 医学 Q3 CLINICAL NEUROLOGY
Antonio Moffa, Lucrezia Giorgi, Domiziana Nardelli, Francesco Iafrati, Giannicola Iannella, Rodolfo Lugo, Peter M Baptista, Claudio Vicini, Manuele Casale
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Abstract

Purpose: Patients with Obstructive Sleep Apnea (OSA) often experience poor sleep quality and excessive daytime sleepiness, which significantly affect their daily lives. Among the therapeutic options, Barbed Pharyngoplasty (BP) is widely used, showing an overall improvement in the primary efficacy parameters. However, the impact of this surgical intervention on sleep architecture remains unclear. The purpose of this study is to assess potential changes in sleep architecture in patients with moderate to severe OSA who have successfully undergone BP.

Methods: Adult patients affected by moderate-severe OSA who underwent Alianza BP were enrolled. Each patient underwent polysomnography preoperatively and six months postoperatively, using the WatchPAT device for consistent data acquisition.

Results: This study enrolled 27 patients. Although not statistically significant, improvements were observed in Total Sleep Time (TST), Sleep Efficiency, REM, light, and deep sleep, significant improvements were noted in the Apnea-Hypopnea Index (AHI), Oxygen Desaturation Index (ODI), Respiratory Disturbance Index (RDI), and Epworth Sleepiness Scale (ESS). Positive correlations were found between AHI improvement and changes in light sleep and negative correlations with deep sleep. ODI and RDI improvement correlated positively with light sleep and negatively with deep and REM sleep. No correlations were found between these indices and TST and sleep efficiency.

Conclusion: A noteworthy correlation was found between AHI improvement and changes in sleep stages. Increased AHI gain and surgical success were associated with improved deep sleep and reduced light sleep, even though REM sleep remained relatively unchanged. Indeed, BP could be a valid surgical option for improving sleep architecture, by promoting better sleep quality.

新型重塑型咽内呼吸暂停手术对睡眠结构的潜在影响:初步研究。
目的:阻塞性睡眠呼吸暂停(OSA)患者睡眠质量差,白天嗜睡严重,严重影响其日常生活。在治疗方案中,Barbed Pharyngoplasty (BP)被广泛使用,在主要疗效指标上显示出整体的改善。然而,这种手术干预对睡眠结构的影响尚不清楚。本研究的目的是评估成功行BP手术的中重度OSA患者睡眠结构的潜在变化。方法:纳入接受Alianza BP治疗的成人中重度OSA患者。每位患者术前和术后6个月接受多导睡眠图检查,使用WatchPAT设备进行一致的数据采集。结果:本研究纳入了27例患者。总睡眠时间(TST)、睡眠效率、快速眼动(REM)、浅睡眠和深度睡眠均有显著改善,呼吸暂停低通气指数(AHI)、氧去饱和指数(ODI)、呼吸障碍指数(RDI)和Epworth嗜睡量表(ESS)均有显著改善。AHI改善与轻度睡眠变化呈正相关,与深度睡眠变化呈负相关。ODI和RDI的改善与轻度睡眠呈正相关,与深度和快速眼动睡眠负相关。这些指标与TST和睡眠效率无相关性。结论:AHI改善与睡眠阶段改变之间存在显著相关性。AHI增加和手术成功与深度睡眠改善和浅睡眠减少有关,即使快速眼动睡眠保持相对不变。事实上,通过促进更好的睡眠质量,BP可能是改善睡眠结构的有效手术选择。
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来源期刊
Sleep and Breathing
Sleep and Breathing 医学-呼吸系统
CiteScore
5.20
自引率
4.00%
发文量
222
审稿时长
3-8 weeks
期刊介绍: The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep. Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.
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